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2024-05-04 04:47:08, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_032414               1393 bp    mRNA    linear   PRI 12-DEC-2023
DEFINITION  Homo sapiens prokineticin 1 (PROK1), mRNA.
ACCESSION   NM_032414
VERSION     NM_032414.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Goto S, Ozaki Y, Ozawa F, Yoshihara H, Ujvari D, Kitaori T and
            Sugiura-Ogasawara M.
  TITLE     Impaired decidualization and relative increase of PROK1 expression
            in the decidua of patients with unexplained recurrent pregnancy
            loss showing insulin resistance
  JOURNAL   J Reprod Immunol 160, 104155 (2023)
   PUBMED   37801889
  REMARK    GeneRIF: Impaired decidualization and relative increase of PROK1
            expression in the decidua of patients with unexplained recurrent
            pregnancy loss showing insulin resistance.
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Raia-Barjat T, Chauleur C, Collet C, Rancon F, Hoffmann P, Desseux
            M, Lemaitre N, Benharouga M, Giraud A and Alfaidy N.
  TITLE     EG-VEGF maternal levels predict spontaneous preterm birth in the
            second and third trimesters in pregnant women with risk factors for
            placenta-mediated complications
  JOURNAL   Sci Rep 13 (1), 19921 (2023)
   PUBMED   37963927
  REMARK    GeneRIF: EG-VEGF maternal levels predict spontaneous preterm birth
            in the second and third trimesters in pregnant women with risk
            factors for placenta-mediated complications.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Tagai N, Goi T, Shimada M and Kurebayashi H.
  TITLE     Plasma Prokineticin 1, a prognostic biomarker in colorectal cancer
            patients with curative resection: a retrospective cohort study
  JOURNAL   World J Surg Oncol 19 (1), 302 (2021)
   PUBMED   34657605
  REMARK    GeneRIF: Plasma Prokineticin 1, a prognostic biomarker in
            colorectal cancer patients with curative resection: a retrospective
            cohort study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Zhang X, Sheng Y, Li B, Wang Q, Liu X and Han J.
  TITLE     Ovarian cancer derived PKR1 positive exosomes promote angiogenesis
            by promoting migration and tube formation in vitro
  JOURNAL   Cell Biochem Funct 39 (2), 308-316 (2021)
   PUBMED   32876972
  REMARK    GeneRIF: Ovarian cancer derived PKR1 positive exosomes promote
            angiogenesis by promoting migration and tube formation in vitro.
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Ujvari D, Graells Brugalla C and Hirschberg AL.
  TITLE     Dihydrotestosterone potentiates insulin to up-regulate
            prokineticin-1 in decidualizing human endometrial stromal cells
  JOURNAL   J Cell Mol Med 24 (5), 3242-3245 (2020)
   PUBMED   31991505
  REMARK    GeneRIF: Dihydrotestosterone potentiates insulin to up-regulate
            prokineticin-1 in decidualizing human endometrial stromal cells.
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   LeCouter J, Lin R, Tejada M, Frantz G, Peale F, Hillan KJ and
            Ferrara N.
  TITLE     The endocrine-gland-derived VEGF homologue Bv8 promotes
            angiogenesis in the testis: Localization of Bv8 receptors to
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2685-2690 (2003)
   PUBMED   12604792
  REMARK    GeneRIF: Bv8 and EG-VEGF, along with other factors such as VEGF-A,
            may maintain the integrity and also regulate proliferation of the
            blood vessels in the testis
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Zhang L, Yang N, Conejo-Garcia JR, Katsaros D, Mohamed-Hadley A,
            Fracchioli S, Schlienger K, Toll A, Levine B, Rubin SC and Coukos
            G.
  TITLE     Expression of endocrine gland-derived vascular endothelial growth
            factor in ovarian carcinoma
  JOURNAL   Clin Cancer Res 9 (1), 264-272 (2003)
   PUBMED   12538479
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Soga T, Matsumoto Si, Oda T, Saito T, Hiyama H, Takasaki J,
            Kamohara M, Ohishi T, Matsushime H and Furuichi K.
