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Previous release (v1)
2024-11-01 12:33:02, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_012898 1490 bp mRNA linear ROD 14-JUN-2024
DEFINITION Rattus norvegicus alpha-2-HS-glycoprotein (Ahsg), mRNA.
ACCESSION NM_012898
VERSION NM_012898.6
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1490)
AUTHORS Kukla,M., Menzyk,T., Dembinski,M., Winiarski,M., Garlicki,A.,
Bociaga-Jasik,M., Skonieczna,M., Hudy,D., Maziarz,B.,
Kusnierz-Cabala,B., Kapusta,M., Skladany,L., Grgurevic,I.,
Mikolasevic,I., Filipec-Kanizaj,T., Wojcik-Bugajska,M.,
Grodzicki,T., Rogula,T. and Stygar,D.
TITLE Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin,
Predisposes to More Serious COVID-19 Course
JOURNAL Biomolecules 11 (10), 1422 (2021)
PUBMED 34680053
REMARK GeneRIF: Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or
Irisin, Predisposes to More Serious COVID-19 Course.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1490)
AUTHORS Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
Kichler,A., Otsu,K. and Mayr,M.
TITLE Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
Activity in Human Atrial Fibrillation
JOURNAL Circulation 134 (11), 817-832 (2016)
PUBMED 27559042
REFERENCE 3 (bases 1 to 1490)
AUTHORS Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
TITLE Extracellular matrix remodelling in response to venous
hypertension: proteomics of human varicose veins
JOURNAL Cardiovasc Res 110 (3), 419-430 (2016)
PUBMED 27068509
REFERENCE 4 (bases 1 to 1490)
AUTHORS Naito,C., Hashimoto,M., Watanabe,K., Shirai,R., Takahashi,Y.,
Kojima,M., Watanabe,R., Sato,K., Iso,Y., Matsuyama,T.A., Suzuki,H.,
Ishibashi-Ueda,H. and Watanabe,T.
TITLE Facilitatory effects of fetuin-A on atherosclerosis
JOURNAL Atherosclerosis 246, 344-351 (2016)
PUBMED 26828753
REMARK GeneRIF: Fetuin-A exerts the stimulatory effects on inflammatory
responses in HUVECs, macrophage foam cell formation, and
proliferation and collagen production in HASMCs, leading to the
development of atherosclerosis.
Erratum:[Atherosclerosis. 2016 Oct;253:346. doi:
10.1016/j.atherosclerosis.2016.05.009. PMID: 27184817]
REFERENCE 5 (bases 1 to 1490)
AUTHORS Shen,X., Yang,L., Yan,S., Zheng,H., Liang,L., Cai,X. and Liao,M.
TITLE Fetuin A promotes lipotoxicity in beta cells through the TLR4
signaling pathway and the role of pioglitazone in anti-lipotoxicity
JOURNAL Mol Cell Endocrinol 412, 1-11 (2015)
PUBMED 25986658
REMARK GeneRIF: The protective effects of pioglitazone on lipotoxicity in
beta cells may involve the inhibition of the activation of the
Fetuin A and TLR4 signaling pathway.
REFERENCE 6 (bases 1 to 1490)
AUTHORS Rauth,G., Poschke,O., Fink,E., Eulitz,M., Tippmer,S., Kellerer,M.,
Haring,H.U., Nawratil,P., Haasemann,M., Jahnen-Dechent,W. et al.
TITLE The nucleotide and partial amino acid sequences of rat fetuin.
Identity with the natural tyrosine kinase inhibitor of the rat
insulin receptor
JOURNAL Eur J Biochem 204 (2), 523-529 (1992)
PUBMED 1371750
REFERENCE 7 (bases 1 to 1490)
AUTHORS Brown,W.M., Christie,D.L., Dziegielewska,K.M., Saunders,N.R. and
Yang,F.
TITLE The rat protein encoded by clone pp63 is a fetuin/alpha 2-HS
glycoprotein-like molecule, but is it the tyrosine kinase inhibitor
pp63?
JOURNAL Cell 68 (1), 7-8 (1992)
PUBMED 1370655
REFERENCE 8 (bases 1 to 1490)
AUTHORS Colombo,B.M., Falquerho,L., Manenti,G., Dragani,T.A. and Le Cam,A.
TITLE Expression of the pp63 gene encoding the insulin receptor tyrosine
kinase inhibitor in proliferating liver and in liver tumors
JOURNAL Biochem Biophys Res Commun 180 (2), 967-971 (1991)
PUBMED 1659407
REFERENCE 9 (bases 1 to 1490)
AUTHORS Haasemann,M., Nawratil,P. and Muller-Esterl,W.
TITLE Rat tyrosine kinase inhibitor shows sequence similarity to human
alpha 2-HS glycoprotein and bovine fetuin
JOURNAL Biochem J 274 (Pt 3) (Pt 3), 899-902 (1991)
PUBMED 1707273
REFERENCE 10 (bases 1 to 1490)
AUTHORS Falquerho,L., Patey,G., Paquereau,L., Rossi,V., Lahuna,O.,
Szpirer,J., Szpirer,C., Levan,G. and Le Cam,A.
TITLE Primary structure of the rat gene encoding an inhibitor of the
insulin receptor tyrosine kinase
JOURNAL Gene 98 (2), 209-216 (1991)
PUBMED 1849862
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000011.1.
