2024-04-20 14:32:41, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_053449 4015 bp mRNA linear ROD 08-NOV-2023 DEFINITION Rattus norvegicus histone deacetylase 4 (Hdac4), mRNA. ACCESSION NM_053449 XM_001067733 XM_343629 VERSION NM_053449.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4015) AUTHORS Zhang D, Du J, Yu M and Suo L. TITLE Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering microRNA-26a-5p JOURNAL Cell Biol Toxicol 39 (5), 2243-2257 (2023) PUBMED 35554780 REMARK GeneRIF: Urine-derived stem cells-extracellular vesicles ameliorate diabetic osteoporosis through HDAC4/HIF-1alpha/VEGFA axis by delivering microRNA-26a-5p. REFERENCE 2 (bases 1 to 4015) AUTHORS Yang Y, Wang Z, Xu Y, Liu X, Sun Y and Li W. TITLE Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis JOURNAL Inflamm Res 71 (9), 1109-1121 (2022) PUBMED 35854140 REMARK Erratum:[Inflamm Res. 2023 Apr;72(4):893. PMID: 36806965] REFERENCE 3 (bases 1 to 4015) AUTHORS Moreno-Ruperez A, Priego T, Gonzalez-Nicolas MA, Lopez-Calderon A, Lazaro A and Martin AI. TITLE Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats JOURNAL Int J Mol Sci 23 (7), 3641 (2022) PUBMED 35408999 REMARK GeneRIF: Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats. Publication Status: Online-Only REFERENCE 4 (bases 1 to 4015) AUTHORS Festa Ortega JF, Heidor R, Auriemo AP, Marques Affonso J, Pereira D' Amico T, Herz C, de Conti A, Ract J, Gioieli LA, Purgatto E, Lamy E, P Pogribny I and Salvador Moreno F. TITLE Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis JOURNAL Carcinogenesis 42 (8), 1026-1036 (2021) PUBMED 33999989 REMARK GeneRIF: Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis. Erratum:[Carcinogenesis. 2021 Oct 26;42(10):1304. PMID: 34605906] REFERENCE 5 (bases 1 to 4015) AUTHORS Wei W, Chen W and He N. TITLE HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation JOURNAL J Transl Med 19 (1), 258 (2021) PUBMED 34118928 REMARK GeneRIF: HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4015) AUTHORS Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W and Verdin E. TITLE Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR JOURNAL Mol Cell 9 (1), 45-57 (2002) PUBMED 11804585 REFERENCE 7 (bases 1 to 4015) AUTHORS Lu J, McKinsey TA, Zhang CL and Olson EN. TITLE Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases JOURNAL Mol Cell 6 (2), 233-244 (2000) PUBMED 10983972 REFERENCE 8 (bases 1 to 4015) AUTHORS Grozinger CM and Schreiber SL. TITLE Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization JOURNAL Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000) PUBMED 10869435 REFERENCE 9 (bases 1 to 4015) AUTHORS Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP and Khochbin S. TITLE mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity JOURNAL J Biol Chem 275 (20), 15594-15599 (2000) PUBMED 10748098 REFERENCE 10 (bases 1 to 4015) AUTHORS Grozinger CM, Hassig CA and Schreiber SL. TITLE Three proteins define a class of human histone deacetylases related to yeast Hda1p JOURNAL Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999) PUBMED 10220385 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000215.1. On or before Sep 1, 2012 this sequence version replaced XM_001067733.2, XM_343629.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132262 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-78 JACYVU010000215.1 25819778-25819855 c 79-317 JACYVU010000215.1 25786923-25787161 c 318-389 JACYVU010000215.1 25698379-25698450 c 390-631 JACYVU010000215.1 25672874-25673115 c 632-782 JACYVU010000215.1 25656525-25656675 c 783-903 JACYVU010000215.1 25646887-25647007 c 904-1025 JACYVU010000215.1 25640673-25640794 c 1026-1157 JACYVU010000215.1 25636185-25636316 c 1158-1270 JACYVU010000215.1 25632544-25632656 c 1271-1387 JACYVU010000215.1 25629686-25629802 c 1388-1586 JACYVU010000215.1 25629399-25629597 c 1587-1810 JACYVU010000215.1 25627090-25627313 c 1811-2065 JACYVU010000215.1 25621082-25621336 c 2066-2252 JACYVU010000215.1 25618243-25618429 c 2253-2386 JACYVU010000215.1 25616483-25616616 c 2387-2492 JACYVU010000215.1 25613929-25614034 c 2493-2539 JACYVU010000215.1 25610331-25610377 c 2540-2647 JACYVU010000215.1 25606936-25607043 c 2648-2703 JACYVU010000215.1 25604906-25604961 c 2704-2791 JACYVU010000215.1 25604055-25604142 c 2792-2911 JACYVU010000215.1 25601707-25601826 c 2912-3009 JACYVU010000215.1 25600871-25600968 c 3010-3128 JACYVU010000215.1 25593797-25593915 c 3129-3262 JACYVU010000215.1 25592259-25592392 c 3263-3347 JACYVU010000215.1 25578991-25579075 c 3348-3489 JACYVU010000215.1 25578032-25578173 c 3490-4015 JACYVU010000215.1 25577284-25577809 c FEATURES Location/Qualifiers source 1..4015 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="9" /map="9q36" gene 1..4015 /gene="Hdac4" /note="histone deacetylase 4" /db_xref="GeneID:363287" /db_xref="RGD:619979" exon 1..78 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 79..317 /gene="Hdac4" /inference="alignment:Splign:2.1.0" CDS 296..3529 /gene="Hdac4" /EC_number="3.5.1.98" /note="HD4" /codon_start=1 /product="histone deacetylase 4" /protein_id="NP_445901.1" /db_xref="GeneID:363287" /db_xref="RGD:619979" /translation="
