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Previous release (v1)
2024-06-27 01:10:03, GGRNA.v2 : RefSeq release 224 (May, 2024)
LOCUS NM_001425146 6186 bp mRNA linear PRI 10-APR-2024
DEFINITION Homo sapiens DEAD-box helicase 6 (DDX6), transcript variant 4,
mRNA.
ACCESSION NM_001425146 XM_024448377 XM_054367877
VERSION NM_001425146.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6186)
AUTHORS Ripin,N., Macedo de Vasconcelos,L., Ugay,D.A. and Parker,R.
TITLE DDX6 modulates P-body and stress granule assembly, composition, and
docking
JOURNAL J Cell Biol 223 (6) (2024)
PUBMED 38536035
REMARK GeneRIF: DDX6 modulates P-body and stress granule assembly,
composition, and docking.
REFERENCE 2 (bases 1 to 6186)
AUTHORS Deng,X., Liu,Z., Wang,B., Ma,J. and Meng,X.
TITLE The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to
the malignant behavior of pancreatic cancer
JOURNAL FASEB J 38 (7), e23581 (2024)
PUBMED 38551642
REMARK GeneRIF: The DDX6/KIFC1 signaling axis, as regulated by YY1,
contributes to the malignant behavior of pancreatic cancer.
REFERENCE 3 (bases 1 to 6186)
AUTHORS Naito,S., Tanaka,H., Jiang,J.J., Tarumi,M., Hashimoto,A.,
Tanaka,Y., Murakami,K., Kubota,S.I., Hojyo,S., Hashimoto,S. and
Murakami,M.
TITLE DDX6 is involved in the pathogenesis of inflammatory diseases via
NF-kappaB activation
JOURNAL Biochem Biophys Res Commun 703, 149666 (2024)
PUBMED 38377944
REMARK GeneRIF: DDX6 is involved in the pathogenesis of inflammatory
diseases via NF-kappaB activation.
REFERENCE 4 (bases 1 to 6186)
AUTHORS Majerciak,V., Zhou,T., Kruhlak,M.J. and Zheng,Z.M.
TITLE RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote
biogenesis of stress granules
JOURNAL Nucleic Acids Res 51 (17), 9337-9355 (2023)
PUBMED 37427791
REMARK GeneRIF: RNA helicase DDX6 and scaffold protein GW182 in P-bodies
promote biogenesis of stress granules.
REFERENCE 5 (bases 1 to 6186)
AUTHORS Shih,C.Y., Chen,Y.C., Lin,H.Y. and Chu,C.Y.
TITLE RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal
Differentiation in Human Cells
JOURNAL Int J Mol Sci 24 (4), 3197 (2023)
PUBMED 36834609
REMARK GeneRIF: RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal
Differentiation in Human Cells.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6186)
AUTHORS Akiyama,K., Akao,Y., Yokoyama,M., Nakagawa,Y., Noguchi,T., Yagi,K.
and Nishi,Y.
TITLE Expression of two dead box genes (DDX1 and DDX6) is independent of
that of MYCN in human neuroblastoma cell lines
JOURNAL Biochem Mol Biol Int 47 (4), 563-568 (1999)
PUBMED 10319407
REFERENCE 7 (bases 1 to 6186)
AUTHORS Zhang,W.J. and Wu,J.Y.
TITLE Functional properties of p54, a novel SR protein active in
constitutive and alternative splicing
JOURNAL Mol Cell Biol 16 (10), 5400-5408 (1996)
PUBMED 8816452
REFERENCE 8 (bases 1 to 6186)
AUTHORS Akao,Y., Marukawa,O., Morikawa,H., Nakao,K., Kamei,M., Hachiya,T.
and Tsujimoto,Y.
TITLE The rck/p54 candidate proto-oncogene product is a 54-kilodalton
D-E-A-D box protein differentially expressed in human and mouse
tissues
JOURNAL Cancer Res 55 (15), 3444-3449 (1995)
PUBMED 7614484
REFERENCE 9 (bases 1 to 6186)
AUTHORS Akao,Y., Seto,M., Yamamoto,K., Iida,S., Nakazawa,S., Inazawa,J.,
Abe,T., Takahashi,T. and Ueda,R.
TITLE The RCK gene associated with t(11;14) translocation is distinct
from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations
JOURNAL Cancer Res 52 (21), 6083-6087 (1992)
PUBMED 1394235
REFERENCE 10 (bases 1 to 6186)
AUTHORS Lu,D. and Yunis,J.J.