On Feb 13, 2023 this sequence version replaced NM_012898.5.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: FQ210159.1, FQ209720.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760400, SAMEA5760476
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-285 JAXUCZ010000011.1 91632299-91632583 c
286-396 JAXUCZ010000011.1 91630392-91630502 c
397-481 JAXUCZ010000011.1 91629977-91630061 c
482-645 JAXUCZ010000011.1 91629504-91629667 c
646-747 JAXUCZ010000011.1 91628150-91628251 c
748-831 JAXUCZ010000011.1 91627190-91627273 c
832-1490 JAXUCZ010000011.1 91625975-91626633 c
FEATURES Location/Qualifiers
source 1..1490
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="11"
/map="11q23"
gene 1..1490
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="alpha-2-HS-glycoprotein"
/db_xref="GeneID:25373"
/db_xref="RGD:2075"
exon 1..285
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
misc_feature 34..36
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="upstream in-frame stop codon"
CDS 73..1131
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="fetuin-A; glycoprotein PP63; 59 kDa bone sialic
acid-containing protein; alpha 2 HS-glycoprotein alpha 2
(fetuin); phosphorylated N-glycoprotein pp63"
/codon_start=1
/product="alpha-2-HS-glycoprotein precursor"
/protein_id="NP_037030.2"
/db_xref="GeneID:25373"
/db_xref="RGD:2075"
/translation="
MKSLVLLLCFAQLWSCQSAPQGAGLGFRELACDDPETEHVALIAVDYLNKHLLQGFRQILNQIDKVKVWSRRPFGEVYELEIDTLETTCHALDPTPLANCSVRQQAEHAVEGDCDFHILKQDGQFRVLHAQCHSTPDSAEDVRKFCPRCPILIRFNDTNVVHTVKTALAAFNAQNNGTYFKLVEISRAQNVPFPVSTLVEFVIAATDCTGQEVTDPAKCNLLAEKQYGFCKATLIHRLGGEEVSVACKLFQTQPQPANANPAGPAPTVGQAAPVAPPAGPPESVVVGPVAVPLGLPDHRTHHDLRHAFSPVASVESASGEVLHSPKVGQPGDAGAAGPVAPLCPGRVRYFKI"
sig_peptide 73..126
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 127..1128
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/product="Alpha-2-HS-glycoprotein. /id=PRO_0000008897"
/note="propagated from UniProtKB/Swiss-Prot (P24090.2)"
misc_feature 148..471
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Cystatin-like domain; Region: CY; smart00043"
/db_xref="CDD:214484"
misc_feature order(271..279,295..297)
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="putative proteinase inhibition site [active]"
/db_xref="CDD:238002"
misc_feature 367..369
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P24090.2); glycosylation site"
misc_feature 472..474
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P02765; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 475..477
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P29699; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 484..486
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:16641100,
ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 499..504
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Cleavage, by trypsin. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (P24090.2); cleavage
site"
misc_feature 517..783
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Cystatin domain; Region: Cystatin; pfam00031"
/db_xref="CDD:425431"
misc_feature 538..540
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P24090.2); glycosylation site"
misc_feature 598..600
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P24090.2); glycosylation site"
misc_feature order(637..645,658..660)
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="putative proteinase inhibition site [active]"
/db_xref="CDD:238002"
misc_feature 838..912
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="propagated from UniProtKB/Swiss-Prot (P24090.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 997..999
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 1009..1011
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 1018..1020
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 1024..1026
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P24090.2); phosphorylation site"
misc_feature 1027..1086
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/note="propagated from UniProtKB/Swiss-Prot (P24090.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 286..396
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
exon 397..481
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
exon 482..645
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
exon 646..747
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
exon 748..831
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
exon 832..1490
/gene="Ahsg"
/gene_synonym="Aa2-066; BSP; pp63"
/inference="alignment:Splign:2.1.0"
ORIGIN
ctagctctccaagctgattatctgggctgcccctgacatttgtccatctcccagggcctctctggagcagccatgaagtccctggtcctgctcctttgttttgctcagctctggagctgccaatcagctccacaaggtgcagggctgggttttcgagaattggcttgtgatgacccggaaacagagcatgtagctttgatagccgtggactacctcaataaacatcttcttcagggattcaggcagatcttgaatcagattgacaaagtcaaggtgtggtctcggcggcccttcggagaggtgtatgagttggaaattgacacgctggagacaacctgccacgctctggacccaacccccttagcaaattgttctgtgaggcaacaggccgagcatgcggtggagggagactgtgacttccacatcctgaaacaagatggccagttcagggtgctacacgcccagtgtcattccacaccagactctgcagaggacgttcggaagttttgcccacgatgcccaatcctgatccggttcaatgacaccaacgtggtccacactgtcaaaactgccctggctgccttcaatgcacagaataatggaacctattttaaactggtggagatttcccgagctcaaaatgtgcctttcccggtgtctactctcgtggagtttgtgatagctgcgactgactgtactggtcaggaggtcacagatccagccaaatgcaacctgctggcagaaaagcaatatggcttctgcaaggcgactctcatccacagacttggtggggaagaggtttcagtggcctgcaagttattccagacacagccccagccagccaatgccaaccctgcaggtcctgcacccacagtgggccaagctgcgcctgtagccccaccagctggcccacctgaatccgtggtggtaggacccgtggcagttcctctaggacttccagaccaccgaacccaccatgacctacggcatgccttctctcctgtggcttctgtggagtcggcctcaggagaagttcttcactcacctaaggtgggccagcctggtgacgctggtgctgctggcccagtggcccccctgtgcccagggagagtcagatacttcaagatctaggcttgactcagggaagtaaggttttggcaggcaggacatagccaccactgaagtagagggcttgtccactgaccaagcaagtaccacatcatagcttgaattccaggtctcttcattccccagagaaaaggggcagagaggtgatggttaaatttgttgaaagccagcagcagcaacactagcacttgtggggtgacagactactgtcatttgtttctttgccttctcactgacctcatacaaagcagttgcaagcgcgactgtgaaaggtgctctcaccaaacttcaatctacccataaataaaagtacccgaaggagctttcttaaacaagaaggttctgagccgagtgtggttgtg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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