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Previous release (v1)
2024-11-01 12:44:37, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001427454 7570 bp mRNA linear ROD 24-JUN-2024
DEFINITION Rattus norvegicus LDL receptor related protein 8 (Lrp8), mRNA.
ACCESSION NM_001427454 XM_039111151
VERSION NM_001427454.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 7570)
AUTHORS Tavazoie,M.F., Pollack,I., Tanqueco,R., Ostendorf,B.N., Reis,B.S.,
Gonsalves,F.C., Kurth,I., Andreu-Agullo,C., Derbyshire,M.L.,
Posada,J., Takeda,S., Tafreshian,K.N., Rowinsky,E., Szarek,M.,
Waltzman,R.J., Mcmillan,E.A., Zhao,C., Mita,M., Mita,A.,
Chmielowski,B., Postow,M.A., Ribas,A., Mucida,D. and Tavazoie,S.F.
TITLE LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer
JOURNAL Cell 172 (4), 825-840 (2018)
PUBMED 29336888
REFERENCE 2 (bases 1 to 7570)
AUTHORS Ampuero,E., Jury,N., Hartel,S., Marzolo,M.P. and van Zundert,B.
TITLE Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates
Dendritogenesis of Mature Hippocampal Neurons
JOURNAL J Cell Physiol 232 (5), 1187-1199 (2017)
PUBMED 27653801
REMARK GeneRIF: These results indicate that reelin/ApoER2/PSD95 signaling
is important for neuronal structure maintenance in mature neurons.
REFERENCE 3 (bases 1 to 7570)
AUTHORS Burrell,T.C., Divekar,S.D., Weeber,E.J. and Rebeck,G.W.
TITLE Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels
and phosphorylation
JOURNAL PLoS One 9 (10), e110845 (2014)
PUBMED 25340851
REMARK GeneRIF: total levels of ApoER2 and surface levels of ApoER2 are
increased by active Fyn
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 7570)
AUTHORS Larios,J.A., Jausoro,I., Benitez,M.L., Bronfman,F.C. and
Marzolo,M.P.
TITLE Neurotrophins regulate ApoER2 proteolysis through activation of the
Trk signaling pathway
JOURNAL BMC Neurosci 15, 108 (2014)
PUBMED 25233900
REMARK GeneRIF: Results highlight a novel relationship between
neurotrophins and the reelin-ApoER2 system, suggesting that these
two pathways might be linked to regulate brain development,
neuronal survival, and some pathological conditions
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 7570)
AUTHORS Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
TITLE Structural basis for endosomal trafficking of diverse transmembrane
cargos by PX-FERM proteins
JOURNAL Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
PUBMED 23382219
REFERENCE 6 (bases 1 to 7570)
AUTHORS Posse De Chaves,E.I., Vance,D.E., Campenot,R.B., Kiss,R.S. and
Vance,J.E.
TITLE Uptake of lipoproteins for axonal growth of sympathetic neurons
JOURNAL J Biol Chem 275 (26), 19883-19890 (2000)
PUBMED 10867025
REFERENCE 7 (bases 1 to 7570)
AUTHORS D'Arcangelo,G., Homayouni,R., Keshvara,L., Rice,D.S., Sheldon,M.
and Curran,T.
TITLE Reelin is a ligand for lipoprotein receptors
JOURNAL Neuron 24 (2), 471-479 (1999)
PUBMED 10571240
REFERENCE 8 (bases 1 to 7570)
AUTHORS Stockinger,W., Hengstschlager-Ottnad,E., Novak,S., Matus,A.,
Huttinger,M., Bauer,J., Lassmann,H., Schneider,W.J. and Nimpf,J.
TITLE The low density lipoprotein receptor gene family. Differential
expression of two alpha2-macroglobulin receptors in the brain
JOURNAL J Biol Chem 273 (48), 32213-32221 (1998)
PUBMED 9822699
REFERENCE 9 (bases 1 to 7570)
AUTHORS Kim,D.H., Iijima,H., Goto,K., Sakai,J., Ishii,H., Kim,H.J.,
Suzuki,H., Kondo,H., Saeki,S. and Yamamoto,T.
