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Previous release (v1)
2024-04-20 08:33:54, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NR_031650 106 bp RNA linear PRI 30-OCT-2023
DEFINITION Homo sapiens microRNA 1248 (MIR1248), microRNA.
ACCESSION NR_031650
VERSION NR_031650.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 106)
AUTHORS Ma T, Guo J, Han J, Li L, Ren Y, Huang J, Diao G, Zheng X and Zheng
Y.
TITLE Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis
and cisplatin resistance in cervical cancer
JOURNAL Mol Carcinog 62 (11), 1645-1658 (2023)
PUBMED 37431919
REMARK GeneRIF: Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated
metastasis and cisplatin resistance in cervical cancer.
REFERENCE 2 (bases 1 to 106)
AUTHORS Wang C, Wang B, Liang W, Zhou C, Lin W, Meng Z, Wu W, Wu M, Liao Y,
Li X, Zhao J and He Y.
TITLE Hsa-miR-1248 suppressed the proliferation, invasion and migration
of colorectal cancer cells via inhibiting PSMD10
JOURNAL BMC Cancer 22 (1), 922 (2022)
PUBMED 36028821
REMARK GeneRIF: Hsa-miR-1248 suppressed the proliferation, invasion and
migration of colorectal cancer cells via inhibiting PSMD10.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 106)
AUTHORS Yang T, Li M, Li H, Shi P, Liu J and Chen M.
TITLE Downregulation of circEPSTI1 represses the proliferation and
invasion of non-small cell lung cancer by inhibiting TRIM24 via
miR-1248 upregulation
JOURNAL Biochem Biophys Res Commun 530 (1), 348-354 (2020)
PUBMED 32828310
REMARK GeneRIF: Downregulation of circEPSTI1 represses the proliferation
and invasion of non-small cell lung cancer by inhibiting TRIM24 via
miR-1248 upregulation.
REFERENCE 4 (bases 1 to 106)
AUTHORS Xiao S, Zhang D, Liu Z, Jin W, Huang G, Wei Z, Wang D and Deng C.
TITLE Diabetes-induced glucolipotoxicity impairs wound healing ability of
adipose-derived stem cells-through the miR-1248/CITED2/HIF-1alpha
pathway
JOURNAL Aging (Albany NY) 12 (8), 6947-6965 (2020)
PUBMED 32294623
REMARK GeneRIF: Diabetes-induced glucolipotoxicity impairs wound healing
ability of adipose-derived stem cells-through the
miR-1248/CITED2/HIF-1alpha pathway.
REFERENCE 5 (bases 1 to 106)
AUTHORS Kozomara A and Griffiths-Jones S.
TITLE miRBase: integrating microRNA annotation and deep-sequencing data
JOURNAL Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
PUBMED 21037258
REFERENCE 6 (bases 1 to 106)
AUTHORS Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu
AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ and Marra MA.
TITLE Application of massively parallel sequencing to microRNA profiling
and discovery in human embryonic stem cells
JOURNAL Genome Res 18 (4), 610-621 (2008)
PUBMED 18285502
REMARK Erratum:[Genome Res. 2009 May;19(5):958]
REFERENCE 7 (bases 1 to 106)
AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright
AJ.
TITLE miRBase: microRNA sequences, targets and gene nomenclature
JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006)
PUBMED 16381832
COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation
provided by NCBI staff in collaboration with miRBase. The reference
sequence was derived from AC112907.7.