  TITLE     Molecular cloning and characterization of prokineticin receptors
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 173-179 (2002)
   PUBMED   12427552
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard-Telm L,
            Frantz G, Rangell L, DeGuzman L, Keller GA, Peale F, Gurney A,
            Hillan KJ and Ferrara N.
  TITLE     Identification of an angiogenic mitogen selective for endocrine
            gland endothelium
  JOURNAL   Nature 412 (6850), 877-884 (2001)
   PUBMED   11528470
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Li M, Bullock CM, Knauer DJ, Ehlert FJ and Zhou QY.
  TITLE     Identification of two prokineticin cDNAs: recombinant proteins
            potently contract gastrointestinal smooth muscle
  JOURNAL   Mol Pharmacol 59 (4), 692-698 (2001)
   PUBMED   11259612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390797.16, BM544315.1, AY029225.1 and AL358215.16.
            
            On Nov 23, 2018 this sequence version replaced NM_032414.2.
            
            Summary: The protein encoded by this gene induces proliferation,
            migration, and fenestration (the formation of membrane
            discontinuities) in capillary endothelial cells derived from
            endocrine glands. It has little or no effect on a variety of other
            endothelial and non-endothelial cell types. Its expression is
            restricted to the steroidogenic glands (ovary, testis, adrenal, and
            placenta), is induced by hypoxia, and often complementary to the
            expression of vascular endothelial growth factor (VEGF), suggesting
            that these molecules function in a coordinated manner. [provided by
            RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.162299.1,
                                           SRR5189667.173366.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271331.4/ ENSP00000271331.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL390797.16        57819-57835
            18-20               BM544315.1         27-29
            21-1389             AY029225.1         1-1369
            1390-1393           AL358215.16        3754-3757
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1393
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="prokineticin 1"
                     /db_xref="GeneID:84432"
                     /db_xref="HGNC:HGNC:18454"
                     /db_xref="MIM:606233"
     exon            1..140
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="alignment:Splign:2.1.0"
     variation       2
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:531773932"
     variation       3
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1287884174"
     variation       6
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664083429"
     variation       7
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664083454"
     variation       11
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373868477"
     variation       12
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368008753"
     variation       13
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:765953691"
     variation       15
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1339643333"
     variation       16
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:548526757"
     variation       20
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:758263967"
     variation       22
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368380049"
     variation       23..27
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="gagag"
                     /replace="gagagag"
                     /db_xref="dbSNP:1557935546"
     variation       23
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371071753"
     variation       27
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374039613"
     variation       28
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:780785532"
     variation       30
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1570687420"
     misc_feature    33..35
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="upstream in-frame stop codon"
     variation       35
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2101146613"
     variation       39
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:754212649"
     variation       40
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368109229"
     variation       41
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371989983"
     variation       43..46
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="gt"
                     /replace="gtgt"
                     /db_xref="dbSNP:1664084168"
     variation       45
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1173491859"
     variation       48
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664084223"
     variation       52
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1477109758"
     variation       55
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1474056456"
     variation       56
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:1664084325"
     variation       57..60
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="ccc"
                     /replace="cccc"
                     /db_xref="dbSNP:1664084385"
     variation       57
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:748725857"
     variation       59
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1423411178"
     variation       62
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:772436275"
     CDS             69..386
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="black mamba toxin-related protein; mambakine;
                     EG-VEGF; endocrine-gland-derived vascular endothelial
                     growth factor"
                     /codon_start=1
                     /product="prokineticin-1 precursor"
                     /protein_id="NP_115790.1"
                     /db_xref="CCDS:CCDS825.1"
                     /db_xref="GeneID:84432"
                     /db_xref="HGNC:HGNC:18454"
                     /db_xref="MIM:606233"
                     /translation="
MRGATRVSIMLLLVTVSDCAVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF"
     misc_feature    69..359
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="Region: Prokineticin; pfam06607"
                     /db_xref="CDD:148298"
     sig_peptide     69..125
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     126..383
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /product="Prokineticin-1. /id=PRO_0000025807"
                     /note="propagated from UniProtKB/Swiss-Prot (P58294.1)"
     variation       69
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:777930135"
     variation       70
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1291167652"
     variation       78
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1481578008"
     variation       79
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664084631"
     variation       80
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1383388616"
     variation       82
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116864400"
     variation       83
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150575109"
     variation       84
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187548600"
     variation       85
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140497394"
     variation       87
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1292840132"
     variation       92
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:962015942"
     variation       93
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1317319473"
     variation       94
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1240865409"
     variation       95
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:775116623"
     variation       96
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113657477"
     variation       98
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:763892922"
     variation       98
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="gg"
                     /db_xref="dbSNP:1283766105"
     variation       99
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664085301"
     variation       100
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1225122067"
     variation       101
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372328778"
     variation       105
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376619747"
     variation       108
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:761252649"
     variation       112
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664085634"
     variation       114
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1186803207"
     variation       115
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664085742"
     variation       118..124
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="ctg"
                     /replace="ctgactg"
