LOCUS       NR_182048               1624 bp    RNA     linear   PRI 04-DEC-2023
DEFINITION  Homo sapiens zinc fingers and homeoboxes 2 (ZHX2), transcript
            variant 21, non-coding RNA.
ACCESSION   NR_182048
VERSION     NR_182048.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1624)
  AUTHORS   Creasy KT, Ren H, Jiang J, Peterson ML and Spear BT.
  TITLE     Elongation of very long chain fatty acids-3 (Elovl3) is activated
            by ZHX2 and is a regulator of cell cycle progression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (6), G582-G592 (2023)
   PUBMED   37847682
  REMARK    GeneRIF: Elongation of very long chain fatty acids-3 (Elovl3) is
            activated by ZHX2 and is a regulator of cell cycle progression.
REFERENCE   2  (bases 1 to 1624)
  AUTHORS   Tan S, Wang Z, Li N, Guo X, Zhang Y, Ma H, Peng X, Zhao Y, Li C,
            Gao L, Li T, Liang X and Ma C.
  TITLE     Transcription factor Zhx2 is a checkpoint that programs macrophage
            polarization and antitumor response
  JOURNAL   Cell Death Differ 30 (9), 2104-2119 (2023)
   PUBMED   37582865
  REMARK    GeneRIF: Transcription factor Zhx2 is a checkpoint that programs
            macrophage polarization and antitumor response.
REFERENCE   3  (bases 1 to 1624)
  AUTHORS   Ding R, Shi H, Guo Y, Zeng W and Fan J.
  TITLE     Zinc fingers and homeoboxes 2 inhibition could suppress the
            proliferation of ovarian cancer cells by apoptosis pathway
  JOURNAL   Clin Transl Oncol 25 (7), 2116-2126 (2023)
   PUBMED   36746874
  REMARK    GeneRIF: Zinc fingers and homeoboxes 2 inhibition could suppress
            the proliferation of ovarian cancer cells by apoptosis pathway.
REFERENCE   4  (bases 1 to 1624)
  AUTHORS   Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H,
            Liao C, Baldwin AS, Gong K and Zhang Q.
  TITLE     USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (36), e2119854119 (2022)
   PUBMED   36037364
  REMARK    GeneRIF: USP13 promotes deubiquitination of ZHX2 and tumorigenesis
            in kidney cancer.
REFERENCE   5  (bases 1 to 1624)
  AUTHORS   Tan S, Guo X, Li M, Wang T, Wang Z, Li C, Wu Z, Li N, Gao L, Liang
            X and Ma C.
  TITLE     Transcription factor Zhx2 restricts NK cell maturation and
            suppresses their antitumor immunity
  JOURNAL   J Exp Med 218 (9) (2021)
   PUBMED   34279541
  REMARK    GeneRIF: Transcription factor Zhx2 restricts NK cell maturation and
            suppresses their antitumor immunity.
REFERENCE   6  (bases 1 to 1624)
  AUTHORS   Liu G, Clement LC, Kanwar YS, Avila-Casado C and Chugh SS.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J Biol Chem 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   7  (bases 1 to 1624)
  AUTHORS   de Andrade TG, Peterson KR, Cunha AF, Moreira LS, Fattori A, Saad
            ST and Costa FF.
  TITLE     Identification of novel candidate genes for globin regulation in
            erythroid cells containing large deletions of the human beta-globin
            gene cluster
  JOURNAL   Blood Cells Mol Dis 37 (2), 82-90 (2006)
   PUBMED   16952470
  REMARK    GeneRIF: ZHX2, a transcriptional repressor, may participate in
            globin gene regulation.
REFERENCE   8  (bases 1 to 1624)
  AUTHORS   Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N,
            Smolyar A, Hill DE, Barabasi AL, Vidal M and Zoghbi HY.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 1624)
  AUTHORS   Kawata H, Yamada K, Shou Z, Mizutani T and Miyamoto K.
  TITLE     The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a
            heterodimer with ZHX3
  JOURNAL   Gene 323, 133-140 (2003)
   PUBMED   14659886
REFERENCE   10 (bases 1 to 1624)
  AUTHORS   Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M,
            Sekiguchi T, Kajitani T and Miyamoto K.
  TITLE     Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX
            family, functions as a transcriptional repressor
  JOURNAL   Biochem J 373 (Pt 3), 747-757 (2003)
   PUBMED   12741956
  REMARK    GeneRIF: identification as a transcriptional repressor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016405.8 and AC104316.3.
            
