ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2024-04-26 18:06:31, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_004202 1337 bp mRNA linear PRI 25-DEC-2022
DEFINITION Homo sapiens thymosin beta 4 Y-linked (TMSB4Y), mRNA.
ACCESSION NM_004202
VERSION NM_004202.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1337)
AUTHORS Lu B, Yu Y, Xing XL and Liu RY.
TITLE miR-183/TMSB4Y, a new potential signaling axis, involving in the
progression of laryngeal cancer via modulating cell adhesion
JOURNAL J Recept Signal Transduct Res 42 (2), 133-140 (2022)
PUBMED 33356743
REMARK GeneRIF: miR-183/TMSB4Y, a new potential signaling axis, involving
in the progression of laryngeal cancer via modulating cell
adhesion.
REFERENCE 2 (bases 1 to 1337)
AUTHORS Wong HY, Wang GM, Croessmann S, Zabransky DJ, Chu D, Garay JP,
Cidado J, Cochran RL, Beaver JA, Aggarwal A, Liu ML, Argani P,
Meeker A, Hurley PJ, Lauring J and Park BH.
TITLE TMSB4Y is a candidate tumor suppressor on the Y chromosome and is
deleted in male breast cancer
JOURNAL Oncotarget 6 (42), 44927-44940 (2015)
PUBMED 26702755
REMARK GeneRIF: Suggest Y chromosome gene TMSB4Y may function as a tumor
suppressor gene in male breast cancer.
REFERENCE 3 (bases 1 to 1337)
AUTHORS Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK,
Safari A, Liu D and Songyang Z.
TITLE Genome-wide YFP fluorescence complementation screen identifies new
regulators for telomere signaling in human cells
JOURNAL Mol Cell Proteomics 10 (2), M110.001628 (2011)
PUBMED 21044950
REFERENCE 4 (bases 1 to 1337)
AUTHORS Lee HR, Yoon SY, Kang HB, Park S, Kim KE, Cho YH, Kim S, Kim CW,
Cho BJ, Lee WJ, Bang SI, Park H and Cho D.
TITLE Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
JOURNAL Immunol Lett 123 (1), 72-76 (2009)
PUBMED 19369144
REMARK GeneRIF: T beta 4 is a key activator of NK cell cytotoxicity.
REFERENCE 5 (bases 1 to 1337)
AUTHORS Torikai H, Akatsuka Y, Miyazaki M, Warren EH 3rd, Oba T, Tsujimura
K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K and Takahashi T.
TITLE A novel HLA-A*3303-restricted minor histocompatibility antigen
encoded by an unconventional open reading frame of human TMSB4Y
gene
JOURNAL J Immunol 173 (11), 7046-7054 (2004)
PUBMED 15557202
REMARK GeneRIF: TMSB4Y has been found to encode a novel
HLA-A*3303-restricted minor histocompatibility H-Y antigen,
revealed during cytotoxicity assays of T cell lines from a
female-to-male hemopoietic stem cell transplantation patient.
REFERENCE 6 (bases 1 to 1337)
AUTHORS Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L,
Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A,
Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R,
Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R,
McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S,
Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP,
Waterston RH, Wilson RK, Rozen S and Page DC.
TITLE The male-specific region of the human Y chromosome is a mosaic of
discrete sequence classes
JOURNAL Nature 423 (6942), 825-837 (2003)
PUBMED 12815422
REFERENCE 7 (bases 1 to 1337)
AUTHORS Lahn BT and Page DC.
TITLE Functional coherence of the human Y chromosome
JOURNAL Science 278 (5338), 675-680 (1997)
PUBMED 9381176
REFERENCE 8 (bases 1 to 1337)
AUTHORS Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA and Yin HL.
TITLE Thymosin beta 10 and thymosin beta 4 are both actin monomer
sequestering proteins
JOURNAL J Biol Chem 268 (1), 502-509 (1993)
PUBMED 8416954
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC119763.1 and BC022482.1.
