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2024-03-29 10:26:22, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_052981               1230 bp    mRNA    linear   ROD 15-JUL-2023
DEFINITION  Rattus norvegicus cyclin H (Ccnh), mRNA.
ACCESSION   NM_052981
VERSION     NM_052981.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Wang KC, Nguyen P, Weiss A, Yeh YT, Chien HS, Lee A, Teng D,
            Subramaniam S, Li YS and Chien S.
  TITLE     MicroRNA-23b regulates cyclin-dependent kinase-activating kinase
            complex through cyclin H repression to modulate endothelial
            transcription and growth under flow
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (7), 1437-1445 (2014)
   PUBMED   24855060
  REMARK    GeneRIF: Hemodynamic forces modulate EC proliferative phenotype
            through the miR-23b/CAK/cyclin H pathway.
REFERENCE   2  (bases 1 to 1230)
  AUTHORS   Wang Y, Liu F, Mao F, Hang Q, Huang X, He S, Wang Y, Cheng C, Wang
            H, Xu G, Zhang T and Shen A.
  TITLE     Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7)
            stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer
            cell migration
  JOURNAL   J Biol Chem 288 (13), 9028-9034 (2013)
   PUBMED   23393140
REFERENCE   3  (bases 1 to 1230)
  AUTHORS   Fujii W, Nishimura T, Kano K, Sugiura K and Naito K.
  TITLE     CDK7 and CCNH are components of CDK-activating kinase and are
            required for meiotic progression of pig oocytes
  JOURNAL   Biol Reprod 85 (6), 1124-1132 (2011)
   PUBMED   21778139
REFERENCE   4  (bases 1 to 1230)
  AUTHORS   Wu G, Cao J, Peng C, Yang H, Cui Z, Zhao J, Wu Q, Han J, Li H, Gu X
            and Zhang F.
  TITLE     Temporal and spatial expression of cyclin H in rat spinal cord
            injury
  JOURNAL   Neuromolecular Med 13 (3), 187-196 (2011)
   PUBMED   21710280
  REMARK    GeneRIF: Data suggest that cyclin H may play a proliferative role
            in spinal cord injury (SCI).
REFERENCE   5  (bases 1 to 1230)
  AUTHORS   Egly JM and Coin F.
  TITLE     A history of TFIIH: two decades of molecular biology on a pivotal
            transcription/repair factor
  JOURNAL   DNA Repair (Amst) 10 (7), 714-721 (2011)
   PUBMED   21592869
  REMARK    Review article
REFERENCE   6  (bases 1 to 1230)
  AUTHORS   Laes JF, Quan X, Ravoet M, Stieber D, Van Vooren P, Van Reeth T,
            Szpirer J and Szpirer C.
  TITLE     Analysis of candidate genes included in the mammary cancer
            susceptibility 1 (Mcs1) region
  JOURNAL   Mamm Genome 12 (3), 199-206 (2001)
   PUBMED   11252168
REFERENCE   7  (bases 1 to 1230)
  AUTHORS   Jin K, Nagayama T, Chen J, Stetler AR, Kawaguchi K, Simon RP and
            Graham SH.
  TITLE     Molecular cloning of a cell cycle regulation gene cyclin H from
            ischemic rat brain: expression in neurons after global cerebral
            ischemia
  JOURNAL   J Neurochem 73 (4), 1598-1608 (1999)
   PUBMED   10501206
REFERENCE   8  (bases 1 to 1230)
  AUTHORS   Kershnar E, Wu SY and Chiang CM.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
REFERENCE   9  (bases 1 to 1230)
  AUTHORS   Drapkin R, Le Roy G, Cho H, Akoulitchev S and Reinberg D.
  TITLE     Human cyclin-dependent kinase-activating kinase exists in three
            distinct complexes
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6488-6493 (1996)
   PUBMED   8692842
REFERENCE   10 (bases 1 to 1230)
  AUTHORS   Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J and Pan ZQ.
  TITLE     Isolation and characterization of two human transcription factor
            IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6482-6487 (1996)
   PUBMED   8692841
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10538]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1.
