LOCUS       NM_152848               1516 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Ly49 inhibitory receptor 2 (Ly49i2), mRNA.
ACCESSION   NM_152848 XM_346718
VERSION     NM_152848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Ma BJ and Kane KP.
  TITLE     Recognition of class I MHC by a rat Ly49 NK cell receptor is
            dependent on the identity of the P2 anchor amino acid of bound
            peptide
  JOURNAL   J Immunol 187 (6), 3267-3276 (2011)
   PUBMED   21841133
  REMARK    GeneRIF: the identity of the P2 peptide anchor residue is an
            integral component of MHC-I recognition by Ly49i2
REFERENCE   2  (bases 1 to 1516)
  AUTHORS   Naper C, Hayashi S, Joly E, Butcher GW, Rolstad B, Vaage JT and
            Ryan JC.
  TITLE     Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC
            class Ia molecule (RT1-A1c)
  JOURNAL   Eur J Immunol 32 (7), 2031-2036 (2002)
   PUBMED   12115624
  REMARK    GeneRIF: Ly49i2 is an inhibitory natural killer cell receptor for
            specific MHC class Ia molecule (RT1-A1(c))
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000151.1 and AY115572.1.
            
            On Mar 2, 2021 this sequence version replaced NM_152848.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY115572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JACYVU010000151.1  812417-812530       c
            115-314             JACYVU010000151.1  810587-810786       c
            315-404             JACYVU010000151.1  809098-809187       c
            405-623             JACYVU010000151.1  807994-808212       c
            624-709             JACYVU010000151.1  805494-805579       c
            710-712             AY115572.1         711-713
            713-766             JACYVU010000151.1  805437-805490       c
            767-870             JACYVU010000151.1  798429-798532       c
            871-1516            JACYVU010000151.1  787909-788554       c
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1516
                     /gene="Ly49i2"
                     /note="Ly49 inhibitory receptor 2"
                     /db_xref="GeneID:260324"
                     /db_xref="RGD:628669"
     exon            1..114
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="Ly49i2"
                     /note="upstream in-frame stop codon"
     exon            115..314
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1045
                     /gene="Ly49i2"
                     /note="inhibitory NK cell receptor for MHC class I
                     ligands; killer cell lectin-like receptor 5-like"
                     /codon_start=1
                     /product="Ly49 inhibitory receptor 2"
                     /protein_id="NP_690061.2"
                     /db_xref="GeneID:260324"
                     /db_xref="RGD:628669"
                     /translation="

MTEQEVTYTTVRFHKSSVFQNEVRSEETQSAKEIGHRESSVPWKLIVIALGILCSVLLVTVAVLVTNCLQYNHETHELQETQNSQHNCSTMENDIKLKEEMLRNMSIESTRYNALLDLINREQKRWYNKTKTVLAAPQHTGGCVEMHWLCYGIKCYYFIIDKRTWRKCIQTCQNYSLSFLKIHDKDELKFLQDHIIRDSYWIGLSYNNNKKEWSWIDNTTLNCDLVAMISLHKTGNCKYFSMTGLHDDDCGKRHLCICEKGIEKYPAPLCSVNERSQSAL"

     misc_feature    320..676
                     /gene="Ly49i2"
                     /note="Ly49-like protein, N-terminal region; Region: Ly49;
                     pfam08391"
                     /db_xref="CDD:429969"
     misc_feature    635..982
                     /gene="Ly49i2"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(797..799,881..883,932..934,938..943)
                     /gene="Ly49i2"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     exon            315..404
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..623
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..766
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..870
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1516
                     /gene="Ly49i2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtttttcttttttctctgagcctattagtgtatacagacaagtaaagttcaacttttccaccaactgagtgatcaatttcctccacgagaatcgcttcaggatagagacacagatctaggtaccttcctataggtggacatttaaactttgaaaaaaaaaacaattctcaaggctccagtatacttcatatattcaaaaagatgactgaacaggaggttacttacacaactgtgagatttcataagtcgtcagtgttccagaacgaagtgaggtctgaggagactcaaagtgctaaagaaataggccacagagagagttcagtcccctggaagctcattgttatagctcttggaatcctctgttcagttctgctggtaactgttgcagtattggtgacaaactgtttgcagtataatcatgaaacacatgaactgcaagaaactcaaaactctcaacataactgcagcaccatggaaaatgacatcaaattaaaggaagaaatgctgagaaatatgtctatagagagtactcgttacaatgctcttctggacttaatcaacagagaacagaagagatggtacaacaaaactaagactgttttagctgcccctcagcacacaggtggttgtgttgaaatgcattggttatgctatggtataaaatgttattatttcatcatcgacaaaagaacatggcgtaaatgtatacagacctgccagaattacagcttatcctttctgaagatacatgataaggatgaactgaagttccttcaggaccacattattcgagacagttactggattggattgtcatataataataataaaaaggaatggtcatggattgacaacaccacattgaattgtgatttggtggcaatgatatcactacacaaaacaggaaattgtaaatatttcagtatgacaggtctacatgatgatgactgtggtaaaagacatctctgtatctgtgaaaagggaatagaaaaatatcctgccccattgtgcagtgtgaacgaaaggtcacagtctgctctgtgaataaagagatgagttgcaaagcgaagaagtcttctgaaatttgtcttaagagcagacacagtattcccttctggcacatggagcagcttgcatgtggagaatggacatcctttgttccaagacccaaatgattttcctcacattctctcctgaatgacacacagaaccacatggagaactcaataaataatgcacacatcacatattcttttggatatttctacagcccatggcttgttagtacaattaataacaaatctgcagttgtgggttttcatgtagaggttagttactatttggttttttgtttgtttgtttgtttgtttgtttttttttctgttttttgattttttttttggtgtagaaaaagttagcatttttaaaaccttttgagatgaggaactgtggatgggaggactgattgtggttatgtcttgactgttaataaataaaatgattttgaaaacctta

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