2024-04-24 07:49:17, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_133322 4158 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus potassium voltage-gated channel subfamily Q member 2 (Kcnq2), mRNA. ACCESSION NM_133322 VERSION NM_133322.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4158) AUTHORS Tonomura S, Ling J and Gu JG. TITLE Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats JOURNAL Mol Brain 15 (1), 64 (2022) PUBMED 35858950 REMARK GeneRIF: Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats. Publication Status: Online-Only REFERENCE 2 (bases 1 to 4158) AUTHORS Kim KW, Kim K, Kim HJ, Kim BI, Baek M and Suh BC. TITLE Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family JOURNAL Proc Natl Acad Sci U S A 118 (47) (2021) PUBMED 34785595 REMARK GeneRIF: Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family. REFERENCE 3 (bases 1 to 4158) AUTHORS Manville RW and Abbott GW. TITLE The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels JOURNAL Cell Physiol Biochem 55 (S3), 157-170 (2021) PUBMED 34318654 REMARK GeneRIF: The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels. REFERENCE 4 (bases 1 to 4158) AUTHORS Djouhri L, Zeidan A and Abd El-Aleem SA. TITLE Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy JOURNAL Neurosci Lett 736, 135277 (2020) PUBMED 32739272 REMARK GeneRIF: Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy. REFERENCE 5 (bases 1 to 4158) AUTHORS Bian G, Liu J, Guo Y, Yang Y, Li L, Qiao H, Li W, Xu T and Zhang Q. TITLE Kv7.2 subunit-containing M-type potassium channels in the lateral habenula are involved in the regulation of working memory in parkinsonian rats JOURNAL Neuropharmacology 168, 108012 (2020) PUBMED 32067988 REMARK GeneRIF: Kv7.2 subunit-containing M-type potassium channels in the lateral habenula are involved in the regulation of working memory in parkinsonian rats. REFERENCE 6 (bases 1 to 4158) AUTHORS Pan Z, Selyanko AA, Hadley JK, Brown DA, Dixon JE and McKinnon D. TITLE Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents JOURNAL J Physiol 531 (Pt 2), 347-358 (2001) PUBMED 11230508 REFERENCE 7 (bases 1 to 4158) AUTHORS Jow F and Wang K. TITLE Cloning and functional expression of rKCNQ2 K(+) channel from rat brain JOURNAL Brain Res Mol Brain Res 80 (2), 269-278 (2000) PUBMED 11038262 REFERENCE 8 (bases 1 to 4158) AUTHORS Watanabe H, Nagata E, Kosakai A, Nakamura M, Yokoyama M, Tanaka K and Sasai H. TITLE Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability JOURNAL J Neurochem 75 (1), 28-33 (2000) PUBMED 10854243 REFERENCE 9 (bases 1 to 4158) AUTHORS Schwake M, Pusch M, Kharkovets T and Jentsch TJ. TITLE Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy JOURNAL J Biol Chem 275 (18), 13343-13348 (2000) PUBMED 10788442 REFERENCE 10 (bases 1 to 4158) AUTHORS Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE and McKinnon D. TITLE KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel JOURNAL Science 282 (5395), 1890-1893 (1998) PUBMED 9836639 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000123.1. On Nov 26, 2020 this sequence version replaced NM_133322.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF087453.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132262 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-411 JACYVU010000123.1 3851063-3851473 c 412-502 JACYVU010000123.1 3831290-3831380 c 503-629 JACYVU010000123.1 3830233-3830359 c 630-805 JACYVU010000123.1 3829726-3829901 c 806-931 JACYVU010000123.1 3828539-3828664 c 932-1042 JACYVU010000123.1 3826182-3826292 c 1043-1138 JACYVU010000123.1 3825547-3825642 c 1139-1233 JACYVU010000123.1 3821640-3821734 c 1234-1263 JACYVU010000123.1 3819987-3820016 c 1264-1332 JACYVU010000123.1 3816948-3817016 c 1333-1362 JACYVU010000123.1 3814124-3814153 c 1363-1586 JACYVU010000123.1 3805282-3805505 c 1587-1695 JACYVU010000123.1 3804498-3804606 c 1696-1827 JACYVU010000123.1 3803885-3804016 c 1828-1951 JACYVU010000123.1 3799299-3799422 c 1952-4158 JACYVU010000123.1 3796520-3798726 c FEATURES Location/Qualifiers source 1..4158 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="3" /map="3q43" gene 1..4158 /gene="Kcnq2" /note="potassium voltage-gated channel subfamily Q member 2" /db_xref="GeneID:170848" /db_xref="RGD:621504" exon 1..411 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" misc_feature 98..100 /gene="Kcnq2" /note="upstream in-frame stop codon" CDS 116..2674 /gene="Kcnq2" /note="potassium voltage-gated channel, KQT-like subfamily, member 2; KQT-like 2; potassium channel subunit alpha KvLQT2; voltage-gated potassium channel subunit Kv7.2; potassium channel, voltage-gated KQT-like subfamily Q, member 2" /codon_start=1 /product="potassium voltage-gated channel subfamily KQT member 2" /protein_id="NP_579856.2" /db_xref="GeneID:170848" /db_xref="RGD:621504" /translation="
