2024-04-29 04:40:04, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001399249 2649 bp mRNA linear ROD 02-OCT-2023 DEFINITION Rattus norvegicus methyltransferase 14, N6-adenosine-methyltransferase subunit (Mettl14), mRNA. ACCESSION NM_001399249 XM_006233266 VERSION NM_001399249.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2649) AUTHORS Li Y, Li J, Yu Q, Ji L and Peng B. TITLE METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis JOURNAL Neurobiol Dis 185, 106253 (2023) PUBMED 37541353 REMARK GeneRIF: METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis. REFERENCE 2 (bases 1 to 2649) AUTHORS Wang C, Zhu X, Chen R, Zhang X and Lian N. TITLE Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury JOURNAL eNeuro 10 (6) (2023) PUBMED 37094938 REMARK GeneRIF: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury. Publication Status: Online-Only REFERENCE 3 (bases 1 to 2649) AUTHORS Li X, Xu X, Zhang Q, Ling M, Li X and Tan X. TITLE METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis JOURNAL Am J Physiol Cell Physiol 324 (5), C1089-C1100 (2023) PUBMED 36878846 REMARK GeneRIF: METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis. REFERENCE 4 (bases 1 to 2649) AUTHORS Meng L, Lin H, Huang X, Weng J, Peng F and Wu S. TITLE METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA JOURNAL Cell Death Dis 13 (1), 38 (2022) PUBMED 35013106 REMARK GeneRIF: METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Publication Status: Online-Only REFERENCE 5 (bases 1 to 2649) AUTHORS Feng MG, Yang SL, Luo DW, Peng SL, Lou FZ and Xiao JG. TITLE [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats] JOURNAL Sichuan Da Xue Xue Bao Yi Xue Ban 52 (3), 423-429 (2021) PUBMED 34018360 REMARK GeneRIF: [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats]. REFERENCE 6 (bases 1 to 2649) AUTHORS Zhou J, Wan J, Gao X, Zhang X, Jaffrey SR and Qian SB. TITLE Dynamic m(6)A mRNA methylation directs translational control of heat shock response JOURNAL Nature 526 (7574), 591-594 (2015) PUBMED 26458103 REFERENCE 7 (bases 1 to 2649) AUTHORS Liu N, Dai Q, Zheng G, He C, Parisien M and Pan T. TITLE N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions JOURNAL Nature 518 (7540), 560-564 (2015) PUBMED 25719671 REFERENCE 8 (bases 1 to 2649) AUTHORS Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, Hacohen N, Zhang F, Carr SA, Lander ES and Regev A. TITLE Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites JOURNAL Cell Rep 8 (1), 284-296 (2014) PUBMED 24981863 REFERENCE 9 (bases 1 to 2649) AUTHORS Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z and Zhao JC. TITLE N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells JOURNAL Nat Cell Biol 16 (2), 191-198 (2014) PUBMED 24394384 REFERENCE 10 (bases 1 to 2649) AUTHORS Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W and He C. TITLE A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation JOURNAL Nat Chem Biol 10 (2), 93-95 (2014) PUBMED 24316715 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JACYVU010000078.1. On Jan 5, 2022 this sequence version replaced XM_006233266.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC166789.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00132261, SAMD00132262 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-217 JACYVU010000078.1 10212237-10212453 c 218-306 JACYVU010000078.1 10209974-10210062 c 307-394 JACYVU010000078.1 10209115-10209202 c 395-475 JACYVU010000078.1 10207627-10207707 c 476-563 JACYVU010000078.1 10207183-10207270 c 564-654 JACYVU010000078.1 10203169-10203259 c 655-796 JACYVU010000078.1 10201794-10201935 c 797-889 JACYVU010000078.1 10201030-10201122 c 890-1006 JACYVU010000078.1 10200546-10200662 c 1007-1217 JACYVU010000078.1 10199210-10199420 c 1218-2649 JACYVU010000078.1 10196206-10197637 c FEATURES Location/Qualifiers source 1..2649 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="2" /map="2q42" gene 1..2649 /gene="Mettl14" /gene_synonym="RGD1304822" /note="methyltransferase 14, N6-adenosine-methyltransferase subunit" /db_xref="GeneID:295428" /db_xref="RGD:1304822" exon 1..217 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" CDS 152..1522 /gene="Mettl14" /gene_synonym="RGD1304822" /EC_number="2.1.1.62" /note="methyltransferase-like protein 14; N6-adenosine-methyltransferase subunit METTL14; methyltransferase like 14" /codon_start=1 /product="N6-adenosine-methyltransferase non-catalytic subunit" /protein_id="NP_001386178.1" /db_xref="GeneID:295428" /db_xref="RGD:1304822" /translation="