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPAAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCMSSDPRYWYGKTQHSSLDQSSPPQSGVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSTPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRISLFPGTHLTPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTGLGALPLHTQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKMISKPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEEEVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMGIHSEYWRCLQRLSPTVGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL"
misc_feature <563..748 /gene="Hdac4" /note="Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase; Region: ClassIIa_HDAC4_Gln-rich-N; cd10162" /db_xref="CDD:197398" misc_feature order(569..571,581..583,614..619,626..628,647..649, 659..664) /gene="Hdac4" /note="dimer interface A, B [polypeptide binding]; other site" /db_xref="CDD:197398" misc_feature 644..1231 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Interaction with MEF2A. /evidence=ECO:0000250" misc_feature 689..796 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 905..970 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 920..922 /gene="Hdac4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q6NZM9; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 1010..1276 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1028..1030 /gene="Hdac4" /note="Phosphoserine, by CaMK4 and SIK1. /evidence=ECO:0000250|UniProtKB:P56524; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 1337..1354 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: PxLPxI/L motif, mediates interaction with ANKRA2 and 14-3-3 proteins. /evidence=ECO:0000250|UniProtKB:P56524" misc_feature 1340..1342 /gene="Hdac4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P56524; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 1691..1693 /gene="Hdac4" /note="Phosphoserine, by CaMK4 and SIK1. /evidence=ECO:0000250|UniProtKB:P56524; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 1817..1885 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1919..2041 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1982..1984 /gene="Hdac4" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 2162..2233 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 2183..2185 /gene="Hdac4" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 2186..2188 /gene="Hdac4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P56524; propagated from UniProtKB/Swiss-Prot (Q99P99.2); phosphorylation site" misc_feature 2234..3445 /gene="Hdac4" /note="Histone deacetylase 4; Region: HDAC4; cd10006" /db_xref="CDD:212530" misc_feature 2252..3526 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Histone deacetylase. /evidence=ECO:0000250" misc_feature order(2678..2683,2705..2710,2792..2794,2798..2800, 3074..3076,3194..3196) /gene="Hdac4" /note="active site" /db_xref="CDD:212530" misc_feature 3425..3526 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Nuclear export signal. /evidence=ECO:0000250" misc_feature 3449..3526 /gene="Hdac4" /note="propagated from UniProtKB/Swiss-Prot (Q99P99.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" exon 318..389 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 390..631 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 632..782 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 783..903 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 904..1025 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 1026..1157 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 1158..1270 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 1271..1387 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 1388..1586 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 1587..1810 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 1811..2065 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2066..2252 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2253..2386 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2387..2492 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2493..2539 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2540..2647 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2648..2703 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2704..2791 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2792..2911 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 2912..3009 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 3010..3128 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 3129..3262 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 3263..3347 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 3348..3489 /gene="Hdac4" /inference="alignment:Splign:2.1.0" exon 3490..4015 /gene="Hdac4" /inference="alignment:Splign:2.1.0" ORIGIN