            Summary: The members of the zinc fingers and homeoboxes gene family
            are nuclear homodimeric transcriptional repressors that interact
            with the A subunit of nuclear factor-Y (NF-YA) and contain two
            C2H2-type zinc fingers and five homeobox DNA-binding domains. This
            gene encodes member 2 of this gene family. In addition to forming
            homodimers, this protein heterodimerizes with member 1 of the zinc
            fingers and homeoboxes family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2274116.1,
                                           SRR14038196.1951658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AC016405.8         114417-114708       c
            293-355             AC016405.8         32824-32886         c
            356-1624            AC104316.3         95485-96753
FEATURES             Location/Qualifiers
     source          1..1624
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..1624
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="zinc fingers and homeoboxes 2"
                     /db_xref="GeneID:22882"
                     /db_xref="HGNC:HGNC:18513"
                     /db_xref="MIM:609185"
     misc_RNA        1..1624
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /product="zinc fingers and homeoboxes 2, transcript
                     variant 21"
                     /db_xref="GeneID:22882"
                     /db_xref="HGNC:HGNC:18513"
                     /db_xref="MIM:609185"
     exon            1..292
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     exon            293..355
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1624
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="hexamer: AATAAA"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="hexamer: ACTAAA"
     polyA_site      1621
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
     polyA_site      1624
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="major polyA site"
ORIGIN      

atgtgggttttggcgtagattccccactgatcgaggcattttttttccctttttttttcctttttttttttcttttaaaaattttggccatcgttctccgtacgggggctttttctgtctgtctgtctggctggcaggctggctttccccctctttcccacggagcccgagccgggcgcccggtggggagtggggagtgggtggggggagccagcagagttccattttggaacgcccgtgccgcgtctccgcgttcccagcccgggtccccgcgttcacagccccagcgcaggtctggatgtaccgactgcttttggaataaaaagattcccaggatgtgagcaacacgggaccgggaagtctgttagaactgctgtgctgatcaacgggacgctccgtctttgaagaaagaagagatggtctctccccagccatgggccacccttgccagtgactccaagtggaactacttagctcgcgtgtgcctggagggtgcgggaagtccagcgactctcagacgcacctcccagaggaccggtgggaattgttcatagtgccaaagtcctactactgcgttttcaatgggtccttgtacatagtttgctcctctgccctagccctcacctcttgctatactggaaccgatttgtacaatgtgggaattttgttacctttttaatcaagggcaacttccttttccagcactaccattgtaaggtttttttcaggagggagggctaaccaccttgcttttctcttttctctttttcttttttttatttttgttttattaatttggggaaaggggtgttagcattagtgccatgatatctactggattttaagtagggagactttatttttaaaggtaggttgaaatttgggagatttctcggcaggaagggctgaaatccaggcccctgtctcaacttggagagaggtgacagacggcagatcttccaaatcaaattcctttccagttcttcccctggctgcctttttgggggtccctgccttagccccacacaaggctttctgaactgccaagaggggatctggcttctcaactgctcggcctcttgggccaggctgtgcccagccagccctgggagaactgggtagcaggtggctgacttctttaagcacctttctaaataccagcagaagaggctcccgcctctgttagcatgatcagtactattgtgacattaaaacaacaacaataagatcttcctatctggagggtacagaggtgaatggctttggttttcatttctcttcttcactgccttttctcggtgtggtatttgacaagattttagctcaaagcctcaccatgaattgattttttttgtttgtgtgtgtgtttgttttgggacaattttagatacctgagtgcactttttcagttagtcctaacttttaaaagaaggaaaaccaagagacatatctggtgtacgtgttgcagtatgaactctggttgcaatccctccccgtcccacactgccccccatttgagtacaccgcacaagtcaaacgctaggaagtttgaataaaaccaatttttctaacttgttgctcatttgttgtaactcaataaagcaaagactaaacatttttataa

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