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Previous release (v1)
2025-09-13 15:29:41, GGRNA.v2 : RefSeq release 231 (Jul, 2025)
LOCUS NM_001439454 3335 bp mRNA linear ROD 15-MAY-2025
DEFINITION Rattus norvegicus protein kinase cAMP-dependent type I regulatory
subunit alpha (Prkar1a), transcript variant 2, mRNA.
ACCESSION NM_001439454
VERSION NM_001439454.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3335)
AUTHORS Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
Chung,K.H., Eddy,E.M. and Cho,C.
TITLE SPATC1L maintains the integrity of the sperm head-tail junction
JOURNAL EMBO Rep 19 (9) (2018)
PUBMED 30026308
REFERENCE 2 (bases 1 to 3335)
AUTHORS Gilbert,M.L., Yang,L., Su,T. and McKnight,G.S.
TITLE Expression of a dominant negative PKA mutation in the kidney
elicits a diabetes insipidus phenotype
JOURNAL Am J Physiol Renal Physiol 308 (6), F627-F638 (2015)
PUBMED 25587115
REMARK GeneRIF: role for PKA signaling in both short- and long-term
regulation of AQP2, characterizing a novel mouse model of diabetes
insipidus
REFERENCE 3 (bases 1 to 3335)
AUTHORS Burgers,P.P., van der Heyden,M.A., Kok,B., Heck,A.J. and
Scholten,A.
TITLE A systematic evaluation of protein kinase A-A-kinase anchoring
protein interaction motifs
JOURNAL Biochemistry 54 (1), 11-21 (2015)
PUBMED 25097019
REFERENCE 4 (bases 1 to 3335)
AUTHORS Nishimura,T., Fujii,W., Sugiura,K. and Naito,K.
TITLE Cytoplasmic anchoring of cAMP-dependent protein kinase (PKA) by
A-kinase anchor proteins (AKAPs) is required for meiotic arrest of
porcine full-grown and growing oocytes
JOURNAL Biol Reprod 90 (3), 58 (2014)
PUBMED 24501172
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3335)
AUTHORS Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
TITLE Proteomic screening of glutamatergic mouse brain synaptosomes
isolated by fluorescence activated sorting
JOURNAL EMBO J 33 (2), 157-170 (2014)
PUBMED 24413018
REFERENCE 6 (bases 1 to 3335)
AUTHORS Lazar,S., Galiani,D. and Dekel,N.
TITLE cAMP-Dependent PKA negatively regulates polyadenylation of c-mos
mRNA in rat oocytes
JOURNAL Mol Endocrinol 16 (2), 331-341 (2002)
PUBMED 11818504
REMARK GeneRIF: cAMP-Dependent PKA negatively regulates polyadenylation of
c-mos mRNA in rat oocytes
REFERENCE 7 (bases 1 to 3335)
AUTHORS Kirschner,L.S., Carney,J.A., Pack,S.D., Taymans,S.E., Giatzakis,C.,
Cho,Y.S., Cho-Chung,Y.S. and Stratakis,C.A.
TITLE Mutations of the gene encoding the protein kinase A type I-alpha
regulatory subunit in patients with the Carney complex
JOURNAL Nat Genet 26 (1), 89-92 (2000)
PUBMED 10973256
REFERENCE 8 (bases 1 to 3335)
AUTHORS Imaizumi-Scherrer,T., Faust,D.M., Benichou,J.C., Hellio,R. and
Weiss,M.C.
TITLE Accumulation in fetal muscle and localization to the neuromuscular
junction of cAMP-dependent protein kinase A regulatory and
catalytic subunits RI alpha and C alpha
JOURNAL J Cell Biol 134 (5), 1241-1254 (1996)
PUBMED 8794865
REFERENCE 9 (bases 1 to 3335)
AUTHORS Greene,R.M., Lloyd,M.R., Uberti,M., Nugent,P. and Pisano,M.M.
TITLE Patterns of cyclic AMP-dependent protein kinase gene expression
during ontogeny of the murine palate
JOURNAL J Cell Physiol 163 (3), 431-440 (1995)
PUBMED 7775586
REFERENCE 10 (bases 1 to 3335)
AUTHORS Kuno,T., Ono,Y., Hirai,M., Hashimoto,S., Shuntoh,H. and Tanaka,C.
