2024-04-27 09:59:50, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_013173 4398 bp mRNA linear ROD 08-NOV-2023 DEFINITION Rattus norvegicus solute carrier family 11 member 2 (Slc11a2), transcript variant 1, mRNA. ACCESSION NM_013173 VERSION NM_013173.2 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 4398) AUTHORS Irollo E, Nash B, Luchetta J, Brandimarti R and Meucci O. TITLE The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain JOURNAL J Neuroimmune Pharmacol 18 (3), 495-508 (2023) PUBMED 37661197 REMARK GeneRIF: The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain. REFERENCE 2 (bases 1 to 4398) AUTHORS Wolff NA, Garrick MD, Zhao L, Garrick LM, Ghio AJ and Thevenod F. TITLE A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese JOURNAL Sci Rep 8 (1), 211 (2018) PUBMED 29317744 REMARK GeneRIF: DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition. Publication Status: Online-Only REFERENCE 3 (bases 1 to 4398) AUTHORS Naito Y, Sawada H, Oboshi M, Okuno K, Yasumura S, Okuhara Y, Eguchi A, Nishimura K, Soyama Y, Asakura M, Ishihara M, Tsujino T and Masuyama T. TITLE Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome JOURNAL Heart Vessels 32 (11), 1410-1414 (2017) PUBMED 28669019 REMARK GeneRIF: impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Taken together, impaired these intestinal iron transporters may become a novel therapeutic target for cardio-renal anemia syndrome. REFERENCE 4 (bases 1 to 4398) AUTHORS Han M, Chang J and Kim J. TITLE Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity JOURNAL J Neurochem 138 (6), 918-928 (2016) PUBMED 27331785 REMARK GeneRIF: Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption REFERENCE 5 (bases 1 to 4398) AUTHORS Mackenzie K, Foot NJ, Anand S, Dalton HE, Chaudhary N, Collins BM, Mathivanan S and Kumar S. TITLE Regulation of the divalent metal ion transporter via membrane budding JOURNAL Cell Discov 2, 16011 (2016) PUBMED 27462458 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 4398) AUTHORS Fleming MD, Trenor CC 3rd, Su MA, Foernzler D, Beier DR, Dietrich WF and Andrews NC. TITLE Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene JOURNAL Nat Genet 16 (4), 383-386 (1997) PUBMED 9241278 REFERENCE 7 (bases 1 to 4398) AUTHORS Sassa,S. and Bernstein,S.E. TITLE Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease JOURNAL Exp Hematol 6 (5), 479-487 (1978) PUBMED 658175 REFERENCE 8 (bases 1 to 4398) AUTHORS Edwards,J.A. and Hoke,J.E. TITLE Red cell iron uptake in hereditary microcytic anemia JOURNAL Blood 46 (3), 381-388 (1975) PUBMED 807277 REFERENCE 9 (bases 1 to 4398) AUTHORS Kreimer-Birnbaum,M., Bannerman,R.M., Russell,E.S. and Bernstein,S.E. TITLE Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v, ha-ha, nb-nb, mk-mk, f-f and sla-Y) JOURNAL Comp Biochem Physiol A Comp Physiol 43 (1), 21-30 (1972) PUBMED 4404581 REFERENCE 10 (bases 1 to 4398) AUTHORS Bannerman,R.M., Edwards,J.A., Kreimer-Birnbaum,M., McFarland,E. and Russell,E.S. TITLE Hereditary microcytic anaemia in the mouse; studies in iron distribution and metabolism JOURNAL Br J Haematol 23 (2), 235-245 (1972) PUBMED 5070129 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF008439.1. On Aug 3, 2012 this sequence version replaced NM_013173.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF008439.