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2024-03-28 17:41:19, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_001107754            2753 bp    mRNA    linear   ROD 04-DEC-2023
DEFINITION  Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA.
ACCESSION   NM_001107754 XM_001079281 XM_230377
VERSION     NM_001107754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2753)
  AUTHORS   Yang P, Wang Y, Ge W, Jing Y, Hu H, Yin J, Xue M, Wang Y, Li X, Li
            X, Shi Y, Tan J, Li Y and Yan S.
  TITLE     m6A methyltransferase METTL3 contributes to sympathetic
            hyperactivity post-MI via promoting TRAF6-dependent mitochondrial
            ROS production
  JOURNAL   Free Radic Biol Med 209 (Pt 2), 342-354 (2023)
   PUBMED   37898386
  REMARK    GeneRIF: m6A methyltransferase METTL3 contributes to sympathetic
            hyperactivity post-MI via promoting TRAF6-dependent mitochondrial
            ROS production.
REFERENCE   2  (bases 1 to 2753)
  AUTHORS   Wei B, Su Z, Yang H, Feng Y, Meng C and Liang Z.
  TITLE     Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by
            alleviating pyroptosis in vitro and in vivo rat models
  JOURNAL   Biol Direct 18 (1), 23 (2023)
   PUBMED   37165439
  REMARK    GeneRIF: Inhibition of TRAF6 improves hyperlipidemic acute
            pancreatitis by alleviating pyroptosis in vitro and in vivo rat
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2753)
  AUTHORS   Xia P, Marjan M, Liu Z, Zhou W, Zhang Q, Cheng C, Zhao M, Tao Y,
            Wang Z and Ye Z.
  TITLE     Chrysophanol postconditioning attenuated cerebral
            ischemia-reperfusion injury induced NLRP3-related pyroptosis in a
            TRAF6-dependent manner
  JOURNAL   Exp Neurol 357, 114197 (2022)
   PUBMED   35932799
  REMARK    GeneRIF: Chrysophanol postconditioning attenuated cerebral
            ischemia-reperfusion injury induced NLRP3-related pyroptosis in a
            TRAF6-dependent manner.
REFERENCE   4  (bases 1 to 2753)
  AUTHORS   Zhang T and Ge J.
  TITLE     Mechanism of CREB1 in cardiac function of rats with heart failure
            via regulating the microRNA-376a-3p/TRAF6 axis
  JOURNAL   Mamm Genome 33 (3), 490-501 (2022)
   PUBMED   35217880
  REMARK    GeneRIF: Mechanism of CREB1 in cardiac function of rats with heart
            failure via regulating the microRNA-376a-3p/TRAF6 axis.
REFERENCE   5  (bases 1 to 2753)
  AUTHORS   Wei B, Wu Q, Yang X, Lai C, Su Z and Liang Z.
  TITLE     Effect of TRAF6 in acute pancreatitis-induced intestinal barrier
            injury via TLR4/NF-kappaB signal pathway
  JOURNAL   Tissue Cell 76, 101792 (2022)
   PUBMED   35405432
  REMARK    GeneRIF: Effect of TRAF6 in acute pancreatitis-induced intestinal
            barrier injury via TLR4/NF-kappaB signal pathway.
REFERENCE   6  (bases 1 to 2753)
  AUTHORS   Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A and Reed JC.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   7  (bases 1 to 2753)
  AUTHORS   Lomaga MA, Henderson JT, Elia AJ, Robertson J, Noyce RS, Yeh WC and
            Mak TW.
  TITLE     Tumor necrosis factor receptor-associated factor 6 (TRAF6)
            deficiency results in exencephaly and is required for apoptosis
            within the developing CNS
  JOURNAL   J Neurosci 20 (19), 7384-7393 (2000)
   PUBMED   11007897
REFERENCE   8  (bases 1 to 2753)
  AUTHORS   Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, Nakao
            K, Nakamura K, Katsuki M, Yamamoto T and Inoue J.
  TITLE     Severe osteopetrosis, defective interleukin-1 signalling and lymph
            node organogenesis in TRAF6-deficient mice
  JOURNAL   Genes Cells 4 (6), 353-362 (1999)
   PUBMED   10421844
REFERENCE   9  (bases 1 to 2753)
  AUTHORS   Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony
            S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A,
            Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey
            DL, Dunstan CR, Boyle WJ, Goeddel DV and Mak TW.
