2024-04-18 12:39:16, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_207586 1538 bp mRNA linear ROD 12-NOV-2023 DEFINITION Rattus norvegicus chitinase, acidic (Chia), mRNA. ACCESSION NM_207586 XM_227565 VERSION NM_207586.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1538) AUTHORS Verwer PE, ten Kate MT, Falcone FH, Morroll S, Verbrugh HA, Bakker-Woudenberg IA and van de Sande WW. TITLE Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats JOURNAL PLoS One 8 (10), e75848 (2013) PUBMED 24155872 REMARK GeneRIF: Invasive pulmonary aspergillosis in immunocompromised rats caused a dramatic increase in chitinase activity. Publication Status: Online-Only REFERENCE 2 (bases 1 to 1538) AUTHORS Cho WS, Kim TH, Lee HM, Lee SH, Lee SH, Yoo JH, Kim YS and Lee SH. TITLE Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis JOURNAL Laryngoscope 120 (5), 870-875 (2010) PUBMED 20422678 REFERENCE 3 (bases 1 to 1538) AUTHORS Wu,A.C., Lasky-Su,J., Rogers,C.A., Klanderman,B.J. and Litonjua,A. TITLE Polymorphisms of chitinases are not associated with asthma JOURNAL J Allergy Clin Immunol 125 (3), 754-757 (2010) PUBMED 20226308 REFERENCE 4 (bases 1 to 1538) AUTHORS Yang CJ, Liu YK, Liu CL, Shen CN, Kuo ML, Su CC, Tseng CP, Yen TC and Shen CR. TITLE Inhibition of acidic mammalian chitinase by RNA interference suppresses ovalbumin-sensitized allergic asthma JOURNAL Hum Gene Ther 20 (12), 1597-1606 (2009) PUBMED 19548841 REFERENCE 5 (bases 1 to 1538) AUTHORS Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM and Burchard EG. TITLE Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein JOURNAL J Biol Chem 284 (29), 19650-19658 (2009) PUBMED 19435888 REFERENCE 6 (bases 1 to 1538) AUTHORS Ramanathan M Jr, Lee WK and Lane AP. TITLE Increased expression of acidic mammalian chitinase in chronic rhinosinusitis with nasal polyps JOURNAL Am J Rhinol 20 (3), 330-335 (2006) PUBMED 16871939 REFERENCE 7 (bases 1 to 1538) AUTHORS Bierbaum S, Nickel R, Koch A, Lau S, Deichmann KA, Wahn U, Superti-Furga A and Heinzmann A. TITLE Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma JOURNAL Am J Respir Crit Care Med 172 (12), 1505-1509 (2005) PUBMED 16179638 REFERENCE 8 (bases 1 to 1538) AUTHORS Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q and Elias JA. TITLE Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation JOURNAL Science 304 (5677), 1678-1682 (2004) PUBMED 15192232 REFERENCE 9 (bases 1 to 1538) AUTHORS Zimmermann N, Mishra A, King NE, Fulkerson PC, Doepker MP, Nikolaidis NM, Kindinger LE, Moulton EA, Aronow BJ and Rothenberg ME. TITLE Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways JOURNAL J Immunol 172 (3), 1815-1824 (2004) PUBMED 14734765 REFERENCE 10 (bases 1 to 1538) AUTHORS Boot RG, Blommaart EF, Swart E, Ghauharali-van der Vlugt K, Bijl N, Moe C, Place A and Aerts JM. TITLE Identification of a novel acidic mammalian chitinase distinct from chitotriosidase JOURNAL J Biol Chem 276 (9), 6770-6778 (2001) PUBMED 11085997 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY486074.1. On Aug 30, 2012 this sequence version replaced NM_207586.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY486074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN12840130, SAMN16676784 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1538 AY486074.1 3-1540 FEATURES Location/Qualifiers source 1..1538 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="2" /map="2q34" gene 1..1538 /gene="Chia" /note="chitinase, acidic" /db_xref="GeneID:113901" /db_xref="RGD:1303058" exon 1..48 /gene="Chia" /inference="alignment:Splign:2.1.0" CDS 24..1445 /gene="Chia" /EC_number="3.2.1.14" /note="eosinophil chemotactic cytokine; acidic mammalian chitinase; AMCase; small acid mammalian chitinase" /codon_start=1 /product="acidic mammalian chitinase precursor" /protein_id="NP_997469.1" /db_xref="GeneID:113901" /db_xref="RGD:1303058" /translation="