ggagcgcctgacgggcgtagggcgcggcctatccccgcgcggctctgcgctcgagggggagcagcatcatggttcaacgttcatctctgcaaggccaggtgacaacttctgctcttcttgtggattacttggtttacaagacgctgccagtgggacttcgagtttgcgcagctgggacccgggcctcctcagttttgtacctgcatgttctcgtgggaatttggagcgtgttggagccactgtttacctggacatcttgagccatttcgaacttaaggcactgacgctgctagcaatgagctcccaaagccatccagatggactttctggccgagaccagcctgtggagctgctgaatcctgcccgcgtgaaccacatgcccagcacggtggacgtggctacagcgctgcctctgcaggtggcccctgcagcagtacccatggacctgcgcttggaccaccagttctcactgcccttggaacctgcactgcgggagcagcaactgcagcaggaactcctagcactgaagcagaagcagcagatccagcggcagatcctcattgcagagttccagcgtcagcatgagcagttgtcccgacagcatgaggcacagctgcatgaacatatcaagcagcagcaggagatgctggccatgaagcaccagcaggagctgctggagcaccagcggaaactggagcggcaccggcaagagcaggagctggagaagcagcaccgtgagcagaagctgcagcagctcaagaacaaggagaagggcaaagagagtgctgtggcgagcacagaggtgaagatgaagctgcaggagtttgttctcaacaagaagaaggctctggcccaccggaacctgaaccactgcatgtccagcgacccccgctactggtatgggaagacacagcacagctcccttgaccagagctctccaccccagagtggggtgtcagcctcctacaaccaccctgtcttgggaatgtacgacgccaaagatgacttccctcttaggaaaacagcttctgaacctaacctgaaattacggtcaaggcttaagcagaaagtagctgagagacggagcagccccctgctgcgcaggaaagatggccctgtggccactgctctaaaaaagcgacccctggatgttacagactccgcatgtagcagcgcccctggctccggtcccagctcccccaatagcagctctggcaacgtcagcaccgagaatggcattgcacccaccgtgcccagcactccagctgagacgagcttggcacacagacttgtgactcgagaaggctctgttgccccacttcctctctatacatcaccatccttgcccaacatcaccctgggacttcctgccactggccctgctgctggtgcagcaggccagcaggatgctgagaggcttgctctcccagccctccagcagcgaatctccttgttccctgggacccacctcaccccatacctgagcacctcgcccctggagcgggacggtggagcagctcacaaccccctcctgcagcacatggtcctgctggagcagccacccacccagacgccccttgtcacaggcctgggggcactgcccctccacacacagtccctggttggtgcggacagggtgtccccatccattcacaagctgcggcagcaccgacctctggggcgcacgcagtcagcacccctgccgcagaacgcacaggccctgcagcacctggtgatccagcagcagcaccagcagtttctggagaagcacaagcaacagttccagcagcagcagctgcacctcagcaagatgatttctaaacccagtgagccacctcggcagcctgagagccacccggaggagacagaggaggagctccgtgaacaccaggccttgctggatgagccctacctagatcggctccctgggcagaaggagccctccttagctggtgtgcaggtgaagcaggagcccatcgagagtgaggaggaagaagtagaggccactcgagaggcggaacccagccagcgcccagccactgaacaggagcttctctttagacagcaagctcttctgctggagcagcagaggatccaccagttaaggaactaccaggcatctatggaggctgctggcatccctgtgtcatttggcagccacagacctctgtctcgcgcacagtcctccccagcatctgccaccttccccatgtcagtccaggagccccccaccaaaccaaggttcaccacaggccttgtgtatgacacactcatgttgaagcaccagtgcacctgtgggaacaccaacagccacccggagcatgctgggaggatccagagcatctggtcccgcctgcaggagactggcctccgtggcaagtgtgagtgcatccgcggacgcaaggccacactggaagagctgcagacagtgcactcggaggcccacacactcctctatggcacaaaccctctcaacagacagaaactggacagctcgctgacctccgtgtttgtcaggcttccttgtggtggtgttggggtggatagtgataccatatggaatgaggtgcactcgtctggggcagcccgcctggctgtaggctgtgtagtggagctggtcttcaaggtggccacgggagagctaaagaatggctttgctgtggttcgtcccccaggacaccatgccgaggagagtacacccatgggtttctgctactttaattctgtggcaattgcagccaaacttctccagcagaggttgaatgtgagcaagatcctcattgtagactgggatgtgcaccatgggaatgggacccagcaggccttctacaatgaccccaatgttctctacatgtccctgcaccgctatgacgatgggaacttcttcccaggaagtggagcaccagatgaggtgggcacagggccaggcgtgggtttcaatgtcaacatggccttcacgggtggcctcgatccccccatgggagacgccgagtacctggcagccttcagaacggtggtcatgccaatcgcaaatgagtttgccccagatgtggtactggtgtcctcgggcttcgatgctgtggagggccaccccacacctcttggagggtacaatctctctgccaaatgtttcgggtacttgacaaaacagctgatgggcttagctggtggccggatcgtgctggccctggagggaggccatgacctgacagccatctgtgatgcttctgaagcatgtgtttctgctctgctgggaaatgagcttgagcctctgccagaaaaggttctacatcagagacccaatgccaatgccgtccactccatggagaaagtgatgggcatccacagtgagtactggcgctgcctgcagcgtttgtcccccactgtggggcactctctgattgaggcgcagaagtgtgagaatgaagaagctgagacagtcaccgccatggcctcgctgtctgtaggcgtcaaacctgctgagaagagatctgaggaggagcccatggaggaggagccaccactgtagccgaagctgctgttctctcctttgtctgtctgtcttaaggctcagccaagaaactttcccgtgtcactcctgcgtcctgccttggtgctctctctgagtgcgaagggacagcaggtgtgaagcagcaacgggaggcctttctgccgccctggaccacaggtctggagacgcacacgaacaccaggtgtggcagatcagatggaacacaggacagtgcgcaacacgtgggcacacagacatgccgcagaagccaagcacacgctgctggggtcccccaggaaagccacgaaggaagaagcttgtggcaacttgggcagagttgctgaattgagttgacatgaggaaaatgaaaatcaaagatctaataatacagaacaaacttgattaaaactggtgcttaacatttgattcttacccacaatcccacagtctccgtgtaaaccactcaactcatcttgtagcttttttaaaaaaaaaaaaaaacaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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