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the
stability and translation of mRNAs. miRNAs are transcribed by RNA
polymerase II as part of capped and polyadenylated primary
transcripts (pri-miRNAs) that can be either protein-coding or
non-coding. The primary transcript is cleaved by the Drosha
ribonuclease III enzyme to produce an approximately 70-nt stem-loop
precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and
antisense miRNA star (miRNA*) products. The mature miRNA is
incorporated into a RNA-induced silencing complex (RISC), which
recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or
destabilization of the target mRNA. The RefSeq represents the
predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Sequence Note: This record represents a predicted microRNA
stem-loop as defined by miRBase. Some sequence at the 5' and 3'
ends may not be included in the intermediate precursor miRNA
produced by Drosha cleavage.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-106 AC112907.7 62761-62866 c
FEATURES Location/Qualifiers
source 1..106
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q27.3"
gene 1..106
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/note="microRNA 1248"
/db_xref="GeneID:100302143"
/db_xref="HGNC:HGNC:35314"
/db_xref="miRBase:MI0006383"
precursor_RNA 1..106
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/product="microRNA 1248"
/db_xref="GeneID:100302143"
/db_xref="HGNC:HGNC:35314"
/db_xref="miRBase:MI0006383"
exon 1..106
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/inference="alignment:Splign:2.1.0"
variation 3
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:890606179"
ncRNA 4..30
/ncRNA_class="miRNA"
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/product="hsa-miR-1248"
/db_xref="miRBase:MIMAT0005900"
/db_xref="GeneID:100302143"
/db_xref="HGNC:HGNC:35314"
/db_xref="miRBase:MI0006383"
variation 5
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/db_xref="dbSNP:372744748"
variation 6..11
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="ctt"
/replace="cttctt"
/db_xref="dbSNP:768764819"
variation 6
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:1249058099"
variation 8
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:1393385728"
variation 9
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:202149708"
variation 10
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:760474964"
variation 12
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:768431834"
variation 13
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1196100585"
variation 13
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="t"
/replace="tttat"
/db_xref="dbSNP:1560085325"
variation 14..17
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="ataa"
/replace="ataataa"
/db_xref="dbSNP:1359731819"
variation 14
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:776351814"
variation 15
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="t"
/db_xref="dbSNP:1344604555"
variation 15
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="t"
/replace="tt"
/db_xref="dbSNP:1560085331"
variation 16
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:761728419"
variation 17
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="t"
/db_xref="dbSNP:572865136"
variation 19
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:750374080"
variation 21
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/db_xref="dbSNP:1171124595"
variation 22..25
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="tg"
/replace="tgtg"
/db_xref="dbSNP:1387518826"
variation 22
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:1721733919"
variation 23
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:376591367"
variation 24
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:1721734373"
variation 26
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/db_xref="dbSNP:1721734537"
variation 27
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:752808710"
variation 29..36
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="aaattgca"
/db_xref="dbSNP:2108458840"
variation 33
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="t"
/db_xref="dbSNP:548165979"
variation 35
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1296461475"
variation 37
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="t"
/db_xref="dbSNP:756129308"
variation 38
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:2108458856"
variation 39
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:538395242"
variation 40
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:754020514"
variation 41
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:757643215"
variation 43
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:376257420"
variation 44..57
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="ggaccatgtcttgg"
/db_xref="dbSNP:1560085370"
variation 47
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:746405150"
variation 48
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:772632941"
variation 51
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1721736821"
variation 53
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:1721737053"
variation 54
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:1721737216"
variation 55
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="t"
/db_xref="dbSNP:1721737401"
variation 56..57
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="gg"
/replace="ggg"
/db_xref="dbSNP:1465600479"
variation 57
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:1387332524"
variation 58..62
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="tttt"
/replace="ttttt"
/db_xref="dbSNP:753546148"
variation 59
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="t"
/db_xref="dbSNP:1428996733"
variation 62
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:941841627"
variation 64
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="cc"
/db_xref="dbSNP:1721738725"
variation 64
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1721738478"
regulatory 65..70
/regulatory_class="polyA_signal_sequence"
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/note="hexamer: AATAAT"
variation 65
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1721738885"
variation 66
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:779492327"
variation 68
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1721739215"
variation 69
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1721739395"
variation 71
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="t"
/db_xref="dbSNP:746518055"
variation 72
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:73063489"
variation 73
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:776443366"
variation 74
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1427327558"
variation 75
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1721740311"
variation 77..82
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="agagta"
/db_xref="dbSNP:749091759"
variation 77..80
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="ag"
/replace="agag"
/db_xref="dbSNP:1560085404"
variation 77
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:529062650"
variation 80
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="g"
/replace="t"
/db_xref="dbSNP:1327885356"
variation 81
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:769515729"
variation 82..88
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="acaca"
/replace="acacaca"
/db_xref="dbSNP:757125227"
variation 82
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="t"
/db_xref="dbSNP:1156807363"
variation 83
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="t"
/db_xref="dbSNP:374023366"
variation 84
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1721742021"
variation 87
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/db_xref="dbSNP:1201666943"
variation 88..95
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="aagaa"
/replace="aagaagaa"
/db_xref="dbSNP:1232279858"
polyA_site 89
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/note="major polyA site"
variation 90
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:568460640"
variation 94
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1263485176"
variation 96..101
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="aa"
/replace="aagtaa"
/db_xref="dbSNP:778952832"
variation 96
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:1235148789"
variation 98
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/db_xref="dbSNP:367929995"
variation 99
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="t"
/replace="tt"
/db_xref="dbSNP:1560085446"
variation 100
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="a"
/replace="g"
/db_xref="dbSNP:766352944"
variation 105
/gene="MIR1248"
/gene_synonym="hsa-mir-1248; mir-1248; MIRN1248"
/replace="c"
/replace="g"
/db_xref="dbSNP:1329059214"
ORIGIN
tttaccttcttgtataagcactgtgctaaaattgcagacactaggaccatgtcttggtttttgcaataatgctagcagagtacacacaagaagaaaagtaacagca
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]