TITLE Human apolipoprotein E receptor 2. A novel lipoprotein receptor of
the low density lipoprotein receptor family predominantly expressed
in brain
JOURNAL J Biol Chem 271 (14), 8373-8380 (1996)
PUBMED 8626535
REFERENCE 10 (bases 1 to 7570)
AUTHORS Kinoshita,M., Teramoto,T., Kato,H., Hashimoto,Y., Naito,C., Toda,G.
and Oka,H.
TITLE Partial purification of the apolipoprotein E receptor of rat liver
membrane
JOURNAL J Biochem 97 (6), 1803-1806 (1985)
PUBMED 2993274
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000005.1.
On Jan 25, 2024 this sequence version replaced XM_039111151.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMEA5760383,
SAMEA5760389 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
inferred exon combination :: based on alignments, homology
RefSeq Select criteria :: based on expression
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-239 JAXUCZ010000005.1 127792299-127792537
240-359 JAXUCZ010000005.1 127793252-127793371
360-482 JAXUCZ010000005.1 127823399-127823521
483-611 JAXUCZ010000005.1 127831053-127831181
612-992 JAXUCZ010000005.1 127833935-127834315
993-1115 JAXUCZ010000005.1 127835149-127835271
1116-1154 JAXUCZ010000005.1 127837835-127837873
1155-1274 JAXUCZ010000005.1 127839052-127839171
1275-1400 JAXUCZ010000005.1 127839244-127839369
1401-1575 JAXUCZ010000005.1 127842062-127842236
1576-1803 JAXUCZ010000005.1 127843918-127844145
1804-1922 JAXUCZ010000005.1 127845143-127845261
1923-2062 JAXUCZ010000005.1 127845488-127845627
2063-2204 JAXUCZ010000005.1 127847010-127847151
2205-2357 JAXUCZ010000005.1 127848052-127848204
2358-2582 JAXUCZ010000005.1 127849220-127849444
2583-2651 JAXUCZ010000005.1 127851939-127852007
2652-2824 JAXUCZ010000005.1 127856259-127856431
2825-3001 JAXUCZ010000005.1 127857354-127857530
3002-7570 JAXUCZ010000005.1 127859639-127864207
FEATURES Location/Qualifiers
source 1..7570
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q34"
gene 1..7570
/gene="Lrp8"
/note="LDL receptor related protein 8"
/db_xref="GeneID:362558"
/db_xref="RGD:1305729"
exon 1..239
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
CDS 125..3040
/gene="Lrp8"
/note="low-density lipoprotein receptor-related protein 8;
low density lipoprotein receptor-related protein 8,
apolipoprotein e receptor"
/codon_start=1
/product="low-density lipoprotein receptor-related protein
8 precursor"
/protein_id="NP_001414383.1"
/db_xref="GeneID:362558"
/db_xref="RGD:1305729"
/translation="
MGRPERGALRPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDEDDCPKRTCTDSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQVAPIFQGNRRRPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSPSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISSYDRPLWAEPCLGETRDLEDPAPAHKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP"
sig_peptide 125..217
/gene="Lrp8"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
exon 240..359
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 360..482
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 483..611
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 612..992
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 993..1115
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1116..1154
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1155..1274
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1275..1400
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1401..1575
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1576..1803
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1804..1922
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 1923..2062
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 2063..2204
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 2205..2357
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 2358..2582
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 2583..2651
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 2652..2824
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 2825..3001
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
exon 3002..7570
/gene="Lrp8"
/inference="alignment:Splign:2.1.0"
ORIGIN
ggcagcggtggtggtggcggcggcggcagcggcagccccggcgccgcggcaaggacttggcgggctgaggcgcggcggcggcgcgggggtctcggggcgcggcggccggagccccgggcccgccatgggccgcccagagcggggcgcgctccggccgctggcgttgttgctgttgctgctgctgctgctgctacagcttcagcatctttccacagcggatccgctgcctggcggccaagggccggtcaaggaatgtgaagaggaccagtttcggtgtcggaacgagcgttgtatcccctcggtgtggagatgcgatgaagacaacgactgctcggacaacagcgacgaggacgactgccccaagaggacctgcacagacagcgactttacctgtgataatggccactgcatcccggagcggtggaagtgtgacggcgaggaggagtgtcctgatggatctgatgaatcgaaggccacgtgttccagtgaagaatgtcctgccgagaagctaagctgcggacccaccagccacaagtgtgtgcctgcctcatggcgctgtgacggggagaaggactgtgagggtggagcagacgaggccggctgtcctaccttgtgcgccccgcacgagttccagtgcagcaaccgctcctgcctggcctctgtgttcgtgtgcgatggtgacgatgactgcggcgacggcagcgacgagcgaggctgctcggacccggcctgcccgccccgcgagttccgctgtggaggaggcggcacctgcatccctgagcgctgggtctgcgacggccagttcgactgcgaggaccgctcggatgaggccgctgagctctgcgggcgagcgggccaggggaccacggccacgccagcagcctgcgcccctaccacccagttcacctgccgcagcggcgagtgcatacacctgggctggcgctgcgatggcgaccgcgactgcaaggacaagtctgacgaggccgactgctcaccaggaccctgccgtgagaatgacttccagtgtggggatgggacttgcattcttgcaatcaaacggtgcaaccaggagcgggactgcctggacgggagtgatgaagccggctgcctgcaggttgcaccaatattccagggaaacaggaggaggcccagggggctgaacgagtgtctgcacaacaatggtggctgctcccacatctgcactgacctcaagatcggctttgagtgtacatgcccagcaggcttccagctcttggaccaaaagacctgtggtgacattgacgaatgccaggacccagatgcctgcagccaaatctgtgtgaattacaagggctactttaagtgtgaatgccaccccggctatgagatggatacgctgaccaagaactgtaaagctgtagctggcaggagcccatccctaatcttcacgaaccgacacgaagtacggcgaatagacctggtgaagcgggactactcacgcctcatccccatgctcaagaatgtcgtggcgctggacgtggaagtggataccaatcgaatatattggtgtgacctttcctaccgcaagatctacagcgcccacatggacaaggccagtatcccggacgagcaggtggtcctcattggtgagcagctgcactctccagagggcctggcggtggactgggtccataagcacatctactggacagactcaggcaataagaccgtctcagtcgccacaaccgatggacgccgccgctgtactctcttcaaccgtgatctcagcgagccccgagccattgctgtcgaccccctgcgagggttcatgtactggtctgactggggtttccaggcaaagattgagaaggctgggctcaatggtgcagaccggcaaacactggtttcagacaacatcgagtggcccaacggaatcaccctggacttgctgagccagcgtttgtactgggtggactccaagctgcaccagctatccagcatcgacttcaatggaggcaacagaaagatgctgattttctccactgacttcctgagtcacccttttggggtagctgtatttgaggacaaggtattctggacggatctggagaatgaggccattttcagcgcaaatcggctcaatggcctggagatctccatcctggctgagaaccttaataacccacatgacattgtaatcttccatgagctgaagcagccaaaggctgcagatgcctgtgagctgagtgcccagcccaatggcggctgtgaatacctgtgccttcctgctcctcagatctccagccactctcccaagtacacctgtgcctgtcctgacacaatgtggctgggcccagacatgaagagatgctaccgagcacctccgtctacctcaactacaaccttagcctctgctatgacaaggacagtacctgctactacgggagcccctgggacaaccatccacgactctacctaccagaaccacagcacagagatgccaagccagacagctgccgtccctcactcagtgaacatccctaaggctcacagcaccagcccgtccaccctgagccctgcaaccagcaaccactcccagcactatgggaatgaaggcagccagatgggttcaacagtcaccgctgctgtcattgggatcatcgtgcccatagtggtaatagccctgctgtgtatgagtgggtacctcatctggagaaactggaagcggaagaataccaagagcatgaatttcgacaacccagtgtacaggaagacaacagaagaggaagaggaagatgaacttcacatagggaggacggctcagattggccatgtctaccccgcagcaatcagcagctatgatcgcccactgtgggcagagccctgtcttggggagaccagagacctggaagacccagcccctgcccacaaggagctttttgtcttgccgggagaaccaaggtcacagctgcaccaactcccgaagaaccctctttccgagctgcctgtcgtcaagtgcaagcgagtggcattaagtcttgaagatgacggactgccctgaggatgggcccgcccacttcgtgcctcatggagttcagtcctatgcactactctctctggatggtgtgtgattggatgaatgccatttctatatatgggtctgtgtgagcgtgtgtgagtgcgtgtaactttttttaaatttatgttgcggaaaggtaaccacaaagttatgatgaactgcagacatccaaaggatgtgaacgtttttatatgtataatgttttatacactttttaactggttgcactacccgtgaagaattcatgggacagccactgctgagtgactaacatgatgcacataaccaaacggggccaatggtacaaactttactcatcatttgaatacagtatttacagaggatgtttgatttgagagcttttttaggtttgaggagcttggtttttttttttttttttgtaaataaaattatgctttgtggctatccatcaacataagtataaaaagaaagaacacttcaactcctttccccatctagattatttattaacatatttcaaaagtaaggttagctctataaataatttagagaagcgagagtatttatttttggtatgattggcccactgcacagactctgtgtttatgtgtgtgtgtttgtgtgagagaaaaaaacctgtagggaagaggcgcgctatgactattgctcacatacatacaaacagttattttaaaatggtccacaagaggggtgtctagttttcagagacaccttcagaaactttgctcagagaacacagatgccatggtttgtgcagagatgtggtgggaaaggtagatcttttcacctatggctactcctgaggtcctgacaagccagcacaaagcttttcagttcctctgaggctgtcatgatgcccacctaggctttctggtcagtgtgcagatactgcacgggggttacaagccctcatgagctcaagacagcagagtccttccttcaaaattcagcttagtgagggctcgggtcagcttcagtaagcttcctctgaagcacctgaaggtcgggcctttagagcagctgttctcaacctttgtaggtcaaaaagaccctttcacaagggtcacttaaggcatcggaaaacacagattcttacattatggtccataacagtagcaaaattacagttatgaagtagaaatgaagtgatgttatggttgggtcagtacaacatggactgtattaaagcttctgaggcgttaggaaggctgagaacccctactctagagctaagtgaaggcatttctaggatttccaagtttactgtaagaacaggctcaggcactgaagctctgagtcgcgtgaatgaggacgacaattttggaataggtttggttacacctatttctcatccccttactttctaccatttttcttacgtaggggaaacattttaagaaaatacacatttcttacgaccgtatgttcacatggataagactaagtccaaaagtgtgaatacgtccaaatttatattttggggaaataccatgagatattatagcatatcgggcatgtttcattgctttataaataaaaggagaaactctaggtgtttgtatagaattttcttcatatgtaacacctttacattttctgagccttggggatggggtgggagaaatgccatttttctgtctgtggaatcctctattggaaatgtaatcccatagtcccagaaggaattcagtccccactagctctctctgttctataatccactccagctgaatgaccaggacaactatgacacttctgtgtttggcttaagtggtggcagactaatgtctaaatttggcacaactggaatttgacatttgagacatatgtttccgtgttcccacatgacagcttcccccaaaccggtgaagctcgaatggctcacctgcttgacgccctttcgacttccaggcaggccatctggaggcctgtcctcctcttcccaggagcttgctctgtgtcactcatgttgtcctaacctttaaaaaatggctgtgttccaagcttggccattatgtctggcgacttctttttggatgcgtgtgttgatggtcttgagatattaattgaataaatgcggctggcccctgactccattccagtctcaagaacaggtagcccaactcctctggagctcacccatctctgttcatccagggatgaaaaggaaaatcagttcttactgaaaataaggtggaagtgaaagcatcaaaatttatacaaggcaggcattgtctttttctttttttctttaatctgccttcaaggaaaccgagaccgtgatagttagtgcatagtttctgaacttttagtcagatcctagccttcacaacagggttgaaacataccatctagggtttccaaaaggtgattaataagattaaattattatcaaaataccatgtttcctgaatgcgcgacagctgcagtctgaaagtaacctacagtaaacagacggacaaatccaggggcggctggagagcggaagcactctgaggaggcagacccacttcctcctatcctcggagacttttcgagccgcagtctgggtttaattcagatcttctgttgcccttctcctctgcatgtgtatccacagctggtaacatccagaagaaagcttagtgataaaccaagagggcagaaagttcagctaactacttatgaaaacgaagcgaaccctctcttctctggaagagaactttgggcggcctgagcaaggtctcaagcctgcttcctctcccacagctctctgccctgtgggttgatgaaggcactaacagagatgaccttcccgaaacatcagactataactttgtttactcttcagcatgtgtgtacacggagagggacagactgagatggcttctgactcaaggagtaagaagaatgagaggggatttaaatggatggcagtgaatcctgttgagcccttcagttattctcatgtctttgcaacatactctctaaaacgattcactagctgctgtgtgcccggcattgcaaacatcacaggtgcattcaacgtttttcaccctttcagaactcacagcagtacatgtggatacaagaaaagaaagtaaatttcccatagatttcacttagactactcccagggcagagagagagagagagagagagagagagagagagagagagagagaccattttacctgaagaggtgaaaaaattcggtctacatagaagtgccccaaagccaagtcttaaacattaaaaagtggtgttcaggctgcttctgtgagaagagagattgggctaagactgaggagtgaatcggcaacaggacttttaaggaaaacatggattcattacacctggaataaagaactttaagaggtttggcaagatgtgaaactggatggaagaaaatttcaacataggcactttataaaataatgtctgatctaagtaagtggacatttctttggtcagttcctgtgtgcaaggcatcatgggaaactcactgccagcactttgcaggcatccacctcaagctgtccggtggccacggggagatgacgttatttacttattcgagtcagagattttgatgtggttagtgagaacagacaggcagtgggattttgaactgaagcatgccatgttgccgagcagcacctttgagatgttctcgcctgtgaggaagagaagatgataaagagacagaatctggagagggcaccccaatcacactacagtcaggtgctaccgggtggaggagaaaccattctaaccccacagcactacaagactcctatcccaccacgcattcaccatttcacgaaacggcagtaagtcagcagtttcaaattatgtgatttccttccccataaatgcatgcagatagggagtcggtctccgtacactatatttttagggtgtttgggagtttccaggatgtgaagaatttagaaggcggaggattcagggcctcagattctcagctaactagataaagcttcagtcaggctgggcaccatgtgcacagtcttaagaatcagcaggaaatgcatttgcaaaacacatgctgtaaaaaattaattttaaaaaagctacctgtataaatatatatatttaaaagcaaggttttgatacttttttttacaaaaactacaagagaagactgtacaacccacaggcttttaaaatagcattttgttctctataagctgttaatatgaggggtaaggtactggtttgcaaactcacacaatccaatggattttcttgtttgtcaccccgctctccaaattaccataattggtgtaatagtagggcatgtaaagttattgggtcacataaaccatttctgctcttgtcatcctgggttccgttagctcctgtactcaggaatctagcttcttccagaggcagagggaccgaagcaagtgtgctccatttcactcgctgtactgacatcatccaaatgtggacatttgtaaaatcagcacactatttctatagagacattaaattcattttttaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]