TITLE Molecular cloning and cDNA structure of the regulatory subunit of
type I cAMP-dependent protein kinase from rat brain
JOURNAL Biochem Biophys Res Commun 146 (2), 878-883 (1987)
PUBMED 3619906
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000010.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR23984936.554193.1,
SRR26360186.2810821.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760386
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on expression
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-123 JAXUCZ010000010.1 95120924-95121046
124-306 JAXUCZ010000010.1 95123812-95123994
307-477 JAXUCZ010000010.1 95129397-95129567
478-569 JAXUCZ010000010.1 95130302-95130393
570-631 JAXUCZ010000010.1 95130563-95130624
632-678 JAXUCZ010000010.1 95131564-95131610
679-837 JAXUCZ010000010.1 95132272-95132430
838-898 JAXUCZ010000010.1 95134126-95134186
899-1020 JAXUCZ010000010.1 95135161-95135282
1021-1102 JAXUCZ010000010.1 95136017-95136098
1103-3335 JAXUCZ010000010.1 95136800-95139032
FEATURES Location/Qualifiers
source 1..3335
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="10"
/map="10q32.1"
gene 1..3335
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="protein kinase cAMP-dependent type I regulatory
subunit alpha"
/db_xref="GeneID:25725"
/db_xref="RGD:3391"
exon 1..123
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 124..306
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
CDS 130..1275
/gene="Prkar1a"
/gene_synonym="RIIA"
/EC_number="2.7.11.1"
/note="protein kinase cAMP-dependent type 1 regulatory
subunit alpha; protein kinase, cAMP-dependent, regulatory,
type I, alpha; protein kinase, cAMP-dependent, regulatory
subunit type I alpha"
/codon_start=1
/product="cAMP-dependent protein kinase type I-alpha
regulatory subunit"
/protein_id="NP_001426383.1"
/db_xref="GeneID:25725"
/db_xref="RGD:3391"
/translation="
MASGSMAASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEARQIQSLQKSGIRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV"
misc_feature 130..132
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="N-acetylmethionine.
/evidence=ECO:0000250|UniProtKB:P10644; propagated from
UniProtKB/Swiss-Prot (P09456.2); acetylation site"
misc_feature 133..537
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="propagated from UniProtKB/Swiss-Prot (P09456.2);
Region: Dimerization and phosphorylation"
misc_feature 133..135
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="N-acetylalanine, in cAMP-dependent protein kinase
type I-alpha regulatory subunit, N-terminally processed.
/evidence=ECO:0000250|UniProtKB:P00514; propagated from
UniProtKB/Swiss-Prot (P09456.2); acetylation site"
misc_feature 136..138
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
misc_feature 322..417
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="propagated from UniProtKB/Swiss-Prot (P09456.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 352..354
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P10644; propagated from
UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
misc_feature 358..360
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P10644; propagated from
UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
misc_feature 376..378
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
misc_feature 415..429
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="propagated from UniProtKB/Swiss-Prot (P09456.2);
Region: Pseudophosphorylation motif"
misc_feature 430..432
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9DBC7; propagated from
UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
misc_feature 901..903
/gene="Prkar1a"
/gene_synonym="RIIA"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P09456.2); phosphorylation site"
exon 307..477
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 478..569
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 570..631
