LOCUS       NM_012927               3639 bp    mRNA    linear   ROD 21-NOV-2023
DEFINITION  Rattus norvegicus cadherin 6 (Cdh6), mRNA.
ACCESSION   NM_012927 XM_346617
VERSION     NM_012927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Fouillade C, Baron-Menguy C, Domenga-Denier V, Thibault C, Takamiya
            K, Huganir R and Joutel A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   Marthiens V, Padilla F, Lambert M and Mege RM.
  TITLE     Complementary expression and regulation of cadherins 6 and 11
            during specific steps of motoneuron differentiation
  JOURNAL   Mol Cell Neurosci 20 (3), 458-475 (2002)
   PUBMED   12139922
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Machell NH, Blaschuk OW and Farookhi R.
  TITLE     Expression and localization of P-, K-, and OB-cadherin in the
            prepubertal rat ovary
  JOURNAL   Mol Reprod Dev 61 (2), 142-154 (2002)
   PUBMED   11803548
  REMARK    GeneRIF: expressed throughout prepubertal ovarian development
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Hu E, Chen Z, Fredrickson TA, Spurr N, Gentle S, Sims M, Zhu Y,
            Halsey W, Van Horn S, Mao J, Sathe GM and Brooks DP.
  TITLE     Rapid isolation of tissue-specific genes from rat kidney
  JOURNAL   Exp Nephrol 9 (2), 156-164 (2001)
   PUBMED   11150865
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Johnson KJ, Patel SR and Boekelheide K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Xiang YY, Tanaka M, Suzuki M, Igarashi H, Kiyokawa E, Naito Y,
            Ohtawara Y, Shen Q, Sugimura H and Kino I.
  TITLE     Isolation of complementary DNA encoding K-cadherin, a novel rat
            cadherin preferentially expressed in fetal kidney and kidney
            carcinoma
  JOURNAL   Cancer Res 54 (11), 3034-3041 (1994)
   PUBMED   8187093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000066.1.
            
            On Feb 5, 2021 this sequence version replaced NM_012927.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            37 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D25290.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132285, SAMEA5756307
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JACYVU010000066.1  9864538-9864654     c
            118-481             JACYVU010000066.1  9784169-9784532     c
            482-776             JACYVU010000066.1  9749417-9749711     c
            777-896             JACYVU010000066.1  9745464-9745583     c
            897-1064            JACYVU010000066.1  9742815-9742982     c
            1065-1252           JACYVU010000066.1  9739756-9739943     c
            1253-1506           JACYVU010000066.1  9737253-9737506     c
            1507-1643           JACYVU010000066.1  9730157-9730293     c
            1644-1765           JACYVU010000066.1  9727648-9727769     c
            1766-1883           JACYVU010000066.1  9726481-9726598     c
            1884-2135           JACYVU010000066.1  9726089-9726340     c
            2136-3639           JACYVU010000066.1  9718495-9719998     c
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3639
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="cadherin 6"
                     /db_xref="GeneID:25409"
                     /db_xref="RGD:2322"
     exon            1..117
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            118..481
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    200..202
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="upstream in-frame stop codon"
     CDS             254..2626
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="K-cadherin; kidney cadherin; cadherin 6, type 2,
                     K-cadherin"
                     /codon_start=1
                     /product="cadherin-6 precursor"
                     /protein_id="NP_037059.2"
                     /db_xref="GeneID:25409"
                     /db_xref="RGD:2322"
                     /translation="

MRTYRYFLLLFWVGQPYPTFSNPLSKRTSGFPAKRRALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHDMFDVITDQETQEGIITVKKLLDFEKKRVYTLKVEASNPHIEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQIREDAQINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAMEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFISQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGMDSDKDS"