On Nov 23, 2018 this sequence version replaced NM_004202.2.
Summary: This gene lies within the male specific region of
chromosome Y. Its homolog on chromosome X escapes X inactivation
and encodes an actin sequestering protein. [provided by RefSeq, Jul
2008].
##Evidence-Data-START##
Transcript exon combination :: SRR3476690.1073402.1,
SRR3476690.971176.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1966682, SAMEA1968832
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000284856.4/ ENSP00000284856.3
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-755 BC119763.1 91-845
756-1337 BC022482.1 351-932
FEATURES Location/Qualifiers
source 1..1337
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="Y"
/map="Yq11.221"
gene 1..1337
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="thymosin beta 4 Y-linked"
/db_xref="GeneID:9087"
/db_xref="HGNC:HGNC:11882"
/db_xref="MIM:400017"
exon 1..537
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/inference="alignment:Splign:2.1.0"
variation 9
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:2079759905"
variation 13
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:757261455"
variation 24
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:2079759929"
variation 36
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2150433178"
variation 64
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:2319533"
variation 65
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2079759953"
variation 190
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="t"
/db_xref="dbSNP:2079759964"
variation 217
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:370276852"
misc_feature 243..245
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="upstream in-frame stop codon"
variation 261
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:570780654"
variation 282
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:1213858131"
variation 303..306
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="gggg"
/replace="ggggg"
/db_xref="dbSNP:34464846"
variation 306
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:764526646"
variation 312
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2079760013"
variation 315
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:13303743"
variation 316
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:13303967"
variation 324
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:1603489611"
variation 327
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:13305898"
variation 333
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:1275287784"
variation 334
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:13305904"
variation 335
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:13305905"
variation 351
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:1005517418"
variation 362
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:13303859"
variation 364
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:13303862"
variation 369
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:1039998769"
variation 379
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:13304089"
variation 388
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:749749880"
variation 391
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:1400455457"
variation 402
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:769135193"
variation 414
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:2079760210"
variation 424..429
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="ct"
/replace="cttcct"
/db_xref="dbSNP:2079760224"
variation 427
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:774548459"
variation 428
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:13305267"
CDS 438..572
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="thymosin, beta 4, Y chromosome"
/codon_start=1
/product="thymosin beta-4, Y-chromosomal"
/protein_id="NP_004193.1"
/db_xref="CCDS:CCDS14786.1"
/db_xref="GeneID:9087"
/db_xref="HGNC:HGNC:11882"
/db_xref="MIM:400017"
/translation="
MSDKPGMAEIEKFDKSKLKKTETQEKNPLSSKETIEQERQAGES"
misc_feature 438..569
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="propagated from UniProtKB/Swiss-Prot (O14604.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 444..560
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="Thymosin beta-4 family; Region: Thymosin;
pfam01290"
/db_xref="CDD:396038"
variation 439
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="t"
/db_xref="dbSNP:1367984481"
variation 450
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:747847087"
variation 458
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:1426016210"
variation 464
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:1303159099"
variation 478
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:771735497"
variation 483
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:866083329"
variation 484
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:772813332"
variation 491
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:1280905291"
variation 492
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:760181444"
variation 500..502
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="aga"
/db_xref="dbSNP:1222995343"
variation 508
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="t"
/db_xref="dbSNP:770286667"
variation 509