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 632..678
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 679..837
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 838..898
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 899..1020
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 1021..1102
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
exon 1103..3335
/gene="Prkar1a"
/gene_synonym="RIIA"
/inference="alignment:Splign:2.1.0"
ORIGIN
ggagccgtcgcggacccgctatcgcagactggagtgaggctgcgagctgagccctctggacgctcggtacccccggcagcctcgccctgcgctactcaggcccgcgccgccgcccgtcctcagagaaccatggcgtctggcagtatggcagccagtgaggaagagcggagtctccgggaatgcgagctctatgtgcagaagcacaacatccaggccctgctgaaggactccatcgtgcagctgtgcactgctcggcccgagaggcccatggcattccttcgggaatactttgagaggctggagaaggaggaggcaagacagattcagagcctacagaaatccggcattcgtacagactcgagggaggatgagatctctcctccacccccaaatccggtggtgaagggccgtcggcgccgcggtgctatcagcgctgaggtttacactgaggaagatgctgcgtcctacgttagaaaggttataccaaaagattataagacaatggctgctttagccaaggccatcgaaaagaacgtgttattttcacaccttgatgacaatgagagaagtgacatttttgatgcaatgtttccagtctcctttattgctggagagacagttattcagcaaggggatgaaggggataacttctatgtgattgatcaaggagaaatggatgtgtatgtcaataatgaatgggcaaccagtgttggggaaggagggagctttggagagctggctttgatttacggaacacccagagcagccactgtcaaagcaaagacaaacgtgaaactgtggggcattgaccgagacagctaccggagaatcctcatgggaagcactctgcgaaagaggaagatgtatgaagaatttcttagtaaagtgtctattttagagtctctggacaagtgggagcgtctcacagtagctgatgcactggagcctgtccagtttgaagatggacagaagattgtggtgcaaggagaaccgggggatgagttcttcattattttagagggcacggccgctgtgctgcagcgtcggtcagaaaacgaagagtttgttgaagtgggacgcctggggccttctgactattttggtgaaattgccctgctgatgaatcgtcctcgggctgccactgtggttgcgcgtggccctttgaagtgcgttaagttggaccgacctcggtttgaacgcgtccttggcccatgctcagatatcctcaagcgaaacatccagcagtacaacagctttgtgtcactgtccgtctgagatccgcctcctgtgcctctcctccccagtctatgcttcactcacgcagactgctttctcctccctctctgcagcgccaagtggccactggcttcacagcttcttgtctctgtatactaaaggttgctttattgcaccattttccattggagcgttactgaatgctcactcacaaataaatagagttgtatggactcggctgtcaccgcttctctgtgcagtgctagtgttcaacctgggcagccagtgccgtgctttctgctgagggcggtccctgcaccatgaattaccataatgatgtaataacagtgcgggggttttaagtgacatggatttccatttccatatgacacaagtgacatatttagactgtggccatgtttgctgtatttctttatagaataaatgactttaacctttaaggaatagaagaatgaatatagaaaaatcctagcacagtagaaagactcctgcctgtaattaaagtagcttaagtgtgggaagtgcccatgttttgctaattaccagacacattcaactagttcagtcccctctcagcctggtttggtttgtctgtggctagtgtttcttctccaactctgaaatactttggtgtggctggctgtctatacctgcctttaagttgaaatcaagccgtagatggcaagtactgggtggtgacctaaccacgcctgtcagagctcacaggttctgataactttaccctgctggtgccaaatgctgaagaggtgcaggatagtgagggcgggggcgtcactcgggagttaactgcgtaactgtgtgatcggccctcacgccctcactgagggttctcggacgttggagttacttagacaacaggctccagagagaagggaatggaggcagtgttgctaaggcggatggagtgtaggtgtccagaaacaggaagctgtgtgtctgggtttatgttaccaggtgggtagggcgtggctgtgctgtggtctgataggccatcctgctgagagtcctgccttttcctgtctaaccttgaatttctctggtaaactttctttattgttttttgtttgtttgtgtgtgtgtgtgtttaaagtaaacttgtgttctcaactgtatttcagtattttccacccttatgtgttacattattccaatgataacccaacagtttatttttattactgttattttttaaacaaaattcacagttcgtaactaggcatgtttatcttgtgacttatgtacaatgtcgggttctatttgggagtgactgtgttttccatgggtgtgcaagtgggcctgattaataatcccctccctcctttcccagttaacttaaattgttgggtacggtagattttttttttttcttggtagcttaaaaagctgttagattgttactaacttgggaaaaagtttcatttaggttttagtgtggggtagaaagctgccttgttgccatatctaaaacttccataatctatattaaatgagggtttctgtacttcctttgtggttggctatcttttttatatttaaaaaaataaaaattatgttactagcttaaagcttaatttgatatttgtttaaatgccaaaacaatgtacttaagtgaatgatgtagcacgccgtaaaatgcatttcatgtgtgtggatccccttggtctgtacggagggagatacacgccccgctttctaagtgtcccacgcaatgctagctcgctatgcactcccttttgtagttttacttagagttttcaagataagtctaaatttaaaaattaccacgtttaaagctctatctttgtgcaatttaaatcagtcagaagtcatggttggcatactgtgtccttgtggactctaggcaccggtgtccctggatgggtgggtgaatttaggagatctgctgagaaagtggagctggccaaagggacagttgctgtttcctggacactagtctgatacactctgtgctaatctaatcgctgttcttttgttacacactgttccatggtaggtcacagaataaaaagatgaaatcatttaaattcttaaatgaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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