2024-03-28 17:05:11, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_013181 1434 bp mRNA linear ROD 22-MAR-2023 DEFINITION Rattus norvegicus protein kinase cAMP-dependent type I regulatory subunit alpha (Prkar1a), mRNA. ACCESSION NM_013181 XM_579380 VERSION NM_013181.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1434) AUTHORS Kim J, Kwon JT, Jeong J, Kim J, Hong SH, Kim J, Park ZY, Chung KH, Eddy EM and Cho C. TITLE SPATC1L maintains the integrity of the sperm head-tail junction JOURNAL EMBO Rep 19 (9) (2018) PUBMED 30026308 REFERENCE 2 (bases 1 to 1434) AUTHORS Gilbert ML, Yang L, Su T and McKnight GS. TITLE Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype JOURNAL Am J Physiol Renal Physiol 308 (6), F627-F638 (2015) PUBMED 25587115 REMARK GeneRIF: role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus REFERENCE 3 (bases 1 to 1434) AUTHORS Burgers PP, van der Heyden MA, Kok B, Heck AJ and Scholten A. TITLE A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs JOURNAL Biochemistry 54 (1), 11-21 (2015) PUBMED 25097019 REFERENCE 4 (bases 1 to 1434) AUTHORS Nishimura T, Fujii W, Sugiura K and Naito K. TITLE Cytoplasmic anchoring of cAMP-dependent protein kinase (PKA) by A-kinase anchor proteins (AKAPs) is required for meiotic arrest of porcine full-grown and growing oocytes JOURNAL Biol Reprod 90 (3), 58 (2014) PUBMED 24501172 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 1434) AUTHORS Biesemann C, Gronborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, Jahn O, Brose N and Herzog E. TITLE Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting JOURNAL EMBO J 33 (2), 157-170 (2014) PUBMED 24413018 REFERENCE 6 (bases 1 to 1434) AUTHORS Lazar S, Galiani D and Dekel N. TITLE cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes JOURNAL Mol Endocrinol 16 (2), 331-341 (2002) PUBMED 11818504 REMARK GeneRIF: cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes REFERENCE 7 (bases 1 to 1434) AUTHORS Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS and Stratakis CA. TITLE Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex JOURNAL Nat Genet 26 (1), 89-92 (2000) PUBMED 10973256 REFERENCE 8 (bases 1 to 1434) AUTHORS Imaizumi-Scherrer T, Faust DM, Benichou JC, Hellio R and Weiss MC. TITLE Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha JOURNAL J Cell Biol 134 (5), 1241-1254 (1996) PUBMED 8794865 REFERENCE 9 (bases 1 to 1434) AUTHORS Greene RM, Lloyd MR, Uberti M, Nugent P and Pisano MM. TITLE Patterns of cyclic AMP-dependent protein kinase gene expression during ontogeny of the murine palate JOURNAL J Cell Physiol 163 (3), 431-440 (1995) PUBMED 7775586 REFERENCE 10 (bases 1 to 1434) AUTHORS Kuno,T., Ono,Y., Hirai,M., Hashimoto,S., Shuntoh,H. and Tanaka,C. TITLE Molecular cloning and cDNA structure of the regulatory subunit of type I cAMP-dependent protein kinase from rat brain JOURNAL Biochem Biophys Res Commun 146 (2), 878-883 (1987) PUBMED 3619906 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000220.1. On Nov 26, 2020 this sequence version replaced NM_013181.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M17086.1, SRR8487230.66449.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-89 JACYVU010000220.1 51445900-51445988 90-272 JACYVU010000220.1 51449175-51449357 273-443 JACYVU010000220.1 51454761-51454931 444-535 JACYVU010000220.1 51455666-51455757 536-597 JACYVU010000220.1 51455927-51455988 598-644 JACYVU010000220.1 51456928-51456974 645-803 JACYVU010000220.1 51457636-51457794 804-864 JACYVU010000220.1 51459490-51459550 865-986 JACYVU010000220.1 51460525-51460646 987-1068 JACYVU010000220.1 51461381-51461462 1069-1434 JACYVU010000220.1 51462164-51462529 FEATURES Location/Qualifiers source 1..1434 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="10" /map="10q32.1" gene 1..1434 /gene="Prkar1a" /gene_synonym="RIIA" /note="protein kinase cAMP-dependent type I regulatory subunit alpha" /db_xref="GeneID:25725" /db_xref="RGD:3391" exon 1..89 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" misc_feature 69..71 /gene="Prkar1a" /gene_synonym="RIIA" /note="upstream in-frame stop codon" exon 90..272 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" CDS 96..1241 /gene="Prkar1a" /gene_synonym="RIIA" /EC_number="2.7.11.1" /note="protein kinase cAMP-dependent type 1 regulatory subunit alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; protein kinase, cAMP-dependent, regulatory subunit type I alpha" /codon_start=1 /product="cAMP-dependent protein kinase type I-alpha regulatory subunit" /protein_id="NP_037313.1" /db_xref="GeneID:25725" /db_xref="RGD:3391" /translation="
MASGSMAASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEARQIQSLQKSGIRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV"
