ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2024-04-16 15:31:46, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_019195 1952 bp mRNA linear ROD 12-NOV-2023
DEFINITION Rattus norvegicus Cd47 molecule (Cd47), mRNA.
ACCESSION NM_019195
VERSION NM_019195.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1952)
AUTHORS Takayasu H.
TITLE Upregulated TSP1 and CD47 expression in the lung in
nitrofen-induced congenital diaphragmatic hernia
JOURNAL Pediatr Int 65 (1), e15447 (2023)
PUBMED 36528876
REMARK GeneRIF: Upregulated TSP1 and CD47 expression in the lung in
nitrofen-induced congenital diaphragmatic hernia.
REFERENCE 2 (bases 1 to 1952)
AUTHORS Ye F, Hua Y, Keep RF, Xi G and Garton HJL.
TITLE CD47 blocking antibody accelerates hematoma clearance and
alleviates hydrocephalus after experimental intraventricular
hemorrhage
JOURNAL Neurobiol Dis 155, 105384 (2021)
PUBMED 33945877
REMARK GeneRIF: CD47 blocking antibody accelerates hematoma clearance and
alleviates hydrocephalus after experimental intraventricular
hemorrhage.
REFERENCE 3 (bases 1 to 1952)
AUTHORS Gao Y, Zhang D, Yang C, Duan X, Li X and Zhong D.
TITLE Two validated liquid chromatography-mass spectrometry methods with
different pretreatments for the quantification of an anti-CD47
monoclonal antibody in rat and cynomolgus monkey serum compared
with an electrochemiluminescence method
JOURNAL J Pharm Biomed Anal 175, 112792 (2019)
PUBMED 31377653
REMARK GeneRIF: For the quantification of an anti-CD47 monoclonal
antibody.
REFERENCE 4 (bases 1 to 1952)
AUTHORS Li Y, Zhao K, Zong P, Fu H, Zheng Y, Bao D, Yin Y, Chen Q, Lu L,
Dai Y, Hou D and Kong X.
TITLE CD47 deficiency protects cardiomyocytes against
hypoxia/reoxygenation injury by rescuing autophagic clearance
JOURNAL Mol Med Rep 19 (6), 5453-5463 (2019)
PUBMED 31059044
REMARK GeneRIF: The CD47 antibody or SiCD47 can protect cardiomyocytes
against H/R injury through increasing autophagic flux and
autophagic clearance. CD47 deficiency may offer a potential
therapeutic approach for preventing myocardial I/R injury.
REFERENCE 5 (bases 1 to 1952)
AUTHORS Bitar MS.
TITLE Diabetes Impairs Angiogenesis and Induces Endothelial Cell
Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling
JOURNAL Int J Mol Sci 20 (3), 673 (2019)
PUBMED 30720765
REMARK GeneRIF: Evidence linking the overexpression of TSP1-CD47 signaling
in diabetes to a number of parameters associated with endothelial
dysfunction including impaired angiogenesis, cellular senescence
and a heightened state of oxidative stress was found.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1952)
AUTHORS de Vries HE, Hendriks JJ, Honing H, De Lavalette CR, van der Pol
SM, Hooijberg E, Dijkstra CD and van den Berg TK.
TITLE Signal-regulatory protein alpha-CD47 interactions are required for
the transmigration of monocytes across cerebral endothelium
JOURNAL J Immunol 168 (11), 5832-5839 (2002)
PUBMED 12023387
REFERENCE 7 (bases 1 to 1952)
AUTHORS Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown EJ,
Maliszewski C, Lindberg FP, Oldenborg A, Ullrich A, Delespesse G
and Sarfati M.
TITLE Bidirectional negative regulation of human T and dendritic cells by
CD47 and its cognate receptor signal-regulator protein-alpha:
down-regulation of IL-12 responsiveness and inhibition of dendritic
cell activation
JOURNAL J Immunol 167 (5), 2547-2554 (2001)
PUBMED 11509594
REFERENCE 8 (bases 1 to 1952)
AUTHORS Verdrengh M, Lindberg FP, Ryden C and Tarkowski A.
TITLE Integrin-associated protein (IAP)-deficient mice are less
susceptible to developing Staphylococcus aureus-induced arthritis
JOURNAL Microbes Infect 1 (10), 745-751 (1999)
PUBMED 10816079
REFERENCE 9 (bases 1 to 1952)
AUTHORS Huang AM, Wang HL, Tang YP and Lee EH.
