LOCUS       NM_017224               2025 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus solute carrier family 22 member 6 (Slc22a6),
            mRNA.
ACCESSION   NM_017224
VERSION     NM_017224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Taniguchi T, Omura K, Motoki K, Sakai M, Chikamatsu N, Ashizawa N,
            Takada T and Iwanaga T.
  TITLE     Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting
            the renal transporters OAT1/3 and ABCG2
  JOURNAL   Sci Rep 11 (1), 7232 (2021)
   PUBMED   33790363
  REMARK    GeneRIF: Hypouricemic agents reduce indoxyl sulfate excretion by
            inhibiting the renal transporters OAT1/3 and ABCG2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Nosetto EC, Campagno RV, Torres AM and Brandoni A.
  TITLE     Distribution of the organic anion transporters Oat1 and Oat3
            between renal membrane microdomains in obstructive jaundice
  JOURNAL   Pflugers Arch 472 (6), 711-719 (2020)
   PUBMED   32451678
  REMARK    GeneRIF: Distribution of the organic anion transporters Oat1 and
            Oat3 between renal membrane microdomains in obstructive jaundice.
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Bush KT, Singh P and Nigam SK.
  TITLE     Gut-derived uremic toxin handling in vivo requires OAT-mediated
            tubular secretion in chronic kidney disease
  JOURNAL   JCI Insight 5 (7), 133817 (2020)
   PUBMED   32271169
  REMARK    GeneRIF: Gut-derived uremic toxin handling in vivo requires
            OAT-mediated tubular secretion in chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Minocha E, Chaturvedi CP and Nityanand S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Zhang Z, Tachikawa M, Uchida Y and Terasaki T.
  TITLE     Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion
            Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of
            Rats
  JOURNAL   Mol Pharm 15 (3), 911-922 (2018)
   PUBMED   29436232
  REMARK    GeneRIF: Study results indicate that Oat1 and Oat3 at the
            blood-arachnoid barrier provide a distinct clearance pathway of
            organic anion drugs from cerebrospinal fluid independently of
            choroid plexus.
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Race JE, Grassl SM, Williams WJ and Holtzman EJ.
  TITLE     Molecular cloning and characterization of two novel human renal
            organic anion transporters (hOAT1 and hOAT3)
  JOURNAL   Biochem Biophys Res Commun 255 (2), 508-514 (1999)
   PUBMED   10049739
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Lu R, Chan BS and Schuster VL.
  TITLE     Cloning of the human kidney PAH transporter: narrow substrate
            specificity and regulation by protein kinase C
  JOURNAL   Am J Physiol 276 (2), F295-F303 (1999)
   PUBMED   9950961
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Hosoyamada M, Sekine T, Kanai Y and Endou H.
  TITLE     Molecular cloning and functional expression of a multispecific
            organic anion transporter from human kidney
  JOURNAL   Am J Physiol 276 (1), F122-F128 (1999)
   PUBMED   9887087
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Sweet DH, Wolff NA and Pritchard JB.
  TITLE     Expression cloning and characterization of ROAT1. The basolateral
            organic anion transporter in rat kidney
  JOURNAL   J Biol Chem 272 (48), 30088-30095 (1997)
   PUBMED   9374486
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Sekine T, Watanabe N, Hosoyamada M, Kanai Y and Endou H.
  TITLE     Expression cloning and characterization of a novel multispecific
            organic anion transporter
  JOURNAL   J Biol Chem 272 (30), 18526-18529 (1997)
   PUBMED   9228014
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104692.1.
            
            On Jun 3, 2007 this sequence version replaced NM_017224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104692.1, AF008221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2025
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="solute carrier family 22 member 6"
                     /db_xref="GeneID:29509"
                     /db_xref="RGD:69338"
     exon            1..414
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1701
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="organic cationic transporter-like 1; rROAT1;
                     organic anion transporter 1; renal organic anion
                     transporter 1; solute carrier family 22 (organic anion
                     transporter), member 6"
                     /codon_start=1
                     /product="solute carrier family 22 member 6"
                     /protein_id="NP_058920.1"
                     /db_xref="GeneID:29509"
                     /db_xref="RGD:69338"
                     /translation="

MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEAWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTLSKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRGKQNQQQQEQQKQMMPLQASTQEKNGL"

     misc_feature    73..135
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    76..1590
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="cation transport protein; Region: 2A0119;
                     TIGR00898"
                     /db_xref="CDD:273328"
     misc_feature    160..162
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35956.1); glycosylation site"
     misc_feature    211..213
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35956.1); glycosylation site"
     misc_feature    319..321
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35956.1); glycosylation site"
     misc_feature    382..384
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35956.1); glycosylation site"
     misc_feature    451..513
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    538..606
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    631..693
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    718..780
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    790..852
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    1057..1119
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    1150..1212
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    1231..1293
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    1321..1383
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    1498..1560
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     transmembrane region"
     misc_feature    1585..1698
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /note="propagated from UniProtKB/Swiss-Prot (O35956.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            415..518
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..673
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..842
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..966
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1082
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1297
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1406
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1610
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1997
                     /gene="Slc22a6"
                     /gene_synonym="Oat1; Orctl1; Paht; Roat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gactggaggtcctcagtcattgaccactcagcctggcccagccccatggccttcaatgacctcctgaaacaggtggggggcgtcggacgcttccagttgatccaggtcaccatggtggttgctcccctactgctgatggcttcccacaacaccttgcagaacttcactgccgctatcccccctcatcactgccgcccacctgccaatgccaatctcagcaaagatggaggtctggaggcctggctgcccctggacaagcaaggacaacccgaatcttgcctccgctttacttccccccagtggggaccacccttttacaatggcacagaagccaatggcaccagagtcacagagccctgcattgatggctgggtctatgacaacagcaccttcccttcaaccatcgtgactgagtggaaccttgtgtgctctcatcgggctttccgccagctggcccagtccctgtacatggtgggagtgctgctgggagccatggtgtttggctacctggcggacaggctgggccgccggaaggtgctgatcttgaactacctgcagacagctgtgtcgggaacctgtgcagcctatgcacccaactatactgtctactgcgttttccggctcctctcgggcatgtctttggctagcattgcaatcaactgcatgacactaaatgtggaatggatgcctatccacacccgtgcctatgtgggcaccttgattggctatgtctacagcctgggccagttcctcctggctggcatcgcctatgctgtgccccactggcgccacctgcagcttgtggtctctgtgccttttttcattgccttcatctactcttggttcttcattgagtcagcccgctggtactcctcctcaggaaggctggacctcaccctccgagccctgcagagagtggcccggatcaatgggaaacaagaagaaggggctaagctaagtatagaggtgctccggaccagcctgcagaaggaactgactctaagcaaaggccaagcctcagccatggagctgctgcgctgccccacccttcgacacctcttcctctgtctctccatgctgtggtttgccactagctttgcctactacgggctggtcatggacctgcagggctttggggtcagcatgtaccttatccaggtgattttcggtgccgtggacctgcctgccaagtttgtatgcttcctagtcatcaactccatggggcgccggcctgcacagatggcctccctgctgctggcaggcatctgcatcctggtgaatggcataataccgaagagccatacgatcattcgcacctccctggctgtgctagggaagggctgcctggcttcctctttcaactgcatcttcctgtacaccggagagctgtaccccacagtgattcggcagacaggcctgggcatgggcagcaccatggcccgggtgggcagcattgtgagcccgctggtgagtatgactgcagagttctacccctccatgcctctcttcatcttcggcgctgtccctgtggtcgccagtgctgtcactgccctgctgccagagaccttgggccagccgctgccagatacagtgcaggacctgaagagcaggagcagaggaaagcagaatcaacagcagcaggaacagcagaagcagatgatgccgctccaggcctcaacacaagagaagaatggactttgagaacggaagggcttcacacagcactaaagggagtggagttctacaggtcctgccgtctacatgaggagggggagtgagtagagggactggaccatccaaatgtggaggctgccattcagagaaatccctccccaaaggtcatgtcagtagacccactaggaacaaaagctctgactatgtgcagcttcttaagcagaatgttctcggcaccggccatcttcctgctcatggtcactccgccacctccaggaccttgcaaagaatctcagacaattaaatgaatctcttctaccttgaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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