  TITLE     TRAF6 deficiency results in osteopetrosis and defective
            interleukin-1, CD40, and LPS signaling
  JOURNAL   Genes Dev 13 (8), 1015-1024 (1999)
   PUBMED   10215628
REFERENCE   10 (bases 1 to 2753)
  AUTHORS   Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z and
            Matsumoto K.
  TITLE     The kinase TAK1 can activate the NIK-I kappaB as well as the MAP
            kinase cascade in the IL-1 signalling pathway
  JOURNAL   Nature 398 (6724), 252-256 (1999)
   PUBMED   10094049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168921.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001107754.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168921.1, SRR8487227.172149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..2753
                     /gene="Traf6"
                     /note="TNF receptor associated factor 6"
                     /db_xref="GeneID:311245"
                     /db_xref="RGD:1306853"
     exon            1..168
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    146..148
                     /gene="Traf6"
                     /note="upstream in-frame stop codon"
     exon            169..486
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1783
                     /gene="Traf6"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase TRAF6; TNF
                     receptor-associated factor 6, E3 ubiquitin protein ligase;
                     RING-type E3 ubiquitin transferase TRAF6"
                     /codon_start=1
                     /product="TNF receptor-associated factor 6"
                     /protein_id="NP_001101224.1"
                     /db_xref="GeneID:311245"
                     /db_xref="RGD:1306853"
                     /translation="
MSLLNCENSCASSQSSSDCCAAMANSCSAAMKDDSVSGCVSTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMHVSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV"
     misc_feature    191..1276
                     /gene="Traf6"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DF45.1);
                     Region: Interaction with TAX1BP1. /evidence=ECO:0000250"
     misc_feature    389..562
                     /gene="Traf6"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in tumor necrosis factor (TNF) receptor-associated
                     factor 6 (TRAF6) and similar proteins; Region:
                     mRING-HC-C3HC3D_TRAF6; cd16643"
                     /db_xref="CDD:438305"
     misc_feature    order(389..394,434..436,440..454,542..556)
                     /gene="Traf6"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:438305"
     misc_feature    order(395..397,401..415,479..481,488..493,506..508)
                     /gene="Traf6"
                     /note="E2 binding site [polypeptide binding]; other site"
                     /db_xref="CDD:438305"
     misc_feature    <584..847
                     /gene="Traf6"
                     /note="PRLI-interacting factor K; Provisional; Region:
                     PLN03086"
                     /db_xref="CDD:178635"
     misc_feature    659..739
                     /gene="Traf6"
                     /note="TNF receptor-associated factor 6 zinc finger 2;
                     Region: TRAF6_Z2; pfam18048"
                     /db_xref="CDD:436235"
     misc_feature    800..973
                     /gene="Traf6"
                     /note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
                     /db_xref="CDD:280357"
     misc_feature    <1007..>1246
                     /gene="Traf6"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]; Region: COG2433"
                     /db_xref="CDD:225288"
     misc_feature    1265..1714
                     /gene="Traf6"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF6 subfamily, TRAF domain,
                     C-terminal MATH subdomain; composed of proteins with
                     similarity to human TRAF6, including the Drosophila
