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2024-03-28 17:05:11, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_013181               1434 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus protein kinase cAMP-dependent type I regulatory
            subunit alpha (Prkar1a), mRNA.
ACCESSION   NM_013181 XM_579380
VERSION     NM_013181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Kim J, Kwon JT, Jeong J, Kim J, Hong SH, Kim J, Park ZY, Chung KH,
            Eddy EM and Cho C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Gilbert ML, Yang L, Su T and McKnight GS.
  TITLE     Expression of a dominant negative PKA mutation in the kidney
            elicits a diabetes insipidus phenotype
  JOURNAL   Am J Physiol Renal Physiol 308 (6), F627-F638 (2015)
   PUBMED   25587115
  REMARK    GeneRIF: role for PKA signaling in both short- and long-term
            regulation of AQP2, characterizing a novel mouse model of diabetes
            insipidus
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Burgers PP, van der Heyden MA, Kok B, Heck AJ and Scholten A.
  TITLE     A systematic evaluation of protein kinase A-A-kinase anchoring
            protein interaction motifs
  JOURNAL   Biochemistry 54 (1), 11-21 (2015)
   PUBMED   25097019
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Nishimura T, Fujii W, Sugiura K and Naito K.
  TITLE     Cytoplasmic anchoring of cAMP-dependent protein kinase (PKA) by
            A-kinase anchor proteins (AKAPs) is required for meiotic arrest of
            porcine full-grown and growing oocytes
  JOURNAL   Biol Reprod 90 (3), 58 (2014)
   PUBMED   24501172
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Biesemann C, Gronborg M, Luquet E, Wichert SP, Bernard V, Bungers
            SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, Jahn O, Brose
            N and Herzog E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Lazar S, Galiani D and Dekel N.
  TITLE     cAMP-Dependent PKA negatively regulates polyadenylation of c-mos
            mRNA in rat oocytes
  JOURNAL   Mol Endocrinol 16 (2), 331-341 (2002)
   PUBMED   11818504
  REMARK    GeneRIF: cAMP-Dependent PKA negatively regulates polyadenylation of
            c-mos mRNA in rat oocytes
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS,
            Cho-Chung YS and Stratakis CA.
  TITLE     Mutations of the gene encoding the protein kinase A type I-alpha
            regulatory subunit in patients with the Carney complex
  JOURNAL   Nat Genet 26 (1), 89-92 (2000)
   PUBMED   10973256
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Imaizumi-Scherrer T, Faust DM, Benichou JC, Hellio R and Weiss MC.
  TITLE     Accumulation in fetal muscle and localization to the neuromuscular
            junction of cAMP-dependent protein kinase A regulatory and
            catalytic subunits RI alpha and C alpha
  JOURNAL   J Cell Biol 134 (5), 1241-1254 (1996)
   PUBMED   8794865
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Greene RM, Lloyd MR, Uberti M, Nugent P and Pisano MM.
  TITLE     Patterns of cyclic AMP-dependent protein kinase gene expression
            during ontogeny of the murine palate
  JOURNAL   J Cell Physiol 163 (3), 431-440 (1995)
   PUBMED   7775586
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Kuno,T., Ono,Y., Hirai,M., Hashimoto,S., Shuntoh,H. and Tanaka,C.
