LOCUS       NM_001397445            1299 bp    mRNA    linear   PRI 17-NOV-2021
DEFINITION  Homo sapiens inward rectifying K+ channel negative regulator
            Kir2.2v (KCNJ17), mRNA.
ACCESSION   NM_001397445
VERSION     NM_001397445.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Paninka RM, Mazzotti DR, Kizys MM, Vidi AC, Rodrigues H, Silva SP,
            Kunii IS, Furuzawa GK, Arcisio-Miranda M and Dias-da-Silva MR.
  TITLE     Whole genome and exome sequencing realignment supports the
            assignment of KCNJ12, KCNJ17, and KCNJ18 paralogous genes in
            thyrotoxic periodic paralysis locus: functional characterization of
            two polymorphic Kir2.6 isoforms
  JOURNAL   Mol Genet Genomics 291 (4), 1535-1544 (2016)
   PUBMED   27008341
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Namba N, Mori R, Tanaka H, Kondo I, Narahara K and Seino Y.
  TITLE     The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1)
            maps to 17p11.2-->p11.1
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 85-87 (1997)
   PUBMED   9533018
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Namba N, Inagaki N, Gonoi T, Seino Y and Seino S.
  TITLE     Kir2.2v: a possible negative regulator of the inwardly rectifying
            K+ channel Kir2.2
  JOURNAL   FEBS Lett 386 (2-3), 211-214 (1996)
   PUBMED   8647284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CP068261.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1299              CP068261.2         22666291-22667589   c
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..1299
                     /gene="KCNJ17"
                     /gene_synonym="KCNJN1; Kir2.2v; Kir2.5"
                     /note="inward rectifying K+ channel negative regulator
                     Kir2.2v"
                     /db_xref="GeneID:123464521"
     CDS             1..1299
                     /gene="KCNJ17"
                     /gene_synonym="KCNJN1; Kir2.2v; Kir2.5"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     inhibitor 1"
                     /codon_start=1
                     /product="inward rectifying K+ channel negative regulator
                     Kir2.2v"
                     /protein_id="NP_001384374.1"
                     /db_xref="GeneID:123464521"
                     /translation="

MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKLHTRRRCHNRFVKKNGQCNIEFANMDEKSQRYLADIFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGRGRTPCVMQVHGFMAAFLFSIKTQTTISYGLRCVTEECPVAVFMVVAQSIVGCIINSFMIGAIMAKMVRPKKRAQTLLFSHNAVVALRDGKLCFMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDHSFLVSPITILHEIDEASPLFGISRQDLQMDDFEIVIILEGIVEATAMTTQARSSYLANEILWGHRFEPVLFEKNQYKIDYLHFHKTYEVPSTPRCSAKDLVENKFLLPRANSFCYKNELAFLSRDEEDEADGDQDGRSREGLIPQARHDFDRLQAGGGVLEQRPYRRESEI"

     misc_feature    4..138
                     /gene="KCNJ17"
                     /gene_synonym="KCNJN1; Kir2.2v; Kir2.5"
                     /note="Inward rectifier potassium channel N-terminal;
                     Region: IRK_N; pfam08466"
                     /db_xref="CDD:430012"
     misc_feature    139..561
                     /gene="KCNJ17"
                     /gene_synonym="KCNJN1; Kir2.2v; Kir2.5"
                     /note="Inward rectifier potassium channel; Region: IRK;
                     pfam01007"
                     /db_xref="CDD:425984"
     misc_feature    580..1095
                     /gene="KCNJ17"
                     /gene_synonym="KCNJN1; Kir2.2v; Kir2.5"
                     /note="Inward rectifier potassium channel C-terminal
                     domain; Region: IRK_C; pfam17655"
                     /db_xref="CDD:435949"
ORIGIN      

atgaccgcagccagccgggccaacccctacagcatcgtgtcatcggaggaggacgggctgcacctggtcaccatgtcgggcgccaatggcttcggcaacggcaagttgcacacgcggcgcaggtgccacaaccgcttcgtcaagaagaatggccagtgcaacattgagttcgccaacatggacgagaagtcacagcgctacctggctgacatattcaccacctgtgtggacatccgctggcggtacatgctgctcatcttctcactggccttccttgcctcctggctgctgtttggtgtcatcttctgggtcattgcggtggcacatggtgacctggagccggctgagggccgcggccgcacaccctgtgtgatgcaggtgcacggcttcatggcggccttcctcttctccatcaagacgcagaccaccatcagctacgggctgcgctgtgtgacagaggagtgcccggtggccgtcttcatggtggtggcccagtccatcgtgggctgcatcatcaactccttcatgattggtgccatcatggccaagatggtaaggcccaagaagcgggcacagacgctgctgttcagccacaatgccgtggtggccctgcgtgatggcaagctctgcttcatgtggcgtgtgggcaacctgcgtaagagccacattgtggaggcccatgtgcgcgcgcagctcatcaagccgcgggtcaccgaggagggcgagtacatcccgctagaccagatcgacatcgatgtgggcttcgacaagggcctggaccacagctttctggtgtcacccatcaccatcctgcacgagattgacgaggccagtccgctcttcggcatcagccggcaggacctgcagatggacgactttgagatcgtgatcatcctggaaggcattgtggaggccacagccatgaccacccaggcccgcagctcctacctggccaatgagatcctgtggggtcaccgctttgagcccgtgctcttcgagaagaaccagtacaagattgactacttgcacttccacaagacctatgaggtgccctctacaccccgctgcagcgcgaaggatctggtggagaacaagttcctgctgcccagggccaactccttctgctacaagaacgagctggccttcctgagccgtgacgaggaggatgaggcggacggagaccaggatggccgaagccgggaaggcctcatcccccaggccaggcatgactttgacagactccaggctggtggcggggtcctggagcagcggccctacagacgggagtcagagatctaa

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