LOCUS       NM_001030900           13317 bp    mRNA    linear   VRT 24-SEP-2023
DEFINITION  Gallus gallus argonaute 3, RISC catalytic component (AGO3), mRNA.
ACCESSION   NM_001030900 NM_001397398 XM_417775
VERSION     NM_001030900.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 13317)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13317)
  AUTHORS   Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P,
            Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci
            P, Hayashizaki Y and Buerstedde JM.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
REFERENCE   3  (bases 1 to 13317)
  AUTHORS   Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong
            WT, Tickle C, Brown WR, Wilson SA and Hubbard SJ.
  TITLE     A comprehensive collection of chicken cDNAs
  JOURNAL   Curr Biol 12 (22), 1965-1969 (2002)
   PUBMED   12445392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000339.1.
            
            On or before Nov 25, 2021 this sequence version replaced
            NM_001397398.1, NM_001030900.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ719770.1, KX059705.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               JAENSK010000339.1  4212456-4212741     c
            287-458             JAENSK010000339.1  4206541-4206712     c
            459-579             JAENSK010000339.1  4205007-4205127     c
            580-788             JAENSK010000339.1  4204161-4204369     c
            789-925             JAENSK010000339.1  4203013-4203149     c
            926-1060            JAENSK010000339.1  4201664-4201798     c
            1061-1148           JAENSK010000339.1  4200419-4200506     c
            1149-1296           JAENSK010000339.1  4200130-4200277     c
            1297-1416           JAENSK010000339.1  4199715-4199834     c
            1417-1539           JAENSK010000339.1  4198655-4198777     c
            1540-1673           JAENSK010000339.1  4198306-4198439     c
            1674-1858           JAENSK010000339.1  4197692-4197876     c
            1859-2018           JAENSK010000339.1  4197264-4197423     c
            2019-2109           JAENSK010000339.1  4196017-4196107     c
            2110-2304           JAENSK010000339.1  4195493-4195687     c
            2305-2439           JAENSK010000339.1  4195031-4195165     c
            2440-2541           JAENSK010000339.1  4194463-4194564     c
            2542-2741           JAENSK010000339.1  4193132-4193331     c
            2742-13317          JAENSK010000339.1  4181960-4192535     c
FEATURES             Location/Qualifiers
     source          1..13317
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="23"
                     /map="23"
     gene            1..13317
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="argonaute 3, RISC catalytic component"
                     /db_xref="CGNC:14656"
                     /db_xref="GeneID:419628"
     exon            1..286
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    265..267
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="upstream in-frame stop codon"
     CDS             268..2850
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /EC_number="3.1.26.n2"
                     /note="argonaute RISC catalytic component 3; eukaryotic
                     translation initiation factor 2C, 3"
                     /codon_start=1
                     /product="protein argonaute-3"
                     /protein_id="NP_001026071.2"
                     /db_xref="CGNC:14656"
                     /db_xref="GeneID:419628"
                     /translation="

MEISSAGPVGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYDADPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    277..2844
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="protein argonaute; Provisional; Region: PLN03202"
                     /db_xref="CDD:215631"
     misc_feature    1444..2721
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1855..1857,1867..1869,1903..1914,1921..1923,
                     1945..1947,1954..1956,1966..1968,1978..1980)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    1855..1968
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZLG4.1);
                     Region: Interaction with guide RNA.
                     /evidence=ECO:0000250|UniProtKB:Q9H9G7"
     misc_feature    order(2059..2061,2065..2067,2275..2277,2689..2691)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="active site"
                     /db_xref="CDD:240015"
     misc_feature    2539..2682
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZLG4.1);
                     Region: Interaction with guide RNA.
