LOCUS       XM_054321049            1752 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens pregnancy specific beta-1-glycoprotein 8
            (PSG8), transcript variant X1, mRNA.
ACCESSION   XM_054321049
VERSION     XM_054321049.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060943) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..1752
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="pregnancy specific beta-1-glycoprotein 8; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 10 ESTs, 9 long SRA reads, 3 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:440533"
                     /db_xref="HGNC:HGNC:9525"
                     /db_xref="MIM:176397"
     CDS             98..1078
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /codon_start=1
                     /product="pregnancy-specific beta-1-glycoprotein 8 isoform
                     X1"
                     /protein_id="XP_054177024.1"
                     /db_xref="GeneID:440533"
                     /db_xref="HGNC:HGNC:9525"
                     /db_xref="MIM:176397"
                     /translation="

MGLLSAPPCTQRITWKGLLLTASLLNFWNPPTTAQVTIEAQPTKVSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETIYSNASLLIQNVTQEDAGSYTLHIIMGGDENRGVTGHFTFTLYLETPKPSISSSKLNPREAMEAVSLTCDPETPDASYLWWMNGQSLPMSHRLQLSETNRTLFLLGVTKYTAGPYECEIRNPVSASRSDPFTLNLLHGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLFIPQITTKHSGLYACSVRNSATGKESSKSMTVKVSDWTLP"

     misc_feature    203..472
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="First immunoglobulin (Ig)-like domain of
                     carcinoembryonic antigen (CEA) related cell adhesion
                     molecule (CEACAM); Region: IgV_CEACAM_D1; cd05774"
                     /db_xref="CDD:409430"
     misc_feature    206..262
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="FR1 [structural motif]; Region: FR1"
                     /db_xref="CDD:409430"
     misc_feature    206..214
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409430"
     misc_feature    227..235
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409430"
     misc_feature    242..265
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409430"
     misc_feature    263..286
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="CDR1 [structural motif]; Region: CDR1"
                     /db_xref="CDD:409430"
     misc_feature    287..304
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="FR2 [structural motif]; Region: FR2"
                     /db_xref="CDD:409430"
     misc_feature    287..301
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409430"
     misc_feature    305..370
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="CDR2 [structural motif]; Region: CDR2"
                     /db_xref="CDD:409430"
     misc_feature    329..346
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409430"
     misc_feature    359..370
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409430"
     misc_feature    389..469
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="FR3 [structural motif]; Region: FR3"
                     /db_xref="CDD:409430"
     misc_feature    389..406
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409430"
     misc_feature    410..424
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409430"
     misc_feature    <416..535
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:448366"
     misc_feature    452..469
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409430"
     misc_feature    452..469
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    512..523
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    539..805
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Immunoglobulin (Ig)-like domain of human
                     carcinoembryonic antigen (CEA) related cell adhesion
                     molecule (CEACAM) domains 2, 4, and 6, and similar
                     domains; Region: IgI_hCEACAM_2_4_6_like; cd05740"
                     /db_xref="CDD:409402"
     misc_feature    539..553
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409402"
     misc_feature    560..577
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand A' [structural motif]; Region: Ig strand
                     A'"
                     /db_xref="CDD:409402"
     misc_feature    590..610
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409402"
     misc_feature    629..646
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409402"
     misc_feature    650..661
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409402"
     misc_feature    671..685
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand D [structural motif]; Region: Ig strand
                     D"
                     /db_xref="CDD:409402"
     misc_feature    692..709
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409402"
     misc_feature    737..763
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409402"
     misc_feature    773..802
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409402"
     misc_feature    830..1057
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Fifth immunoglobulin (Ig)-like domain of the
                     carcinoembryonic antigen (CEA) related cell adhesion
                     molecule 5 (CEACAM5) and similar domains; member of the
                     C2-set IgSF domains; Region: IgC2_CEACAM5-like; cd20948"
                     /db_xref="CDD:409540"
     misc_feature    830..850
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand A [structural motif]; Region: Ig strand
                     A"
                     /db_xref="CDD:409540"
     misc_feature    863..886
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409540"
     misc_feature    902..922
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409540"
     misc_feature    929..946
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand C' [structural motif]; Region: Ig strand
                     C'"
                     /db_xref="CDD:409540"
     misc_feature    953..973
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409540"
     misc_feature    980..1015
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409540"
     misc_feature    1022..1057
                     /gene="PSG8"
                     /gene_synonym="PSG1"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409540"
ORIGIN      

agaaggaggcaggacagcactgctgagagctgtgctcaggaagcttctggatcctaggctcatctccacagaggagaacacacagacagcagagaccatggggctcctctcagcccctccctgcacacagcgcatcacctggaaggggctcctgctcacagcatcacttttaaacttctggaacccacccacgactgcccaagtcacgattgaagcccagccaaccaaagtttctgaggggaaggatgttcttctacttgtccacaatttgccccagaatcttactggctacatctggtacaaagggcaaatcagggacctctaccattacattacatcatatgtagtagacggtcaaataattatatatgggcctgcatacagtggacgagaaacaatatattccaatgcatccctgctgatccagaatgtcacccaggaagacgcaggatcctacaccttacacatcataatgggaggtgatgagaatagaggagtaactggacatttcaccttcaccttatatctggagactcccaagccctccatctccagcagcaaattaaaccccagggaggccatggaggctgtgagcttaacctgtgatcctgagactccggacgcaagctacctgtggtggatgaatggtcagagcctccctatgtctcacaggttgcagttgtctgaaaccaacaggaccctctttctattgggtgtcacaaagtacactgcaggaccctatgaatgtgaaatacggaacccagtgagtgccagccgcagtgacccattcaccctgaatctcctccatggtccagacctccccagaatttacccttcattcacctattaccgttcaggagaagtcctctacttgtcctgttctgcggactctaacccaccggcacagtattcttggacaattaatgggaagtttcagctatcaggacaaaagctctttatcccccaaattactacaaagcatagcgggctctatgcttgctctgttcgtaactcagccactggcaaggaaagctccaaatccatgacagtaaaagtctctgactggacattaccctgaattctactagttcctccaattccattttcttccatggaatcgctaagaaaaagacccactctgttccagaagccctataagctggaggtggacaactcaatgtaaatttcatgggaaaacccttgtacctgaagcgtgagccactcagaactcactaaaatgttcgacaccataacaacagatgctcaaactgtaaaccaggacaacaagtggatgacttcacactgtggacagtttttcccaagatgtcagaacaagactccccatcatgatgaggctctcacccctcttaactgtccttgctcatgcctgcctctttcacttggcaggataatgcagtcattagaatttcacatgtagtagcttctgagggtaacaatagagtgtcagatatgtcatctcaacccaaacttttacataacatctcagggggaaatgtggctctctccaccttgcatacaggactcccaatagaaatgaacacagagatattgcccgtgtgtttgcagataagatggtttctatgaagaggtaggaaagctgaaattataatagagtcccctttaaatgcacattctgtggatggctctcgccatttcctaagagatacattgtaaaatgtgacagtaatactgattctagcagaataaaacatgtaccacatttgctaatac

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