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132262 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-4398 AF008439.1 12-4409 FEATURES Location/Qualifiers source 1..4398 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="7" /map="7q36" gene 1..4398 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /note="solute carrier family 11 member 2" /db_xref="GeneID:25715" /db_xref="RGD:3684" CDS 1..1779 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /note="isoform 1 is encoded by transcript variant 1; DMT-1; NRAMP 2; divalent cation transporter 1; natural resistance-associated macrophage protein 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2); divalent metal transporter 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2" /codon_start=1 /product="natural resistance-associated macrophage protein 2 isoform 1" /protein_id="NP_037305.2" /db_xref="GeneID:25715" /db_xref="RGD:3684" /translation="
MGKKQPRAAASAAPNCELKSYSKSTDPQVSTMVLDPEEKIPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLYGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLRGMFVPSCSGCHTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNEQVVEVCRNSSSPHADLFPNDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLLVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGLSFLDCGRSVSISKVLLSEDTSGGNTK"
misc_feature 295..1494 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /note="NRAMP (natural resistance-associated macrophage protein) metal ion transporters; Region: nramp; TIGR01197" /db_xref="CDD:162246" exon 1..55 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 56..127 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 128..276 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 277..402 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 403..522 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 523..629 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 630..700 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 701..768 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 769..924 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 925..1083 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 1084..1170 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 1171..1290 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 1291..1440 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 1441..1514 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 1515..1668 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" exon 1669..4320 /gene="Slc11a2" /gene_synonym="Dmt1; Nramp2" /inference="alignment:Splign:2.1.0" ORIGIN
atggggaagaagcagccgagggcagcagcaagtgctgctccaaactgtgagctaaaatcctattctaagagcacagatcctcaggtatctaccatggtgttggatcctgaagaaaagattccagacgatggtgcttctggggaccatggagactcggccagcctcggtgccatcaaccctgcttacagcaactcttccctcccacattccaccggggattctgaggagcccttcaccacctactttgatgagaaaatccccattcctgaggaggagtactcttgttttagtttccgtaaactctgggccttcacaggacctggttttcttatgagcattgcctacctggatccaggaaacattgaatctgatttacagtctggagcagtggctggatttaagttgctctgggtgctcctgctggccactattgtggggctgctgctccagcgtctcgcagctcgactgggagtggtcaccggcttgcaccttgctgaagtgtgtcaccgtcagtatcccaaggtcccacggatcatcctgtggctaatggtggagttggcaatcattggttctgatatgcaggaagtcattggctcagccatcgccatcaatctcctgtctgccggaagggttcccctgtatggtggagtcctcatcaccatcgcagatacttttgtatttctctttttggacaaatatggcttgcggaagctggaagcattttttggctttctcatcactatcatggccctcacatttggatatgagtatgttacagtgaaacccagccaaagccaagtactcaggggcatgttcgtgccatcctgttcaggctgccacacccctcaggtggagcaggcggtgggcatcgtgggagctgtgatcatgccacacaacatgtacctgcactctgccttagtcaagtctagacaagtgaaccgggccaataagcaggaagttcgagaagccaataagtacttcttcatcgagtcctgcattgcactctttgtttccttcatcatcaatgtctttgtcgtctccgtctttgctgaagcattttttgagaaaaccaatgagcaggtggttgaggtctgcagaaatagcagcagcccccatgctgacctctttcctaacgacaactctaccctggctgtggacatctacaaagggggtgttgtgcttggatgttacttcgggcctgcggccctctacatctgggcggtggggatcctggctgctggacagagctccaccatgactggaacctattctggccagtttgtcatggagggattcctgaacctaaaatggtcgcgctttgcccgcgtgatcctgaccaggtctattgccatcatccctaccctgcttgttgctgtcttccaagatgtggagcatctgacagggatgaatgatttcctgaatgttctgcagagcctacagctcccctttgccctcatccctatcctcaccttcacaagcctgcggccagtgatgagtgagttctccaacggaataggctggaggatcgcaggcggcatcttggtccttctcgtctgctccatcaacatgtactttgtcgtggtctacgtccaggagctagggcatgtggcactgtatgtggtggctgcagtggttagcgtggcttatctgggctttgtgttctacttgggttggcagtgtttgattgcgttgggcctgtcgttcctggactgtgggcgctcggtaagcatctctaaagtcctgctgagcgaagataccagcggtggcaatactaagtaaacactgggtcagcctgtctgtctgtctttgcagggagccatcagagccagtgtgtttctatggtttactgtgtgaacatagccacaagtatgtgccgttgcacagactgcatttagggaccaactgttagttgggaaacactggggtgggtgtgtggtgtgtgtgtgtgtgttgtttccttctgtctttgtcaaatagcatgctgctattaaatgcttggtggcctaaaactctgtgtagcctaggctgccttcaaacttacagcaatcctcctggctcagcctcctgggtgctgggattccaggcatgtctaccgctcctggctgtcacgagtgcttacaagatgactggttttgtcaggggaggtcttaccctgtagcattaggcagcaccttgaaaaggtgagccttgagctgttttgaacactaaattcctaaatagctgtccaaggccatggctcggttttagttctgagaaacccaaccagactgttgtcatcatttgaattgcagaattagagaccgctatttttgagttcaggatttctgtttgtttggtgcatttcattttgtttttcaagacaagggtttcttccttgttgtcctggaacttactctgtagaccagcctggctttgaactcacagagatcctcctgcctctgcctctgcttcccgactgctaggattagaggcatacaccaccactgccctgctaagctcagagttttttatttctactttggaattcctcagtggaaagaaaggtagagcaggagagggggtgtggtcaagtgatggctcccctccaggtccttgcaggtttaccttaaggagtggagcttagcagggcttcatctgtagtcctgaggctagtgacttccctgttaatagcaagcatcccgatagtgtttcatctcgagtacacacagtcctggaatctccgccttcctctcctgagagagtgcggatggcaaaagactactgtagcacttgtgaactggctcacagcaaatcccagagctgaccgcactactcccgaaagtacccttcaccaaatcttggctctgacccaccgctgtttcatgcccaagataactcagaaggcaacctcaggagctctggacccaaaccttgcaaagtcagtagttgtcactgtgatgcaaagtcctctccctgcaaggtgggactaggctgcctcctcacagcccttccctcggagagaaagcctcttgagaccaggctgcggagctctggagattcagcacgggactacagaactgctgctctcagttcagccacttctgtcctggcacgtgggagacatgattctgtcacatcaagtcctgtctgtttgctggaaaggaataatacaagtttgtataatcattgccttggtggcaacaggagctacagtgacttcgaaggatgtcgtcctctttgccgctttcccagttcgactgtcccgacaaatgacctgcattgtggtgccactgtggcattagtgctagcatttcacacagtcagaagctcagcctgcatagagtcctgtgaggcatgaagggtaaatgcagtttcactcagcctggttgacctcagccccacagctaacacaacacagtcaggccgcgggtccctcactgcggcattctcaacccctgggttgccacccatttgcagcccctatatccaaaaccatttacattatgatttataacagtagcagcattagttgtgaaatagcaaagattttatggttgggggttaccaccacaaagggtcgcagcagcaggaagtttgagaaccctgcaccacagggtccatctcacacctgcctctgccaccattgttcccaaaactgactggaaactgagcttttgaaactgtctcgatgtggtgcttgagggccagattgacagtagcagaattactggaatggatgctctagtgacatctgcatttgtacaggggcggggttgggcggggcggggcggggttgggcagggtgtgttcagagtcactgtacttacagtccagcccagagctgctggcagtcatgcccaggggtctgccttgtgcgtgctagcaaggctgtgctgcagatctcacttcctgccccagagttctgctgtagtatgttcgtttacagtgatagacggttccattgtgtacgacggtctctgactctatgcctacagtatttacagtgtcaaagattaaaagtgtcgcctgtccatttggccgtcactgggaaacagtgcttccaacagtgctctgtacgtaacctgtaagcatttcaaccccgccacgccagtgtggcctggcgttacgttggcgagccatcttgtacgttctcacttggtcctcgttcttctgcgacctgaaatagttgttccctctgctctgggagctggcggctggggaacagcagcagcttgtcttgtaaggtcctgccaggagggcaacaagtgactataaggaggctgttagtgagcctctgacagcttgtgaacttgctgtaattaaaacaaaaacttccctgttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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