LOCUS       NM_012923               3198 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cyclin G1 (Ccng1), mRNA.
ACCESSION   NM_012923
VERSION     NM_012923.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3198)
  AUTHORS   Liu,Y., Fu,X., Wang,X., Liu,Y. and Song,X.
  TITLE     Long non-coding RNA OIP5-AS1 facilitates the progression of ovarian
            cancer via the miR-128-3p/CCNG1 axis
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33760168
REFERENCE   2  (bases 1 to 3198)
  AUTHORS   Xu,G., Bu,S., Wang,X. and Ge,H.
  TITLE     Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity
            of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing
            Apoptosis
  JOURNAL   Radiat Res 195 (4), 378-384 (2021)
   PUBMED   33543294
REFERENCE   3  (bases 1 to 3198)
  AUTHORS   Guo,J.Y., Wang,X.Q. and Sun,L.F.
  TITLE     MicroRNA-488 inhibits ovarian cancer cell metastasis through
            regulating CCNG1 and p53 expression
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (6), 2902-2910 (2020)
   PUBMED   32271408
REFERENCE   4  (bases 1 to 3198)
  AUTHORS   Xu,Y., Zhang,Q., Miao,C., Dongol,S., Li,Y., Jin,C., Dong,R., Li,Y.,
            Yang,X. and Kong,B.
  TITLE     CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3
            expression promotes high-grade serous ovarian cancer (HGSOC)
            tumorigenesis and progression
  JOURNAL   Cancer Med 8 (1), 351-362 (2019)
   PUBMED   30565428
REFERENCE   5  (bases 1 to 3198)
  AUTHORS   Ohno,S., Ikeda,J.I., Naito,Y., Okuzaki,D., Sasakura,T.,
            Fukushima,K., Nishikawa,Y., Ota,K., Kato,Y., Wang,M., Torigata,K.,
            Kasama,T., Uchihashi,T., Miura,D., Yabuta,N., Morii,E. and
            Nojima,H.
  TITLE     Comprehensive phenotypic analysis of knockout mice deficient in
            cyclin G1 and cyclin G2
  JOURNAL   Sci Rep 6, 39091 (2016)
   PUBMED   27982046
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3198)
  AUTHORS   Chen,D.S., Zhu,N.L., Hung,G., Skotzko,M.J., Hinton,D.R., Tolo,V.,
            Hall,F.L., Anderson,W.F. and Gordon,E.M.
  TITLE     Retroviral vector-mediated transfer of an antisense cyclin G1
            construct inhibits osteosarcoma tumor growth in nude mice
  JOURNAL   Hum Gene Ther 8 (14), 1667-1674 (1997)
   PUBMED   9322869
REFERENCE   7  (bases 1 to 3198)
  AUTHORS   Zhu,N.L., Wu,L., Liu,P.X., Gordon,E.M., Anderson,W.F., Starnes,V.A.
            and Hall,F.L.
  TITLE     Downregulation of cyclin G1 expression by retrovirus-mediated
            antisense gene transfer inhibits vascular smooth muscle cell
            proliferation and neointima formation
  JOURNAL   Circulation 96 (2), 628-635 (1997)
   PUBMED   9244236
REFERENCE   8  (bases 1 to 3198)
  AUTHORS   Endo,Y., Fujita,T., Tamura,K., Tsuruga,H. and Nojima,H.
  TITLE     Structure and chromosomal assignment of the human cyclin G gene
  JOURNAL   Genomics 38 (1), 92-95 (1996)
   PUBMED   8954786
REFERENCE   9  (bases 1 to 3198)
  AUTHORS   Zauberman,A., Lupo,A. and Oren,M.
  TITLE     Identification of p53 target genes through immune selection of
            genomic DNA: the cyclin G gene contains two distinct p53 binding
            sites
  JOURNAL   Oncogene 10 (12), 2361-2366 (1995)
   PUBMED   7784084
REFERENCE   10 (bases 1 to 3198)
  AUTHORS   Tamura,K., Kanaoka,Y., Jinno,S., Nagata,A., Ogiso,Y., Shimizu,K.,
            Hayakawa,T., Nojima,H. and Okayama,H.
  TITLE     Cyclin G: a new mammalian cyclin with homology to fission yeast
            Cig1
  JOURNAL   Oncogene 8 (8), 2113-2118 (1993)
   PUBMED   8336937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB805791.1 and BC081852.1.
            
            On Jan 9, 2008 this sequence version replaced NM_012923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081852.1, FQ211975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CB805791.1         22-50
            30-3198             BC081852.1         1-3169
FEATURES             Location/Qualifiers
     source          1..3198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3198
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /note="cyclin G1"
                     /db_xref="GeneID:25405"
                     /db_xref="RGD:2295"
     exon            1..231
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    145..147
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /note="upstream in-frame stop codon"
     CDS             232..1116
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /note="cyclin-G"
                     /codon_start=1
                     /product="cyclin-G1"
                     /protein_id="NP_037055.1"
                     /db_xref="GeneID:25405"
                     /db_xref="RGD:2295"
                     /translation="

