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Previous release (v1)
2026-10-15 05:16:50, GGRNA.v2 : RefSeq release 233 (Jan, 2026)
LOCUS NM_001108789 4927 bp mRNA linear ROD 27-MAR-2024
DEFINITION Rattus norvegicus exportin 5 (Xpo5), mRNA.
ACCESSION NM_001108789 XM_001064242 XM_343534
VERSION NM_001108789.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4927)
AUTHORS Rachagani,S., Macha,M.A., Menning,M.S., Dey,P., Pai,P., Smith,L.M.,
Mo,Y.Y. and Batra,S.K.
TITLE Changes in microRNA (miRNA) expression during pancreatic cancer
development and progression in a genetically engineered
KrasG12D;Pdx1-Cre mouse (KC) model
JOURNAL Oncotarget 6 (37), 40295-40309 (2015)
PUBMED 26516699
REFERENCE 2 (bases 1 to 4927)
AUTHORS Cho,S.H., Ko,J.J., Kim,J.O., Jeon,Y.J., Yoo,J.K., Oh,J., Oh,D.,
Kim,J.W. and Kim,N.K.
TITLE 3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1,
RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a
Korean Population
JOURNAL PLoS One 10 (7), e0131125 (2015)
PUBMED 26147304
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4927)
AUTHORS Okamura,M., Inose,H. and Masuda,S.
TITLE RNA Export through the NPC in Eukaryotes
JOURNAL Genes (Basel) 6 (1), 124-149 (2015)
PUBMED 25802992
REMARK Review article
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4927)
AUTHORS Liu,S., An,J., Lin,J., Liu,Y., Bao,L., Zhang,W. and Zhao,J.J.
TITLE Single nucleotide polymorphisms of microRNA processing machinery
genes and outcome of hepatocellular carcinoma
JOURNAL PLoS One 9 (3), e92791 (2014)
PUBMED 24676133
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 4927)
AUTHORS Guo,Z., Wang,H., Li,Y., Li,B., Li,C. and Ding,C.
TITLE A microRNA-related single nucleotide polymorphism of the XPO5 gene
is associated with survival of small cell lung cancer patients
JOURNAL Biomed Rep 1 (4), 545-548 (2013)
PUBMED 24648983
REFERENCE 6 (bases 1 to 4927)
AUTHORS Okada,C., Yamashita,E., Lee,S.J., Shibata,S., Katahira,J.,
Nakagawa,A., Yoneda,Y. and Tsukihara,T.
TITLE A high-resolution structure of the pre-microRNA nuclear export
machinery
JOURNAL Science 326 (5957), 1275-1279 (2009)
PUBMED 19965479
REFERENCE 7 (bases 1 to 4927)
AUTHORS Yi,R., Doehle,B.P., Qin,Y., Macara,I.G. and Cullen,B.R.
TITLE Overexpression of exportin 5 enhances RNA interference mediated by
short hairpin RNAs and microRNAs
JOURNAL RNA 11 (2), 220-226 (2005)
PUBMED 15613540
REFERENCE 8 (bases 1 to 4927)
AUTHORS Yi,R., Qin,Y., Macara,I.G. and Cullen,B.R.
TITLE Exportin-5 mediates the nuclear export of pre-microRNAs and short
hairpin RNAs
JOURNAL Genes Dev 17 (24), 3011-3016 (2003)
PUBMED 14681208
REFERENCE 9 (bases 1 to 4927)
AUTHORS Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
Paraskeva,E., Hartmann,E. and Gorlich,D.
TITLE Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
transport pathways to confine translation to the cytoplasm
JOURNAL EMBO J 21 (22), 6205-6215 (2002)
PUBMED 12426392
REMARK GeneRIF: Identification and functional characterization of the
mouse and Drosophila exportin 5 orthologs.
REFERENCE 10 (bases 1 to 4927)
AUTHORS Brownawell,A.M. and Macara,I.G.
TITLE Exportin-5, a novel karyopherin, mediates nuclear export of
double-stranded RNA binding proteins
JOURNAL J Cell Biol 156 (1), 53-64 (2002)
PUBMED 11777942
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000009.1.
