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Previous release (v1)
2024-04-24 20:28:13, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_031650 3218 bp mRNA linear ROD 22-MAR-2023
DEFINITION Rattus norvegicus solute carrier organic anion transporter family
member 1B2 (Slco1b2), transcript variant 1, mRNA.
ACCESSION NM_031650
VERSION NM_031650.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3218)
AUTHORS Chen S, Li K, Jiang J, Wang X, Chai Y, Zhang C, Deng Q, Shuai L,
Feng K, Ma K and Zhang L.
TITLE Low expression of organic anion-transporting polypeptide 1B3
predicts a poor prognosis in hepatocellular carcinoma
JOURNAL World J Surg Oncol 18 (1), 127 (2020)
PUBMED 32534581
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3218)
AUTHORS Ma X, Shang X, Qin X, Lu J, Liu M and Wang X.
TITLE Characterization of organic anion transporting polypeptide 1b2
knockout rats generated by CRISPR/Cas9: a novel model for drug
transport and hyperbilirubinemia disease
JOURNAL Acta Pharm Sin B 10 (5), 850-860 (2020)
PUBMED 32528832
REFERENCE 3 (bases 1 to 3218)
AUTHORS Alam K, Farasyn T, Ding K and Yue W.
TITLE Characterization of Liver- and Cancer-type-Organic Anion
Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in
Normal and Cancerous Human Tissues
JOURNAL Drug Metab Lett 12 (1), 24-32 (2018)
PUBMED 29577869
REFERENCE 4 (bases 1 to 3218)
AUTHORS Verboom MC, Kloth JSL, Swen JJ, van der Straaten T, Bovee JVMG,
Sleijfer S, Reyners AKL, Mathijssen RHJ, Guchelaar HJ, Steeghs N
and Gelderblom H.
TITLE Genetic polymorphisms in angiogenesis-related genes are associated
with worse progression-free survival of patients with advanced
gastrointestinal stromal tumours treated with imatinib
JOURNAL Eur J Cancer 86, 226-232 (2017)
PUBMED 29054076
REFERENCE 5 (bases 1 to 3218)
AUTHORS Sun B, Chen Y, Xiang T, Zhang L, Chen Z, Zhang S, Zhou H and Chen
S.
TITLE The Chinese Herb Jianpijiedu Contributes to the Regulation of
OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation
Liver Cancer Pretreated with Food Restriction and Diarrhea
JOURNAL Biomed Res Int 2015, 752850 (2015)
PUBMED 26665149
REFERENCE 6 (bases 1 to 3218)
AUTHORS Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK,
Winterhalter KH, Meier PJ and Hagenbuch B.
TITLE Localization of organic anion transporting polypeptide 4 (Oatp4) in
rat liver and comparison of its substrate specificity with Oatp1,
Oatp2 and Oatp3
JOURNAL Pflugers Arch 443 (2), 188-195 (2001)
PUBMED 11713643
REFERENCE 7 (bases 1 to 3218)
AUTHORS Ismair MG, Stieger B, Cattori V, Hagenbuch B, Fried M, Meier PJ and
Kullak-Ublick GA.
TITLE Hepatic uptake of cholecystokinin octapeptide by organic
anion-transporting polypeptides OATP4 and OATP8 of rat and human
liver
JOURNAL Gastroenterology 121 (5), 1185-1190 (2001)
PUBMED 11677211
REFERENCE 8 (bases 1 to 3218)
AUTHORS Choudhuri S, Ogura K and Klaassen CD.
TITLE Cloning of the full-length coding sequence of rat liver-specific
organic anion transporter-1 (rlst-1) and a splice variant and
partial characterization of the rat lst-1 gene
JOURNAL Biochem Biophys Res Commun 274 (1), 79-86 (2000)
PUBMED 10903899
REFERENCE 9 (bases 1 to 3218)
AUTHORS Cattori V, Hagenbuch B, Hagenbuch N, Stieger B, Ha R, Winterhalter
KE and Meier PJ.
TITLE Identification of organic anion transporting polypeptide 4 (Oatp4)
as a major full-length isoform of the liver-specific transporter-1
(rlst-1) in rat liver
JOURNAL FEBS Lett 474 (2-3), 242-245 (2000)
PUBMED 10838093
REFERENCE 10 (bases 1 to 3218)
AUTHORS Kakyo M, Unno M, Tokui T, Nakagomi R, Nishio T, Iwasashi H, Nakai
D, Seki M, Suzuki M, Naitoh T, Matsuno S, Yawo H and Abe T.
