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Previous release (v1)
2026-01-25 15:10:38, GGRNA : RefSeq release 232 (Sep, 2025)
Summary:
Results:
Matches are highlighted with green background.
Overlapping matches are dark colored.
misc_feature <213..317 /gene="PIWIL1" /gene_synonym="CT80.1; HIWI; MIWI; PIWI" /note="PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301" /db_xref="CDD:469713" misc_feature 273..1604 /gene="PIWIL1" /gene_synonym="CT80.1; HIWI; MIWI; PIWI" /note="PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is...
misc_feature 191..553 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(347..349,392..394,434..436,446..448,500..502, 521..523,527..529) /gene="AGO4" /gene_synonym="EIF2C4" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_...
misc_feature 100..441 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(235..237,280..282,322..324,334..336,388..390, 409..411,415..417) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_...
misc_feature 1055..1396 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1190..1192,1235..1237,1277..1279,1289..1291, 1343..1345,1364..1366,1370..1372) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD...
misc_feature 1050..1391 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1185..1187,1230..1232,1272..1274,1284..1286, 1338..1340,1359..1361,1365..1367) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD...
linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 328..690 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(484..486,529..531,571..573,583..585,637..639, 658..660,664..666) /gene="AGO4" /gene_synonym="EIF2C4" /note="nucleic acid-binding...
linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 535..897 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(691..693,736..738,778..780,790..792,844..846, 865..867,871..873) /gene="AGO4" /gene_synonym="EIF2C4" /note="nucleic acid-binding...
linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 718..1080 /gene="AGO4" /gene_synonym="EIF2C4" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(874..876,919..921,961..963,973..975,1027..1029, 1048..1050,1054..1056) /gene="AGO4" /gene_synonym="EIF2C4" /note="nucleic acid-binding...
linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 1909..2271 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(2065..2067,2110..2112,2152..2154,2164..2166, 2218..2220,2239..2241,2245..2247) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid...
linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 974..1336 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1130..1132,1175..1177,1217..1219,1229..1231, 1283..1285,1304..1306,1310..1312) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid-...
linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 1140..1502 /gene="AGO3" /gene_synonym="EIF2C3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1296..1298,1341..1343,1383..1385,1395..1397, 1449..1451,1470..1472,1476..1478) /gene="AGO3" /gene_synonym="EIF2C3" /note="nucleic acid...
pfam08699" /db_xref="CDD:462567" misc_feature 778..1140 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(934..936,979..981,1021..1023,1033..1035,1087..1089, 1108..1110,1114..1116) /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES;...
pfam08699" /db_xref="CDD:462567" misc_feature 6238..6600 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(6394..6396,6439..6441,6481..6483,6493..6495, 6547..6549,6568..6570,6574..6576) /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES...
pfam08699" /db_xref="CDD:462567" misc_feature 8433..8795 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(8589..8591,8634..8636,8676..8678,8688..8690, 8742..8744,8763..8765,8769..8771) /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES...
pfam08699" /db_xref="CDD:462567" misc_feature 924..1286 /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1080..1082,1125..1127,1167..1169,1179..1181, 1233..1235,1254..1256,1260..1262) /gene="AGO2" /gene_synonym="CASC7; EIF2C2; LESKRES;...
pfam08699" /db_xref="CDD:462567" misc_feature 886..1248 /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1042..1044,1087..1089,1129..1131,1141..1143, 1195..1197,1216..1218,1222..1224) /gene="AGO1" /gene_synonym="EIF2C; EIF2C1; GERP95;...
H. and Harata,M. TITLE The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment JOURNAL Exp Cell Res 314 (4), 859-868 (2008) PUBMED 18163988 REMARK GeneRIF: Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. REFERENCE 8 (bases 1 to 3579) AUTHORS Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J., Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y. TITLE A YY1-INO80...
and Endoplasmic Reticulum Stress. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2994) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and prostate cancer...
and Endoplasmic Reticulum Stress. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2996) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and prostate cancer...
and Endoplasmic Reticulum Stress. Publication Status: Online-Only REFERENCE 6 (bases 1 to 3166) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and prostate cancer...
retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##...
and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. REFERENCE 9 (bases 1 to 12771) AUTHORS Muller,P., Kuttenkeuler,D., Gesellchen,V., Zeidler,M.P. and Boutros,M. TITLE Identification of JAK/STAT signalling components by genome-wide RNA interference JOURNAL Nature 436 (7052), 871-875 (2005) PUBMED 16094372 REFERENCE 10 (bases 1 to 12771) AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K., Dohner,H., Stilgenbauer,S. and Lichter,P. TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel...
degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development. Publication Status: Online-Only REFERENCE 4 (bases 1 to 1039) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development. Publication Status: Online-Only REFERENCE 4 (bases 1 to 1105) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1505) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1505) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1518) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1518) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1584) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1584) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1592) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1592) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1644) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1644) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1806) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1806) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 2 (bases 1 to 1125) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1509) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1509) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1548) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1548) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
variants across the allele frequency spectrum in human populations JOURNAL Nat Commun 10 (1), 4141 (2019) PUBMED 31515488 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 868) AUTHORS Deng,Q., Li,K.Y., Chen,H., Dai,J.H., Zhai,Y.Y., Wang,Q., Li,N., Wang,Y.P. and Han,Z.G. TITLE RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma JOURNAL Hepatology 59 (2), 518-530 (2014) PUBMED 23929653 REMARK GeneRIF: DUSP21 plays an important role in sustaining hepatocellular carcinoma (HCC)...