                     /db_xref="dbSNP:774546256"
     variation       121
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664085886"
     variation       123..126
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="tg"
                     /replace="tgtg"
                     /db_xref="dbSNP:759975762"
     variation       123
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:752181916"
     variation       127
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:766997758"
     variation       128
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664086155"
     variation       129
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:750139281"
     variation       136
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1174739584"
     variation       137
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:1664086384"
     variation       137
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664086337"
     variation       140
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:755728168"
     exon            141..266
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="alignment:Splign:2.1.0"
     variation       142
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202098995"
     variation       143
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:764763469"
     variation       149
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:758631433"
     variation       149
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="gg"
                     /db_xref="dbSNP:1368751434"
     variation       150
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149887149"
     variation       151
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:532479267"
     variation       153
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664129629"
     variation       155
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:781470960"
     variation       156
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1202018938"
     variation       157
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1250364907"
     variation       161
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:745897801"
     variation       162
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:780076706"
     variation       165
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664129943"
     variation       169
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1467456571"
     variation       171
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1255255326"
     variation       172
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1272936322"
     variation       173
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:749125320"
     variation       174
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1570688652"
     variation       176
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1191115119"
     variation       177
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1219553510"
     variation       177
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="t"
                     /replace="tt"
                     /db_xref="dbSNP:763604097"
     variation       178
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200512156"
     variation       181
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:774097959"
     variation       182
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:748129530"
     variation       185
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:909508876"
     variation       187
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:771947784"
     variation       189
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1462136226"
     variation       190
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:772739896"
     variation       192
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1274740119"
     variation       199
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664131167"
     variation       201
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1391999268"
     variation       202
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:760109897"
     variation       205
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664131344"
     variation       206
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2101149661"
     variation       209
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1037256521"
     variation       210
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62623571"
     variation       211
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141353448"
     variation       213
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:764406554"
     variation       216
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1331785917"
     variation       218
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1276984331"
     variation       219
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1570688703"
     variation       220
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664131882"
     variation       221
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664131934"
     variation       223
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:751951334"
     variation       224
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:757864792"
     variation       225
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664132192"
     variation       226
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:768102447"
     variation       228
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1450162274"
     variation       230
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142388637"
     variation       231
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141461032"
     variation       232..234
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="gg"
                     /replace="ggg"
                     /db_xref="dbSNP:753551131"
     variation       232
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:756092160"
     variation       233
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2101149740"
     variation       237
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1252850774"
     variation       239
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138146720"
     variation       240
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:755200880"
     variation       244
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1475692387"
     variation       247
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:778697807"
     variation       250
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:772001059"
     variation       251
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:773074032"
     variation       252
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1348748333"
     variation       254
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:746949920"
     variation       255
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1346934245"
     variation       256
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200271858"
     variation       257
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:776177506"
     variation       261
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1355532310"
     exon            267..1393
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="alignment:Splign:2.1.0"
     variation       267
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7514102"
     variation       269
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:970609476"
     variation       272..278
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="cttc"
                     /replace="cttcttc"
                     /db_xref="dbSNP:1217206791"
     variation       274
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2101151933"
     variation       275
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1280566880"
     variation       276
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1375979831"
     variation       281
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664170039"
     variation       282
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1366498633"
     variation       285
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:779040857"
     variation       286
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:554631181"
     variation       290
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142813074"
     variation       291
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:758246302"
     variation       293
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1429680644"
     variation       298
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1276563561"
     variation       299
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1442114504"
     variation       304
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1182789116"
     variation       305
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1234396495"
     variation       307
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="gg"
