LOCUS       NM_001001752            1929 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Gallus gallus cytochrome P450 family 2 subfamily C member 18
            (CYP2C18), mRNA.
ACCESSION   NM_001001752
VERSION     NM_001001752.3
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Baader M, Gnerre C, Stegeman JJ and Meyer UA.
  TITLE     Transcriptional activation of cytochrome P450 CYP2C45 by drugs is
            mediated by the chicken xenobiotic receptor (CXR) interacting with
            a phenobarbital response enhancer unit
  JOURNAL   J Biol Chem 277 (18), 15647-15653 (2002)
   PUBMED   11867618
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAENSK010000231.1.
            
            On Sep 23, 2021 this sequence version replaced NM_001001752.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ430583.1, SRR12888532.306707.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA103992484
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAENSK010000231.1  4555874-4556082
            210-372             JAENSK010000231.1  4556413-4556575
            373-522             JAENSK010000231.1  4557073-4557222
            523-683             JAENSK010000231.1  4557637-4557797
            684-860             JAENSK010000231.1  4558242-4558418
            861-1002            JAENSK010000231.1  4558601-4558742
            1003-1190           JAENSK010000231.1  4559133-4559320
            1191-1332           JAENSK010000231.1  4559805-4559946
            1333-1929           JAENSK010000231.1  4560555-4561151
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="6"
                     /map="6"
     gene            1..1929
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /note="cytochrome P450 family 2 subfamily C member 18"
                     /db_xref="GeneID:414833"
     exon            1..209
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1514
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P-450 2C45"
                     /codon_start=1
                     /product="cytochrome P450 family 2 subfamily C member 18"
                     /protein_id="NP_001001752.2"
                     /db_xref="GeneID:414833"
                     /translation="

MLLLGAASVVLLVCVACLLSIVQWRKRTGKGKMPEGPTPLPIVGNILEVKPKNLAKTLEKLAEKYGPVFSVQLGSTPVVVLSGYEAVKEALIDRADEFAARGHMPIGDRANKGLGIIFSNNEGWLHVRRFALSTLRNFGMGKRSIEERIQEEAEHLLEEITKTKRLPFDPTFKLSCAVSNVICSIVFGKRYDYKDKKFLSLMNNMNNTFEMMNSRWGQLYQMFSYVLDYLPGPHNNIFKEIDAVKAFVAEEVKLHQASLDPSAPQDFIDCFLSKMQEEKDNPKSHFHMTNLITSTFDLFIAGTETTSTTTRYGLLLLLKYPKIQEKVQEEIDRVVGRSRRPCVADRTQMPYTDAVVHEIQRFITLIPTSLPHAVTKDIHFRDYIIPKGTTVMPLLSTALYDSKEFPNPTEFNPGHFLNQNGTFRKSDFFIPFSAGKRICPGEGLARMEIFLLLTAILQNFTLKPVISPEELSITPTLSGTGNVPPYYQLCAIPR"

     misc_feature    222..1496
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /note="cytochrome P450 (CYP) superfamily; Region:
                     cytochrome_P450; cl41757"
                     /db_xref="CDD:425388"
     misc_feature    order(399..401,411..413,432..434,573..575,918..923,
                     930..935,942..947,954..956,1107..1109,1137..1139,
                     1143..1145,1212..1214,1320..1328,1338..1352,1359..1364)
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /note="heme binding site [chemical binding]; other site"
                     /db_xref="CDD:410651"
     misc_feature    order(651..656,918..920,927..932,942..944,1131..1142)
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /note="chemical substrate binding pocket [chemical
                     binding]; other site"
                     /db_xref="CDD:410651"
     exon            210..372
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            373..522
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            523..683
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            684..860
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1002
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1190
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1332
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1929
                     /gene="CYP2C18"
                     /gene_synonym="CYP2C45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcactcagaagctcgtgcccacgtgggagatgttgctcctgggagcagcgagtgtggtcctcctggtttgtgttgcttgcctgctctccatcgtgcaatggagaaaaaggactggaaaggggaagatgcctgagggaccaactccccttcccatcgtagggaacatactggaggtgaaaccaaagaatttagccaaaacccttgagaagctcgctgagaaatatgggcccgtcttctcagtgcaactgggttcaactccagtagtggtgctatctggatatgaggcggtgaaagaagccttgattgatcgtgcggatgagtttgctgccagaggacacatgcctatcggggaccgggcaaacaaaggattaggcattattttcagcaacaacgagggatggttacacgttcggcggtttgctctcagcactctgcgcaactttgggatggggaagaggagcattgaagagaggatccaggaggaagctgagcacttgcttgaagagatcacaaaaacaaagagactgccctttgacccaacattcaagctgagctgcgctgtctccaacgtcatatgctccattgtctttgggaagcgatatgactataaagacaagaagttcctatctctgatgaacaacatgaacaacacatttgagatgatgaactcccgctggggacagttataccagatgttctcctacgttctggattatttgcccggcccacataacaatatattcaaagaaattgatgctgtaaaagcctttgtggcagaagaggtaaagctgcaccaagcctccctggatcccagcgctccccaggatttcatcgactgcttcctcagcaaaatgcaggaggaaaaagacaatcccaaatcacacttccacatgacaaacctgataacgtccaccttcgacttgttcattgctggaacggagacaacaagcaccaccacacgatacgggcttctgcttcttctcaaatatcccaagatacaagagaaagttcaagaagagattgaccgggtagtaggacgatcacgaagaccttgcgtggctgaccggacccagatgccctacacagacgcagtggtccacgaaatccagcgcttcatcactctcatccctacgagcctccctcatgctgtgaccaaagacatccacttcagagactacatcattcccaagggcaccacagtcatgcccctcctcagtactgcactctatgacagcaaggagtttccaaacccaaccgagtttaatcctggacatttcttgaaccagaatggcacctttaggaagagcgacttcttcattcccttctcagcagggaaacgcatttgccctggagagggcctggcacgcatggagatattcttactcctgaccgccatcctgcagaacttcaccttgaagcctgtcatcagccctgaggaactcagcatcacccctacactgagtgggacaggaaatgttcctccctactaccagctctgtgctatcccccgctgaggggcacaaaacctcactgctgtgctcctcagccagactgctcctttacacctccccaactcaaaccagtggcaggagcgttgccccaccaacccaaagcctccacatgacagcccgcagacaaagtcccaggcagatcaaacccggatactttgaacacctccctgaactgctcctcctcaccacagcgcagaaggtaatgatgcacctcactgcagtgacattctgtgcatgtgctccctgagcacagcagtcccactgaacagctgatttgctcacagctgtgactccatggctgtccatcccctgcttctagggctgtatgtgtcccacccagagcagcacactttgcacagtgactgtgttgcgtatgtgtatgctaatgacccaataaagagcaatctatttaggagga

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