                     protein DTRAF2. TRAF molecules serve as adapter...;
                     Region: MATH_TRAF6; cd03776"
                     /db_xref="CDD:239745"
     misc_feature    order(1274..1276,1280..1282,1364..1369,1463..1465,
                     1472..1474,1523..1525)
                     /gene="Traf6"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:239745"
     misc_feature    1277..1780
                     /gene="Traf6"
                     /note="propagated from UniProtKB/Swiss-Prot (B5DF45.1);
                     Region: Interaction with TANK.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4K3"
     misc_feature    order(1388..1390,1442..1444,1580..1588,1616..1630)
                     /gene="Traf6"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239745"
     exon            487..637
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            638..796
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            797..868
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..946
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..2707
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
cgcggctggggctgaggctccggccgtcggcggacgcagtagccgcggcccaggaaccgggagtttggcgtcggagacacttgatctcggagtgctgcgtgtataggcggcgcgtggcggcccgggggagctttctagtcggttgtgaagcctctgcgtgtgcgatcgattgactgacaacaaagctactatgagtctcttaaactgtgaaaacagctgtgcgtccagccagtcttcaagcgactgctgtgctgccatggccaactcctgcagtgctgccatgaaagatgacagtgtgagtggctgtgtcagcacggggaacctgtccagctccttcatggaggagatccagggatatgatgtggagtttgacccacctttggaaagcaagtatgagtgccccatctgcttgatggctttacgggaagcagtgcaaacaccatgtggccacaggttctgcaaagcctgcatcaccaagtccataagggatgcaggtcacaagtgcccagttgacaatgaaatactgctggaaaatcaactgtttcctgacaattttgcaaagcgagagattctttccctgacggtaaagtgtccaaataaaggctgtgtgcaaaagatggagctgagacatctcgaggatcatcaagtacattgtgaattcgctctagtgatttgtccccaatgccaacgttttttccaaaagtgccagattaataaacacattatcgaggattgtcccaggagacaggtttcttgtgtaaactgtgctgtgcccatgccgtatgaagagaaagagatccacgatcaaagctgtcctctggcaaatatcatctgtgaatactgtggtacaatcctcataagagaacagatgcctaatcattatgatctagactgcccaacagctccagtcccctgcacattcagtgtgtttggctgtcacgaaaagatgcagaggaatcacttggcacggcacttgcaagagaacacccagttgcacatgagactgttggcccaggctgttcataatgttaacctctctttgcggccatgcgatgcctcctctccatcccggggatgtcgtcctgaggacccaaattatgaggaaacggtcaaacagttggaggggcgcctagtaagacaggaccatcaaatccgggagctgaccgccaaaatggaaacgcagagcatgcatgtgagcgagctcaagcggaccattcgaagcctcgaggacaaagttgccgagatggaagcacagcagtgtaatggcatttacatttggaagattggcaactttgggatgcacttgaaatcccaagaagaggaaagacctgtggtcattcatagccctggattctacacaggcagacctgggtacaagctgtgcatgcgcctgcacctccagctaccgacggctcagcgctgtgcaaactacatttccctctttgtccacacaatgcaaggagagtatgacagccacctcccctggcccttccagggtacaatacgcctcacgatccttgatcagtctgaagcagtaataaggcaaaaccacgaagaggtcatggatgctaagccagaactgcttgcctttcagcggcccaccatcccacggaaccccaaaggttttggctatgtgacattcatgcacctggaagccttaagacagggaaccttcatcaaggatgatacgttattagtgcgctgtgaagtctctacccgctttgacatggggggccttcggaaggaggggttccagccacggagtactgatgcaggcgtgtagcctccacttacctgtgttcaaaaactaggagccatatggaaaaaccgtgccttccgcacctggtccagtaaacaaacggtgggagaggtgtaaggccagcagcagatgtcatcagcgaggtcacattacacttcttaccgttaaccaatatctggggcaattcccatggggacctccgtgtcccctgtgtcttcagaaccttaacatttgaagggccagacgctcatcaatttgtcagggaacctcttcactgtgcttccatgggcttttttgtccatgtactttactgaaaaaaaaaaaggccagaattaatgtactggagctcaatcgtttaatactggtgccttaaacacttaaagtgcttttagggcatgtattaaacgtgaggatcaccattgcctgtgctgctgccagtggaaaggttactgctctggtgttgagttctcatttagttgacccctgtgaatttcagaggctttgaaccatgatccctggaaagctgaagttctcatgtactccctcctccattgaccagggactggtttaacccttacttataaatagcacgaatgtattgtccattgaacaccaagggtttctcccctgccttcattgttgaaatatgctctaggcagcatcttcccggtttgtaagactgtggtcatgtggttgccaactgttcagtgtgactgtcatgtaacctttcttgtctgttcagtatagcttggtttccacagcctgtcgcacatcttctgttgcttgcaaacacaaaatcgccagcctaaacaagtgatcagctcaccagccattaaatggcatctcatggatgatgacagcaattcttatagccaggaaacttcagccctcttaactaccttccaatttagcttagttgattgaaataaaactgatttcctcaaggggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]