LOCUS       NM_012891               2115 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Rattus norvegicus acyl-CoA dehydrogenase, very long chain (Acadvl),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012891
VERSION     NM_012891.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Choi J, Ravipati A, Nimmagadda V, Schubert M, Castellani RJ and
            Russell JW.
  TITLE     Potential roles of PINK1 for increased PGC-1alpha-mediated
            mitochondrial fatty acid oxidation and their associations with
            Alzheimer disease and diabetes
  JOURNAL   Mitochondrion 18, 41-48 (2014)
   PUBMED   25260493
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Kim JE, Choi SI, Lee HR, Hwang IS, Lee YJ, An BS, Lee SH, Kim HJ,
            Kang BC and Hwang DY.
  TITLE     Selenium significantly inhibits adipocyte hypertrophy and abdominal
            fat accumulation in OLETF rats via induction of fatty acid
            beta-oxidation
  JOURNAL   Biol Trace Elem Res 150 (1-3), 360-370 (2012)
   PUBMED   23076603
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Fujikawa T, Hirata T, Hosoo S, Nakajima K, Wada A, Yurugi Y, Soya
            H, Matsui T, Yamaguchi A, Ogata M and Nishibe S.
  TITLE     Asperuloside stimulates metabolic function in rats across several
            organs under high-fat diet conditions, acting like the major
            ingredient of Eucommia leaves with anti-obesity activity
  JOURNAL   J Nutr Sci 1, e10 (2012)
   PUBMED   25191539
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Yamagishi
            N, Wang D, Yanagiba Y, Ito Y, Wang J, Tanaka N, Ikeda K, Yamori Y
            and Nakajima T.
  TITLE     The modulation of hepatic adenosine triphosphate and inflammation
            by eicosapentaenoic acid during severe fibrotic progression in the
            SHRSP5/Dmcr rat model
  JOURNAL   Life Sci 90 (23-24), 934-943 (2012)
   PUBMED   22569299
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Buhrke T, Lengler I and Lampen A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Aoyama T, Souri M, Ueno I, Kamijo T, Yamaguchi S, Rhead WJ, Tanaka
            K and Hashimoto T.
  TITLE     Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and
            molecular characterization of its deficiency in two patients
  JOURNAL   Am J Hum Genet 57 (2), 273-283 (1995)
   PUBMED   7668252
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Aoyama T, Ueno I, Kamijo T and Hashimoto T.
  TITLE     Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial
            acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in
            long-chain fatty acid beta-oxidation system. cDNA and deduced amino
            acid sequence and distinct specificities of the cDNA-expressed
            protein
  JOURNAL   J Biol Chem 269 (29), 19088-19094 (1994)
   PUBMED   8034667
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Izai K, Uchida Y, Orii T, Yamamoto S and Hashimoto T.
  TITLE     Novel fatty acid beta-oxidation enzymes in rat liver mitochondria.
            I. Purification and properties of very-long-chain acyl-coenzyme A
            dehydrogenase
  JOURNAL   J Biol Chem 267 (2), 1027-1033 (1992)
   PUBMED   1730632
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Bana,J. and Kralik,J.
  TITLE     [1st experiences with complex analysis of urinary calculi]
  JOURNAL   Rozhl Chir 57 (12), 813-820 (1978)
   PUBMED   734536
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Bem,Z. and Birecka,A.
  TITLE     [A rare type of bone involvement in scleroderma (author's transl)]
  JOURNAL   Pol Przegl Radiol Med Nukl 42 (2), 115-117 (1978)
   PUBMED   704385
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D30647.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012891.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30647.1, BC087036.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2115              D30647.1           3-2117
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2115
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="acyl-CoA dehydrogenase, very long chain"
                     /db_xref="GeneID:25363"
                     /db_xref="RGD:2014"
     exon            1..81
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1987
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /EC_number="1.3.8.9"
                     /note="very long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; Very long chain Acyl-Coa dehydrogenase;
                     VLCAD very-long-chain acyl-CoA dehydrogenase;
                     acyl-Coenzyme A dehydrogenase, very long chain"
                     /codon_start=1
                     /product="very long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_037023.1"
                     /db_xref="GeneID:25363"
                     /db_xref="RGD:2014"
                     /translation="

MQSARMTPSVGRQLLRLGARSSRSAALQGQPRPTSAQRLYASEATQAVLEKPETLSSDASTREKPARAESKSFAVGMFKGQLTTDQVFPYPSVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAVPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDILRLFVALQGCMDKGKELTGLGNALKNPLGNVGLLIGEASKQLRRRTGIGSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQSNPQQQELFRNFRSISKAMVENGGLVTSNPLRV"

