2024-04-29 14:48:45, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_024385 1602 bp mRNA linear ROD 20-MAR-2023 DEFINITION Rattus norvegicus hematopoietically expressed homeobox (Hhex), mRNA. ACCESSION NM_024385 VERSION NM_024385.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1602) AUTHORS Wadey KS, Brown BA, Sala-Newby GB, Jayaraman PS, Gaston K and George SJ. TITLE Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism JOURNAL Vascul Pharmacol 99, 34-44 (2017) PUBMED 28927755 REMARK GeneRIF: Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism. REFERENCE 2 (bases 1 to 1602) AUTHORS Simpson MT, Venkatesh I, Callif BL, Thiel LK, Coley DM, Winsor KN, Wang Z, Kramer AA, Lerch JK and Blackmore MG. TITLE The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons JOURNAL Mol Cell Neurosci 68, 272-283 (2015) PUBMED 26306672 REMARK GeneRIF: These findings suggest a role for HHEX in restricting axon growth in the developing central nervous system. REFERENCE 3 (bases 1 to 1602) AUTHORS Falix FA, Weeda VB, Labruyere WT, Poncy A, de Waart DR, Hakvoort TB, Lemaigre F, Gaemers IC, Aronson DC and Lamers WH. TITLE Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning JOURNAL Dev Biol 396 (2), 201-213 (2014) PUBMED 25446530 REFERENCE 4 (bases 1 to 1602) AUTHORS Stuckey DW, Di Gregorio A, Clements M and Rodriguez TA. TITLE Correct patterning of the primitive streak requires the anterior visceral endoderm JOURNAL PLoS One 6 (3), e17620 (2011) PUBMED 21445260 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 1602) AUTHORS Williams H, Jayaraman PS and Gaston K. TITLE DNA wrapping and distortion by an oligomeric homeodomain protein JOURNAL J Mol Biol 383 (1), 10-23 (2008) PUBMED 18755198 REFERENCE 6 (bases 1 to 1602) AUTHORS Keng VW, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, Tanaka T, Sato A, Muramatsu I, Okabe M, Sato M and Noguchi T. TITLE Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage JOURNAL Biochem Biophys Res Commun 276 (3), 1155-1161 (2000) PUBMED 11027604 REMARK Erratum:[Biochem Biophys Res Commun 2000 Dec 20;279(2):739] REFERENCE 7 (bases 1 to 1602) AUTHORS Pellizzari L, D'Elia A, Rustighi A, Manfioletti G, Tell G and Damante G. TITLE Expression and function of the homeodomain-containing protein Hex in thyroid cells JOURNAL Nucleic Acids Res 28 (13), 2503-2511 (2000) PUBMED 10871399 REFERENCE 8 (bases 1 to 1602) AUTHORS Martinez Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D and Beddington RS. TITLE The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation JOURNAL Development 127 (11), 2433-2445 (2000) PUBMED 10804184 REFERENCE 9 (bases 1 to 1602) AUTHORS Brickman JM, Jones CM, Clements M, Smith JC and Beddington RS. TITLE Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function JOURNAL Development 127 (11), 2303-2315 (2000) PUBMED 10804173 REFERENCE 10 (bases 1 to 1602) AUTHORS Tanaka T, Inazu T, Yamada K, Myint Z, Keng VW, Inoue Y, Taniguchi N and Noguchi T. TITLE cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein JOURNAL Biochem J 339 (Pt 1) (Pt 1), 111-117 (1999) PUBMED 10085234 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000047.1. On Nov 26, 2020 this sequence version replaced NM_024385.