                     /db_xref="dbSNP:750008855"
     variation       314
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664170618"
     variation       315
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1177963013"
     variation       316
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1424770949"
     variation       318
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2101151993"
     variation       319
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:569785372"
     variation       322
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1455511814"
     variation       327
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1249714522"
     variation       328
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:777541714"
     variation       331
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:746961192"
     variation       336
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1410249556"
     variation       337
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:770879794"
     variation       338
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:780590461"
     variation       340
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:1230837166"
     variation       340
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664171311"
     variation       341
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:745347535"
     variation       342
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:769578549"
     variation       344
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664171609"
     variation       346..350
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="ggtac"
                     /replace="ggtacggtac"
                     /db_xref="dbSNP:1229848150"
     variation       347
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1372423534"
     variation       349
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:775227583"
     variation       350
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1273219368"
     variation       351
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:762684376"
     variation       352
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199818265"
     variation       353
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664172138"
     variation       355
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:773601408"
     variation       357
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1456301807"
     variation       358
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:568449592"
     variation       359
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:766865983"
     variation       360
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1469816454"
     variation       361
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1196661669"
     variation       362..364
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="gga"
                     /db_xref="dbSNP:1664172583"
     variation       368
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:753867092"
     variation       371
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139466708"
     variation       373
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1289115637"
     variation       374
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1305074896"
     variation       375
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664172891"
     variation       384
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:765286687"
     variation       388
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149653585"
     variation       389
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372826229"
     variation       394
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1331165239"
     variation       398
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1473700672"
     variation       400
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664173256"
     variation       404
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664173303"
     variation       405
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:890721039"
     variation       409
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1395660390"
     variation       412
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202241741"
     variation       413
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1242792473"
     variation       414
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1443752148"
     variation       415
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:751320705"
     variation       418
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1003759933"
     variation       420
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2101152196"
     variation       421
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375792638"
     variation       422
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664173838"
     variation       425
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664173898"
     variation       427
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1271974961"
     variation       428
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:781120514"
     variation       429
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2101152219"
     variation       430
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148766737"
     variation       431
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1482842383"
     variation       433
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1273652910"
     variation       434
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:769489772"
     variation       435
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:779710230"
     variation       437
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:748995132"
     variation       438
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:768372286"
     variation       444
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664174551"
     variation       455
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1417059259"
     variation       457
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2101152249"
     variation       470
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1210298140"
     variation       476
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1326662177"
     variation       478..480
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="cc"
                     /replace="ccc"
                     /db_xref="dbSNP:1291859900"
     variation       478
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1267049628"
     variation       479
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:558664911"
     variation       480
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1026423971"
     variation       482
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664175110"
     variation       484
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664175167"
     variation       485
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:575221867"
     variation       486
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101152275"
     variation       487
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:761243001"
     variation       488
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664175332"
     variation       490
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:544312493"
     variation       496
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1022361666"
     variation       498
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664175489"
     variation       500
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:796586597"
     variation       503
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1024225338"
     variation       505
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664175661"
     variation       511
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664175718"
     variation       513
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101152297"
     variation       515
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664175773"
     variation       517
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:970620924"
     variation       520
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:764569964"
     variation       521
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368957657"
     variation       524
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:1195291176"
     variation       528
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1033484846"
     variation       531
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:999967295"
     variation       533
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1281014430"
     variation       536
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1386767253"
     variation       537
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2101152318"
     variation       543
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664176334"
     variation       547
