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Previous release (v1)
2024-06-27 01:15:20, GGRNA.v2 : RefSeq release 224 (May, 2024)
LOCUS NM_001425147 6125 bp mRNA linear PRI 10-APR-2024
DEFINITION Homo sapiens DEAD-box helicase 6 (DDX6), transcript variant 5,
mRNA.
ACCESSION NM_001425147
VERSION NM_001425147.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6125)
AUTHORS Ripin,N., Macedo de Vasconcelos,L., Ugay,D.A. and Parker,R.
TITLE DDX6 modulates P-body and stress granule assembly, composition, and
docking
JOURNAL J Cell Biol 223 (6) (2024)
PUBMED 38536035
REMARK GeneRIF: DDX6 modulates P-body and stress granule assembly,
composition, and docking.
REFERENCE 2 (bases 1 to 6125)
AUTHORS Deng,X., Liu,Z., Wang,B., Ma,J. and Meng,X.
TITLE The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to
the malignant behavior of pancreatic cancer
JOURNAL FASEB J 38 (7), e23581 (2024)
PUBMED 38551642
REMARK GeneRIF: The DDX6/KIFC1 signaling axis, as regulated by YY1,
contributes to the malignant behavior of pancreatic cancer.
REFERENCE 3 (bases 1 to 6125)
AUTHORS Naito,S., Tanaka,H., Jiang,J.J., Tarumi,M., Hashimoto,A.,
Tanaka,Y., Murakami,K., Kubota,S.I., Hojyo,S., Hashimoto,S. and
Murakami,M.
TITLE DDX6 is involved in the pathogenesis of inflammatory diseases via
NF-kappaB activation
JOURNAL Biochem Biophys Res Commun 703, 149666 (2024)
PUBMED 38377944
REMARK GeneRIF: DDX6 is involved in the pathogenesis of inflammatory
diseases via NF-kappaB activation.
REFERENCE 4 (bases 1 to 6125)
AUTHORS Majerciak,V., Zhou,T., Kruhlak,M.J. and Zheng,Z.M.
TITLE RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote
biogenesis of stress granules
JOURNAL Nucleic Acids Res 51 (17), 9337-9355 (2023)
PUBMED 37427791
REMARK GeneRIF: RNA helicase DDX6 and scaffold protein GW182 in P-bodies
promote biogenesis of stress granules.
REFERENCE 5 (bases 1 to 6125)
AUTHORS Shih,C.Y., Chen,Y.C., Lin,H.Y. and Chu,C.Y.
TITLE RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal
Differentiation in Human Cells
JOURNAL Int J Mol Sci 24 (4), 3197 (2023)
PUBMED 36834609
REMARK GeneRIF: RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal
Differentiation in Human Cells.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6125)
AUTHORS Akiyama,K., Akao,Y., Yokoyama,M., Nakagawa,Y., Noguchi,T., Yagi,K.
and Nishi,Y.
TITLE Expression of two dead box genes (DDX1 and DDX6) is independent of
that of MYCN in human neuroblastoma cell lines
JOURNAL Biochem Mol Biol Int 47 (4), 563-568 (1999)
PUBMED 10319407
REFERENCE 7 (bases 1 to 6125)
AUTHORS Zhang,W.J. and Wu,J.Y.
TITLE Functional properties of p54, a novel SR protein active in
constitutive and alternative splicing
JOURNAL Mol Cell Biol 16 (10), 5400-5408 (1996)
PUBMED 8816452
REFERENCE 8 (bases 1 to 6125)
AUTHORS Akao,Y., Marukawa,O., Morikawa,H., Nakao,K., Kamei,M., Hachiya,T.
and Tsujimoto,Y.
TITLE The rck/p54 candidate proto-oncogene product is a 54-kilodalton
D-E-A-D box protein differentially expressed in human and mouse
tissues
JOURNAL Cancer Res 55 (15), 3444-3449 (1995)
PUBMED 7614484
REFERENCE 9 (bases 1 to 6125)
AUTHORS Akao,Y., Seto,M., Yamamoto,K., Iida,S., Nakazawa,S., Inazawa,J.,
Abe,T., Takahashi,T. and Ueda,R.
TITLE The RCK gene associated with t(11;14) translocation is distinct
from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations
JOURNAL Cancer Res 52 (21), 6083-6087 (1992)
PUBMED 1394235
REFERENCE 10 (bases 1 to 6125)
AUTHORS Lu,D. and Yunis,J.J.