On Nov 26, 2008 this sequence version replaced NM_001108789.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
[ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-172 JAXUCZ010000009.1 22275574-22275745 c
173-225 JAXUCZ010000009.1 22273946-22273998 c
226-294 JAXUCZ010000009.1 22273877-22273945 c
295-367 JAXUCZ010000009.1 22272431-22272503 c
368-505 JAXUCZ010000009.1 22269670-22269807 c
506-688 JAXUCZ010000009.1 22269326-22269508 c
689-715 JAXUCZ010000009.1 22269034-22269060 c
716-901 JAXUCZ010000009.1 22268493-22268678 c
902-978 JAXUCZ010000009.1 22267817-22267893 c
979-1078 JAXUCZ010000009.1 22265400-22265499 c
1079-1162 JAXUCZ010000009.1 22264698-22264781 c
1163-1288 JAXUCZ010000009.1 22263832-22263957 c
1289-1379 JAXUCZ010000009.1 22262351-22262441 c
1380-1508 JAXUCZ010000009.1 22261702-22261830 c
1509-1639 JAXUCZ010000009.1 22260110-22260240 c
1640-1795 JAXUCZ010000009.1 22257480-22257635 c
1796-1837 JAXUCZ010000009.1 22256192-22256233 c
1838-1927 JAXUCZ010000009.1 22255702-22255791 c
1928-2127 JAXUCZ010000009.1 22254910-22255109 c
2128-2227 JAXUCZ010000009.1 22253304-22253403 c
2228-2409 JAXUCZ010000009.1 22252345-22252526 c
2410-2510 JAXUCZ010000009.1 22246109-22246209 c
2511-2607 JAXUCZ010000009.1 22245532-22245628 c
2608-2744 JAXUCZ010000009.1 22244926-22245062 c
2745-2842 JAXUCZ010000009.1 22243942-22244039 c
2843-2889 JAXUCZ010000009.1 22242567-22242613 c
2890-2987 JAXUCZ010000009.1 22242057-22242154 c
2988-3050 JAXUCZ010000009.1 22241446-22241508 c
3051-3133 JAXUCZ010000009.1 22240876-22240958 c
3134-3241 JAXUCZ010000009.1 22240451-22240558 c
3242-3379 JAXUCZ010000009.1 22239713-22239850 c
3380-3544 JAXUCZ010000009.1 22239398-22239562 c
3545-4927 JAXUCZ010000009.1 22237760-22239142 c
FEATURES Location/Qualifiers
source 1..4927
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="9"
/map="9q12"
gene 1..4927
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/note="exportin 5"
/db_xref="GeneID:363194"
/db_xref="RGD:1311522"
exon 1..172
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
CDS 68..3682
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/codon_start=1
/product="exportin-5"
/protein_id="NP_001102259.2"
/db_xref="GeneID:363194"
/db_xref="RGD:1311522"
/translation="
MEMEQVNALCEELVKAVTVMMDPSSTQRYRLEALKFCEEFKEKCPICVPCGLKLAEKTQIAIVRHFGLQILEHVVKFRWNSMSRLEKVYLKNSVMELIANGTLSILEEENHIKDVLSRIVVEMIKREWPQHWPDMLMELDTLSRQGETQRELVMFILLRLAEDVVTFQTLPTQRRRDIQQTLTQNMERILNFLLSTLQENVNKYQQMKTDASQEAEAQANCRVSIAALNTLAGYIDWVSLNHITAENCKLVETLCLLLNEQELQLGAAECLLIAVSRKGKLEDRKRLMILFGDVAMHYVLSAAQTADGGGLVEKHYLFLKRLCQVLCALGNLLCALLALDANIQTPVNFGMYLESFLAFTTHPSQFLRSSTHMTWGALFRHEVLSRDPSLLAVIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQHGEVVRCVCRLDPKTSFQMAAEWLKYQLSAAIDTGPVNSCSTAGTGEGGFCSIFSPSYVQWEAMTFFLESVINQMFRTLEKEELPVNEGIELLQLVLNFEMKDPLILSCVLTNVSALFPFVTYKPAFLPQVFSKLFSFVTFESVGESKAPRTRAVRNVRRHACSSINKMCRDYPDLVLPNFDMLYSHVKQLLSNELLLTQMEKCALMEALVLVSNQFKDYERQKLFLEELMAPVVNIWLSEEMCRALSDIDAFIAYVGADLKSCDPAAQDPCGLNRARMSFCVYSILGVMRRTTWPSDLEEAKAGGFVVGYTPSGNPVFRNPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEPFTKALDIVESEKTAILGLPQPLLEINDHPVYRTILERMQRFFGILYENCYHILGKAGPSMQQDFYTVEDLATQLLGSAFVNLNNIPDFRLRSMLRVFVKPLVLFCPPEHYETLISPILGPLFTYLHMRLSQKWHVINQRSVLCGEDEIAEDNPESQEMLEEQLVRMLTREVMDLIMACCVSKKTAEHTATPTADGDDEEMMATEVAPSSVVELTDLGKCLMKHEDVCTALLITAFNSLTWKDTLSCQRATTQLCWPLLKQVMSGTLLADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEINKESLDQFDCKLLNPSLQKAADKRRKDHFKRLIAGCIGKPLGEQFRKEVHIKNLPWLFKKSKPMLETEVLDSEEGGLATIFEP"
misc_feature 164..367
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/note="Importin-beta N-terminal domain; Region: IBN_N;
smart00913"
/db_xref="CDD:197981"
misc_feature 392..880