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:957924955"
     variation       548
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:989698680"
     variation       549
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142413820"
     variation       556
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1570689733"
     variation       558
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664176608"
     variation       565
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:913687906"
     variation       577
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1458520696"
     variation       578
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664176764"
     variation       579..585
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="gaggatg"
                     /replace="gaggatggaggatg"
                     /db_xref="dbSNP:1664176866"
     variation       579
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664176813"
     variation       585
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664176916"
     variation       592
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:753896835"
     variation       603
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1185659227"
     variation       605
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1185425348"
     variation       608
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2101152346"
     variation       612
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:529698394"
     variation       613
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1428832418"
     variation       614
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1570689746"
     variation       617
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1194881309"
     variation       618
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1190306248"
     variation       621
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367973023"
     variation       628
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:560457377"
     variation       631
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664177410"
     variation       633
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:943615675"
     variation       637
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1039332059"
     variation       641
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:1664177535"
     variation       642
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664177561"
     variation       646
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664177600"
     variation       649
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664177634"
     variation       652
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:532554811"
     variation       655
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:921774958"
     variation       656
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1437152484"
     variation       657
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:552321191"
     variation       658
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:563110415"
     variation       659
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1570689772"
     variation       664
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664178218"
     variation       672
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664178254"
     variation       673
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:920829372"
     variation       674
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664178343"
     variation       678
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664178371"
     variation       679
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664178423"
     variation       682
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74116709"
     variation       683
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1317976144"
     variation       685
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664178759"
     variation       688
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1298073964"
     variation       694
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1048352665"
     variation       695
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:548665576"
     variation       698
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:940418714"
     variation       699
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:568358667"
     variation       700..701
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="cc"
                     /db_xref="dbSNP:1664179032"
     variation       700
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664178996"
     variation       701
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1447491169"
     variation       702
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101152450"
     variation       704
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1247181393"
     variation       706
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1199225204"
     variation       708
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1045726465"
     variation       712
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1264772432"
     variation       716
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1055333914"
     variation       719
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664179461"
     variation       720
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664179498"
     variation       722
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1483079962"
     variation       724
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1208655752"
     variation       728
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664179610"
     variation       733
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1340574660"
     variation       742
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664179673"
     variation       744
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1269991870"
     variation       746
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3748733"
     variation       747
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116271905"
     variation       748
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664179878"
     variation       749
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1001474304"
     variation       751
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1033579716"
     variation       761
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1321788835"
     variation       764
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:958191590"
     variation       765
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:541965572"
     variation       766
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1371227249"
     variation       768
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11552381"
     variation       769
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664180102"
     variation       772..795
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="cag"
                     /replace="caggctcttgggtgcattgctcag"
                     /db_xref="dbSNP:1309846903"
     variation       772
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664180135"
     variation       775
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1011068323"
     variation       779
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664180243"
     variation       780
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1010748827"
     variation       785
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664180299"
     variation       787
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1021169149"
     variation       793
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1172970514"
     variation       801
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664180377"
     variation       805
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:966507471"
     variation       807
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:566801535"
     variation       811
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664180464"
     variation       812
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12568041"
     variation       815
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664180529"
     variation       816
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1259287912"
     variation       818
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1197697433"
     variation       821
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664180635"
     variation       824
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664180665"
     variation       825
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1472666547"
     variation       826
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1253340860"
     variation       827
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1043863115"
     variation       831
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:538955979"
     variation       832