TITLE Expression of integrin-associated protein gene associated with
memory formation in rats
JOURNAL J Neurosci 18 (11), 4305-4313 (1998)
PUBMED 9592107
REFERENCE 10 (bases 1 to 1952)
AUTHORS Nishiyama Y, Tanaka T, Naitoh H, Mori C, Fukumoto M, Hiai H and
Toyokuni S.
TITLE Overexpression of integrin-associated protein (CD47) in rat kidney
treated with a renal carcinogen, ferric nitrilotriacetate
JOURNAL Jpn J Cancer Res 88 (2), 120-128 (1997)
PUBMED 9119739
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC085740.1.
On Nov 15, 2004 this sequence version replaced NM_019195.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC085740.1, D87659.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760400, SAMEA5760476
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1952
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="11"
/map="11q21"
gene 1..1952
/gene="Cd47"
/gene_synonym="Itgp"
/note="Cd47 molecule"
/db_xref="GeneID:29364"
/db_xref="RGD:2308"
exon 1..161
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
CDS 116..1027
/gene="Cd47"
/gene_synonym="Itgp"
/note="leukocyte surface antigen CD47; IAP;
integrin-associated protein; CD47 antigen (Rh-related
antigen, integrin-associated signal transducer)"
/codon_start=1
/product="leukocyte surface antigen CD47 precursor"
/protein_id="NP_062068.1"
/db_xref="GeneID:29364"
/db_xref="RGD:2308"
/translation="
MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVLNVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDTHEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNN"
sig_peptide 116..169
/gene="Cd47"
/gene_synonym="Itgp"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 170..1024
/gene="Cd47"
/gene_synonym="Itgp"
/product="Leukocyte surface antigen CD47.
/id=PRO_0000042209"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1)"
misc_feature 170..172
/gene="Cd47"
/gene_synonym="Itgp"
/note="Pyrrolidone carboxylic acid.
/evidence=ECO:0000250|UniProtKB:Q08722, ECO:0000305;
propagated from UniProtKB/Swiss-Prot (P97829.1);
pyrrolidone-carboxylic-acid site"
misc_feature 173..505
/gene="Cd47"
/gene_synonym="Itgp"
/note="Immunoglobulin variable region (IgV) in Cluster of
Differentiation (CD) 47; Region: IgV_CD47; cd16090"
/db_xref="CDD:409511"
misc_feature 173..247
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR1 [structural motif]; Region: FR1"
/db_xref="CDD:409511"
misc_feature 173..184
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand A [structural motif]; Region: Ig strand
A"
/db_xref="CDD:409511"
misc_feature 191..205
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand A' [structural motif]; Region: Ig strand
A'"
/db_xref="CDD:409511"
misc_feature 215..217
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 224..247
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand B [structural motif]; Region: Ig strand
B"
/db_xref="CDD:409511"
misc_feature 248..274
/gene="Cd47"
/gene_synonym="Itgp"
/note="CDR1 [structural motif]; Region: CDR1"
/db_xref="CDD:409511"
misc_feature 275..301
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR2 [structural motif]; Region: FR2"
/db_xref="CDD:409511"
misc_feature order(278..280,284..286,290..292,452..454,479..481)
/gene="Cd47"
/gene_synonym="Itgp"
/note="SIRP-CD47 complex [polypeptide binding]; other
site"
/db_xref="CDD:409511"
misc_feature 278..295
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand C [structural motif]; Region: Ig strand
C"
/db_xref="CDD:409511"
misc_feature 296..298
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 302..346
/gene="Cd47"
/gene_synonym="Itgp"
/note="CDR2 [structural motif]; Region: CDR2"
/db_xref="CDD:409511"
misc_feature 302..325
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand C' [structural motif]; Region: Ig strand
C'"
/db_xref="CDD:409511"
misc_feature 332..346
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand C' [structural motif]; Region: Ig strand
C'"
/db_xref="CDD:409511"
misc_feature 332..334
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 350..460
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR3 [structural motif]; Region: FR3"
/db_xref="CDD:409511"
misc_feature 353..355
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0007744|PubMed:24090084; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 362..373
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand D [structural motif]; Region: Ig strand