MIEVLTTDSQKLLHQLNTLLEQESRCQPKVCGLKLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQAKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLIRETLPFERRNDLNFERLEAQLKACHCRIIFSKAKPSVLALAIIALEIQALKYVELTEGVECIQKHSKISGRDLTFWQELVSKCLTEYSSNKCSKPNGQKLKWIVSGRTARQLKHSYYRITHLPTIPETMG"

     misc_feature    379..672
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /note="cyclin box found in cyclin-G1 (CCNG1) and similar
                     proteins; Region: CYCLIN_CCNG1; cd20583"
                     /db_xref="CDD:410286"
     exon            232..492
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            493..746
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            747..825
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            826..924
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
     exon            925..3198
                     /gene="Ccng1"
                     /gene_synonym="Ccng; CYCG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tctccccgcggccgggcgcagtccttcaccgcacgctgaaccggaggaaggctgcgcctagtcggggcgctgagggaccctccaccgggacgccggcccctccccgggcctctgctcacttgcccccctgcgagcccgtccccctagtcggcctctcggatcggggacgtggggcgagctgagagcaggcccggggtgggtggtcactgtggagaagacgtggctgtcaagatgatagaagtactgacaactgactctcagaaactgctacaccagctgaacaccctgttggaacaggagtccagatgtcagccaaaggtctgtggcctgaaactgattgagtctgcacatgataatggcctcaggatgactgcaagactccgggactttgaagtcaaagatctactgagtctaactcagttctttggcttcgacacagaaacattttcccttgctgtgaatttactggacagattcttgtctaaaatgaaggtacaggcgaagcatctcggctgtgtcggactgagctgcttttatttggctgtgaaatcgattgaagaggaaaggaacgtcccgctggcaactgatttgatccggataagtcagtataggttcacagtttcagacctgatgagaatggaaaagattgtgttggagaaagtgtgctggaaagtcaaagctactactgccttccaatttctgcagctctattactccctcattcgggagaccttgccatttgaaaggagaaacgatctgaattttgaaagactagaagcccaactgaaggcgtgccactgcaggatcatattttctaaggcaaagccttctgtgctggcgctggcaatcatcgctttggagatccaagcactgaagtatgtggagttaacagaaggagtagaatgtattcagaaacattccaagataagtggccgagatctgaccttctggcaagagcttgtttccaagtgtttaactgaatattcatcaaacaagtgttccaagccgaacggtcagaagttaaaatggatcgtgtctgggcgcactgcacgacaactgaagcacagttattacaggataacccacctcccaacaattcccgaaaccatgggttagttggcaaatctggttgttatcctctgtgtacagaacatttcccagtgagatcgtttttgtgctataacttaaggattgaaatactaccttcaatataaagaatacaggatgaaaacagtaaaggaaacgtgagtttgttggtctagacagagaatactgggaggcattcactgtgtaccgcagtctgaagagaaatgagtatcaaacctctagacacatgctcatactgctgtcaaaggactagcgtagaaaagagagtcctccaaaccggaagtttaaatgtagttactaaaatagcacttctttaacttacatatccccccactgtggcttatttaaagttacagaagtccaagcagaacgacaaaagatgtgacccatatatgaacacattttaatctgttcattgattaggagagtgaatatgaacttgcatgatgcccatgttaggtttctggaaactgccggggtatcttaattctctagtattctccctctgtggcagttgggctaatacaaagtaactatacgcatgagaatataaaatcagtctctgatacatacacatttttaccatcaaaatttcttaatcatagcaaagacttacctttttatgattaggaattttttttttaatgtatggcagcacatgcctttaatcccaacactagggaggcagaggcaggtggatctctttgagttcgaagccaggctggtctttacagtgagttccaggacagctggagagctacagaatggagagacgctgtctcaaaaacactgaaaacaaacaaacaaaccataccagtttgtaggcagacttctgttgggttgggtttgtactgtttgcctatgcagtgggattacagcagcagcaacaaaaactgtccctgaagtctttctctgccactgtgacctgagtttcctatggtacgcgatttattctaagaaacctcagcccctcaccacgttagctgttggcaaatggcctcacagttgcggaaagtcccaattctaggcttgggaaagcaatgcttagatttgaattggcccatgaagcattcaaatcaaggctaaagacataaatgtgaaataaaactgtgaaccttcattttaacattgatctcacttcccagatttaatcaatatatacttaggtggtattaaaaatggtaaactgcctaatttaaatctcaaaatttaaactatgaggtttacatcaaagccaacatttcacaaatgtacttttaaggtattaaaagaggtatttaagcagtaaatggtttcttggcacccataaccaagtaatagttaagttagaggtgggacttttttattgctatgagaattacatttaaacttttgggtgttttataaaaagcagatttcacaagttttgaaaattgtgacctttactgaaatttgttacctttaatatttcttctagaggataggtatttataaaagaaaaattcgtcagaattgctgcctcaatctagtcccatttgagaaaatttgtttctactgtctcaataactggatgaaatatcactctgaaaacttgcctattgcactaaagctagtttaggcttgataaaacactccaggaggtttttaccacagactgtttctattaaaactgctgcttctcatgtacaattttgttttaaaaggaaccgagtacatctgcaaaacctaagtcttaagggacgtcaggaggtaccttcagaattataggatcaccatggtagtggggattctccatgctggccttgaatgtttgatcttcactgctgaaatgtgggtagctcctcagcgccctgtagagcctgagtctacctagaatagctgtaaccattttgacaagtaatggataagaaaattatccattgagaagctaaaaacaaaacaaaacaaaaccaaagaacgggtgtattttattcttaacctttgtaaaccatcactgagaacacttcagttcttcctaacagctgttatgcttcgatttgaaaaaaatactgagtggataaccaactaccatcatgctttgggtacacctttcaataaaattactgaaatgca

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