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182579837"
     variation       836
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1347545879"
     variation       837
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664180942"
     variation       840
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664180970"
     variation       847
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1273352051"
     variation       848
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1451963694"
     variation       849
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:964398624"
     variation       851
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1290310947"
     variation       852
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:575406044"
     variation       853
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1377546826"
     variation       855
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:974404812"
     variation       857
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1353894656"
     variation       859
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1454678676"
     variation       862
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664181393"
     variation       864
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:920890293"
     variation       866
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664181472"
     variation       869
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1399782735"
     variation       872
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664181542"
     variation       875
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1570689860"
     variation       876
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:930856040"
     variation       878
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664181661"
     variation       880
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:996566705"
     variation       886
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664181737"
     variation       887
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1028937562"
     variation       888
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:951936740"
     variation       908
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1047892178"
     variation       912
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664181887"
     variation       914
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664181917"
     variation       915
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:984630817"
     variation       916
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1570689874"
     variation       919
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1232856287"
     variation       921
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1188834934"
     variation       929
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664182073"
     variation       930
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:750590705"
     variation       934
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:962121261"
     variation       935
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373151456"
     variation       936
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664182208"
     variation       938
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:560528317"
     variation       943
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664182261"
     variation       944
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664182291"
     variation       946..949
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="ccc"
                     /replace="cccc"
                     /db_xref="dbSNP:928363262"
     variation       946
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1232171856"
     variation       947
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1226699526"
     variation       953
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664182521"
     variation       954
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1570689893"
     variation       956
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664182577"
     variation       957
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664182624"
     variation       959
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:1664182668"
     variation       961
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664182705"
     variation       964
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1372674310"
     variation       966
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:1284770175"
     variation       968
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664182824"
     variation       971
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:796918840"
     variation       972
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:991114533"
     variation       977
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101152775"
     variation       979
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1045819281"
     variation       982
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:537499735"
     variation       985
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664183097"
     variation       988
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1317418129"
     variation       995
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1570689911"
     variation       1002
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1570689913"
     variation       1003
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101152795"
     variation       1008
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101152797"
     variation       1009
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1570689915"
     variation       1010
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1570689916"
     variation       1021..1031
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="tgtggcctgtg"
                     /replace="tgtggcctgtggcctgtg"
                     /db_xref="dbSNP:1241052980"
     variation       1022
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187313432"
     variation       1023
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664183576"
     variation       1024
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1457537058"
     variation       1025
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1570689920"
     variation       1026..1042
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="cctgtgacct"
                     /replace="cctgtgacctgtgacct"
                     /replace="cctgtgacctgtgacctgtgacct"
                     /db_xref="dbSNP:879675260"
     variation       1026..1027
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="cc"
                     /db_xref="dbSNP:1258768481"
     variation       1028
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664183872"
     variation       1029
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1390432798"
     variation       1032
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664183963"
     variation       1034
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664184013"
     variation       1038
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664184058"
     variation       1040
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1156477157"
     variation       1041..1045
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="ct"
                     /replace="cttct"
                     /db_xref="dbSNP:1664184204"
     variation       1041
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664184147"
     variation       1046
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2101152861"
     variation       1050
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1399668402"
     variation       1053
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1413877759"
     variation       1060
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664184321"
     variation       1069
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1164416128"
     variation       1073
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:916862705"
     variation       1080
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664184443"
     variation       1092
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2101152879"
     variation       1093
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115551791"
     variation       1097
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1183403366"
     variation       1107
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664184603"
     variation       1110
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664184646"
     variation       1117
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664184888"
     variation       1118
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1044837"
     variation       1119
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1250187497"
     variation       1125
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1207044140"
