2024-04-25 16:22:17, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_107020 75 bp RNA linear PRI 08-SEP-2020 DEFINITION Homo sapiens microRNA 8053 (MIR8053), microRNA. ACCESSION NR_107020 VERSION NR_107020.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 75) AUTHORS Wang HJ, Zhang PJ, Chen WJ, Jie D, Dan F, Jia YH and Xie LX. TITLE Characterization and Identification of novel serum microRNAs in sepsis patients with different outcomes JOURNAL Shock 39 (6), 480-487 (2013) PUBMED 23612084 REFERENCE 2 (bases 1 to 75) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res. 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AC092597.1. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-75 AC092597.1 82669-82743 c FEATURES Location/Qualifiers source 1..75 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="4" /map="4p12" gene 1..75 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /note="microRNA 8053" /db_xref="GeneID:102467004" /db_xref="HGNC:HGNC:50137" /db_xref="miRBase:MI0025889" precursor_RNA 1..75 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /product="microRNA 8053" /db_xref="GeneID:102467004" /db_xref="HGNC:HGNC:50137" /db_xref="miRBase:MI0025889" exon 1..75 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /inference="alignment:Splign:2.1.0" variation 6 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="t" /db_xref="dbSNP:967889970" ncRNA 11..34 /ncRNA_class="miRNA" /gene="MIR8053" /gene_synonym="hsa-mir-8053" /product="hsa-miR-8053" /db_xref="miRBase:MIMAT0030980" /db_xref="GeneID:102467004" /db_xref="HGNC:HGNC:50137" /db_xref="miRBase:MI0025889" variation 14 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:1452400649" variation 15 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1723787350" variation 21 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1577785615" variation 22 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="g" /replace="t" /db_xref="dbSNP:376257390" variation 24 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="c" /db_xref="dbSNP:1723787922" variation 28 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:1723788038" variation 30 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="t" /db_xref="dbSNP:1010013836" variation 35 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="" /replace="g" /db_xref="dbSNP:1723788427" variation 36 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="c" /db_xref="dbSNP:1723788627" variation 39 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="t" /db_xref="dbSNP:1723788809" variation 42 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1444597074" variation 43 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1162267583" variation 44 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="c" /db_xref="dbSNP:1454106978" variation 46..47 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="aa" /db_xref="dbSNP:1402531447" variation 47 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="c" /db_xref="dbSNP:1287892947" variation 50 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1392545819" variation 51 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="g" /replace="t" /db_xref="dbSNP:1577785653" variation 54 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="t" /replace="ttgt" /db_xref="dbSNP:1462105553" variation 55 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:2109641387" variation 56 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="t" /replace="taccatttttctctt" /db_xref="dbSNP:1166808724" variation 57 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="t" /db_xref="dbSNP:1723790352" variation 58 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="t" /db_xref="dbSNP:1365273809" variation 62 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="g" /db_xref="dbSNP:1723790731" variation 64 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="c" /replace="t" /db_xref="dbSNP:377511159" variation 65 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1033090563" variation 71 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1723791330" variation 72 /gene="MIR8053" /gene_synonym="hsa-mir-8053" /replace="a" /replace="g" /db_xref="dbSNP:1723791531" ORIGIN
gcttttccactggcgattttggaactcaatggcagaaatgtcaagaagagttttatcctttgccgaaagagaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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