TITLE Cloning, expression and localization of an RNA helicase gene from a
human lymphoid cell line with chromosomal breakpoint 11q23.3
JOURNAL Nucleic Acids Res 20 (8), 1967-1972 (1992)
PUBMED 1579499
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AP004609.1, AP002954.1,
KF510139.1, KF511134.1 and KF510354.1.
On or before Oct 28, 2023 this sequence version replaced
XM_024448377.2, XM_054367877.1.
Summary: This gene encodes a member of the DEAD box protein family.
The protein is an RNA helicase found in P-bodies and stress
granules, and functions in translation suppression and mRNA
degradation. It is required for microRNA-induced gene silencing.
Multiple alternatively spliced variants, encoding the same protein,
have been identified. [provided by RefSeq, Mar 2012].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038193.4495323.1,
SRR14038195.2331770.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-125 AP004609.1 8628-8752 c
126-592 AP004609.1 3060-3526 c
593-656 AP002954.1 159535-159598 c
657-761 AP002954.1 158046-158150 c
762-832 KF510139.1 1-71 c
833-891 AP002954.1 146636-146694 c
892-1038 AP002954.1 143622-143768 c
1039-1133 AP002954.1 141626-141720 c
1134-1256 AP002954.1 138336-138458 c
1257-1385 AP002954.1 137188-137316 c
1386-1502 AP002954.1 135585-135701 c
1503-1566 AP002954.1 134674-134737 c
1567-1668 AP002954.1 133816-133917 c
1669-1851 AP002954.1 133119-133301 c
1852-2698 AP002954.1 129665-130511 c
2699-2784 KF511134.1 1-86 c
2785-3747 AP002954.1 128617-129579 c
3748-4126 KF510354.1 1-379
4127-6186 AP002954.1 126177-128236 c
FEATURES Location/Qualifiers
source 1..6186
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.3"
gene 1..6186
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="DEAD-box helicase 6"
/db_xref="GeneID:1656"
/db_xref="HGNC:HGNC:2747"
/db_xref="MIM:600326"
exon 1..125
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 126..592
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
misc_feature 384..386
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="upstream in-frame stop codon"
CDS 393..1844
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/EC_number="3.6.4.13"
/note="isoform 1 is encoded by transcript variant 4;
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA
helicase, 54kD); DEAD box-6; probable ATP-dependent RNA
helicase DDX6; oncogene RCK; DEAD box protein 6;
ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box
polypeptide 6; DEAD (Asp-Glu-Ala-Asp) box helicase 6"
/codon_start=1
/product="probable ATP-dependent RNA helicase DDX6 isoform
1"
/protein_id="NP_001412075.1"
/db_xref="GeneID:1656"
/db_xref="HGNC:HGNC:2747"
/db_xref="MIM:600326"
/translation="
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP"
misc_feature 393..512
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 498..500
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:17525332; propagated from
UniProtKB/Swiss-Prot (P26196.2); phosphorylation site"
misc_feature 678..764
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: Q motif"
misc_feature 1128..1139
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: DEAD box"
misc_feature 1248..1340
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: Gyf binding.
/evidence=ECO:0000269|PubMed:31439631"
misc_feature 1311..1841
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="propagated from UniProtKB/Swiss-Prot (P26196.2);
Region: RecA-like domain 2.
