LOCUS       NM_134432               1958 bp    mRNA    linear   ROD 17-DEC-2023
DEFINITION  Rattus norvegicus angiotensinogen (Agt), mRNA.
ACCESSION   NM_134432
VERSION     NM_134432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Paes-Leme B, Monteiro LDRN, Gholami K, Hoe SZ, Ferguson AV, Murphy
            D, Antunes-Rodrigues J, Rorato R, Reis LC and Mecawi AS.
  TITLE     Fasting increases circulating angiotensin levels and brain Agtr1a
            expression in male rats
  JOURNAL   J Neuroendocrinol 35 (11), e13334 (2023)
   PUBMED   37667574
  REMARK    GeneRIF: Fasting increases circulating angiotensin levels and brain
            Agtr1a expression in male rats.
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Sykora M, Kratky V, Kopkan L, Tribulova N and Szeiffova Bacova B.
  TITLE     Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically
            Overloaded Rat Heart
  JOURNAL   Int J Mol Sci 24 (4), 3490 (2023)
   PUBMED   36834901
  REMARK    GeneRIF: Anti-Fibrotic Potential of Angiotensin (1-7) in
            Hemodynamically Overloaded Rat Heart.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Liu H, Xue Y and Chen L.
  TITLE     Angiotensin II increases the firing activity of pallidal neurons
            and participates in motor control in rats
  JOURNAL   Metab Brain Dis 38 (2), 573-587 (2023)
   PUBMED   36454502
  REMARK    GeneRIF: Angiotensin II increases the firing activity of pallidal
            neurons and participates in motor control in rats.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Raquel HA, Manica LA, Ceroni A and Michelini LC.
  TITLE     Exercise training improves cardiovascular control in sinoaortic
            denervated SHR by reducing the elevated angiotensin II and
            augmenting angiotensin-(1-7) availability within autonomic and
            neuroendocrine PVN nuclei
  JOURNAL   Peptides 153, 170798 (2022)
   PUBMED   35405300
  REMARK    GeneRIF: Exercise training improves cardiovascular control in
            sinoaortic denervated SHR by reducing the elevated angiotensin II
            and augmenting angiotensin-(1-7) availability within autonomic and
            neuroendocrine PVN nuclei.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Samara VA, Das S, Reddy MA, Tanwar VS, Stapleton K, Leung A,
            Abdollahi M, Ganguly R, Lanting L and Natarajan R.
  TITLE     Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates
            Chondrogenesis in Vascular Smooth Muscle Cells
  JOURNAL   Cells 10 (10), 2696 (2021)
   PUBMED   34685676
  REMARK    GeneRIF: Angiotensin II-Induced Long Non-Coding RNA Alivec
            Regulates Chondrogenesis in Vascular Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS,
            Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM et al.
  TITLE     Molecular basis of human hypertension: role of angiotensinogen
  JOURNAL   Cell 71 (1), 169-180 (1992)
   PUBMED   1394429
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Hermann K, Rittweger R and Ring J.
  TITLE     Urinary excretion of angiotensin I, II, arginine vasopressin and
            oxytocin in patients with anaphylactoid reactions
  JOURNAL   Clin Exp Allergy 22 (9), 845-853 (1992)
   PUBMED   1422942
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Mauzy CA, Hwang O, Egloff AM, Wu LH and Chung FZ.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Tucker,B.J., Mundy,C.A., Maciejewski,A.R., Printz,M.P.,
            Ziegler,M.G., Pelayo,J.C. and Blantz,R.C.
  TITLE     Changes in glomerular hemodynamic response to angiotensin II after
            subacute renal denervation in rats
  JOURNAL   J Clin Invest 78 (3), 680-688 (1986)
   PUBMED   3745432
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Ohkubo,H., Nakayama,K., Tanaka,T. and Nakanishi,S.
  TITLE     Tissue distribution of rat angiotensinogen mRNA and structural
            analysis of its heterogeneity
  JOURNAL   J Biol Chem 261 (1), 319-323 (1986)
   PUBMED   3753601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078741.1.
            
            On Aug 8, 2004 this sequence version replaced NM_134432.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1958
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensinogen"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
     exon            1..170
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="upstream in-frame stop codon"
     exon            171..1029
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1634
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensin II; serpin A8; angiotensinogen (serpin
                     peptidase inhibitor, clade A, member 8)"
                     /codon_start=1
                     /product="angiotensinogen precursor"
                     /protein_id="NP_602308.1"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
                     /translation="

MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV"

     sig_peptide     201..272
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     273..1631
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /product="Angiotensinogen. /id=PRO_0000032468"
                     /note="propagated from UniProtKB/Swiss-Prot (P01015.1)"
     misc_feature    282..1625
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="serpin family A member 8, angiotensinogen; Region:
                     serpinA8_AGT; cd02054"
                     /db_xref="CDD:381010"
     misc_feature    order(282..323,474..479,486..488,498..500,507..509,
                     516..521,639..641,648..653,660..665,672..677,1263..1265,
                     1284..1286,1368..1373)
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="renin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381010"
     misc_feature    1083..1085
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01015.1); glycosylation site"
     misc_feature    1155..1157
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01015.1); glycosylation site"
     misc_feature    order(1476..1511,1536..1553)
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="reactive center loop (RCL); other site"
                     /db_xref="CDD:381010"
     exon            1030..1297
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1442
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1934
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccttgctccatcttggctaagcctggattcccatggtcccccgacctgggtcctcccccagcctctgtacagagtagcctgggaatagatccatcttcaccccctcgagtataaataaggctgcttggttcaccaggggatagctgtgcttgtctgggctggagctaaaggacacacagaagcaagtccacagatccgtgatgactcccacgggggcaggcctgaaggccaccatcttctgcatcctgacctgggtcagcctgacagctggggaccgcgtatacatccacccctttcatctcctctactacagcaagagcacctgcgcccagctggagaaccccagtgtggagacgctcccagagccaacctttgagcctgtgcccattcaggccaagacctcccccgtggatgagaagaccctgcgagataagctcgtgctggccactgagaagctagaggctgaggatcggcagcgagctgcccaggtcgcgatgattgccaacttcatgggtttccgcatgtacaagatgctgagtgaggcaagaggtgtagccagtggggccgtcctctctccaccggccctctttggcaccctggtctctttctaccttggatcgttggatcccacggccagccagttgcaggtgctgctgggcgtccctgtgaaggagggagactgcacctcccggctggacggacataaggtcctcactgccctgcaggctgttcagggcttgctggtcacccagggtggaagcagcagccagacacccctgctacagtccaccgtggtgggcctcttcactgccccaggcttgcgcctaaaacagccatttgttgagagcttgggtcccttcacccccgccatcttccctcgctctctggacttatccactgacccagttcttgctgcccagaaaatcaacaggtttgtgcaggctgtgacagggtggaagatgaacttgccactagagggggtcagcacggacagcaccctatttttcaacacctacgttcacttccaagggaagatgagaggcttctcccagctgactgggctccatgagttctgggtggacaacagcacctcagtgtctgtgcccatgctctcgggcactggcaacttccagcactggagtgacgcccagaacaacttctccgtgacacgcgtgcccctgggtgagagtgtcaccctgctgctgatccagccccagtgcgcctcagatctcgacagggtggaggtcctcgtcttccagcacgacttcctgacttggataaagaacccgcctcctcgggccatccgtctgaccctgccgcagctggaaattcggggatcctacaacctgcaggacctgctggctcaggccaagctgtctacccttttgggtgctgaggcaaatctgggcaagatgggtgacaccaacccccgagtgggagaggttctcaacagcatcctccttgaactccaagcaggcgaggaggagcagcccacagagtctgcccagcagcctggctcacccgaggtgctggacgtgaccctgagcagtccgttcctgttcgccatctacgagcgggactcaggtgcgctgcactttctgggcagagtggataacccccaaaatgtggtgtgatgcctcctgtgtagccatggagacaaggccagcgtcagagagctatcctgggcaaaaatcagtgccttcacccctggcttcccgtcactccttccagcaaggcagaggccgtctccttggagatggcgctaactgagaataaatgatgagcagcagcctcctggggtgtgggtttgtttggacactggggtgagagccaggagctggcactctgtataggaggactgccatcctggaaaaaaaaaatggaccaaacaactgtttgtgaaataaaaaaaaaaaaattccctttttatttgaaaaaaaaaaaaaaaaaaaaaaaaa

//