LOCUS       NM_001108390            2110 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus Nedd4 family interacting protein 2 (Ndfip2),
            mRNA.
ACCESSION   NM_001108390 XM_001077197 XM_341374
VERSION     NM_001108390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B
            and Kumar S.
  TITLE     Regulation of the divalent metal ion transporter DMT1 and iron
            homeostasis by a ubiquitin-dependent mechanism involving Ndfips and
            WWP2
  JOURNAL   Blood 112 (10), 4268-4275 (2008)
   PUBMED   18776082
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Cristillo AD, Nie L, Macri MJ and Bierer BE.
  TITLE     Cloning and characterization of N4WBP5A, an inducible,
            cyclosporine-sensitive, Nedd4-binding protein in human T
            lymphocytes
  JOURNAL   J Biol Chem 278 (36), 34587-34597 (2003)
   PUBMED   12796489
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y,
            Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB697675.1, CO398212.1, DY565248.1, FM044778.1, DV728397.1 and
            BP495172.1.
            
            On Jul 9, 2010 this sequence version replaced NM_001108390.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV767579.1, SRR8487231.125098.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               CB697675.1         1-217
            218-825             CO398212.1         1-608
            826-1141            DY565248.1         388-703
            1142-1595           FM044778.1         191-644
            1596-2108           DV728397.1         147-659
            2109-2110           BP495172.1         3-4                 c
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q22"
     gene            1..2110
                     /gene="Ndfip2"
                     /note="Nedd4 family interacting protein 2"
                     /db_xref="GeneID:361089"
                     /db_xref="RGD:1309716"
     exon            1..424
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    50..52
                     /gene="Ndfip2"
                     /note="upstream in-frame stop codon"
     CDS             101..1114
                     /gene="Ndfip2"
                     /codon_start=1
                     /product="NEDD4 family-interacting protein 2"
                     /protein_id="NP_001101860.2"
                     /db_xref="GeneID:361089"
                     /db_xref="RGD:1309716"
                     /translation="

MGRRRSQRACASAPSMLSSARGSPELRRRSASEAEVSAAAEGATGSEVAPPGDRGGRTRGSGRGSAATASSTGEAEGAERGADTPARKPDPEAGRMDHHQLGTGRYQVLHNEDDNSESSAPEQPSASSSAAQPVEAAASAPALDADSSPPPYSSITVDGPTTSDADVYSEFYPVPPPYSVATSLPTYDEAEKAKAAALAAAAADAPQRNQEEECPPRDDFSDVEQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL"

     misc_feature    407..1111
                     /gene="Ndfip2"
                     /note="NEDD4 family-interacting protein 2; Region: NDFIP2;
                     cd22306"
                     /db_xref="CDD:412070"
     exon            425..590
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..724
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..818
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..943
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1010
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1116
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..2110
                     /gene="Ndfip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgcccactcccgaccggctgacaacctagagggctccccgggacttgcctgacttttccatctcctcccacctagggacaccttcggagcggggcctccgatgggacgccggcggagccagagagcatgcgcgtccgccccgagcatgctcagtagcgcgcgcggctccccggagctccgacgccgatcggcgagcgaagcggaggtctccgccgcagccgagggagcgacaggaagtgaagtggccccgccgggcgaccgcggcggcagaacgcgaggcagcggaaggggctctgcggcgacggcgtcgtcgaccggggaggccgagggagctgagcgcggggcagacacgcccgctcggaagccggaccccgaggcgggcaggatggatcaccaccagctggggactggccgctaccaggtgcttcacaacgaggacgataactcagaatcatctgccccagagcagccgtcagcttccagctcagcagcacagcctgtggaggctgctgcctcagcgccagccctggacgccgactcttctcctccaccttacagcagcatcactgtggacggtcccacaacttcagatgctgacgtgtacagtgagttttaccctgtgccccctccgtacagcgtcgctacctctctcccgacatacgatgaggctgaaaaggctaaagctgctgccctggccgctgcagcagcagacgcacctcaaagaaaccaagaggaagagtgtccacccagggatgacttcagtgatgtggagcagctcagagtaggcaatgatggcattttcatgctggcctttttcatggcattcatattcaactggcttggattctgcttatccttctgtatcaccaataccatagctggaagatacggtgctatctgtggatttggcctctcactgatcaaatggatccttattgtcaggttttcggactattttactggctatttcaatggacaatattggctttggtggatatttcttgtacttggcctgctccttttcttcagaggatttgttaattacctaaaggtcagaaacatgtctgaaagtatggcagctgcgcacagaacaagatacttcttccttctctagaggtggcgtcaacccaacattcctctcttacaccaatgtgaaatgtccaagtcgtctgtaaacctacaacttcgctaagatagactactgagcgcagaagcagatgtagtgaggggtggagcgtcggaattaaatgacagggtggtttatgctacaagccatgtctgttcattccttaattctctttggtatctcaatttattttgcacatttgcatatgtgcctgtttaaagggtatgcatatacttgaaagaatctgtaaagttgtagcagcaaagtccagtcctacttggttaatcagtgtttgatacaattggaagagttgagtactaaacagtcttccagcatgtaaatgcttctgacttgaccattagcgtaataaaaattacattattaatcttgtcaaatgctttagtttctggctcttagattcacctagtaattccacacacgaaatattctttgttatatatgatgtttattaaaacttgcagtatgattattagaaagaatttgtcagatttttaaatatgatattatttaggaaatctgtaaataaccatgcataagttgctctttacattcttttcttaaattgtgtctagatatcttttcattaattttaaattaagtaaactaaatacatagaaataaacttcattaaagatggagtggtttagggtgaactttaagaaagtatgagtataccaaatgctgtttaaagaacaagttagggccacaccagttttaggggttttcagatgagaaccttacattttaagattactcaccttacaattcttacaagaagagattgctttagaccttatatttattacatctaagacaatttaaaaaattaatttaccaaatatattctcatttgcatttgtctttccaaaagccaataaaagtatctttcagtattactgtaatcatttttttctttaaatgtttactctgttaagcttagcaaataaaatcttgttctgttaa

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