TITLE Molecular characterization and functional regulation of a novel rat
liver-specific organic anion transporter rlst-1
JOURNAL Gastroenterology 117 (4), 770-775 (1999)
PUBMED 10500057
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AF208545.2 and JACYVU010000151.1.
On Jul 19, 2012 this sequence version replaced NM_031650.2.
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ271682.1, AF208545.2 [ECO:0000332]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2497 AF208545.2 1-2497
2498-3218 JACYVU010000151.1 10936337-10937057
FEATURES Location/Qualifiers
source 1..3218
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="4"
/map="4q44"
gene 1..3218
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="solute carrier organic anion transporter family
member 1B2"
/db_xref="GeneID:58978"
/db_xref="RGD:69300"
exon 1..40
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 41..198
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
misc_feature 43..45
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="upstream in-frame stop codon"
CDS 115..2178
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="isoform 1 is encoded by transcript variant 1;
solute carrier family 21 member 10; sodium-independent
organic anion-transporting polypeptide 4; solute carrier
organic anion transporter family, member 1b3; solute
carrier family 21 (organic anion transporter) member 10;
solute carrier family (organic anion transporter) member
10; organic anion transporting polypeptide 4;
liver-specific transporter-1; liver-specific organic anion
transporter 1"
/codon_start=1
/product="solute carrier organic anion transporter family
member 1B2 isoform 1"
/protein_id="NP_113838.1"
/db_xref="GeneID:58978"
/db_xref="RGD:69300"
/translation="
MDHTQQSRKAAEAQPSRSKQTRFCDGFKLFLAALSFSYICKALGGVVMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFFMGYYKYAKENDIGSLGNSTLTCFINQMTSPTGPSPEIVEKGCEKGLKSHMWIYVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPILGFIMSSVFAKIYVDVGYVDLNSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPKIPKRSQEERKNSVSLHAPKTDEEKKHMTNLTKQEEQDPSNMTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQANFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPLLCENKPFAGLTLTYDGMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFYDCSCISNSGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAMGFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNLALKTPPLFLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNGYYCVPYDEQSNETPL"
misc_feature 196..1779
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="Major Facilitator Superfamily; Region: MFS;
cl28910"
/db_xref="CDD:452895"
misc_feature 199..258
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature order(235..240,247..252,259..261,355..357,658..663,
667..675,682..684,742..744,751..756,763..765,1138..1140,
1147..1152,1159..1167,1174..1176,1261..1263,1273..1275,
1396..1401,1411..1413,1423..1425,1612..1614,1621..1626,
1633..1635)
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="putative chemical substrate binding pocket
[chemical binding]; other site"
/db_xref="CDD:349949"
misc_feature 316..378
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 397..471
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 514..516
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); glycosylation site"
misc_feature 610..696
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 754..816
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 871..945
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 970..1047
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 982..984
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); phosphorylation site"
misc_feature 988..990
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9JJL3; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); phosphorylation site"
misc_feature 1099..1164
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 1225..1296
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 1309..1380
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 1600..1602
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); glycosylation site"
misc_feature 1645..1647
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); glycosylation site"
misc_feature 1708..1776
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 1804..1881
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 1984..2037
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="propagated from UniProtKB/Swiss-Prot (Q9QZX8.2);