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:776688710"
variation 510..512
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace=""
/replace="gag"
/db_xref="dbSNP:767010230"
variation 520
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="c"
/db_xref="dbSNP:1361438432"
exon 538..1337
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/inference="alignment:Splign:2.1.0"
variation 542
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:750618349"
variation 564
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:1403066060"
variation 615
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:373131786"
variation 623
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:779997636"
variation 634
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:777729379"
variation 653
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:2079760833"
variation 660
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:915563936"
variation 667
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:2079760856"
variation 669
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:971364381"
variation 685
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:764645663"
variation 695
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2079760899"
variation 724
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:758314420"
variation 734
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:2079760940"
variation 737
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="g"
/db_xref="dbSNP:2079760949"
variation 750
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:2079760968"
variation 766
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:1421922429"
variation 785
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:1603489623"
variation 788
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:758097554"
variation 806
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2079761019"
variation 898
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:1569516579"
variation 931..934
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="ca"
/replace="caca"
/db_xref="dbSNP:2079761052"
variation 938
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:2079761070"
variation 941
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="t"
/db_xref="dbSNP:113175306"
variation 953
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:766079614"
variation 1005
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2079761109"
variation 1035
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:567308105"
variation 1058
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:751287111"
variation 1076
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:919133519"
variation 1092
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:929099880"
variation 1108
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:1047181223"
variation 1120
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:909945567"
variation 1138
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:2079761231"
variation 1174
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="g"
/replace="t"
/db_xref="dbSNP:2079761243"
variation 1260..1261
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace=""
/replace="ttctttgcttaatgatttcccttaagtctc"
/db_xref="dbSNP:2079761259"
variation 1289
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2150433260"
variation 1301
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="t"
/db_xref="dbSNP:941355751"
variation 1304
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="c"
/replace="t"
/db_xref="dbSNP:1603489624"
variation 1305
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="g"
/db_xref="dbSNP:2079761300"
regulatory 1315..1320
/regulatory_class="polyA_signal_sequence"
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="hexamer: AATAAA"
variation 1315
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/replace="a"
/replace="t"
/db_xref="dbSNP:2079761317"
polyA_site 1337
/gene="TMSB4Y"
/gene_synonym="TB4Y"
/note="major polyA site"
ORIGIN
gttgtttgcagagaggccgtggctacaaaatggaagtgcttttgcgacctgggctccattttaggaattcttgcccgattttaaccacttgaacgcggaagtggctttcctattctcttccaagccagcctttaattttaaacgctgtaattaacagttcacaggggtcaaattcctttattccggaacattccactttgagagggatctgtcctctttggtcccctgcgttttcaaatatttgaggaaaggtgtcgcctctttttctgtggaaagaggaagctcatgagcgcgaaacagcaggggacggagggcgagaagggctttctcaggttgcgggtcggagggcagaagcacagttcccagtacagagacccggacaggtggctgtttctcacgctcactttggattgctccctacggcttcctccgcagccatgtctgacaaacctggtatggctgagatcgagaaattcgataagtcgaaactgaagaagacagaaacgcaagagaagaatccattgtcttccaaagaaactatcgaacaggagaggcaagcaggcgaatcttaaacaggcatgtgccaccaatatctactgtacattctacaagcattgctttcttattttacttcttttacttgtttaacttggttagatgcaaacacgttggatgagtttgaaaggactatgctgcccttttgacatcaaagacctgctgacaatggaggccacgcctgcttctcccatcgcctgtctggctggcagggaaggaaaatagcttgaatgttggtgaaagacttagcggagtgggagggcagtgaaatctagagtaaaaccaagttgggccaagtgtcctgcagaatctaaaatgaagtttaatcagcgtgccatttttgttgttgtttgaaagattttaatttttggaatgcacagtttttatttaaaaaagacatttttaaaccactgcttgtgagattgcttgttgattggaaagagtgttttattcaccatttaaacgtttgcaaagtggcgtgccccttggcctcacaggcaaagaataacttaaaagctgacgatttgaataaattatgttacagtatgaaatatgttttacctggatatgtaaaataccttctttattctagctaattgggagatgattttttttggctaattgagattacctttagattatgttttcaaaactggcttatactgtaatctacaactaataagcactaatttagagttcagctatattgttgcatgtagtgagaagggacttaattacaaacttaagacgtaagtgtgcaataaagtaagctaagaagaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]