  TITLE     Molecular cloning and cDNA structure of the regulatory subunit of
            type I cAMP-dependent protein kinase from rat brain
  JOURNAL   Biochem Biophys Res Commun 146 (2), 878-883 (1987)
   PUBMED   3619906
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000220.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17086.1, SRR8487230.66449.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JACYVU010000220.1  51445900-51445988
            90-272              JACYVU010000220.1  51449175-51449357
            273-443             JACYVU010000220.1  51454761-51454931
            444-535             JACYVU010000220.1  51455666-51455757
            536-597             JACYVU010000220.1  51455927-51455988
            598-644             JACYVU010000220.1  51456928-51456974
            645-803             JACYVU010000220.1  51457636-51457794
            804-864             JACYVU010000220.1  51459490-51459550
            865-986             JACYVU010000220.1  51460525-51460646
            987-1068            JACYVU010000220.1  51461381-51461462
            1069-1434           JACYVU010000220.1  51462164-51462529
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1434
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="protein kinase cAMP-dependent type I regulatory
                     subunit alpha"
                     /db_xref="GeneID:25725"
                     /db_xref="RGD:3391"
     exon            1..89
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    69..71
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="upstream in-frame stop codon"
     exon            90..272
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1241
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /EC_number="2.7.11.1"
                     /note="protein kinase cAMP-dependent type 1 regulatory
                     subunit alpha; protein kinase, cAMP-dependent, regulatory,
                     type I, alpha; protein kinase, cAMP-dependent, regulatory
                     subunit type I alpha"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type I-alpha
                     regulatory subunit"
                     /protein_id="NP_037313.1"
                     /db_xref="GeneID:25725"
                     /db_xref="RGD:3391"
                     /translation="
MASGSMAASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEARQIQSLQKSGIRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV"
     misc_feature    96..98
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P10644; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); acetylation site"
     misc_feature    99..503
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="propagated from UniProtKB/Swiss-Prot (P09456.2);
                     Region: Dimerization and phosphorylation"
     misc_feature    99..101
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="N-acetylalanine, in cAMP-dependent protein kinase
                     type I-alpha regulatory subunit, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:P00514; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); acetylation site"
     misc_feature    102..104
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
     misc_feature    135..284
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="dimerization/docking (D/D) domain of the Type I
                     alpha Regulatory subunit of cAMP-dependent protein kinase;
                     Region: DD_RIalpha_PKA; cd12101"
                     /db_xref="CDD:438522"
     misc_feature    order(138..140,147..152,177..182,186..191,198..203)
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="AKAP interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:438522"
     misc_feature    order(147..149,156..161,174..176,183..188,195..200,
                     207..212,222..224,228..239,243..248,255..260,267..269)
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:438522"
     misc_feature    288..383
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="propagated from UniProtKB/Swiss-Prot (P09456.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    318..320
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P10644; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
     misc_feature    324..326
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10644; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
     misc_feature    342..344
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
     misc_feature    381..395
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="propagated from UniProtKB/Swiss-Prot (P09456.2);
                     Region: Pseudophosphorylation motif"
     misc_feature    396..398
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DBC7; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
     misc_feature    504..833
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    order(696..701,726..734)
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(792..800,810..818)
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     misc_feature    858..1205
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; Region: CAP_ED;
                     cd00038"
                     /db_xref="CDD:237999"
     misc_feature    867..869
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
     misc_feature    order(1068..1073,1098..1106)
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:237999"
     misc_feature    order(1164..1172,1182..1190)
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="flexible hinge region; other site"
                     /db_xref="CDD:237999"
     exon            273..443
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            444..535
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            536..597
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            598..644
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            645..803
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            804..864
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            865..986
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1068
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1434
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
ggcgttgagggaggcagacgcgaggaggaacggaggagaggcggagatcaccgaacagcagaacaatctagaggatccctcgacacctgagaaccatggcgtctggcagtatggcagccagtgaggaagagcggagtctccgggaatgcgagctctatgtgcagaagcacaacatccaggccctgctgaaggactccatcgtgcagctgtgcactgctcggcccgagaggcccatggcattccttcgggaatactttgagaggctggagaaggaggaggcaagacagattcagagcctacagaaatccggcattcgtacagactcgagggaggatgagatctctcctccacccccaaatccggtggtgaagggccgtcggcgccgcggtgctatcagcgctgaggtttacactgaggaagatgctgcgtcctacgttagaaaggttataccaaaagattataagacaatggctgctttagccaaggccatcgaaaagaacgtgttattttcacaccttgatgacaatgagagaagtgacatttttgatgcaatgtttccagtctcctttattgctggagagacagttattcagcaaggggatgaaggggataacttctatgtgattgatcaaggagaaatggatgtgtatgtcaataatgaatgggcaaccagtgttggggaaggagggagctttggagagctggctttgatttacggaacacccagagcagccactgtcaaagcaaagacaaacgtgaaactgtggggcattgaccgagacagctaccggagaatcctcatgggaagcactctgcgaaagaggaagatgtatgaagaatttcttagtaaagtgtctattttagagtctctggacaagtgggagcgtctcacagtagctgatgcactggagcctgtccagtttgaagatggacagaagattgtggtgcaaggagaaccgggggatgagttcttcattattttagagggcacggccgctgtgctgcagcgtcggtcagaaaacgaagagtttgttgaagtgggacgcctggggccttctgactattttggtgaaattgccctgctgatgaatcgtcctcgggctgccactgtggttgcgcgtggccctttgaagtgcgttaagttggaccgacctcggtttgaacgcgtccttggcccatgctcagatatcctcaagcgaaacatccagcagtacaacagctttgtgtcactgtccgtctgagatccgcctcctgtgcctctcctccccagtctatgcttcactcacgcagactgctttctcctccctctctgcagcgccaagtggccactggcttcacagcttcttgtctctgtatactaaaggttgctttattgcaccattttccattggagcgttactgaatgctcactcacaaataaatagagttgtatgg
//

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]