LOCUS       NM_001376913            5971 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus testis and ovary specific TOPAZ 1 (Topaz1), mRNA.
ACCESSION   NM_001376913 XM_238565
VERSION     NM_001376913.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5971)
  AUTHORS   Luangpraseuth-Prosper A, Lesueur E, Jouneau L, Pailhoux E, Cotinot
            C and Mandon-Pepin B.
  TITLE     TOPAZ1, a germ cell specific factor, is essential for male meiotic
            progression
  JOURNAL   Dev Biol 406 (2), 158-171 (2015)
   PUBMED   26358182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000200.1.
            
            On Nov 27, 2019 this sequence version replaced XM_238565.9.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1169              JACYVU010000200.1  25317026-25318194
            1170-3597           JACYVU010000200.1  25318924-25321351
            3598-3662           JACYVU010000200.1  25327771-25327835
            3663-3787           JACYVU010000200.1  25328968-25329092
            3788-3852           JACYVU010000200.1  25335082-25335146
            3853-3986           JACYVU010000200.1  25339835-25339968
            3987-4072           JACYVU010000200.1  25343400-25343485
            4073-4198           JACYVU010000200.1  25344123-25344248
            4199-4262           JACYVU010000200.1  25344920-25344983
            4263-4414           JACYVU010000200.1  25349570-25349721
            4415-4507           JACYVU010000200.1  25349898-25349990
            4508-4623           JACYVU010000200.1  25353955-25354070
            4624-4690           JACYVU010000200.1  25358299-25358365
            4691-4865           JACYVU010000200.1  25359420-25359594
            4866-4966           JACYVU010000200.1  25360414-25360514
            4967-5132           JACYVU010000200.1  25364922-25365087
            5133-5297           JACYVU010000200.1  25365714-25365878
            5298-5501           JACYVU010000200.1  25367297-25367500
            5502-5685           JACYVU010000200.1  25369018-25369201
            5686-5971           JACYVU010000200.1  25371373-25371658
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5971
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /note="testis and ovary specific TOPAZ 1"
                     /db_xref="GeneID:301075"
                     /db_xref="RGD:1563398"
     exon            1..1169
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    905..907
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /note="upstream in-frame stop codon"
     CDS             953..5905
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /note="testis- and ovary-specific PAZ domain-containing
                     protein 1; testis and ovary specific PAZ domain containing
                     1"
                     /codon_start=1
                     /product="protein TOPAZ1"
                     /protein_id="NP_001363842.1"
                     /db_xref="GeneID:301075"
                     /db_xref="RGD:1563398"
                     /translation="