REFERENCE 4 (bases 1 to 1029) AUTHORS Koslowski,M., Tureci,O., Huber,C. and Sahin,U. TITLE Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2 JOURNAL Mol Cancer 8, 77 (2009) PUBMED 19781065 REMARK GeneRIF: RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1029) AUTHORS Koslowski,M., Sahin,U., Dhaene,K.,...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1736) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1736) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 2 (bases 1 to 1584) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 2 (bases 1 to 1649) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 2 (bases 1 to 1697) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 2 (bases 1 to 1731) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...
TITLE ADAM28: Another ambivalent protease in cancer JOURNAL Cancer Lett 494, 18-26 (2020) PUBMED 32861707 REMARK GeneRIF: ADAM28: Another ambivalent protease in cancer. Review article REFERENCE 4 (bases 1 to 2106) AUTHORS Zhao,Z., Qiu,H.Y., Fu,L. and Li,J. TITLE [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells] JOURNAL Shanghai Kou Qiang Yi Xue 29 (5), 476-481 (2020) PUBMED 33543212 REMARK GeneRIF: [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. REFERENCE...
Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway REFERENCE 6 (bases 1 to 731) AUTHORS Fan,T., Jiang,G., Suo,Z., Liu,H., Xu,P., Ji,Z., Zhang,L. and Yang,G. TITLE Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells JOURNAL Int J Oncol 35 (2), 359-367 (2009) PUBMED 19578750 REMARK GeneRIF: TAp63gamma could induce apoptosis in human esophageal squamous cancer EC9706 cells, through at least releasing AIF and Bit1 from...
Synonym: BIT1; CFAP37; CGI-147; IMNEPD; PTH; PTH 2; PTH2
NM_016077.5 -
Homo sapiens (human) -
NCBI -
UCSC -
RefEx(expression)
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1994) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1994) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
PUBMED 33961781 REFERENCE 6 (bases 1 to 1720) AUTHORS Gambe,A.E., Matsunaga,S., Takata,H., Ono-Maniwa,R., Baba,A., Uchiyama,S. and Fukui,K. TITLE A nucleolar protein RRS1 contributes to chromosome congression JOURNAL FEBS Lett 583 (12), 1951-1956 (2009) PUBMED 19465021 REMARK GeneRIF: RNA interference experiments revealed that RRS1-depleted cells show abnormalities in chromosome alignment and spindle organization, which result in mitotic delay. REFERENCE 7 (bases 1 to 1720) AUTHORS Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E., Lamond,A.I. and Mann,M. TITLE Nucleolar proteome...
definitive endoderm JOURNAL Gene Expr Patterns 10 (2-3), 127-134 (2010) PUBMED 20153842 REFERENCE 9 (bases 1 to 2432) AUTHORS Ahn,S., Nelson,C.D., Garrison,T.R., Miller,W.E. and Lefkowitz,R.J. TITLE Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference JOURNAL Proc Natl Acad Sci U S A 100 (4), 1740-1744 (2003) PUBMED 12582207 REFERENCE 10 (bases 1 to 2432) AUTHORS Cheng,Z.J., Zhao,J., Sun,Y., Hu,W., Wu,Y.L., Cen,B., Wu,G.X. and Pei,G. TITLE beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor...
Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1963) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1963) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...
promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling. REFERENCE 5 (bases 1 to 1985) AUTHORS Li Q, Jin J, Liu J, Wang L and He Y. TITLE Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo JOURNAL Oncol Res 24 (3), 205-214 (2016) PUBMED 27458102 REMARK GeneRIF: we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin. REFERENCE 6 (bases 1 to 1985) AUTHORS Guo H, Jin X, Zhu T, Wang T, Tong P, Tian L, Peng Y,...
promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling. REFERENCE 5 (bases 1 to 1980) AUTHORS Li Q, Jin J, Liu J, Wang L and He Y. TITLE Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo JOURNAL Oncol Res 24 (3), 205-214 (2016) PUBMED 27458102 REMARK GeneRIF: we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin. REFERENCE 6 (bases 1 to 1980) AUTHORS Guo H, Jin X, Zhu T, Wang T, Tong P, Tian L, Peng Y,...
REFERENCE 4 (bases 1 to 1167) AUTHORS Koslowski,M., Tureci,O., Huber,C. and Sahin,U. TITLE Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2 JOURNAL Mol Cancer 8, 77 (2009) PUBMED 19781065 REMARK GeneRIF: RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1167) AUTHORS Koslowski,M., Sahin,U., Dhaene,K.,...
of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 975) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...
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GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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