     sig_peptide     254..307
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P55280.1)"
     misc_feature    488..724
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Cadherin repeats; Region: CA; smart00112"
                     /db_xref="CDD:214520"
     misc_feature    740..1045
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(761..766,926..928,932..934,1031..1033,1037..1042)
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1016..1018
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); glycosylation site"
     misc_feature    1028..1117
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="propagated from UniProtKB/Swiss-Prot (P55280.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1067..1390
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1088..1093,1259..1261,1265..1267,1379..1381,
                     1385..1390)
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1415..1705
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1433..1438,1592..1594,1598..1600,1691..1693,
                     1697..1702)
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1448..1450
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); glycosylation site"
     misc_feature    1562..1564
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); glycosylation site"
     misc_feature    1616..1618
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); glycosylation site"
     misc_feature    1727..2020
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    1859..1861
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); glycosylation site"
     misc_feature    2099..2161
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="propagated from UniProtKB/Swiss-Prot (P55280.1);
                     transmembrane region"
     misc_feature    2162..2599
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Cadherin cytoplasmic region; Region: Cadherin_C;
                     pfam01049"
                     /db_xref="CDD:426014"
     misc_feature    2609..2611
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); phosphorylation site"
     misc_feature    2621..2623
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P97326; propagated from
                     UniProtKB/Swiss-Prot (P55280.1); phosphorylation site"
     exon            482..776
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            777..896
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1064
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1252
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1506
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1643
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1765
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1883
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2135
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..3639
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccgagagctgcagttccaggcacagcagcaagaagcacagagccggcgaccgtggcggaggcaggagcatcctgggcgagtggcagggtgtccccaggagccggaaggcaaacagagataccctctgaaagccaagcagagaacattaaggaagaaaggaggaatgagcctgggtctggtgcggtgaaaagagacgcattaaggaaaggggaactcactacccagacgctccactgccagccttgccatcagcatgagaacttaccggtacttcctgctgctcttttgggtcggccagccctacccaactttctcaaacccgttatctaaaaggactagtggcttcccagcaaagaggagggccctggagctctctgccaacagcaggaatgagctgagccgttcaaaaaggagttggatgtggaatcagttcttcctcctggaggaatacacgggatcagattatcagtacgtcggcaagttacattcagaccaggatagaggagatggatcacttaaatatatcctttcaggagatggagcgggagatctcttcattatcaatgaaaacacaggcgacatacaagccaccaagaggctggacagggaagagaaacccgtttacatccttcgagcccaagctatcaacagaaggacagggagacccgtcgagcctgagtctgaattcatcatcaagatccatgacatcaatgataatgagccaatattcaccaaggatgtttacacagccacagtccccgagatggcagatgtcggaacatttgtagtccaagtcacagcaactgatgccgatgacccgacgtacgggaacagtgctaaagtcgtgtacagcatcctgcagggacagccctacttttcagtggagtcggaaacaggtatcatcaagacagcgttgctcaacatggatcgagaaaacagagagcagtaccaagtggtgattcaggccaaggacatgggcggccagatgggaggactgtcggggaccacgaccgtgaacatcacactgacagatgtcaatgacaatcctcctcgcttcccccagagtacctatcagtttaagactcccgagtcttctccaccaggaacaccaattggcaggatcaaagccagtgatgctgatgtgggagaaaatgcagagatcgagtacagcatcacagacggtgagggacatgatatgtttgacgtcatcaccgaccaggaaacccaggaagggattataactgtcaaaaagctcttggattttgaaaagaagagagtgtacaccctcaaggtggaagcctccaatccccacatcgaaccccgatttctctacctgggtccgttcaaagactcggccacagtgagaatcgtggtagatgacgtagatgaacctcctgtcttcagcaaactggcctacatcctacagatacgagaggatgctcagataaacacaaccataggctctgtcgcagctcaggatcctgacgctgccaggaatcctgtcaagtactcggtggatagacacacagatatggacaggatattcaacattgattctggaaatggctccatttttacatcaaaacttctcgaccgggaaacgctgttgtggcataacatcacagtgatagcaacggagattaataatccaaagcaaagcagccgcgtgcctctatatattaaagttctcgacgtcaatgacaatgccccagaatttgctgagttctatgaaacttttgtctgtgaaaaagcaaaggcggatcagctgattcagaccctgcacgctgttgacaaggatgatccttacagtggacaccaattctccttctctttggccccagaagcagccagtggctctaattttaccatacaagacaacaaagacaacactgcagggatcctaactcggaaaaatggctataacagacacgagatgagcacttatctcctgccggtggtcatttcagacaacgactacccagtccaaagcagcactgggacagtgactgtccgggtctgtgcatgtgaccaccatggaaacatgcagtcctgccacgccgaggccctcatccaccccacagggctgagcacaggggctctggtggccatccttctgtgcatcgtgatcctactagtgacagtggtgctgttcgcagctctgaggcggcagcgaaagaaagagcctttgatcatttccaaagaggacatcagagacaacattgtcagttacaacgacgaaggtggcggagaggaagacacccaggcctttgatatcggaaccctgaggaaccctgaagccatggaggacagcaaatcgcgcagggacattgtgcctgaagctctttttctaccacggcggactccaacagctcgtgacaacacggatgtcagagatttcattagccaaaggttaaaggaaaatgacacggacccaacagcccctccctacgactccttggccacctatgcctacgaaggcactggctcggtggccgactccctgagctcactagaatcagtgaccacagatggagaccaagattatgactatttgagtgactggggccctcggttcaaaaagctggcagatatgtacggagggatggacagtgacaaagactcctaatctgttgccttttcattttccaatatgacactggaatatgtgacgtggctattcctttctatttatccactattccgtgaggggttctccgttgtacccgttccaaaagtcaatggctgcagtccgtgtggatccaatgttagagacttttttctagtacacttttatgagcttctaagaggcaaatttttattttttagttcatgcagttaaccaagttagcccagcaggcacgctgcgggaggagaggaaggaacggcgtttttcccgtgttccccttagagcaggttggccacgccccttactgctggcctagactctactttggttcacggcctccattccgctgaatgctccaaatgtacatttcacatgctacacatgctaatggaagaagggatcatactttgatgattaaaaatatagttttagtatttaaaaggggggaggaaacaattgggaaattgttcctggtctatcagttgtcaaggagataattaactatgaaggggtttgtaaggatatgcgtgtgtcaaggaatataaagtggggcatcctgtctgtgctggaagaggtgtttctggcatcaacaaatactcgtaatgctgaatccttccatgttctaagatggcttagaagcaaatcaagtggtatcatgttcaaagacagtaacgaaagacagggctgtgttccctgacaagattttgttgcatgtgataaacagatgcttcaccatcatgccaaacaaaggaaaaaagagaaatagctttacaaaaaaaaattaacaaaggacatatttagggaatttcaaggttttgtactaccaacagtatcccgggtcccttcattctttcaactatcagtaaactaatgagaagtaggtctaatcatataagcgtccttgagagaatttcctgaggcaaatgttaactctttgtctgtagttgttgttactattatcctactatacctgagtgtagcagtgtgaagtacaataattcatattcttcaaa

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