MAKLILVTGLVLLLNVQLGSAYNLVCYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNQITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKELREAFEQEAIESNRPRLMVTAAVAAGISNIQAGYEIPELSQYLDFIHVMTYDLHGSWDGYTGENSPLYKLPTETGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPEYGHTYILSNPSDTGIGAPTSGNGPAGPYTRQAGFWAYYEICTFLRNGATQDWDAPQEVPYAYKGNEWVGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALDIPTAGCTAPDLPSEPVTTPPGSGSGGGSSGGGSEGSGFCAGKADGLYPVADDRNAFWHCINGITYQQHCQAGLVFDTSCNCCNWP"
sig_peptide 24..86 /gene="Chia" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 87..1442 /gene="Chia" /product="Acidic mammalian chitinase. /id=PRO_0000011946" /note="propagated from UniProtKB/Swiss-Prot (Q6RY07.1)" misc_feature 93..1184 /gene="Chia" /note="This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active...; Region: GH18_chitolectin_chitotriosidase; cd02872" /db_xref="CDD:119351" misc_feature order(102..104,114..116,318..323,435..437,441..446, 579..584,651..653,657..662,675..677,822..824,828..830, 912..914,1101..1103) /gene="Chia" /note="active site" /db_xref="CDD:119351" misc_feature 1206..1286 /gene="Chia" /note="propagated from UniProtKB/Swiss-Prot (Q6RY07.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1299..1442 /gene="Chia" /note="Chitin-binding domain type 2; Region: ChtBD2; smart00494" /db_xref="CDD:214696" exon 49..78 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 79..280 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 281..337 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 338..503 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 504..628 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 629..752 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 753..938 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 939..1058 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 1059..1200 /gene="Chia" /inference="alignment:Splign:2.1.0" exon 1201..1538 /gene="Chia" /inference="alignment:Splign:2.1.0" ORIGIN
gcgggggcagtactgaagacaacatggccaagctcattcttgtcacaggtctggttcttctgctgaatgttcagctggggtctgcctacaatctggtatgctacttcaccaactgggcccagtatcggccaggcctggggagtttcaagcctgatgacattaatccctgcctgtgtactcacctgatctatgcctttgctgggatgcagaacaatcaaatcaccaccatagaatggaatgatgttactctctataaagctttcaatgacttgaaaaacaggaacagcaaactgaaaactctcctggcaattggaggttggaactttggaactgctcctttcaccaccatggtttccacttctcagaaccgccagacctttattacctcagtcatcaaattcctgcgacagtatgggtttgatggactggacctggactgggaatacccaggttcacgtgggagccctcctcaggacaagcatctcttcactgtcctggtgaaggaactacgtgaagcttttgagcaggaggctattgagagcaacaggcccagattgatggttactgctgctgtagctgctggcatttccaacatccaggctggctacgagatccctgaactttctcagtacctggatttcatccacgtcatgacatatgacctccatggctcctgggatggctacactggggagaacagtcctctttacaaactccctactgagactggcagcaatgcctacctcaatgtggattatgtcatgaattactggaaggataatggagccccagctgagaagctcattgttggatttccagagtatggacacacctacatcctaagcaacccttctgatactggaattggtgcccctacctctggtaatggccctgctgggccctataccaggcaggctgggttctgggcctactatgagatttgtacctttctgagaaatggagccactcaggactgggatgccccccaggaagttccctatgcctacaagggcaatgagtgggttggctatgataatatcaagagcttcagtgtcaaggctcagtggcttaagcagaacaactttggtggtgccatgatctgggccattgaccttgatgacttcactggctctttctgtgaccagggaaaattccctctgacttctactttgaataaagcccttgatatacccacagcaggttgcacagcccctgacttaccttctgaaccagtaactactcctccaggaagtgggagtggtggtggaagctctggtggaggttctgaaggcagtggattctgtgctggcaaagcagatggcctctaccctgtggcagatgacagaaatgctttctggcactgcatcaatggaatcacatatcagcagcattgtcaggcagggttagtttttgataccagctgtaattgctgcaactggccatgaaactaatgttcttcacgaaatttctgccttctcccttaatcctcaccaaaggtagcttgcttccatttaaagttatgcaataaaattgatagc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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