LOCUS       NM_001134716            1441 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus C-type lectin domain family 12, member A
            (Clec12a), mRNA.
ACCESSION   NM_001134716 XM_001056731 XM_001067785
VERSION     NM_001134716.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T,
            Kurgyis Z, Holm CK, Heikenwalder M, Lang KS and Ruland J.
  TITLE     The uric acid crystal receptor Clec12A potentiates type I
            interferon responses
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18544-18549 (2019)
   PUBMED   31451663
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Raulf MK, Johannssen T, Matthiesen S, Neumann K, Hachenberg S,
            Mayer-Lambertz S, Steinbeis F, Hegermann J, Seeberger PH,
            Baumgartner W, Strube C, Ruland J and Lepenies B.
  TITLE     The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin
            and Contributes to Cerebral Malaria Development
  JOURNAL   Cell Rep 28 (1), 30-38 (2019)
   PUBMED   31269448
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Flornes LM, Nylenna O, Saether PC, Daws MR, Dissen E and Fossum S.
  TITLE     The complete inventory of receptors encoded by the rat natural
            killer cell gene complex
  JOURNAL   Immunogenetics 62 (8), 521-530 (2010)
   PUBMED   20544345
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168186.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_001067785.1, XM_001056731.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168186.1, GU357484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1441
                     /gene="Clec12a"
                     /note="C-type lectin domain family 12, member A"
                     /db_xref="GeneID:680338"
                     /db_xref="RGD:1592991"
     exon            1..292
                     /gene="Clec12a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    124..126
                     /gene="Clec12a"
                     /note="upstream in-frame stop codon"
     CDS             202..1011
                     /gene="Clec12a"
                     /codon_start=1
                     /product="C-type lectin domain family 12 member A"
                     /protein_id="NP_001128188.1"
                     /db_xref="GeneID:680338"
                     /db_xref="RGD:1592991"
                     /translation="

MSEEIVYADLKFQDSDKKEESQKSDKCGRKVPSAGSYSQHKTVLILILLCLLLFIGVVALGCIFYTTLETEMIKSNQLQRVKEELQENVSLQLMHNLNNSKKIKTLSAMLQNIATQLCQELSKKEPGHKCKPCPKASDWYKDSCYSRFQKYATWQESVEFCSARNASLLKVKNKDELEFIKSKELYNYWLALPPSKMYRSYELLSEKMFLSEGFKRSTYDITKMSCGFIRGEYVYYTNCDEEKYTMCEETASKVQVESVLSDLPEGSIL"

     misc_feature    598..945
                     /gene="Clec12a"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); Region:
                     CLECT_NK_receptors_like; cd03593"
                     /db_xref="CDD:153063"
     misc_feature    order(760..762,844..846,898..900,904..909)
                     /gene="Clec12a"
                     /note="ligand binding surface [chemical binding]; other
                     site"
                     /db_xref="CDD:153063"
     exon            293..391
                     /gene="Clec12a"
                     /inference="alignment:Splign:2.1.0"
     exon            392..580
                     /gene="Clec12a"
                     /inference="alignment:Splign:2.1.0"
     exon            581..732
                     /gene="Clec12a"
                     /inference="alignment:Splign:2.1.0"
     exon            733..839
                     /gene="Clec12a"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1357
                     /gene="Clec12a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atctgttcttgtctgaggccacagactgactgtggctcatgggcacatatttgagagactagcatagtagtttttcaaaaagaaattccagctcgtgaggcggtttaccaagggttgaatgtctaggaagacttgcttaacagtcagccctctcacctttttcaaaggacggtttctggagctttctctgaatattcatcaatgtctgaggaaattgtttatgcagatctcaaattccaggactctgataagaaagaagaaagccagaagtctgacaaatgtgggagaaaagtaccttctgctggttcctattcacaacataaaacagtcttgattctgattcttctatgccttctgctgtttattggagtggtggccttaggatgcatcttttatacaactttggagacagaaatgataaagtcaaatcaattacaaagagtcaaggaagaacttcaggaaaatgtttccctacagctgatgcacaatctcaacaactccaagaaaatcaagactctttctgctatgctgcaaaacatagccacccagttgtgtcaagaactgtcaaagaaagaaccaggtcataaatgtaaaccatgtccaaaggcttcagattggtacaaggacagctgttattctcgattccagaagtatgcaacatggcaagagagtgttgagttctgctctgctcggaatgccagcctcctgaaggttaagaacaaggatgagctggaatttataaagtccaaggagctatacaattattggctagcattgcctccaagtaaaatgtatagatcttatgagctactgagtgagaagatgttcctctctgaagggtttaaaagaagcacatatgacataactaagatgtcctgtggctttataaggggggaatatgtttattatacaaactgtgatgaagagaaatataccatgtgtgaagagacagccagcaaggtacaggtggaaagtgtgctaagtgaccttccagagggtagcattctgtagttgcttgtctctagctactatcctactatagtggtttgaatgagaatggcccccggcggctcatttgtttgattatgtggtcctcagttgctggaactgtttcagaagcatgggaaggtgtgaccttgtttgaggaggtgcatcactgaggatgggctttgagttttcaaaagctcctgccattcccagttagttctgtctctgtctgtgtttgtgaattgagctgtgagctcacagctactcttcaaggccgtgtttgcctgcctgctgccatcctcctcaccacaatggtcatagactctaaccctctggaaccaggagccaaattaaatgcatcctttcataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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