TITLE Cloning, expression and localization of an RNA helicase gene from a
human lymphoid cell line with chromosomal breakpoint 11q23.3
JOURNAL Nucleic Acids Res 20 (8), 1967-1972 (1992)
PUBMED 1579499
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AP004609.1, AP002954.1,
KF510139.1, KF511134.1 and KF510354.1.
Summary: This gene encodes a member of the DEAD box protein family.
The protein is an RNA helicase found in P-bodies and stress
granules, and functions in translation suppression and mRNA
degradation. It is required for microRNA-induced gene silencing.
Multiple alternatively spliced variants, encoding the same protein,
have been identified. [provided by RefSeq, Mar 2012].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DRR138512.233474.1,
ERR4352444.496887.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-67 AP004609.1 8106-8172 c
68-534 AP004609.1 3060-3526 c
535-598 AP002954.1 159535-159598 c
599-703 AP002954.1 158046-158150 c
704-771 KF510139.1 1-68 c
772-830 AP002954.1 146636-146694 c
831-977 AP002954.1 143622-143768 c
978-1072 AP002954.1 141626-141720 c
1073-1195 AP002954.1 138336-138458 c
1196-1324 AP002954.1 137188-137316 c
1325-1441 AP002954.1 135585-135701 c
1442-1505 AP002954.1 134674-134737 c
1506-1607 AP002954.1 133816-133917 c
1608-1790 AP002954.1 133119-133301 c
1791-2637 AP002954.1 129665-130511 c
2638-2723 KF511134.1 1-86 c
2724-3686 AP002954.1 128617-129579 c
3687-4065 KF510354.1 1-379
4066-6125 AP002954.1 126177-128236 c
FEATURES Location/Qualifiers
source 1..6125
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.3"
gene 1..6125
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="DEAD-box helicase 6"
/db_xref="GeneID:1656"
/db_xref="HGNC:HGNC:2747"
/db_xref="MIM:600326"
exon 1..67
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 68..534
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
misc_feature 326..328
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="upstream in-frame stop codon"
CDS 335..1783
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/EC_number="3.6.4.13"
/note="isoform 2 is encoded by transcript variant 5;
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA
helicase, 54kD); DEAD box-6; probable ATP-dependent RNA
helicase DDX6; oncogene RCK; DEAD box protein 6;
ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box
polypeptide 6; DEAD (Asp-Glu-Ala-Asp) box helicase 6"
/codon_start=1
/product="probable ATP-dependent RNA helicase DDX6 isoform
2"
/protein_id="NP_001412076.1"
/db_xref="GeneID:1656"
/db_xref="HGNC:HGNC:2747"
/db_xref="MIM:600326"
/translation="
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP"
misc_feature 335..454
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 440..442
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:17525332; propagated from
UniProtKB/Swiss-Prot (P26196.2); phosphorylation site"
misc_feature 620..706
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: Q motif"
misc_feature 1067..1078
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: DEAD box"
misc_feature 1187..1279
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: Gyf binding.
/evidence=ECO:0000269|PubMed:31439631"
misc_feature 1250..1780
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: RecA-like domain 2.