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPVMPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK"
misc_feature 269..271 /gene="Kcnq2" /note="Phosphoserine, by PKA. /evidence=ECO:0000250|UniProtKB:O43526; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 389..1087 /gene="Kcnq2" /note="Ion transport protein; Region: Ion_trans; pfam00520" /db_xref="CDD:425730" misc_feature 389..451 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); transmembrane region" misc_feature 482..544 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); transmembrane region" misc_feature 614..676 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); transmembrane region" misc_feature 707..778 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); transmembrane region" misc_feature 779..1084 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Mediates interaction with SLC5A3. /evidence=ECO:0000269|PubMed:28793216" misc_feature 809..871 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); transmembrane region" misc_feature 944..961 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Selectivity filter. /evidence=ECO:0000250" misc_feature 989..1051 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); transmembrane region" misc_feature 1064..1681 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Mediates interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:O43526" misc_feature 1325..1522 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1457..2017 /gene="Kcnq2" /note="KCNQ voltage-gated potassium channel; Region: KCNQ_channel; pfam03520" /db_xref="CDD:427346" misc_feature 1457..1459 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 1463..1465 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 1475..1477 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 1487..1489 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 1493..1495 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 1580..1582 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 1850..1918 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2042..2101 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2057..2323 /gene="Kcnq2" /note="Unstructured region on Potassium channel subunit alpha KvLQT2; Region: KCNQ2_u3; pfam16642" /db_xref="CDD:435485" misc_feature 2078..2080 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 2129..2269 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2357..2659 /gene="Kcnq2" /note="Ankyrin-G binding motif of KCNQ2-3; Region: KCNQC3-Ank-G_bd; pfam11956" /db_xref="CDD:432219" misc_feature 2456..2458 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 2462..2464 /gene="Kcnq2" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O88943.1); phosphorylation site" misc_feature 2567..2671 /gene="Kcnq2" /note="propagated from UniProtKB/Swiss-Prot (O88943.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" exon 412..502 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 503..629 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 630..805 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 806..931 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 932..1042 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1043..1138 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1139..1233 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1234..1263 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1264..1332 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1333..1362 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1363..1586 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1587..1695 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1696..1827 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1828..1951 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" exon 1952..4158 /gene="Kcnq2" /inference="alignment:Splign:2.1.0" ORIGIN