/evidence=ECO:0000269|PubMed:31439631"
exon 593..656
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 657..761
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 762..891
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 892..1038
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1039..1133
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1134..1256
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1257..1385
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1386..1502
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1503..1566
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1567..1668
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1669..1851
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
exon 1852..6186
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/inference="alignment:Splign:2.1.0"
regulatory 6162..6167
/regulatory_class="polyA_signal_sequence"
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="hexamer: AATAAA"
polyA_site 6186
/gene="DDX6"
/gene_synonym="HLR2; IDDILF; P54; RCK; Rck/p54"
/note="major polyA site"
ORIGIN
agacgcgcgcccggcgtctccgggtcgctagttccgcgccttcctgcatggaggcgcgccccgagaggctcggacgcggccccttaggcccggcatcagcctccccggccagctggagaagtcagattgacgtgagtgaattcagatataactcaagcttgttagagggctttttaaaaataaaaagttgattccgtgcaagagagcaagttactgctgcttaccgttcagagacttacaggtgcttgcctgcattgcaataaaggactcatttattgagcaagacttatatttatctcttcattttggagagcctaataaactgttattacagtttctctactgactttcaaaagttttgaagtttgaaagacctttgcaattaaaacagcatgagcacggccagaacagagaaccctgttataatgggtctgtccagtcaaaatggtcagctgagaggccctgtgaaacccactggtggccctggaggagggggcacacagacacagcaacagatgaaccagctgaaaaacaccaacacaatcaataatggcactcagcagcaagcacagagtatgaccaccactattaaacctggtgatgactggaaaaagactttaaaactccctccaaaggatctaagaatcaaaacttcggatgtgacctccacaaaaggaaatgagtttgaagattactgtttgaaacgggagttactgatgggaatttttgaaatgggctgggaaaagccatctcctattcaggaggagagcattcccattgctttatctggtagggatatcttagctagagcaaaaaatggaacaggcaagagcggtgcctacctcattcccttacttgaacggctagacctgaagaaggacaatatacaagcaatggtgattgttcccactagagaacttgctctacaggtcagtcaaatttgcatccaggtcagcaaacacatgggaggggccaaagtgatggcaaccacaggaggaaccaatttacgagatgacataatgaggcttgatgatacagtgcacgtggtgattgctacccctgggagaatcctggatcttattaagaaaggagtagcaaaggttgatcatgtccagatgatagtattggatgaggcagataagttgctgtcacaggattttgtgcagataatggaggatattattctcacgctacctaaaaacaggcagattttactatattccgctactttccctcttagtgtacagaagttcatgaattcccatttgcagaaaccctatgagattaacctgatggaggaactaactctgaagggagtaacccagtactacgcatatgtaactgagcgccaaaaagtacactgcctcaacacacttttctccaggcttcagataaaccagtcgatcattttctgtaactcctctcagcgagttgaattgctagccaagaagatttctcaactgggttattcttgcttctatattcatgctaaaatgaggcaggaacatcgaaatcgtgtatttcatgatttccgaaatggcttatgccgcaatcttgtttgcactgatctgtttacccgaggtattgatatacaagctgtgaatgtggtaataaactttgatttcccaaagctggcagagacctatctccatcgtattggaagatcaggtcgctttggtcatcttggcttagccatcaacttgatcacatatgatgatcgcttcaacctgaaaagtattgaggagcagctgggaacagaaattaaacctattccgagcaacattgataagagcctgtatgtggcagaataccacagcgagcctgtagaagatgagaaaccttaacaagcatgctttgacaaattacaaaaggctcgtttggatctgtgacacatcgttttggggggaatgctcctctctttgtgggtttttcatcttttattttggaactatgaagacttaaaagagctcagacattttctttttttaactggtgaagagaaaaaggctgaaaagaaggaatataccttttttgttccacttgtttgcactgtgtgctgactgaacattagttgcactaactgctggtttttaaaaaatgttttctggggaaaggggacaaggaaggaaaagaaagaagagaaggggagaaaccctaaaaagagaagaatcttaatgaacacacaagcttgtcaatgatttcaaaattctccaacagctgactctcgtgcatttcaacttctccctgattcctcatccgttttttaagcctgaagagcttattacttatttgtgcgaagtgccttatgctatgagaccattcagaatatcatcttttagacacagcccgaggaatcaacaatagtaactctttctttccgtttttttttctttttcttttaaaaaatgtcttcttattttggtttcaggttgaagtctcttccctttctacccagtactcgagcccagggctagaagttgaaactcactagtaatgttaaacaccattttttttttctttttggggaggagttgatatgcaactgcagttcatccgcactgtaaatacatgtatttaaaaaaacaatcccaagtaaaaatttcttctgggctgagtagataaaaaacatcatcgctcccaaaggaaagagcagtctatcattgcaggagccatatgacaagcctttgtgctctatagcagacactaaagactgggttacatatgcctccagtagtagtatggcacttgatgtgtagacatgtcagagccttggccctctttcctctgtggcaaagcgtgtcccatagaaaattgggtgtgtatacttgtataactttgtaaataagttttttttctgggttcatatatatatatatatatacatatatatatatttttttttggatgaaggttgctgggattaaggggattagagtgattatgggagcagctaaagatgagaggggctcagttttacgcaacactaaattctagaaagtactttggcctcgtgctgtagagagcagatttctatggtaccctgtgttagtaaaggggcccagaaatctgggatgtactgtttgctgccacactgtctcatctagtacctttggagtaggtttaccagagagagcaaggaagcttcaaaacattgataattcaacatttattttgagaagctctgattttgcttcttccccctttctaaaagtttgaggaatatttcaagctctgcaacagggggcaaagattaatctaccttgcagtgtaggaattctattgagtggcagtgtcattgagcagtatatatataaagcacagatttgcatttcagaatattagccagtaccagctttggtaatgttagcagttctggagcttaattttctgtggatcatttcctgtagtgtgtaaatgtgttgccctctgcccgctttgatacataaacttttgcaggaatgggcaacctgagagctgttaactttcatgctacagaaagctgcttgccattctcttgcattgtgacaagaattgttacctgtcattttgcactgtaaattgctggcagatgctttacagtcaatagtgttgctttaaattgtgcccctcccaacatgcttgatgtttggcctgatctccaggcaaaaggagtgagatgaatcaaaaccagtgaacttttttttttaatgtttttaattcccttttaacccagtgtactaggtcaatcaggaggcatctggaaagggggggaaaaaagcaaaaaacaaaattaaaaaaaattgatttccatattttatttttcaaaaccctaaaatattacaaaataagtcccgcatatactttaatgttttaactcttttggacaaaggaatcaattacttgaagttgcttttttgactctgcctacttctgagcaaactatttgcgactcacccacaattccttggagatcaaaatcctacagatgcctcctgatgggacatagccctaactccttaacaactgtagcaagaactgcacggtacaaacccaaaaaagaacaagctcatctatttggaacccaagcctcatattttctgtccagtcaatgttggttactaaatagaaaacctaattaaggaagtaacttttttccagggaggggtgggagagggaatttaaaaggtgtcaacttttgaccaaaaaaattgtgcccttgtaccgatgcagctctctttctcccccacctcttgcgagataagagggatcattcatgtagaagaaaagagtataaatgcaattctgtatctcgctagagaacgtgtgggtgactaaacaaaaagtgcagtctccttcaccaactttagactgcgtggtgccacatgcctgtgggtccctcttaaagcacagacttaaaatggaaagtattactgaagtatagcctctaatgaggagtggcacttaaactatctgggacaccactactggacacggtcttgtagaggcagctgtccagttttggtgcttgactcttgaataggaattgttaaatggaaagatgctctgaggactaggtcaaagcctggtctttttttttttttttttttttttctttcttttttgggccctcataataagcattgttactattggaagttgttttcacattctttccaatattaaatatgtatttttttaagtaatgataatattttccagtggctcatttggatgagaactaccctctatttttaatattaaaactacatccaactcatcatttagcctttggttgtacagttgtgtaatgggctatggactgttacacaccttaccacctctaggcctatgttttttctttccccatatattctgatggggataaatactgttttgcctctcccataggaatggaatacatttattctaaaatgatctttcacagaagtaagagagagggaaacctaaatatacctctaaattgtttgaagttggtcccagcagcataaaatgggttggccccaaagggttggagggtgggcttggttatcagtatttgttttcagaatgagatgggagcatctttcctttgccacgtgctttgtgcttgataacatcatgcttggttcaaacgacaactcagcacaaagccttgagtataaattgttggaatcaaaacatctcattctgatgacgtggtttaattttttaatttttttttttaataggggtgggagggagggtactttgccccagaagggagggtgtctgcactaaggatttagaaacactttggaagctcataacctcatcagaaactgcctttagccacactcctgaccttctagatgagtaacaaaaaaatgaaataagttcttggaaattaagccatttattttaatttgctatttttttcaatgttctaggtatctttaaatttgttattgtggaatcattttcctgccagatacctttatcaaaattattggcctcatgagagctgaagtaagtcagctttttggtgaactttagtggacttctgtgagattgtagttgtactttgtatctctaaatctaaagatagttttttaaaactcccaaagaaaatctgctctcctttctgatctaaaaactcatctttggggtaaagagttaagtgtccaaaggttgtcacagttcatgaggtcagagggagctagcctggcacctggactctgcccatccacagctgacagattccaacagaagtgtatttaaattctccagtagacaatgctgggtaagggagggggtagggctgggttattaagatacaggctgctgtattttacattggttgtgtgggaaggggagcctggagaaaacaaagtcactattcccttttttgaaacaggaaaaaaaattattttttgttcagtaaaaatggtagagaattccaatgtccctagccacaagggaccagttccactgagaagtgaacagtgggaactcaaaatttcagaaacattgggggaagggaaaattggctttctcttaattggcagatgttccagtggggggggggggggctctgtttttgttgggatgtgttatgttgtatgtacgcatatatggaccggagtctgctgagtttataaggttccaaaaatatggtaaaatcttggtttttgttaatttatctcaataaaagcccactggaactccaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]