2024-04-20 17:34:51, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_031142 1800 bp mRNA linear ROD 20-MAR-2023 DEFINITION Rattus norvegicus double C2 domain beta (Doc2b), mRNA. ACCESSION NM_031142 VERSION NM_031142.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1800) AUTHORS Brouwer I, Giniatullina A, Laurens N, van Weering JRT, Bald D, Wuite GJL and Groffen AJ. TITLE Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes JOURNAL Nat Commun 6, 8387 (2015) PUBMED 26395669 REMARK GeneRIF: acts directly on membranes and stabilizes hemifusion intermediate in cell-free system Publication Status: Online-Only REFERENCE 2 (bases 1 to 1800) AUTHORS Xue R, Gaffaney JD and Chapman ER. TITLE Structural elements that underlie Doc2beta function during asynchronous synaptic transmission JOURNAL Proc Natl Acad Sci U S A 112 (31), E4316-E4325 (2015) PUBMED 26195798 REMARK GeneRIF: these data reveal the key determinants of Doc2beta that underlie its function during the slow phase of synaptic transmission. REFERENCE 3 (bases 1 to 1800) AUTHORS Gaffaney JD, Xue R and Chapman ER. TITLE Mutations that disrupt Ca(2)-binding activity endow Doc2beta with novel functional properties during synaptic transmission JOURNAL Mol Biol Cell 25 (4), 481-494 (2014) PUBMED 24356452 REMARK GeneRIF: Mutations that disrupt Ca(2)-binding activity endow Doc2beta with novel functional properties during synaptic transmission. REFERENCE 4 (bases 1 to 1800) AUTHORS Yu H, Rathore SS, Davis EM, Ouyang Y and Shen J. TITLE Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner JOURNAL Mol Biol Cell 24 (8), 1176-1184 (2013) PUBMED 23427263 REMARK GeneRIF: Doc2b exocytotic functions appear to be distinct from how synaptotagmin-1 promotes synaptic neurotransmitter release. REFERENCE 5 (bases 1 to 1800) AUTHORS Yao J, Gaffaney JD, Kwon SE and Chapman ER. TITLE Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release JOURNAL Cell 147 (3), 666-677 (2011) PUBMED 22036572 REFERENCE 6 (bases 1 to 1800) AUTHORS Ke B, Oh E and Thurmond DC. TITLE Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis JOURNAL J Biol Chem 282 (30), 21786-21797 (2007) PUBMED 17548353 REFERENCE 7 (bases 1 to 1800) AUTHORS Korteweg N, Denekamp FA, Verhage M and Burbach JP. TITLE Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development JOURNAL Eur J Neurosci 12 (1), 165-171 (2000) PUBMED 10651871 REFERENCE 8 (bases 1 to 1800) AUTHORS Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y and Takai Y. TITLE Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport JOURNAL J Biol Chem 273 (46), 30065-30068 (1998) PUBMED 9804756 REFERENCE 9 (bases 1 to 1800) AUTHORS Verhage M, de Vries KJ, Roshol H, Burbach JP, Gispen WH and Sudhof TC. TITLE DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion JOURNAL Neuron 18 (3), 453-461 (1997) PUBMED 9115738 REFERENCE 10 (bases 1 to 1800) AUTHORS Kojima T, Fukuda M, Aruga J and Mikoshiba K. TITLE Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta) JOURNAL J Biochem 120 (3), 671-676 (1996) PUBMED 8902635 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U70778.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U70778.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1800 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="10" /map="10q24" gene 1..1800 /gene="Doc2b" /note="double C2 domain beta" /db_xref="GeneID:81820" /db_xref="RGD:620519" exon 1..528 /gene="Doc2b" /inference="alignment:Splign:2.1.0" CDS 156..1394 /gene="Doc2b" /function="probably functions in vesicular trafficking" /note="doc2-beta; double C2, beta; double C2-like domains, beta" /codon_start=1 /product="double C2-like domain-containing protein beta" /protein_id="NP_112404.1" /db_xref="GeneID:81820" /db_xref="RGD:620519" /translation="
MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAPARSPAATAGPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPVRPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPSWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHWFDCLKNKDKRIERWHTLTNEIPGAVLSD"