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNSKRKCLDEGETDEDKVEEYKDELEMQQEEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGIAANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGTHRGGFTPR"
misc_feature 707..1240 /gene="Mettl14" /gene_synonym="RGD1304822" /note="Region: MT-A70; pfam05063" /db_xref="CDD:368270" exon 218..306 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 307..394 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 395..475 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 476..563 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 564..654 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 655..796 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 797..889 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 890..1006 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 1007..1217 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" exon 1218..2649 /gene="Mettl14" /gene_synonym="RGD1304822" /inference="alignment:Splign:2.1.0" ORIGIN
gcctgtctcgggcgcgccggaaatccctcctgagggacgtgaaagtctccgggtcagaatctcggtgggacgctgtttcctggtttgggaggagggtttgcgttttggcgggcgcggtgtctgtcgggtggtgagaagcaggacctggggcatggacagccgcctgcaggagatccgggaacggcagaagttacggcggcagctcctagctcagcagttgggagctgagagtgcagatagcattggtgctgtgttaaacagcaaagatgaacagagggagatcgctgaaacaagagaaacttgcagggcttcctatgatacttctgctccaaattcaaaacggaagtgtctggatgaaggagagacggatgaagataaagtagaagaatataaggatgaactagaaatgcaacaggaagaagaaaatttgccatatgaagaagagatttacaaagattccagtaccttccttaagggaacgcagagcttaaatccccataatgattactgccagcattttgtagacactggacatagacctcagaatttcatcagggatgtaggcctagccgacagatttgaagaataccctaaacttagggagctcatcagactgaaggatgagctgatagctaagtcaaatactcctcccatgtacttacaggcagacatagaagcctttgacatcagagaattgacacccaagtttgatgtgattcttctggagcctcctctggaagaatactacagagagaccggcatcgctgcaaacgagaagtgctggacgtgggacgatatcatgaagttagaaatcgatgagatcgcagcacctcggtcatttatatttctctggtgcggctctggggaaggattggaccttgggagagtatgtttgcgaaagtggggttacagaagatgtgaagatatttgttggattaaaaccaataagaacaatcctggaaagacaaagaccctagatccaaaggccgttttccagaggacaaaggagcactgccttatggggatcaaaggaaccgtgaagcgaagcacagatggggacttcattcatgctaatgttgacattgacttaattatcacagaggaacctgagattggcaacatagaaaagcccgtggagatttttcacataatagagcacttttgtctcggtagaagacgccttcatctcttcgggagggacagcactatcaggccaggctggctcacagttggaccaacgcttacaaatagtaactacaatgcagaaacctacgcgtcctacttcagtgcccccaattcatacttgactggatgtaccgaggaaattgagaggcttagaccgaagtcacctcctcccaaatccaagtctgaccgtggtggtggagctcccagaggtggagggagagggggaacatctgctggccgtggtcgtgaacgaaatcgatccaatttccgaggagaaagaggtggctttagggggggtcgtggagggacacacagaggtggctttacacctcggtagctgttacaaacgcttaacagtgtcccctctgatcttttttgtgaagacttgcttcagaactcactcccagcttgcactttgctttagtttctcatgctgccagaaagaccttagccacccacccccacccctaggtccttgcagttgtcacagactgtggttctgctcagggtaagtcacatgtgtgcaacactcagtcatgggcttgactgatttcactcaaggctttggcttcttggaaataggagcgcagtggagcacctctcagaggaggatggcaggaatggtgctctttccttgtcgtggctgccgcagccgcagtaggagactgggaacctgggcagagcagaactgagagaggcggtcaccctttttggggcctttaatgttttcttgttaaaacactaaaaagatgtagttcccccccccccttttaaattctaaaaaataacatgaagtatcatttgagtactgaagactcagagatgaaatgaagtcactttcttccagatctgaatctgacggggctggagccctcagggaaggtaatggaagaggcagagcttcctagatttaaaacaaaagcaaaacaaaaaccaaagttatcataatgtaaataacagctgcagatgacatataatcatgcttcttaagaagcaagaggaggcaggcacgtgtcaggtcggagggctgtgtgtgatcttgaacttggactgaccttctaagacaattcatatttcttagcaaaggtaaaaacagatttgctggggggagggatggttcaaacaatctagaaaataaacgcttgatgatgaggaaatgacatacatctttaaagttgttattgaacaaaatttaggtaaaagcaattatagaaaccctaaggatacagcttgagagatggggttgcagttgcctttgattagagctgtgtggtgcagatgtctctgcagggctgatgttcggatctcttggctgtggaaagcttcatactgttgtttttctacaccttaagtcatgtttgaatggatttggctatgccagatgagataatatcattattgttcatggtaactcctttttttattttgctatacttttctaataaaaagtttaaacctttgaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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