/evidence=ECO:0000269|PubMed:31439631"
exon 535..598
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 599..703
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 704..830
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 831..977
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 978..1072
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1073..1195
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1196..1324
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1325..1441
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1442..1505
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1506..1607
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1608..1790
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1791..6125
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
regulatory 6101..6106
/regulatory_class="polyA_signal_sequence"
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="hexamer: AATAAA"
polyA_site 6125
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="major polyA site"
ORIGIN
agaggagccgagttagctcagccaggcggcgacttcggcggcgccacgagagcgggcagcggaggagattgacgtgagtgaattcagatataactcaagcttgttagagggctttttaaaaataaaaagttgattccgtgcaagagagcaagttactgctgcttaccgttcagagacttacaggtgcttgcctgcattgcaataaaggactcatttattgagcaagacttatatttatctcttcattttggagagcctaataaactgttattacagtttctctactgactttcaaaagttttgaagtttgaaagacctttgcaattaaaacagcatgagcacggccagaacagagaaccctgttataatgggtctgtccagtcaaaatggtcagctgagaggccctgtgaaacccactggtggccctggaggagggggcacacagacacagcaacagatgaaccagctgaaaaacaccaacacaatcaataatggcactcagcagcaagcacagagtatgaccaccactattaaacctggtgatgactggaaaaagactttaaaactccctccaaaggatctaagaatcaaaacttcggatgtgacctccacaaaaggaaatgagtttgaagattactgtttgaaacgggagttactgatgggaatttttgaaatgggctgggaaaagccatctcctattcaggagagcattcccattgctttatctggtagggatatcttagctagagcaaaaaatggaacaggcaagagcggtgcctacctcattcccttacttgaacggctagacctgaagaaggacaatatacaagcaatggtgattgttcccactagagaacttgctctacaggtcagtcaaatttgcatccaggtcagcaaacacatgggaggggccaaagtgatggcaaccacaggaggaaccaatttacgagatgacataatgaggcttgatgatacagtgcacgtggtgattgctacccctgggagaatcctggatcttattaagaaaggagtagcaaaggttgatcatgtccagatgatagtattggatgaggcagataagttgctgtcacaggattttgtgcagataatggaggatattattctcacgctacctaaaaacaggcagattttactatattccgctactttccctcttagtgtacagaagttcatgaattcccatttgcagaaaccctatgagattaacctgatggaggaactaactctgaagggagtaacccagtactacgcatatgtaactgagcgccaaaaagtacactgcctcaacacacttttctccaggcttcagataaaccagtcgatcattttctgtaactcctctcagcgagttgaattgctagccaagaagatttctcaactgggttattcttgcttctatattcatgctaaaatgaggcaggaacatcgaaatcgtgtatttcatgatttccgaaatggcttatgccgcaatcttgtttgcactgatctgtttacccgaggtattgatatacaagctgtgaatgtggtaataaactttgatttcccaaagctggcagagacctatctccatcgtattggaagatcaggtcgctttggtcatcttggcttagccatcaacttgatcacatatgatgatcgcttcaacctgaaaagtattgaggagcagctgggaacagaaattaaacctattccgagcaacattgataagagcctgtatgtggcagaataccacagcgagcctgtagaagatgagaaaccttaacaagcatgctttgacaaattacaaaaggctcgtttggatctgtgacacatcgttttggggggaatgctcctctctttgtgggtttttcatcttttattttggaactatgaagacttaaaagagctcagacattttctttttttaactggtgaagagaaaaaggctgaaaagaaggaatataccttttttgttccacttgtttgcactgtgtgctgactgaacattagttgcactaactgctggtttttaaaaaatgttttctggggaaaggggacaaggaaggaaaagaaagaagagaaggggagaaaccctaaaaagagaagaatcttaatgaacacacaagcttgtcaatgatttcaaaattctccaacagctgactctcgtgcatttcaacttctccctgattcctcatccgttttttaagcctgaagagcttattacttatttgtgcgaagtgccttatgctatgagaccattcagaatatcatcttttagacacagcccgaggaatcaacaatagtaactctttctttccgtttttttttctttttcttttaaaaaatgtcttcttattttggtttcaggttgaagtctcttccctttctacccagtactcgagcccagggctagaagttgaaactcactagtaatgttaaacaccattttttttttctttttggggaggagttgatatgcaactgcagttcatccgcactgtaaatacatgtatttaaaaaaacaatcccaagtaaaaatttcttctgggctgagtagataaaaaacatcatcgctcccaaaggaaagagcagtctatcattgcaggagccatatgacaagcctttgtgctctatagcagacactaaagactgggttacatatgcctccagtagtagtatggcacttgatgtgtagacatgtcagagccttggccctctttcctctgtggcaaagcgtgtcccatagaaaattgggtgtgtatacttgtataactttgtaaataagttttttttctgggttcatatatatatatatatatacatatatatatatttttttttggatgaaggttgctgggattaaggggattagagtgattatgggagcagctaaagatgagaggggctcagttttacgcaacactaaattctagaaagtactttggcctcgtgctgtagagagcagatttctatggtaccctgtgttagtaaaggggcccagaaatctgggatgtactgtttgctgccacactgtctcatctagtacctttggagtaggtttaccagagagagcaaggaagcttcaaaacattgataattcaacatttattttgagaagctctgattttgcttcttccccctttctaaaagtttgaggaatatttcaagctctgcaacagggggcaaagattaatctaccttgcagtgtaggaattctattgagtggcagtgtcattgagcagtatatatataaagcacagatttgcatttcagaatattagccagtaccagctttggtaatgttagcagttctggagcttaattttctgtggatcatttcctgtagtgtgtaaatgtgttgccctctgcccgctttgatacataaacttttgcaggaatgggcaacctgagagctgttaactttcatgctacagaaagctgcttgccattctcttgcattgtgacaagaattgttacctgtcattttgcactgtaaattgctggcagatgctttacagtcaatagtgttgctttaaattgtgcccctcccaacatgcttgatgtttggcctgatctccaggcaaaaggagtgagatgaatcaaaaccagtgaacttttttttttaatgtttttaattcccttttaacccagtgtactaggtcaatcaggaggcatctggaaagggggggaaaaaagcaaaaaacaaaattaaaaaaaattgatttccatattttatttttcaaaaccctaaaatattacaaaataagtcccgcatatactttaatgttttaactcttttggacaaaggaatcaattacttgaagttgcttttttgactctgcctacttctgagcaaactatttgcgactcacccacaattccttggagatcaaaatcctacagatgcctcctgatgggacatagccctaactccttaacaactgtagcaagaactgcacggtacaaacccaaaaaagaacaagctcatctatttggaacccaagcctcatattttctgtccagtcaatgttggttactaaatagaaaacctaattaaggaagtaacttttttccagggaggggtgggagagggaatttaaaaggtgtcaacttttgaccaaaaaaattgtgcccttgtaccgatgcagctctctttctcccccacctcttgcgagataagagggatcattcatgtagaagaaaagagtataaatgcaattctgtatctcgctagagaacgtgtgggtgactaaacaaaaagtgcagtctccttcaccaactttagactgcgtggtgccacatgcctgtgggtccctcttaaagcacagacttaaaatggaaagtattactgaagtatagcctctaatgaggagtggcacttaaactatctgggacaccactactggacacggtcttgtagaggcagctgtccagttttggtgcttgactcttgaataggaattgttaaatggaaagatgctctgaggactaggtcaaagcctggtctttttttttttttttttttttttctttcttttttgggccctcataataagcattgttactattggaagttgttttcacattctttccaatattaaatatgtatttttttaagtaatgataatattttccagtggctcatttggatgagaactaccctctatttttaatattaaaactacatccaactcatcatttagcctttggttgtacagttgtgtaatgggctatggactgttacacaccttaccacctctaggcctatgttttttctttccccatatattctgatggggataaatactgttttgcctctcccataggaatggaatacatttattctaaaatgatctttcacagaagtaagagagagggaaacctaaatatacctctaaattgtttgaagttggtcccagcagcataaaatgggttggccccaaagggttggagggtgggcttggttatcagtatttgttttcagaatgagatgggagcatctttcctttgccacgtgctttgtgcttgataacatcatgcttggttcaaacgacaactcagcacaaagccttgagtataaattgttggaatcaaaacatctcattctgatgacgtggtttaattttttaatttttttttttaataggggtgggagggagggtactttgccccagaagggagggtgtctgcactaaggatttagaaacactttggaagctcataacctcatcagaaactgcctttagccacactcctgaccttctagatgagtaacaaaaaaatgaaataagttcttggaaattaagccatttattttaatttgctatttttttcaatgttctaggtatctttaaatttgttattgtggaatcattttcctgccagatacctttatcaaaattattggcctcatgagagctgaagtaagtcagctttttggtgaactttagtggacttctgtgagattgtagttgtactttgtatctctaaatctaaagatagttttttaaaactcccaaagaaaatctgctctcctttctgatctaaaaactcatctttggggtaaagagttaagtgtccaaaggttgtcacagttcatgaggtcagagggagctagcctggcacctggactctgcccatccacagctgacagattccaacagaagtgtatttaaattctccagtagacaatgctgggtaagggagggggtagggctgggttattaagatacaggctgctgtattttacattggttgtgtgggaaggggagcctggagaaaacaaagtcactattcccttttttgaaacaggaaaaaaaattattttttgttcagtaaaaatggtagagaattccaatgtccctagccacaagggaccagttccactgagaagtgaacagtgggaactcaaaatttcagaaacattgggggaagggaaaattggctttctcttaattggcagatgttccagtggggggggggggggctctgtttttgttgggatgtgttatgttgtatgtacgcatatatggaccggagtctgctgagtttataaggttccaaaaatatggtaaaatcttggtttttgttaatttatctcaataaaagcccactggaactccaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]