D"
/db_xref="CDD:409511"
misc_feature 374..376
/gene="Cd47"
/gene_synonym="Itgp"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P97829.1); phosphorylation site"
misc_feature 380..382
/gene="Cd47"
/gene_synonym="Itgp"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P97829.1); phosphorylation site"
misc_feature 395..415
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand E [structural motif]; Region: Ig strand
E"
/db_xref="CDD:409511"
misc_feature 440..463
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand F [structural motif]; Region: Ig strand
F"
/db_xref="CDD:409511"
misc_feature 440..442
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0007744|PubMed:24090084; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 461..472
/gene="Cd47"
/gene_synonym="Itgp"
/note="CDR3 [structural motif]; Region: CDR3"
/db_xref="CDD:409511"
misc_feature 470..502
/gene="Cd47"
/gene_synonym="Itgp"
/note="Ig strand G [structural motif]; Region: Ig strand
G"
/db_xref="CDD:409511"
misc_feature 473..505
/gene="Cd47"
/gene_synonym="Itgp"
/note="FR4 [structural motif]; Region: FR4"
/db_xref="CDD:409511"
misc_feature 536..598
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 539..985
/gene="Cd47"
/gene_synonym="Itgp"
/note="CD47 transmembrane region; Region: CD47; pfam04549"
/db_xref="CDD:367985"
misc_feature 635..697
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 725..727
/gene="Cd47"
/gene_synonym="Itgp"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P97829.1); glycosylation site"
misc_feature 734..796
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 830..892
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
misc_feature 914..976
/gene="Cd47"
/gene_synonym="Itgp"
/note="propagated from UniProtKB/Swiss-Prot (P97829.1);
transmembrane region"
exon 162..509
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 510..599
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 600..707
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 708..800
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 801..893
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 894..986
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 987..1018
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
exon 1019..1942
/gene="Cd47"
/gene_synonym="Itgp"
/inference="alignment:Splign:2.1.0"
ORIGIN
ctgggcggccgttcctgcctatcacggctgcggcgctgctggtcgttctcttgaaggcagcggaggcggcggctgctccagacacctgcggcggcgaccccccggcggcgcggagatgtggcccttggcggcggcgctgttgctgggctcctgctgctgcggttcagctcaactcctgcttagtaaagtcaaatctgtagagttcacgtcatgcaatgacactgtggtcatcccttgcaaagtccttaatgtggaagcccaaagcaccgatgaaatgtttgtgaagtggaagttgaacaaatcgtatattttcatctatgatggaaataaaaatagcactactagagaacaaaactttaccagtgcaaaaatctcggtctcagacttgctcaaaggcattgcctctttgacaatggatacccatgaggctgtggtgggaaactacacctgtgaagtgactgagctttccagagaaggcaaaacagttatagagctgaaaaaccgcccagtttcgtggttttctacaaatgaaaagatcctcattgttattttcccaattttggctatactcctgttctggggaaagtttggtatattaacactcaaatacaagtccagccatacgaataagagaatcattctgctgctggttgccgggctggcgctcacactcatcgtggttgttggcgccatccttttcatcccgggagagaagcccgtgaagaacgcttctggtcttggcctcattgtaatctccacaggaatattaatactgcttcagtacaatgtgtttatgacagcttttggaatgacctctttcaccattgccatattgatcactcaagtgctgggctatgtccttgctgtggtcgggatgtgtctctgcatcatggcttgtgaaccagtgcacggcccccttttgatttcaggtttgggaatcatagctctagcagaattacttggactagtttatatgaagtttgtcgcttccaaccagcggactatacaacctcctaggaataactgaagggaagtgatggactgtaacttgaaagtcagaagtggaagaattcagttgtctgagcaccatggccttcacaactcacagctggaaggaacacacaacagtgactgactttcatctctgaaaaaagtcattgaaccataaatgaatattacagttaagtttatattaaagcagctgtaatttacgtaataaaaaatatatgatgtgctgtgtaaccaatcgaaatccatttttctattgtttctactcaactaggggcaaaagtttcaggggcaacttccaagaatgatgcttgttagatccttgagtctctgaacactgagtttaaatcgattcccagagagactcgccaagcactaaccttcgggttagttacctagagatacctacgagaaacaggggtatccagcaagccttagtaaactcaggttcccagcagctttgccactcatgctgctagctgaataacaagactgccacttctgggtcttagtgacagagactgaagtacaaaaatgaatgtggttgggcaaaccccgtgtggcccctctgtgtgctatgatgttgatggccctgttgtcttcattcttgggcgttgccatcgttcacacacaccccctttgacatacagcgcacccaggttttgaatacttttttttttacagatgtggttttcctttttgcacacaaccctttgcaccctgtcccgtcctgctactttgatttgtgtttcaagatacagtacctttcctcccctttaaacatgatcctgtgacacaattttgtcagttgcagaaaggagccagacttattctcaaagcactgtgctcaaactcttcaaaaaaaaaataaaatagctatggttgtaacatatgtattccagacctctggtttaaaggcaaaaaaaaaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]