     misc_feature    20..229
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="propagated from UniProtKB/Swiss-Prot (P45953.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     transit_peptide 20..139
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="Mitochondrion; propagated from UniProtKB/Swiss-Prot
                     (P45953.1)"
     mat_peptide     140..1984
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /product="Very long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial. /id=PRO_0000000518"
                     /note="propagated from UniProtKB/Swiss-Prot (P45953.1)"
     misc_feature    140..1465
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="propagated from UniProtKB/Swiss-Prot (P45953.1);
                     Region: Catalytic. /evidence=ECO:0000250|UniProtKB:P49748"
     misc_feature    170..172
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    230..232
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    233..1462
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="Very long chain acyl-CoA dehydrogenase; Region:
                     VLCAD; cd01161"
                     /db_xref="CDD:173850"
     misc_feature    398..400
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    order(659..661,665..670,683..688,764..766,770..772,
                     1388..1390,1409..1411,1415..1417)
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="FAD binding site [chemical binding]; other site"
                     /db_xref="CDD:173850"
     misc_feature    order(686..688,1007..1009,1028..1033,1040..1042,
                     1400..1405)
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="substrate binding pocket [chemical binding]; other
                     site"
                     /db_xref="CDD:173850"
     misc_feature    734..736
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P49748; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    845..847
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    851..853
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    911..913
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    965..967
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    1010..1012
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P49748; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    1403..1405
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173850"
     misc_feature    1463..1465
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    1466..1567
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="propagated from UniProtKB/Swiss-Prot (P45953.1);
                     Region: Membrane-anchoring.
                     /evidence=ECO:0000250|UniProtKB:P49748"
     misc_feature    1568..1570
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49748; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); phosphorylation site"
     misc_feature    1583..1585
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49748; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); phosphorylation site"
     misc_feature    1667..1669
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     misc_feature    1685..1687
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P50544; propagated from
                     UniProtKB/Swiss-Prot (P45953.1); acetylation site"
     exon            82..157
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            158..223
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            224..296
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            297..361
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            362..496
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            497..641
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            642..771
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            772..897
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1096
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1201
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1288
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1351
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1453
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1551
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1624
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1697
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1770
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1846
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2102
                     /gene="Acadvl"
                     /gene_synonym="VLCAD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ttccgcggcggctttggagatgcagtcggcccggatgaccccgagtgtggggcgacaactgctgcggctgggggcccgaagctcgcggtctgctgcgcttcagggacaaccccggcctacctctgcccagcgactttatgccagtgaggccactcaggcagttctggaaaagccagagaccctctcctctgatgcttccaccagagaaaaacctgccagggcggaatctaagtcttttgctgtgggaatgttcaaaggccagcttaccaccgaccaggtgttcccatacccatctgtgctcaatgaaggacagacacaatttctcaaagagctggtgggaccagtggcccggttctttgaagaagtgaatgaccctgccaagaatgactccttggagaaggtggaggaggacactttgcagggactcaaagaactgggggcatttggtctgcaagtacccagcgagctgggtggtttgggcctctctaatacccagtacgctcgcttggcagagattgtgggcatgcatgaccttggtgttagcgttaccctgggagcccatcagagcatcggtttcaaaggcatcttgctctatggcacaaaggcccagaaggaaaaatacctccccagagtggcatccgggcaggctttggcggctttctgcctgactgagccctcgagcgggtccgatgtggcctctatccgaagctcagctgtacctagcccctgtggaaagtattatactctcaacggaagcaagatctggatcagtaatgggggtctggcagacattttcactgtctttgccaaaacgccaattaaagatgcagccacgggggccgtgaaagagaagatcacagctttcgtagtggaacggagctttggaggggttacccatgggctccccgaaaagaagatgggcatcaaggcatctaacacatcagaggtgtactttgatggagtcaaggtgccagcagagaatgtgctaggagaagtgggagatggcttcaaggttgctgtcaacatcctcaacaacggaagatttgggatggctgcaaccctagcaggcaccatgaaagccatcattgccaaggcggttgatcatgctactaaccgtacccagtttggggacaaaattcacaactttggggtgatccaggaaaagctggctcggatggctattctgcagtatgtgactgagtccatggcttacatgctgagtgccaacatggaccagggattcaaagacttccagatagaagctgccatcagcaaaatctttggctcggaggcggcctggaaagtgacagatgagtgcatccagataatggggggcatgggcttcatgaaggaaccaggggtagagcgtgtgctccgagatattcgaatcttccggatctttgaagggacaaatgacattcttcgactgtttgtggctctacaaggctgcatggacaaaggaaaggaactcacgggacttggtaatgccctaaagaatcctcttggaaatgttggcctcctcataggagaagcaagcaaacagctgaggcggcggacagggattggcagtggtctgagtctctcgggaattgtccacccagagttgagtcgcagtggtgaactggcagtgcaggctctggaacaatttgccactgtagtggaggcgaagctgatgaagcacaagaaagggattgtcaatgaacagttcctgctgcagcgactggcagatggagccattgacctctacgccatggtggtggttctctccagagcctcaagatccctgagtgagggctacccgacagcacagcatgagaaaatgctctgtgatagttggtgcattgaggctgcaacacggattcgagaaaacatggccagccttcagtccaaccctcagcagcaggagctctttcgtaacttcagaagtatctccaaggccatggtggagaatggtggcctggtcaccagtaacccccttagagtctgaagactcctaatcaggccctagcacagtcgtgtgccttcttctatgccaaacacaggcccccttcatgggggcactggagtacttactgccttaaggacaataaattttctaccaaaaaaaaaaaaaaa

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