     variation       1128
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1316482786"
     variation       1134
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664185132"
     variation       1137
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:1664185169"
     variation       1138
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664185206"
     variation       1141
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:777433002"
     variation       1147
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1570689954"
     variation       1148
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:578013152"
     variation       1156
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:935426424"
     variation       1157
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1354200571"
     variation       1163
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1054353619"
     variation       1166
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:559735643"
     variation       1169
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1435606323"
     variation       1170
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1367072911"
     variation       1179
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:756062563"
     variation       1184
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664185780"
     variation       1186..1187
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:1429592728"
     variation       1193
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1350048964"
     variation       1195
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664185903"
     variation       1198
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664185937"
     variation       1199
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664185966"
     variation       1201
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664186011"
     variation       1206
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664186046"
     variation       1208
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664186099"
     variation       1211
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664186142"
     variation       1213
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664186199"
     variation       1216
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1020801476"
     variation       1218
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664186298"
     variation       1219
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:901905105"
     variation       1223
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664186390"
     variation       1228
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:996214758"
     variation       1233
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1192442470"
     variation       1238
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:577085114"
     variation       1248..1250
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="t"
                     /replace="ttt"
                     /db_xref="dbSNP:1163485870"
     variation       1254
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664186719"
     variation       1255
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:887697232"
     variation       1258
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664186846"
     variation       1259
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1392413323"
     variation       1263
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2101153068"
     variation       1269
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1664186944"
     variation       1272
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1185078220"
     variation       1273
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1557937199"
     variation       1274
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1008717644"
     variation       1275
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1485673976"
     variation       1277
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664187198"
     variation       1280
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1247467279"
     variation       1281
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664187307"
     variation       1284
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1006119582"
     variation       1286
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1489873644"
     variation       1287
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664187488"
     variation       1290
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664187534"
     variation       1291
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1420237739"
     variation       1295
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1018745501"
     variation       1297
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:961935402"
     variation       1298
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664187779"
     variation       1300
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:981665043"
     variation       1301
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:777906873"
     variation       1302
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664187955"
     variation       1307
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1213724335"
     variation       1308
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1367904996"
     variation       1309
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1570690001"
     variation       1311
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664188361"
     variation       1313
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664188384"
     variation       1317
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1456982118"
     variation       1318
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114445205"
     variation       1321
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1664188520"
     variation       1323
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1664188560"
     variation       1324
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1664188601"
     variation       1330
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1364397611"
     variation       1335
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:974412971"
     variation       1339
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:565005218"
     variation       1343
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1292978545"
     variation       1349
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:952348285"
     variation       1351
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1374092738"
     variation       1353
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:531978506"
     variation       1358
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664189404"
     variation       1364
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:946986135"
     variation       1369
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1328303008"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="hexamer: AATAAA"
     variation       1381
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1664189509"
     variation       1383
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1664189535"
     variation       1384
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:979625014"
     variation       1389
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1233665201"
     polyA_site      1393
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="major polyA site"
ORIGIN      
acaaggctgagcgggaggaagcgagaggcatctaagcaggcagtgttttgccttcaccccaagtgaccatgagaggtgccacgcgagtctcaatcatgctcctcctagtaactgtgtctgactgtgctgtgatcacaggggcctgtgagcgggatgtccagtgtggggcaggcacctgctgtgccatcagcctgtggcttcgagggctgcggatgtgcaccccgctggggcgggaaggcgaggagtgccaccccggcagccacaaggtccccttcttcaggaaacgcaagcaccacacctgtccttgcttgcccaacctgctgtgctccaggttcccggacggcaggtaccgctgctccatggacttgaagaacatcaatttttaggcgcttgcctggtctcaggatacccaccatccttttcctgagcacagcctggatttttatttctgccatgaaacccagctcccatgactctcccagtccctacactgactaccctgatctctcttgtctagtacgcacatatgcacacaggcagacatacctcccatcatgacatggtccccaggctggcctgaggatgtcacagcttgaggctgtggtgtgaaaggtggccagcctggttctcttccctgctcaggctgccagagaggtggtaaatggcagaaaggacattccccctcccctccccaggtgacctgctctctttcctgggccctgcccctctccccacatgtatccctcggtctgaattagacattcctgggcacaggctcttgggtgcattgctcagagtcccaggtcctggcctgaccctcaggcccttcacgtgaggtctgtgaggaccaatttgtgggtagttcatcttccctcgattggttaactccttagtttcagaccacagactcaagattggctcttcccagagggcagcagacagtcaccccaaggcaggtgtagggagcccagggaggccaatcagccccctgaagactctggtcccagtcagcctgtggcttgtggcctgtgacctgtgaccttctgccagaattgtcatgcctctgaggccccctcttaccacactttaccagttaaccactgaagcccccaattcccacagcttttccattaaaatgcaaatggtggtggttcaatctaatctgatattgacatattagaaggcaattagggtgtttccttaaacaactcctttccaaggatcagccctgagagcaggttggtgactttgaggagggcagtcctctgtccagattggggtgggagcaagggacagggagcagggcaggggctgaaaggggcactgattcagaccagggaggcaactacacaccaacctgctggctttagaataaaagcaccaactgaactga
//

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]