MRPPTTPPVPTTAPGRQGATGGLRKRGLRLTPEPGEGGGCSLEARGREEESRQKRRMVAQASGREETEGDKLAKENGKVTEAPSDEPQPGTDLVRKTSITNSESLQTVECSEFQSMAFLQSLAKEELVEGIKRRIQIKKCKSSENPPLKITKNEATQNIMVESQDELFKNTPKYSCNSLSPGVEKNCSFESHDFSFLHSEGCNNKNGFEDEPHGVCLHAEENSLKSKKENLRNLAEKDDTKTTKFLKTEKNVIASKLLLEESHLYQNKNNGLTSCLQSEKNKYSVEENNTGRKHRKKMKLSEKEEKGIDLTLSNVCNNSELVLQEHQIGMEGKETETLEHKKSFLKALRKMNHNTLPPVDHLCLPETVGKTSCRHSTNVVLQKTLESSLKEDTKNASETLGCRRLQPEEYFKSMTSSTVKSPSDSHPMGKRSPRGDLKTDTEESKVSCRRIIPMTGKRVWPLYSCARITAECWKKTSLSDLNDSLPGSLGNVRQHDFLMHQTNQTHLPDSKRLQPSLIERTIESSSKEVYDSELSSLSSVSSVEPTLLDIKETIPHDKKTKLEEPSRNGTEVVSSATEDIQLSNITQILTGNKKKKGNLSKLNLTVAPQESQEANNCANKTVHRKACITKQTLVAPDLVKILNTGRLTNFKIPLLKNKTGKRGEVSARSSEREAYSPLELLDSLSGVEAKQNRNKENICTTSGPQSLNIHSVTPGQTSSHTFYNKNSCTSPSFTKKGYDNKTCNHISETGNTISNKESLSIKIENNTFSCDLGYMEQSSFCSKKQEAFVPISSEISGRKMTKSISELKLGFPDILKAYEDDVLLIDVIQDDPELFGISSEGDLSFASEVSKISQEPRVSEEHPSADFKHRHLPGKKEPGDLSKEVALLDPGLLKLEICPSLSAAKEPQHDPKGAAISLEATEETVISENLEDLSEQARASDSDTKCVSSDKATVVEEQENTHEVCKSKDSRSVEAVSTECHLALGPNTLCSSAPPLTLSSHQDVAPAPWTNDFRFPGRYSVLQLQNPETCEIFKREKNFGVFQKPLGLMIPHRYCKLHFNTLRGCERAQCKFVHVPEQGDEKICMDVFKKYIRVNEQRLLHRAAYIFLEYYRKFPPGIHFSLQVLNDLLISLLKHCLLKEVFQVVQLSIMAKMLPALKILLKIFEYVAAMKLRNAVPALIEIFCKFIEAGMIPDPEHLNYIVKLLHQAQASQQEISAVLEAKSRLQVRQLRKNWTCDLDSALSEVENCKEKGDWTKLGNLYISIKMGCEEFADFQRFCACVAETLTEDYKEERPGVPFCEFAETVSKDPQYSEVDKTLLGRIGISAVYFYHRLLLWSKGRKVLDILYELKIHFTSLKGLTGPEKIAPRCQIVNVAAEIFIKSGSLDGAIWVLRESEWITSTPLWPCDRADVLHRHNLLCAIAHEILGKNLYKQTFEVLRNLPGFQNSQEAMGVSQSSLLFNELLDACIESNSLGISSSVADFMVAKSIPIDFSFLRRLITSLGRSCLWLKARAHYKSALSLGCYPPLEGNVYRKLLLVPSYLSEIEMLLAIEIFLVSNASSIQSPGAPTQVLQIVLKRCEESKPRSKDDYQAAVERLIMAARISDPKLFIKHMTVNINKEQVYSLEHCSAVKWLKENMKWAGKVWLFTNH"

     misc_feature    2183..2281
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZUC6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3512..3595
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZUC6.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    4685..5212
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /note="Putative aspartate racemase; Region:
                     Asp_Glu_race_2; pfam14669"
                     /db_xref="CDD:434113"
     exon            1170..3597
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3662
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            3663..3787
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3852
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..3986
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4072
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4198
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4262
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4263..4414
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4507
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..4623
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4690
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4865
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..4966
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..5132
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5297
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            5298..5501
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            5502..5685
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
     exon            5686..5971
                     /gene="Topaz1"
                     /gene_synonym="RGD1563398"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

accaccagatccacaatgttttccactgtagaacacttttcttctacaagcgacaaaactgattaaatattcatgaacggacacagtagaccgggtccaaaataacacataaggttaaactccattccaatcgttaagcaatggaggcttgtgaagggtcaagatgtggcgtaccaggaccctctttcaatggagaggcatggcctggcaacctggtcaaacttgattgaactgatacaagtatggagacatcaataaaattagaagcatgatgttgtaggtcaactgtctgagagccagagccacactaacgggaaagggacctttaacaaagaaagaaagtagagccaagttgatttggtaaatctgtatgcaaggaatccagacgggcagctagaagcttctgcccaacaacaccatagaagcaacttttacagaaataaatgatattttgcatgtcagcagctagggtacctctgagctatctggataaacgtgaaggtaggtattaagccaaagtgggctcccgggagtgtaggagagcagttagaagccactggtagacaaccattgtcagggtgttgaggggtggctgctaagagaaggagcccaggcacctccataagtccaggcctggaggagggtgaggaggcccaaggaggcaccatcacaaacctgtgcagtgaggccctgcctgaggtgagatcctgtcacctccgggtgcagcctgggcccttcgagggagcatgtggacgggcgggctgaccacgaggccctcagccggttgcccccagccgagcccaggccgtccacttccgcttcctgttgcgtcgggtacagggtccgaagccaggccaggccagggtgggcagtagcctgtgtcctgcagcgggagcagcggccctagggcgtctgggctttccagagaggctgcgtgggcggccacgggcggatgcggccgccaacaacgcccccagtccccaccacggcgccagggcgtcaaggcgccaccgggggcctgagaaagcgaggccttcgactgacgccagagccaggcgaggggggaggctgcagcctggaggccagggggcgcgaggaggagagcaggcagaagcggaggatggtggcccaggcttctgggagagaagagacagaaggtgacaagttggccaaagagaatggaaaagtcactgaagccccaagtgatgagccacagccagggactgacctggtaagaaagacatcaataaccaattcggaatctttgcaaacagtggagtgcagtgaatttcaaagtatggctttcttacagtctttggctaaggaagaattggtagaaggtattaagagaagaattcaaattaaaaaatgtaaaagctcagaaaatccacctctcaaaataactaaaaatgaggcaacacaaaatattatggttgaatcacaagatgaactgttcaagaatacaccaaaatattcttgtaacagcttatcacccggagtagaaaaaaattgcagttttgaatcacatgatttcagtttcctccattctgaaggttgtaataataaaaacggctttgaggatgagcctcatggtgtgtgtctacatgcagaagagaactctttgaagtcaaagaaagaaaaccttaggaatcttgcagagaaggatgacacaaaaactactaagttcttaaaaactgaaaaaaatgtaatagccagtaagttactgcttgaagaaagtcatttataccaaaataaaaacaatggcttgacttcttgccttcaaagtgaaaagaacaaatattcagtagaggagaacaacactgggagaaaacacaggaaaaagatgaagttatctgaaaaagaagaaaaaggtatcgatcttactttgtctaatgtgtgtaacaattctgagttggtgctacaagaacaccaaataggtatggaagggaaagaaacagagaccttagaacataaaaaaagttttctaaaagctttaagaaaaatgaaccataatacactccctccagtggaccatttgtgtctcccagaaacagtggggaaaacaagttgtagacattccacaaatgttgtgcttcagaaaacccttgaatcaagtttgaaagaggatacaaaaaatgcttcagagaccttaggatgcagaaggctgcagccagaagaatactttaaatcaatgacaagctctacggtgaaatcacctagtgacagccatcctatgggaaagagatctccacggggagatttgaaaactgacactgaagagtcaaaggttagctgtcgtagaataataccaatgactggtaaaagggtttggcctctttattcttgtgctagaataactgccgagtgttggaagaagacttccttgtcagatttaaatgactcacttccagggtctctgggaaatgttaggcaacatgattttctaatgcaccaaacgaaccagactcacttacctgactccaaacggttacaaccatccttaatagaaagaaccatcgagtcctcgagtaaagaagtgtatgattctgagttaagtagcttgtcttcagtttcttcagtagaacctactttgttggatataaaggaaactataccccatgataaaaagacaaagttagaggaacccagccgaaatgggacagaagtagtttctagtgctaccgaagacatccagttaagtaatataactcaaatcttaacaggaaataagaaaaagaaagggaatttatcaaaacttaatttaacagtggcaccccaagagagccaggaagcaaataactgtgcaaataaaactgttcatcgaaaagcttgtattactaagcaaacacttgtggctccggacttggttaaaatattaaacacaggacggctgactaattttaaaatccctttgctgaagaacaagacaggaaaaagaggagaagtaagtgccagatcatctgaaagagaggcttatagtcccctagagctacttgacagtttatctggagtagaggcaaaacaaaataggaataaggaaaatatctgtacaacttcaggacctcagtctttgaatatacatagtgtaactccagggcaaaccagttctcacacgttctacaataagaattcctgcacttctccaagctttacaaagaaaggttatgataataaaacatgcaatcacatctctgaaacaggaaatactatttcgaataaggagtctctttctattaaaattgaaaataatactttttcttgtgatcttgggtatatggagcaaagttccttctgctctaagaaacaagaagcatttgtgccaatttcctcagaaattagtggtaggaaaatgactaaaagcatttcagaactcaaattggggtttccagatattcttaaagcatatgaagatgatgtcctcttgattgatgtaattcaagatgacccagagctctttggaatctccagtgaaggggatctctcctttgcttcagaagtctccaagataagccaggagcccagagtatctgaagagcacccatcagcagactttaagcacaggcaccttccagggaaaaaagaaccaggcgatttgagtaaagaagttgccttgctggaccctggattgctgaaactggaaatctgtccttccttgtcagcagcaaaggagcctcagcatgatcctaaaggggcagccatctccttagaagctactgaggagactgttataagtgaaaacctagaagacctcagtgaacaagcacgagcttcagactcagacacaaagtgcgtaagttcagacaaggcaactgttgtggaagaacaagagaacactcatgaagtttgcaaaagcaaagattccagaagtgtggaggctgtgtctactgagtgtcacttagccctgggccccaacaccctgtgctcatcagcgcctcctttgactctgagcagtcatcaagatgtagcgccagcaccctggacgaacgatttcagatttccaggaagatattctgtcctacaactgcagaatcctgaaacttgtgaaatatttaaaagggaaaaaaattttggggtgttccagaagcccttaggattgatgataccccacagatactgcaagcttcattttaacacattgcgtggctgtgagcgagcacagtgcaagtttgtccatgtgcctgagcagggggatgaaaagatctgcatggatgtgtttaagaagtacatacgtgtcaatgagcagcgtttgctgcaccgagcagcatacatatttctggaatactacagaaagtttcccccagggatacacttcagtttacaagtgctaaatgaccttttgatttctttactcaagcattgcttattgaaagaagtcttccaggtagtgcagctcagcataatggctaaaatgctgcctgctctgaaaatattactaaaaatatttgagtatgtggcagctatgaagctaaggaatgctgtacctgctttaattgagattttttgcaagttcattgaggctgggatgatacctgacccagagcacttgaactacattgttaagcttttacaccaagcacaggcatcccaacaagaaatatctgcagttctggaagccaaatcgaggttgcaagtgaggcagctgagaaagaactggacgtgtgacttagactcggccttaagtgaagtggagaattgtaaagaaaagggtgactggaccaaattgggaaacctgtacattagcataaaaatgggctgtgaagaatttgcagatttccagagattctgtgcctgtgttgctgaaacactcacagaagattataaagaagaaaggccaggtgttcccttttgtgaatttgctgaaacagttagcaaagatccgcagtacagtgaggtggataagactttgttgggaaggatcggaataagtgctgtgtacttctaccacagactgttgctgtggtctaagggaaggaaggtcttagatatactatatgagctaaaaatacattttacaagtttaaaaggacttacaggacctgaaaaaatagcaccaagatgtcaaattgtaaacgttgcagcagagatttttatcaaaagtgggagcctagatggtgccatttgggtactgagggaatcggagtggataaccagcacaccgctttggccttgcgacagagcggatgtgcttcatcgtcacaacttgctctgcgccatagcgcatgagatcctgggcaagaatctgtacaaacagacatttgaggtcttgcggaaccttccaggctttcagaactctcaagaagcaatgggggtgtcccagtccagccttctctttaatgaactcctggatgcctgcatagaaagtaacagtcttggcatatcatcttctgtagcagacttcatggttgcaaagagcatcccgattgacttttccttcctcaggagactgataacgtccttaggaaggagctgtttgtggctcaaagccagagcccactacaaaagtgctctttcactgggttgctacccaccattagagggaaacgtataccggaaacttctactggttccttcttatttatctgagattgaaatgcttttagctatcgagatatttctggtgtctaacgctagtagtattcagagcccaggagctcccacccaggtgctgcagatcgttttgaaaagatgtgaagaaagcaaacctcgaagcaaggacgattatcaagctgcagtggaaagactgatcatggctgctcggatatccgaccccaagcttttcatcaagcacatgaccgtcaacattaacaaggagcaggtgtacagtctggagcactgctctgccgtgaaatggctgaaagagaatatgaagtgggctggaaaggtttggcttttcactaaccattagttaataaagggttgttgttgggttttctaagttcaagtaatcattgttgaaaataaaagaataaaa

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