misc_feature 96..98 /gene="Prkar1a" /gene_synonym="RIIA" /note="N-acetylmethionine. /evidence=ECO:0000250|UniProtKB:P10644; propagated from UniProtKB/Swiss-Prot (P09456.2); acetylation site" misc_feature 99..503 /gene="Prkar1a" /gene_synonym="RIIA" /note="propagated from UniProtKB/Swiss-Prot (P09456.2); Region: Dimerization and phosphorylation" misc_feature 99..101 /gene="Prkar1a" /gene_synonym="RIIA" /note="N-acetylalanine, in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed. /evidence=ECO:0000250|UniProtKB:P00514; propagated from UniProtKB/Swiss-Prot (P09456.2); acetylation site" misc_feature 102..104 /gene="Prkar1a" /gene_synonym="RIIA" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P09456.2); phosphorylation site" misc_feature 135..284 /gene="Prkar1a" /gene_synonym="RIIA" /note="dimerization/docking (D/D) domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase; Region: DD_RIalpha_PKA; cd12101" /db_xref="CDD:438522" misc_feature order(138..140,147..152,177..182,186..191,198..203) /gene="Prkar1a" /gene_synonym="RIIA" /note="AKAP interaction site [polypeptide binding]; other site" /db_xref="CDD:438522" misc_feature order(147..149,156..161,174..176,183..188,195..200, 207..212,222..224,228..239,243..248,255..260,267..269) /gene="Prkar1a" /gene_synonym="RIIA" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:438522" misc_feature 288..383 /gene="Prkar1a" /gene_synonym="RIIA" /note="propagated from UniProtKB/Swiss-Prot (P09456.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 318..320 /gene="Prkar1a" /gene_synonym="RIIA" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:P10644; propagated from UniProtKB/Swiss-Prot (P09456.2); phosphorylation site" misc_feature 324..326 /gene="Prkar1a" /gene_synonym="RIIA" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P10644; propagated from UniProtKB/Swiss-Prot (P09456.2); phosphorylation site" misc_feature 342..344 /gene="Prkar1a" /gene_synonym="RIIA" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P09456.2); phosphorylation site" misc_feature 381..395 /gene="Prkar1a" /gene_synonym="RIIA" /note="propagated from UniProtKB/Swiss-Prot (P09456.2); Region: Pseudophosphorylation motif" misc_feature 396..398 /gene="Prkar1a" /gene_synonym="RIIA" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q9DBC7; propagated from UniProtKB/Swiss-Prot (P09456.2); phosphorylation site" misc_feature 504..833 /gene="Prkar1a" /gene_synonym="RIIA" /note="effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038" /db_xref="CDD:237999" misc_feature order(696..701,726..734) /gene="Prkar1a" /gene_synonym="RIIA" /note="ligand binding site [chemical binding]; other site" /db_xref="CDD:237999" misc_feature order(792..800,810..818) /gene="Prkar1a" /gene_synonym="RIIA" /note="flexible hinge region; other site" /db_xref="CDD:237999" misc_feature 858..1205 /gene="Prkar1a" /gene_synonym="RIIA" /note="effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038" /db_xref="CDD:237999" misc_feature 867..869 /gene="Prkar1a" /gene_synonym="RIIA" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P09456.2); phosphorylation site" misc_feature order(1068..1073,1098..1106) /gene="Prkar1a" /gene_synonym="RIIA" /note="ligand binding site [chemical binding]; other site" /db_xref="CDD:237999" misc_feature order(1164..1172,1182..1190) /gene="Prkar1a" /gene_synonym="RIIA" /note="flexible hinge region; other site" /db_xref="CDD:237999" exon 273..443 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 444..535 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 536..597 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 598..644 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 645..803 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 804..864 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 865..986 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 987..1068 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" exon 1069..1434 /gene="Prkar1a" /gene_synonym="RIIA" /inference="alignment:Splign:2.1.0" ORIGIN
ggcgttgagggaggcagacgcgaggaggaacggaggagaggcggagatcaccgaacagcagaacaatctagaggatccctcgacacctgagaaccatggcgtctggcagtatggcagccagtgaggaagagcggagtctccgggaatgcgagctctatgtgcagaagcacaacatccaggccctgctgaaggactccatcgtgcagctgtgcactgctcggcccgagaggcccatggcattccttcgggaatactttgagaggctggagaaggaggaggcaagacagattcagagcctacagaaatccggcattcgtacagactcgagggaggatgagatctctcctccacccccaaatccggtggtgaagggccgtcggcgccgcggtgctatcagcgctgaggtttacactgaggaagatgctgcgtcctacgttagaaaggttataccaaaagattataagacaatggctgctttagccaaggccatcgaaaagaacgtgttattttcacaccttgatgacaatgagagaagtgacatttttgatgcaatgtttccagtctcctttattgctggagagacagttattcagcaaggggatgaaggggataacttctatgtgattgatcaaggagaaatggatgtgtatgtcaataatgaatgggcaaccagtgttggggaaggagggagctttggagagctggctttgatttacggaacacccagagcagccactgtcaaagcaaagacaaacgtgaaactgtggggcattgaccgagacagctaccggagaatcctcatgggaagcactctgcgaaagaggaagatgtatgaagaatttcttagtaaagtgtctattttagagtctctggacaagtgggagcgtctcacagtagctgatgcactggagcctgtccagtttgaagatggacagaagattgtggtgcaaggagaaccgggggatgagttcttcattattttagagggcacggccgctgtgctgcagcgtcggtcagaaaacgaagagtttgttgaagtgggacgcctggggccttctgactattttggtgaaattgccctgctgatgaatcgtcctcgggctgccactgtggttgcgcgtggccctttgaagtgcgttaagttggaccgacctcggtttgaacgcgtccttggcccatgctcagatatcctcaagcgaaacatccagcagtacaacagctttgtgtcactgtccgtctgagatccgcctcctgtgcctctcctccccagtctatgcttcactcacgcagactgctttctcctccctctctgcagcgccaagtggccactggcttcacagcttcttgtctctgtatactaaaggttgctttattgcaccattttccattggagcgttactgaatgctcactcacaaataaatagagttgtatgg
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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