                     /evidence=ECO:0000250|UniProtKB:Q9H9G7"
     exon            287..458
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            459..579
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..788
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..925
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1060
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1148
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1296
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1416
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1539
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1673
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1858
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2018
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2109
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2304
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2439
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2541
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2741
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..13317
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acttccggcggcctgtggttcggcgggcgggcggcagcgtgagtcggggctgcggggcggccacgcaacttccgcccgggggggcgccgccgccgctgccgccgcctgaggggacgggagcggccgagaagaggcgccgggctgcggcctaaagggagcgggaagccgccgccgcctctcagcgcagcccgaccggggcccgggcctggcccagctcagctcagcggcggagcccgcagccccgagcggctgcacccagctccatgaatggaaatcagcagcgcaggacccgtcggggcacagcccctgctcatggtgcccagacggcctggctatggcaccatgggcaagcccattaaactgctggccaactgcttccaagttgaaatcccaaagattgatgtctacctctatgaggtggatatcaaaccagataagtgtcctcggagggtgaacagggaggtggtggactcaatggtgcagcattttaaagtgacgatatttggggaccgtcgaccagtttatgatgggaaaagaagcctttatacagccaacccgcttcctgtggccactactggggtggatttggatgtgacattgccaggagaaggtggaaaagatcgtcccttcaaagtgtcaataaagtttgtttctcgggtgagctggcacttgctgcatgaagttttgacaggaagaaccttgcctgagcctctggaactagacaaacctatcagcactaaccctgttcatgctgtcgatgtggtgctacgacacctgccctccatgaagtatacccctgtgggccgctccttcttctcagctccagaaggctatgatcaccccttgggggggggcagggaggtctggtttgggttccatcagtctgtccggcctgccatgtggaagatgatgctcaacattgatgtttctgccactgccttctacaaagcacaacctgtgattcagttcatgtgtgaagttcttgacattcataatattgatgaacaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaagggtctgaaggtagaagtgactcattgtggaacgatgaggcggaaataccgtgtttgtaacgtaaccaggaggcctgcaagtcatcaaacctttcctttacagttagaaaatggccagactgtggagagaacagtagcacagtacttcagagagaaatacaacctccagctgaagtatcctcatctgccttgcctgcaagtgggacaggaacagaaacacacctacctgcctttagaagtttgtaacattgtggctggccaacggtgtatcaagaagctaacagacaatcagacatcaactatgataaaggccacagcaaggtctgctccagataggcaagaggaaataagcagattggtgagaagtgcaaattacgatgcggatccatttgttcaagagttccaattcaaggtccgggatgagatggcccacgtgacggggcgcgtgctccctgcacccatgctgcagtatggaggacggaaccgaacggtggcaacccccagccatggagtttgggacatgcgagggaagcaattccacactggtgttgagatcaaaatgtgggctatagcttgttttgcaacgcagaggcaatgcagagaagaaatactgaagggttttacagaccagctgcgcaagatctccaaggacgcagggatgccgatccaaggccagccctgtttctgtaaatacgcccagggtgcagacagtgtggagcccatgtttcggcacctcaagaacacctattcagggcttcagctcatcattgtcatcctgccaggaaaaacaccggtgtacgcggaggtgaagcgtgtgggagatacgctattgggaatggccacgcagtgtgttcaagtcaaaaatgtcattaaaacatctccacagaccctttcaaacctgtgcctgaagattaacgttaaattaggaggaatcaataacatccttgtacctcatcaacgcccttctgtgttccagcagccagtgatctttctgggagctgatgtcactcaccctcctgctggagatggaaagaaaccttccatagctgctgttgtaggtagtatggatgctcatccaagccgatactgtgccacggtgagagttcagcggccccggcaggagattatccaagacctggcctccatggtgagggagcttctcatccagttctacaagtcaacgcgcttcaagcccacacgtatcatcttctacagggacggggtctctgaaggacagttccgacaggttttgtactacgaactgctagccattagagaagcctgcatcagtttggagaaggattaccagcctggaataacctatattgtggtgcagaaacgacatcatacacggttgttctgtgctgacagaacagagagggttggacgaagtggcaatatcccagctggaacaactgtagatacagacattacacatccatatgagttcgatttttacctctgcagtcatgctggaatacagggtaccagccgtccctcacactatcatgttttgtgggatgataactgttttactgcagatgaacttcagctgctgacttaccagctctgccacacatacgtgcgctgcacacgatcagtttctatacctgcaccagcgtattatgctcacctggtagcattcagagcacgataccatcttgtggacaaagaacacgacagtgctgaaggaagccacgtttcaggacagagcaatggcagagatccacaggccctggcgaaggctgtacagattcaccaagacaccttacgcacgatgtacttcgcttaagtcaataaaaggggagcgtactcgctgacaggaagaactgacaaattaagccacatacaatgtatgtttccagtggggttggtttatggggtgtgcctccgatcgtgcaggggcgagaggctgacccttaaattgacacaaggaagattgtttacttcaccgaggaacacagcactattatgcaatatgaaaccagccaactgctttcgtggcgcggtctcctgtaggaagcaccgccatcattttcctttttaggttcatttctcatagtttgaccctcttatgcctttacctcaagttgctcggcagcacaactcttgttgcaaaaaaaaaaaaaaagaaaaaaaagaataatgataatttaaaagaaaaaaggtgtagtttttaaaaagcaacctgtgtcagaacagtcccagtgattctttgggagagaaaaagtgtgcaaaaatagtttttttttgtcacccaattgaggaatctctctctcagtattgccatcagcattcgaatgcgaacatatctgagtacgtctgaatgtacagcactaagtaggaaaagatggaggggagggaagatgttttgcacactaatcccatcgtttgaacatagtttagccaactgctgcctttcttcacagctttggagtcctcagctccaacagttcccttttaagaagcaaacaaagctagtggtgttactgcaggcagtggtgatcccacctgttcttgctccctggtgactttactaaagctgctgttttacctagtccaaaagtttcaattactttctatctggcaagtcaaatatcttgaagcttcacgtgaggtcgggcgtcccaggctttatgggatggctacagaaaacaccagaactgaaactttagagctaaggtcttcttgacaaaagaaaaatgctagtttacttgctgcctctcacaccttaatgtgatttcatatgtacgtgttttgaagtttagcttcctttgtttcttttatatttattagagtaataataatgctttaatttaattattacagaacatatggtcaacatcaacttttattttttagaaatgtaaccacgtttatttttaaagaactgacaacttgtttttgctatcttttagtgcaataagcgttcgaaaagaaaacggtgtccattgagctgtaccagagcagtgtttgtaccactggctgtgggaggacggacacctccggttttaaaaggacaaagtaaaagccttaattttgaaaggaaagttttatagtcagaaggaatctcgggttttccttttttaaatcaaaaagtagcaaaagtgcttctggaactctgcaggcttcaccgctcgctgccgtggtttggtttaacaaaggaaccggccgtctttttggctttgagacgtggaagatatttgaattaaacaaaaagctttttttattgagatctaagtttttacatgcttaattaaatctgacatcaataaaatgtctggagttatgaaaagtttttaggcttttttcctctttgataacgactttccttttaaaattaagttattggtgacttcatttcactttgcaaataaagtaagagggctgggatagttctacctttaaatcactgaaatgtgaaacagacgaacgggactctttcattccactttaaaggtaaaccaatcgtaagatgtcagagatgagcatttattccgcgaggggactgggaagttttgcactttgtaaactcgtgaactgcatttttgactgtttttttttttttatttgcactggttcatagtatatatactgcagatcgtttctatgggcattgctgttatcccagcccttctgaaccccacctgctctccacatgaaaaccagagggtcggtaaagcagcttttatctcctggcgttctcacagaatgcgctctttgccaatatataccgtgttttgagcctaaaatctgagcccgttttgcttcagcaggcatgactctccccatcttttctgccagaagacaaagtactgtattttgtgcatttgtatattgtactgaaatgtatgtagtgctgttcacaacgctgtctcaaagagctctgctcggcagttggcgtgtaggcgtgctttatctcccagtaccaaggaaggtaat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