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/note="Exportin 1-like protein; Region: Xpo1; pfam08389"
/db_xref="CDD:462459"
misc_feature 1004..3565
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/note="Exportin-5 family; Region: Exportin-5; pfam19273"
/db_xref="CDD:437105"
exon 173..294
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 295..367
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 368..505
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 506..688
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 689..715
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 716..901
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 902..978
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 979..1078
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1079..1162
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1163..1288
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1289..1379
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1380..1508
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1509..1639
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1640..1795
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1796..1837
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1838..1927
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 1928..2127
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2128..2227
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2228..2409
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2410..2510
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2511..2607
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2608..2744
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2745..2842
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2843..2889
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2890..2987
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 2988..3050
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 3051..3133
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 3134..3241
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 3242..3379
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 3380..3544
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
exon 3545..4927
/gene="Xpo5"
/gene_synonym="Exp5; RanBp21"
/inference="alignment:Splign:2.1.0"
ORIGIN
ggtcccgccaggggaaccgtgcgtacctcgtgctcctgggacgccggtggttttcccggcactagccatggagatggagcaagtgaacgcgctgtgcgaggagctagtgaaagcggtgacggtcatgatggaccccagctctacccagcgctaccggctggaagccctcaagttttgtgaagagtttaaagaaaagtgccctatctgtgtcccatgtggcttgaagttggccgaaaaaacacaaattgccatcgtcagacattttggccttcagatcctggaacacgttgtcaagtttcggtggaacagcatgtctcgattggagaaggtctacctgaagaacagtgtcatggagctgattgcaaatggaacactgagcattttggaggaggagaaccatattaaagatgttctgtctagaattgtggtggagatgatcaagcgagagtggcctcagcactggcctgacatgctcatggagttggacactctctccaggcaaggggaaacacagagggaattggtgatgttcatccttttgcgactggctgaggatgtagtgacctttcagacactgcccactcaaagaagaagggatattcagcaaacgttaacacagaacatggaaagaatcttgaattttctactcagtacacttcaggaaaatgtaaacaagtaccagcaaatgaagacagatgcctctcaggaagcagaggctcaagccaactgtcgagtgagcatcgcggcactgaacacgctagcaggctacattgactgggtgtctttgaatcacattactgctgagaactgtaagctggtggaaactctgtgcctgcttctcaatgagcaggagctgcagttgggagccgctgagtgtcttctcattgcagtcagcagaaaaggcaagctggaggaccggaagcgcttgatgatcttgtttggggacgtggccatgcactatgttctctccgccgcacagactgctgatggaggaggcttggtggaaaaacactacctcttcctgaagagactttgtcaggtgttgtgtgctctgggaaatctgctgtgtgcactgctggccttagatgctaacatacaaacaccggtaaactttggaatgtacctggagtcttttcttgctttcacaacccacccaagtcagtttctacgctcttcaacccatatgacgtggggagccctcttcaggcatgaagttctgtcccgggatccgtcgctgttagcggtgataccaaaatatcttcgtgcttctatgacgaacttggtcaagatgggttttccttccaaaacagacagccccagctgtgaatattcccggtttgactttgacagtgatgaggacttcaatgctttcttcaactcctcccgagcccagcatggagaggtggtgaggtgcgtgtgtcgactggatcctaagactagcttccagatggcggcagagtggctcaagtatcagctgtcagctgctattgacactggacctgtgaactcatgttctacagctggaactggagagggaggcttctgctccatcttctcaccttcatacgtgcagtgggaagccatgactttttttttggaaagtgtgatcaaccagatgtttcgaacactagagaaagaagagctcccggtaaatgaggggatagagctgctgcagctggttttgaactttgagatgaaggatcccctcatcctgtcctgtgtcctcaccaatgtctcagcactctttccatttgtcacatacaagcctgccttcttgccccaggtcttctcgaagctcttttcatttgtcacttttgaatctgttggggaaagtaaggcccccaggactcgggcagtcaggaatgtaaggagacatgcgtgttcctccatcaacaagatgtgtcgagactacccagaccttgttctgcccaattttgacatgctttatagccatgtgaagcaactcctctccaatgagctcctcctgacccagatggagaagtgtgctctcatggaagccctggttctcgttagcaaccagtttaaggattatgagcggcagaagttattcctagaggagctgatggcaccggtggtcaacatctggctctctgaagaaatgtgcagagcactgtcagatattgacgccttcattgcctatgtgggtgctgatctgaagagctgtgacccggctgcgcaggacccgtgtggcttgaaccgtgcacgaatgagcttttgtgtgtacagcatcctgggggttatgagacgaactacctggccttccgacctagaagaagccaaagctggggggttcgtggtgggttatacacccagtgggaatccagtcttccgtaacccctgcacagagcagatcctcagacttctcgacaatttgcttgccctcgtaagaactcacaatactttatatacaccggagatgctaaccaaaatggcagagcctttcaccaaggctctggatattgttgaatctgaaaaaacggcaatattaggattacctcagcctctcttggaaatcaatgaccaccctgtctatagaaccattttggaaagaatgcagcggttcttcggcatcctctatgaaaactgttaccacatcctagggaaggcaggcccttccatgcaacaagatttctacactgtggaggaccttgctacccagctccttggttcagctttcgtcaacttgaacaatattcctgacttccggctcagatctatgcttcgtgtcttcgtgaagcccctcgtgctcttctgccccccagaacactatgagaccctgatatctcccatccttggaccgctcttcacctaccttcacatgaggctttctcagaagtggcatgtcatcaaccagaggagtgtcctgtgtggagaagatgagattgcagaggacaaccccgaatctcaagaaatgctggaggaacagctggtgaggatgttaacccgagaagtcatggacctaatcatggcttgttgtgtgtcaaagaagactgccgagcacactgccactcccactgcggatggagacgacgaggagatgatggccaccgaagtagccccttcgtctgttgtggagctcacagacctgggcaaatgcctgatgaagcatgaggatgtttgcacggcactgttgatcacagcatttaattccctgacctggaaggataccctgtcttgccagagggcgaccacacagctctgttggcctctcctcaaacaggtgatgtctgggaccctgctcgcagatgccgtcacgtggctcttcaccagtgtgctgaaagggctgcagatgcatgggcaacacgacgggtgcatggcttccctggtccacttggccttccagatatacgaggcactgcgccccaggtacctagagataagagcagtaatggagcagatccctgaaataaacaaggagtctctggaccaatttgactgcaagcttctaaacccctcccttcaaaaagcagctgataaacgacggaaggaccacttcaaacgcctcatcgctggctgcattgggaaacccttgggagaacagttccgaaaagaagtccacattaagaaccttccctggcttttcaaaaaatccaaaccaatgctggagacagaagtgctggacagtgaggagggtggactggccaccatctttgaaccctgaatcaagcttttgggcgtccttctccggcctcagttgtcatgtcttcttccctgtgtagctatctctaggccttcctcacactgccacctcacttcccaccgagtcagcctggaggagctcagatccaggtctcctgtgagagggcctgagtcatcccactaaagtaaaagggtattgggacctccaccattccaagaaggtgacctgggagtcggcagccacctgcagtatgggcttctccaagaaaagctagagcaccatggctttgcccagagcagctgcaccagtgcagacaggaggaccaaccagggtgccgtgcccagccccactgacctgatcgtccggtttcctttggacggcacttgagccccttgccatggggctttcgggatcctcctccactccaggggcatgtctggccgaggtgctacatgctgacctgtgtctggccagcttcctcgtctcaacctaaagctagaatctggtcgcttggtgggacccgtggtacaggctatttctaaagtctgagcacaccatccagggacaagagctgggcagaattccttagagtggacatcttgcccttctgacggaccctggagggttccccagtgacacaccaaccatacaagagtaatcagaccaaggaggcttctgacgagcgagcagagccactgtccctcctgggactagctgagtccgggtgcctttgagaatctcaatggtcttttaagcttctgaaggtcaaaaagtgttccagtcattgccaacacttttggtccctggaaagggaatgaagcaaaccaagatgggtgtgggacctagttctgcctattgtgacaggcagatgtgacctgtgtgtgtgtatgctaacaggcccactgtccacccagccccaactttgacctggtgtgggacacaggcaggcatggcagagttggagtcagagctaggaggtagctactagggttcgaggtcactgctgcacaaagccggccgtcctccctctgcgtggtgcttggggtctacagattgtaaggtgagctcagtatttccctccagacttgatagctgcctactcctgtctgcttagggctacggaggatgtagttgtatttattatgttgtaatatttttaacatcctatgacttcatgctagagattttctattgtttatagaacttttgtagaaatgctaactctaaagtacatgtgcatgtcagtaaaacctgtttcatacagaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]