            
            On Jun 1, 2021 this sequence version replaced NM_052981.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059109.1, AF154914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JACYVU010000065.1  8340334-8340579
            247-369             JACYVU010000065.1  8341666-8341788
            370-443             JACYVU010000065.1  8346776-8346849
            444-654             JACYVU010000065.1  8347931-8348141
            655-818             JACYVU010000065.1  8352779-8352942
            819-889             JACYVU010000065.1  8355779-8355849
            890-1001            JACYVU010000065.1  8359361-8359472
            1002-1062           JACYVU010000065.1  8359822-8359882
            1063-1230           JACYVU010000065.1  8360751-8360918
FEATURES             Location/Qualifiers
     source          1..1230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..1230
                     /gene="Ccnh"
                     /note="cyclin H"
                     /db_xref="GeneID:84389"
                     /db_xref="RGD:69419"
     exon            1..246
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1101
                     /gene="Ccnh"
                     /codon_start=1
                     /product="cyclin-H"
                     /protein_id="NP_443213.3"
                     /db_xref="GeneID:84389"
                     /db_xref="RGD:69419"
                     /translation="
MYHNSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPNDPLFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAILKQKLERCHSSDLALNMVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDAL"
     misc_feature    133..1053
                     /gene="Ccnh"
                     /note="cyclin ccl1; Region: ccl1; TIGR00569"
                     /db_xref="CDD:129660"
     misc_feature    142..144
                     /gene="Ccnh"
                     /note="Phosphoserine, by CDK8.
                     /evidence=ECO:0000250|UniProtKB:P51946; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A0.2); phosphorylation site"
     misc_feature    523..525
                     /gene="Ccnh"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51946; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A0.2); phosphorylation site"
     misc_feature    1015..1098
                     /gene="Ccnh"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1A0.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1039..1041
                     /gene="Ccnh"
                     /note="Phosphoserine, by CDK8.
                     /evidence=ECO:0000250|UniProtKB:P51946; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A0.2); phosphorylation site"
     misc_feature    1072..1074
                     /gene="Ccnh"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9R1A0.2); phosphorylation site"
     exon            247..369
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            370..443
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            444..654
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            655..818
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            819..889
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1001
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1062
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1230
                     /gene="Ccnh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
gtgaccgtgacgtcacgcgcgcgcctgcggtctgggccgagggttctcgcgttggcagtcgctcgtggctgctgtctcccggagtgtcgctgtttctgtctcggccctgcggcccgtgagggctacagcatgtaccacaacagcagccagaagcggcactggaccttcgctagcgaggagcaactggcgcgtctgcgggccgacgccaaccgcaaattcaagtgcaaagctgtggctaacgggaaggttcttccaaatgatccgttgtttcttgagcctcatgaagaaatgacactttgcaaatactatgaaaaaagattgttggaattttgttcagtgtttaaaccagctatgccacggtctgttgtgggtacagcttgtatgtatttcaagcgtttttatcttaataactcagtaatggaatatcaccctcggataataatgcttacttgtgcatttttggcctgcaaagtagatgaattcaatgtgtctagtcctcagtttgttgggaaccttcgagagagtcctcttggacaggagaaggcactggaacagattttggaatatgaactactacttatacaacaacttaattttcacctcattgtccacaatccatatagaccatttgaaggcttcctcattgatataaagactcgataccccatgttggagaatccagagattttgaggaaaacggctgatgattttcttagtagaattgcattgacagatgcttatcttttgtacacaccctcacaaattgccctgactgccattttatcaagtgcctctagggctggaattactatggaaagctatttatcagagagtctaatgctgaaagaaaacagaacttgcctgtcacagctactggatataatgaaaagcatgagaaatctagtaaaaaagtatgagccacccagatctgaagaagttgctattctgaaacagaagttggagcgatgtcattcttctgaccttgcacttaatatggttacaaagaagaggaaaggctacgaagacgatgactatgtatcaaagaaacccaaacaggaagaggaggagtggacggacgatgacctggtagatgctctctaaccagtgtaaatgactgcagcagtacttactgaccgacggaagtaggaagcatgtctgacattttacttttgtcaaaatagtgcaatgtgaaaacatcaaaatatattaaacttttctaattcttatata
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]