LOCUS       XM_054321018            3285 bp    mRNA    linear   PRI 05-OCT-2023
DEFINITION  PREDICTED: Homo sapiens luteinizing hormone subunit beta (LHB),
            transcript variant X1, mRNA.
ACCESSION   XM_054321018
VERSION     XM_054321018.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060943) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2023_10
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 10/02/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..3285
                     /gene="LHB"
                     /gene_synonym="CGB4; HH23; LSH-B; LSH-beta"
                     /note="luteinizing hormone subunit beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 6 ESTs, 6 long SRA reads, 8 Proteins, and 89% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 24 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:3972"
                     /db_xref="HGNC:HGNC:6584"
                     /db_xref="MIM:152780"
     CDS             2724..3197
                     /gene="LHB"
                     /gene_synonym="CGB4; HH23; LSH-B; LSH-beta"
                     /codon_start=1
                     /product="lutropin subunit beta isoform X1"
                     /protein_id="XP_054176993.1"
                     /db_xref="GeneID:3972"
                     /db_xref="HGNC:HGNC:6584"
                     /db_xref="MIM:152780"
                     /translation="

MGRPGLGAAVSDPGEAVSLSQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL"

     misc_feature    2844..3164
                     /gene="LHB"
                     /gene_synonym="CGB4; HH23; LSH-B; LSH-beta"
                     /note="Glycoprotein hormone beta chain homologues; Region:
                     GHB; smart00068"
                     /db_xref="CDD:214502"
     misc_feature    order(2856..2858,2931..2933,2943..2945,3000..3002,
                     3093..3095,3099..3101)
                     /gene="LHB"
                     /gene_synonym="CGB4; HH23; LSH-B; LSH-beta"
                     /note="cysteine knot motif; other site"
                     /db_xref="CDD:200450"
     misc_feature    order(2877..2879,2886..2888,2928..2969,2997..3002,
                     3108..3110,3114..3116,3123..3140)
                     /gene="LHB"
                     /gene_synonym="CGB4; HH23; LSH-B; LSH-beta"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:200450"
     misc_feature    order(2967..2969,3114..3119,3126..3128,3132..3140)
                     /gene="LHB"
                     /gene_synonym="CGB4; HH23; LSH-B; LSH-beta"
                     /note="receptor binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:200450"
ORIGIN      

aggccaggccagaaggaccagggactacaaactcaccttcagggctcctaagctgctgcggagctagacggcgggctgtgggtggggaggagactagaatattctgagacggggtcaggtgggagttgggagaggtaacgtggagttgctgcccaagatgcagctcagctccagtggccacaccaagacggtttaagaccgagagcggaaccagggaggttgtttttggtggctgggggcttgggtttgagttccttgaacagcagaaggtgcttggatttagggaggtgaggctgggaagggttcgggtatgagaaaggaagctgaagttccctggcgtgggtggcaggaagggctctaaccctggggcggggtgtgagggccgtggccgtcatggctgtcgaggccgaaggagagggattctgaactcgggacccagggcttgggatggggtatgaaatctatgtcttgggtatgcctcctcccccaatcttgctcaggctctaattgcctggacgaagaaccccgagctgtctggccggcctttcacagtatccgaccggggcgtcctggaccgccgccagctctatctgaccacctcggcgcgggactttcggttctatcccaagtaagccgggctctcgctcggcatcgcctcctgcacagcccccgccgtggccggtgcacgccgagcccctgggctggctcccattccctgagccggtggtctcagcctcgacttctgtagcagcaagaaccaaagttcaggcctcagcccctcccttttttttttaagcacccaggagtccttagtgtcacctctcaggaaccgcggtagggacaggaagcctgcacagcggctcgaggggattccggatctgagggcagggcctccttcggtacttgagcccccagatactccttcccaaggaagcgaaagtccccttttacttccctaggatgggaaagctcagtttccaggacgttaagtacctcgaggacccaggaacgcaggcaacgcgtgccgggtcgcgtccttcctaaggggtgctcgcctggaaatgcaggagtttgaatgtgcagactccttagatcccgaggtctgaaactcgtccccaaggatccagctgtatcctcaccatcccgccctgctcccacaggacggagctgtccggatacccccgcaaggactccctgacctactggagcttcgaagagacgccccaggtctggagccacggcccgcagcggccgccctgtccgcgctcctcccggccgccccgaccaccgcgggtccgcgtgccgcgcgtcagcccggtgacctcggccatgccgcaccggggagccctgtctctggctcaggagtcctacagccccctgctgcacccgctccggcggctcgaccgcttctgcccgctggaggcgccctggggcggcccgcactggaagcccctgcggggcatctacagcgtgccgaaagcctacagtaccgagaactccagctatggcagcttgaagccggcgctggtgtgagccgtcagggccagccccaccccagacccgcccccagggccgcgctgccgagcggagctcgggacctccgctcactaggaagggttccggacccagcctgagtcgcactcattacgtctattggcaacgtgggggcgggactagcccagacacccactcagctgcggcatcacggagaggggactaagtccagataatgtccttgcaggctgtggccccgggggcaagacacgcaccctgcgggcgtattaaataatgagttaaatcacctgaaccacacccacttccggggacgctccgggcatcctggcttgagggtagggtgggcggaggtccctaagggagaggtggggctcgggcttaatccctccttgggggcatctgggtcaagtggcttccctggcagcacagtcacggggagaccctctctcactgggcagaagctaagtccgaagcagcgcccctcctgttaggttggactgtggtgcaggaaagcctcaagtggagggttgaggcttcagtccagcacctttctcgggtcatggcctcctcctggctcccaagaccccacaattggcagaggcaggccttcctacaccctactccctgtgcttccagcctcgactagtccctagcactcgacaactgagtctctgaggtcacttcaccgtggtctctgcctcacctctggcgctagaccactgaggggagagggctggggcactctgctgagccactcctgcgcctccctggccatgtgcacctctcgcccccggggggattagtgtccaggttaccccagcatcctatcacctcctggtggccttgccgcccccacaaccccgaggtataaagccagatacacgaggcaggggatgcaccaaggatggagatgctccaggtaagactgcagggcccctgggcaccttccacctccttccaggccatcactggcatgagaaggggcagacccgtgtgagctgtggaaggaggcctctttctggaggggcatgacccccagtaagcttcaggtggggcagttcctgagggtggggatctgaaatgttggggcatctcaggtcctctgggctgtggggtgggctctgaaaggcaggtgtccgggtggtgggtcctgaataggagatgccaggaagggtctctgggtctttgtgggtggtgtaccacgcgggatgggaaggccaggactcggggctgcggtctcagacccgggtgaagcagtgtccttgtcccaggggctgctgctgttgctgctgctgagcatgggcggggcatgggcatccagggagccgcttcggccatggtgccaccccatcaatgccatcctggctgtggagaaggagggctgccccgtgtgcatcaccgtcaacaccaccatctgtgccggctactgccccaccatgatgcgcgtgctgcaggcggtcctgccgcccctgcctcaggtggtgtgcacctaccgtgatgtgcgcttcgagtccatccggctccctggctgcccgcgtggcgtggaccccgtggtctccttccctgtggctctcagctgtcgctgtggaccctgccgccgcagcacctctgactgtgggggtcccaaagaccaccccttgacctgtgaccacccccaactctcaggcctcctcttcctctaaagaccctccccgcagccttccaagtccatcccgactcctggagccctgacaccccgatcctcccacaataaaggcttctcaatccgca

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