agccgcagccgcctcggccatgcggctgccggacccggggcctgggctggggcccgcgccaccccctgcgcgccgcccccgctgagcccgcgccggatagggcgccgccggcaccatggtgcagaagtcgcgcaacggtggcgtgtaccccggcaccagcggggaaaaaaagctcaaggtgggcttcgtggggctggaccccggcgcgcccgactccactcgcgacggcgcgctactcatcgcgggctccgaggcccccaagcgcggcagcgttttgagcaagccgcggacgggcggcgcgggagccgggaagcccccaaagcgcaacgccttctaccgcaagctgcagaatttcctatacaacgtgctagagcggccccgcggttgggcgttcatctaccacgcctacgtgtttcttttagtcttctcctgccttgtgctttccgtgttttccaccatcaaggagtatgagaagagttccgagggggccctctacatcttggaaatcgtgaccatcgtggtattcggtgttgagtactttgtgagaatctgggctgcaggctgctgctgccggtatcgaggctggaggggccggctcaagtttgccaggaagccattctgtgtgatcgacatcatggtgctgattgcctccattgctgtgctggctgctggctcccagggcaatgtctttgccacatctgcacttcggagcttgcggttcttacaaatcttacggatgatccgtatggaccggaggggcggcacctggaagctcctgggatcggtggtctacgctcacagcaaggagctggtgactgcgtggtacattggcttcctctgcctcatcctggcctcgtttctggtgtacttggcagaaaagggtgagaatgaccacttcgacacctacgcggatgcactctggtggggtctgatcaccctgacaaccattggctacggggacaagtaccctcagacctggaacgggaggctgttagcagcgacgtttaccctcattggtgtctcattcttcgctcttcctgctggcattttgggatccggctttgccctgaaagtccaagagcagcatcggcaaaaacactttgagaaacggcggaatcctgcggcaggtctgatccagtctgcctggagattctatgctactaacctctcacgcaccgacctgcactccacgtggcagtactacgagcggacagtcactgtccccatgtacagctcacaaactcaaacctatggggcctccagactcattccgcctctgaaccagctggagctgctgaggaatctcaagagcaaatctggactcaccttcaggaaggagccacagccagagccatcaccaagtcagaaggtcagtttgaaagatcgtgtcttctccagcccccgaggcgtggctgccaaggggaaggggtctccccaggcccagacggtccggcggtcccccagtgcggatcagagtctcgatgacagcccaagcaaggtgcccaagagctggagctttggtgaccgcagccgtgcacgccaggctttccgtatcaagggcgctgcatcccggcagaactcagaagaagcaagcctccctggggaggatatcgtggaggacaacaagagctgtaactgcgagtttgtgactgaagatcttacccctggcctcaaagtcagcatcagagctgtgtgtgttatgcggttcttggtatctaagcgaaagttcaaagagagtctgcgcccatatgacgtgatggatgtcatcgaacagtactcggccggacacttggatatgttgtcccgaatcaagagcctgcagtccagagtggaccagattgtggggcggggcccgacaataacggacaaggaccgcaccaaaggcccagcggagacggaactgcccgaagaccccagcatgatgggacgccttgggaaggtggaaaaacaggtcttgtccatggaaaagaagctagacttcctggtgagcatctacacacagagaatgggcatcccaccagcagagacagaggcctatttcggggccaaggagcctgagccggcaccaccctaccacagcccggaggacagccgtgaccatgcagacaagcatggctgtattattaagattgtccgctccaccagctctacgggccagaggaactacgccgcacccccagtcatgccccctgcccagtgtcccccatccacctcgtggcagcagagccaccagcgccacggcacctcccccgtgggagaccatggctcactggtacgcatcccaccaccccctgcgcacgagcgctcactgtctgcctacagtgggggcaacagagccagtaccgagttcttgaggctggagggcaccccagcctgcaggccctctgaggcagccctgcgggatagcgacacgtccatctccatcccttcggtggaccacgaggagctggagcgttcctttagcggtttcagtatctcccagtccaaggagaacctggatgccctggccagctgttatgcagctgtggcgccgtgcgccaaggtcaggccctacattgcagagggtgagtctgacacagactcagacctctgcacaccgtgtgggccacccccacgctctgccactggtgaaggcccctttggagatgtggcttgggcagggcctaggaagtgagtctgggttgggctgctggccccatgccacacccactcttgttcagttttagagctggagttccagggcctttcttaaagtgacagagcggcatagagtagtgtgggttgtgaggatgctcatgggatctcgctctcagggtcaatgtggagtggaaatgaggcagggttccttagcacatacagtaacattttatagaagttcttttccaaccaggagagggtggttgaggccgggccctggaggcccttgggagctccctatggcagcaaagctagccctgcctagtcttcttgggggacatattgccctgtgagtgaggagggacagcgtgatggttagcctctgtgagtgggggtgtggctgggagcaagtccgtgggaggtagtggtgaaatgaaacaggcccgtctactgctgatagccagtcctgaggcccatgggtctctcagtttagtctgggagctcaggggtatagtaagtcactggaaacggcccactctcacacctgactgcttatccctccatcccgactgcccccagtaaagcattaccagacccactgttgggtgtggctgggcaatgcccctcatccctgggtaacctagctaaagagctgccacaatcttcctccctcttccaggttatgtggatctttccatgggaaccatctttaggtccttctcctggagctgaggaaggagtgaggcctcagggaccaatctggaacttagaattgatccttagactctcttgacttccacctcttaggggaagactcaactcacagccttttctgaaagggtttcttcagcaggttctggctgcctcgtgccaggtactgtagcccagtaggtatgagttgacacttcaaggcctctgctctttcctggtgtggcactggcctccaggctgtggccagcactttaagagaatcaccagataagcagaccagccttagccagggcacctccttgcctgctgcccacttggctctacggattcaggcagggctaaatgacatgacgtcttcaaactgccggctctctctacacgagagcatggcctttgagcctggtcaaggatccttcccaatgaagctggccatccagtcctttatccactagtaggtccctggtctgtggcccctgggtgtttgaggaattgggaacaccttggcctctactctggtgaggaataatccctgtccatcctgtgagtgggcatcttgggccatcagcagctgactttagagggaaacatggtagatataatagagccctcggttgtggccccataatatctggcccagaggtgcctggcattaaatgataacattttggggtgggggccctaaaccctcttgccctcagttttcctggtcactgaggacaagcgctacagagcttgtgcttgggcagagctttatttacttcttccacccttttgaaatgtgtgttctggcaggggtagaggcaacttggg
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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