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D86383.1, BC088135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5756307, SAMEA5760383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-375 JACYVU010000047.1 22211248-22211622 376-554 JACYVU010000047.1 22213573-22213751 555-605 JACYVU010000047.1 22213943-22213993 606-1602 JACYVU010000047.1 22215839-22216835 FEATURES Location/Qualifiers source 1..1602 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="1" /map="1q53" gene 1..1602 /gene="Hhex" /gene_synonym="Hex" /note="hematopoietically expressed homeobox" /db_xref="GeneID:79237" /db_xref="RGD:619932" exon 1..375 /gene="Hhex" /gene_synonym="Hex" /inference="alignment:Splign:2.1.0" CDS 12..827 /gene="Hhex" /gene_synonym="Hex" /codon_start=1 /product="hematopoietically-expressed homeobox protein HHEX" /protein_id="NP_077361.1" /db_xref="GeneID:79237" /db_xref="RGD:619932" /translation="
MQFPHPGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPAAPTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWNPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDELDSLDTSCDQGQDLPSEQNKGASLDSSQCSPSPASPEDPESEISEDSDQEVDIEGDKGYFNAG"
misc_feature order(426..440,444..446,495..497,513..515,552..554, 558..563,570..575,579..587,591..596) /gene="Hhex" /gene_synonym="Hex" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature order(432..434,441..443,561..563,570..575,582..584) /gene="Hhex" /gene_synonym="Hex" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" misc_feature 438..593 /gene="Hhex" /gene_synonym="Hex" /note="Homeobox domain; Region: Homeobox; pfam00046" /db_xref="CDD:425441" exon 376..554 /gene="Hhex" /gene_synonym="Hex" /inference="alignment:Splign:2.1.0" exon 555..605 /gene="Hhex" /gene_synonym="Hex" /inference="alignment:Splign:2.1.0" exon 606..1602 /gene="Hhex" /gene_synonym="Hex" /inference="alignment:Splign:2.1.0" ORIGIN
gcggagcagccatgcagttcccgcacccggggcccgcggctgcgcccgccgtcggagtcccgctgtacgcgcccacgccgctgctgcagcccgctcacccgacgcctttctacatcgacgacatcctgggtcgcgggcccgccgctcccacgcccactcccacgctgccgtcccccaactcctccttcaccagcctcgtgtcctcctaccggaccccggtgtacgagcccacgccggtccaccccgccttctcgcatcaccccgccgccgcgctggccgctgcctatggccccggtggcttcggaggccctctgtacccgttcccgcggacggtgaacgactacacgcacgccctactccgccacgaccccctgggcaagcccttgctctggaaccccttcctacagcgacctctgcacaaaaggaaaggcggtcaagtgaggttttccaacgaccagaccatcgagctggagaagaagttcgagactcagaaatacctctccccacctgagagaaagcgtctggccaagatgttgcagctcagcgagagacaggtcaaaacctggtttcagaatcgcagagctaaatggagacgactgaagcaggagaatcctcaaagcaataaaaaggatgagttggacagtttggacacttcctgtgaccagggccaagacttgcccagtgaacagaataaaggtgcctctttggacagttctcagtgttcaccctccccagcctctccggaagaccctgaatcagagatctcagaggattccgaccaggaagtggacatcgagggtgataaaggctattttaatgctggatgacagtcatcggccgtgaccatgttcagagactggactttagaataccgttctgctacagacaaactgggaaattctgagagaaagaagtaccattcttctagcgttttgaaaatatttggcacggcgtgcattgaaaccatacttttggtttagcgtacgttttccgtaccggtgttaagttgttttgataaagtggctaaatgtgacttcgtttttaaaaagtgaattctttctatttgtgagaagtaatttgaacttttgcctgaagcttaaactataactttaaaggttttgggcggctgttctcgaatgacttttcccaaatgtgtagctgttccctcgacttcagaggtgcacttagaaagggggccagcatttggggatccatggaatgctttcaaagagcacacttggtttttacgtgacaccttacattgctgccttaactccaaagccggttcagagcacttggcccctggtgtctgttctcataagcaagatagttgataagattcttacaatcttgttttgctcggccagtgcctctgaccctggtattaagggatgacgcagtctctacaggcagggaaactgactcacttgtgactgatctcacatgaactagaaatagcaggacaattaaatgtaagtagattgtagatagtgtgttttatagaaaccgtgtctatagcatgtgtatagaattattcgttgtaaaaaaaaccctgcaaaaatgtttgattttttttttaatttaatgaattaactttcatat
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]