misc_feature 156..425 /gene="Doc2b" /note="propagated from UniProtKB/Swiss-Prot (P70610.2); Region: Mediates interaction with DYNLT1. /evidence=ECO:0000250" misc_feature 156..263 /gene="Doc2b" /note="propagated from UniProtKB/Swiss-Prot (P70610.2); Region: Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250" misc_feature 216..>413 /gene="Doc2b" /note="large tegument protein UL36; Provisional; Region: PHA03247" /db_xref="CDD:223021" misc_feature 267..524 /gene="Doc2b" /note="propagated from UniProtKB/Swiss-Prot (P70610.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 534..905 /gene="Doc2b" /note="C2 domain first repeat present in Rabphilin and Double C2 domain; Region: C2A_Rabphilin_Doc2; cd04035" /db_xref="CDD:176000" misc_feature order(624..626,642..644,807..809,813..815,831..833) /gene="Doc2b" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:176000" misc_feature 924..1280 /gene="Doc2b" /note="propagated from UniProtKB/Swiss-Prot (P70610.2); Region: Mediates interaction with STXBP3. /evidence=ECO:0000250" misc_feature 960..1358 /gene="Doc2b" /note="C2 domain second repeat present in Rabphilin and Double C2 domain; Region: C2B_Rabphilin_Doc2; cd08384" /db_xref="CDD:176030" misc_feature order(1044..1046,1062..1064,1224..1226,1230..1232, 1248..1250) /gene="Doc2b" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:176030" misc_feature 1386..1388 /gene="Doc2b" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P70610.2); phosphorylation site" exon 529..608 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 609..683 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 684..793 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 794..920 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 921..1078 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 1079..1160 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 1161..1257 /gene="Doc2b" /inference="alignment:Splign:2.1.0" exon 1258..1800 /gene="Doc2b" /inference="alignment:Splign:2.1.0" ORIGIN
gccgccgccgagcaggcagcagccgcgtcagggccgtccgggggccacaccggcgatgcccgcagcccccgcagcgccccgcgggacccgctgacttacccccgggccggggtcataccgggccgggccgggccgcgagcggcggcgctgcctgcatgaccctccggaggcgcggggagaaggcgaccatcagcatccaagagcatatggccatcgacgtgtgtcccgggcccatccggcctatcaagcagatctccgattacttcccccgcttcccgcggggcctcccccccaccgccgcgccccgcgcctccgcgcccccggacgcccccgcgcgctcgcccgcagccaccgccggcccccgcagcccctccgacggcgcccgcgacgacgacgaagatgtggaccagctcttcggagcctacggtgccagcccaggccccagccccggacccagccccgtgaggccgccggccaagccccccgaggacgaaccggacgccgacggctacgagtcagacgactgcaccgccctgggtacactggacttcagtctgctctatgaccaggagaacaacgcactgcactgcaccatcagcaaagccaagggcctgaagccgatggatcacaatggactggctgatccctacgtcaaactacacttgctgcctggagccagcaaggcaaataagctcagaacaaaaaccctacggaacactctgaacccctcctggaacgagaccctcacctattacgggatcacggatgaggacatgatccgaaagaccctgaggatctccgtgtgtgacgaggacaaattccgccacaacgagttcatcggagagactcgagtgcccctgaagaagctgaaacccaaccacaccaagacattcagcatctgcctggagaagcagctgccggtggacaaggcagaggacaagtccctggaggagcgtggccgcatcctcatctctctcaagtacagctcacagaagcagggcctgctggtgggcatcgttcgctgcgcacacctggcggccatggatgctaacggctactcagacccctacgtgaaaacatatctgaaaccagatgtagacaagaaatccaagcataagaccgcagtcaagaagaaaacactaaaccctgaattcaatgaggagttctgttacgagatcaagcatggagacctagccaaaaagaccctggaggtcactgtctgggactatgatattggaaaatccaatgatttcatcggtggggtggttctgggcatcaatgccaagggtgagcgcctgaagcactggtttgactgtctgaagaacaaggacaagaggattgagcgttggcacacgctcaccaatgagatcccaggggctgtactcagcgactgactgtcccatctgctgccacccacccttgccacccagcccacacaggtccaaccctgggctttctcagctgccaccaagggctgtggccctcacaatgggcaagatccaggttgtctgctcggacatagccactgcagcccctgctaggaggctaggaggccaagagcacccagcctctcgcagagggacaggaaaacacaacatgaaacctgtttcagctcccctggcaccccaaagggccagagctgggagaaatcctcagcctcagctctgtccagtggaagggctatctacagtgaggacctatcagaggtgaggggtggaaccctgctgcaagcacagaaatgggggtactctggctacctggagaccacagagggaggactatgggcaggcagagcccagg
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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