transmembrane region"
misc_feature 2092..2094
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); phosphorylation site"
misc_feature 2113..2115
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9QZX8.2); phosphorylation site"
exon 199..340
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 341..473
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 474..586
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 587..733
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 734..832
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 833..1075
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1076..1240
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1241..1436
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1437..1608
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1609..1778
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1779..1843
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1844..1961
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
exon 1962..3218
/gene="Slco1b2"
/gene_synonym="OATP-4; Oatp4; rlst-1; Slc21a10; Slco1b3"
/inference="alignment:Splign:2.1.0"
ORIGIN
ggttagacatgccacgcttgctctagaagcctgagctcagggtagacgaccatttcaaaagaaatatttatcaacagtgattgcagacgttcccatcacaaccactgttcagtcatggaccacactcagcagtcaaggaaagctgcagaggcccaaccttcacgatcaaagcaaacaaggttctgcgatggattcaagctatttttggcagccctctccttcagctacatatgcaaagcactaggtggagttgttatgaagagttccatcacccaaatcgaaagaagattcgacataccatcttccatttctggtttgattgatggaggctttgaaattgggaatttattagttattgtatttgtgagttactttggatccaaactacacaggccaaagctgattggaattggctgcttcatcatgggcattgggagcattttgacagcgttgccacatttcttcatgggatattacaagtatgcaaaagaaaacgacattggctctctaggcaactctacattgacctgtttcatcaatcaaatgacatcacccactggaccttcacctgagatagtggagaaaggttgtgaaaaggggttaaagtcacacatgtggatttatgtcttgatggggaacatgcttcgtgggataggggaaacaccaatagtgcccctgggaatttcctaccttgatgactttgcaaaagaagggcacacttccatgcacctaggtactctgcatactatagcaatgattggaccaatccttggctttatcatgtcatctgtgtttgctaagatatatgtagacgttggatatgtagacctgaacagtgtccgaataactcctaatgatgctcgttgggttggtgcctggtggctcagcttcattgtgaatggactattatgcattacttcttccatacccttcttttttctgcccaaaattccaaagaggtcacaggaggaaaggaaaaattcagtatctcttcatgcacccaaaacagatgaggagaagaaacacatgactaatttaacaaagcaagaggaacaagatccttccaacatgactggttttctaaggtctctgagaagcatccttaccaatgaaatatatgttatattcttgatactgacgttactacaagtcagcggcttcattggctcctttacttacctgttcaagttcatagagcagcagttcggccggacagcatctcaggccaacttcttgttaggaattataaccatacctactatggcaactgcaatgtttttaggaggatatattgttaaaaaattcaaattgacatcggttggaatcgccaagtttgtatttttcacctcctcagtggcctatgcgtttcagttcttatattttcctctactctgtgaaaacaagccatttgctggcctaaccttgacctacgatggaatgaacccagtggactctcacatagatgtaccactttcttattgtaactcggactgcagttgtgataaaaatcaatgggaacccatctgtggggaaaatggagtcacttacatttcaccttgtctggcaggatgcaaatcttttcgtggtgataagaagccgaataacacagagttctatgactgcagttgtatcagcaactctggaaacaactcagcacatttgggtgaatgcccaagatacaaatgcaaaaccaactattacttttatataattcttcaagtcactgtgtcctttttcactgcaatgggaagcccatctttaatcttgattctgatgaagagcgtccaacctgaattgaaatcacttgcaatgggtttccattcactgattattcgagcactaggagggattctagctccaatctattatggggcattcattgacagaacgtgtattaagtggtctgtcaccagctgtggaaaacgtggtgcatgtaggctatataactccagattatttggattctcctacttgggtttgaacttagctttaaaaactccaccactttttttatatgttgtattaatttatttcacaaagagaaaatataaaagaaatgataacaagacattggaaaatggaagacagttcacagatgaaggaaacccagattctgtaaataaaaatggatactattgtgtaccttatgatgaacaaagcaatgaaacacctctttaaggaaagagaaagatacatctgttgctgtgttttcaaatacccccggggttctttcactgaaatttttcatactttatatgtaatagagaatttataaccctatgcatttataattaaacaaattgcaaatcaaaagaaataagagaacccttgttagggtatagctgtgcatttgtagctaaagatttggagatatataaacaggtattcgcttaagcatttataactcaataaaatagagaatggggcaaggatggacaaaggggaaagggactgtgaaaaattgttgtctttaaaaatcaaaatttgaatcgtactattcatgccagaagcttctgtgataggtgacttcatgatgtggcatattctggtatccccggtaagtcaaatatatatatatatatatatatatatatatatatatatatatatatatatatatttttttttttttttttggagctggggaccgaacccagagccttgcgcttgctaggcaagtgctctaccactgagttaaatccccaaccctaagtcatatatttttaattattaattttaaattgtgtttaatgacatatccatcttctttgtacatactgtacagaatattgagaataaaacagagacgtttaggatgtgagatatctctgtctatctctatctctacccctagcttcacctccttctctgtctccatctccctatctatctatctatctatctatctatctatctatctatcatctatctatccatctatgtatctgtctatctattatctatctatctatctatctatctatctatctatctatctatctatctatctacaatctccccaaatatctaaaattaagatagagtgaatgagacagatatctgtagacactgtattttcttgtgtgatcagatctagtgtggtggatgatagaagttgaacttgctttattgctatgtgttaaaatattttgtttgcattaaaatggcctattgaaatgcttttctgttcctataataaaataacctgatgaaaaagt
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]