LOCUS       NM_001101002            6320 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus POU class 6 homeobox 2 (Pou6f2), mRNA.
ACCESSION   NM_001101002 XM_001055787 XM_001055843 XM_039096067
VERSION     NM_001101002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6320)
  AUTHORS   Yoshida S, Ueharu H, Higuchi M, Horiguchi K, Nishimura N, Shibuya
            S, Mitsuishi H, Kato T and Kato Y.
  TITLE     Molecular cloning of rat and porcine retina-derived POU domain
            factor 1 (POU6F2) from a pituitary cDNA library
  JOURNAL   J Reprod Dev 60 (4), 288-294 (2014)
   PUBMED   24804940
  REMARK    GeneRIF: expressed in the stem/progenitor cells of the rat
            pituitary primordium as well as the diencephalon and retina
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000293.1.
            
            On or before Apr 8, 2021 this sequence version replaced
            XM_039096067.1, NM_001101002.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JACYVU010000293.1  3473027-3473289
            264-435             JACYVU010000293.1  3475322-3475493
            436-527             JACYVU010000293.1  3599621-3599712
            528-756             JACYVU010000293.1  3602822-3603050
            757-1133            JACYVU010000293.1  3741466-3741842
            1134-1274           JACYVU010000293.1  3830951-3831091
            1275-1481           JACYVU010000293.1  3854180-3854386
            1482-1650           JACYVU010000293.1  3870381-3870549
            1651-1819           JACYVU010000293.1  3879763-3879931
            1820-6320           JACYVU010000293.1  3883141-3887641
FEATURES             Location/Qualifiers
     source          1..6320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..6320
                     /gene="Pou6f2"
                     /note="POU class 6 homeobox 2"
                     /db_xref="GeneID:681092"
     exon            1..263
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    228..230
                     /gene="Pou6f2"
                     /note="upstream in-frame stop codon"
     exon            264..435
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..2324
                     /gene="Pou6f2"
                     /note="retina-derived POU-domain factor 1"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 2"
                     /protein_id="NP_001094472.2"
                     /db_xref="GeneID:681092"
                     /translation="

MIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPSKLFGARGNTVLPEPGTPDQHQASQTHPSFPVGPQPLLTAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQQLQLQQQQQQQQPPPPPTSQHPQPASQAPAQSQQPQSQPTPPHQPPPASQQLPAAPAQLPQATQPQQHQPHSHPQNQNQSSPTQQSSSPPQKPTPSPGGHSLPSPLTPPNPLQLVNNPLASQAAAAAAAMGSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQSSQTSVGQAGTQGNLLHLAHGQASTSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPTSAVPLEPLADSPEENC"

     misc_feature    1677..2006
                     /gene="Pou6f2"
                     /note="Pou domain - N-terminal to homeobox domain; Region:
                     Pou; cl22952"
                     /db_xref="CDD:451464"
     misc_feature    order(2070..2084,2088..2090,2139..2141,2157..2159,
                     2196..2198,2202..2207,2214..2219,2223..2231,2235..2240)
                     /gene="Pou6f2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    2076..2237
                     /gene="Pou6f2"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(2076..2078,2085..2087,2205..2207,2214..2219,
                     2226..2228)
                     /gene="Pou6f2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            436..527
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..756
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1133
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1274
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1481
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1650
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1819
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..6320
                     /gene="Pou6f2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaaaaacaacaaacacacagggagaaattctggggaaatttgagaattgcccacctcctttgtcttttgtcagtctctctcttcacctcccaatgccaagtgctccaaaatccagccaacaaacccagtgcctgggatactaatctatcaccgtaaatttagattgacaatactatgggtcgaccgcattgattacattgattctatttcaaatatttacaatacactgagacaagcctaatctattttctaaagagttcaaggatccaatgatagctggacaagtcagtaagcccttgctgtcagtgcggagtgaaatgaatgcggagttgagaggtgaggacaaggctgctacttcagacagcgagctgaatgagcccctgcttgcgcccgtggaatcaaatgacagcgaggacactcccagcaagctcttcggggccagaggaaacacagtcctaccagaaccaggaactcctgaccagcaccaggccagtcagacccatccctcctttccagttggaccacagcctcttctaacggcacagcagttagcctctgctgtggccggggtgatgccgggaggccccccagccctcaatcagcctatcctcatccccttcaacatggcgggacaactaggtggtcagcaaggcctggtcctcacactgcccaccgcgaatctcacaaacatccaagggctggtagcggcagctgcagctggaggcattatgactctgccattgcaaaatttacaagctacctcatccctgaactcccagctgcaacagctccagcaactccagctccagcagcaacagcagcagcaacaaccacctcctccaccaaccagccagcacccacagccagcctcacaggcgcccgcacagtctcagcagccgcagtcccagcccaccccgcctcaccagccaccacctgcttcacagcagttgccagctgccccagctcagctgccgcaggctactcagcctcaacagcatcaacctcattcccatccccagaaccagaaccagtcgtctccaacccagcagagctcaagcccccctcagaaacccaccccatctccaggaggacatagccttccgtcaccactcacaccgcctaaccctctacagctggttaataatcctctagcaagtcaggccgccgctgcagcagcagccatgggctccatagcaagctcacaggcctttggcaatgccctctccagccttcagggggtcacaggtcaactagttactaatgcacaaggacagattattgggaccattccactgatgcctaacccagggccatcgagtcaagcagcaagtggcactcagggccttcaagtacagcctatcacaccccagctcctaaccaatgcccagggccaaatcattgccacggtcatcggaaaccagatcttgcctgtgatcaatacccagggtattaccctgtcccccatcaagccaggccagcagcttcaccaatcttcccagacatcagttggtcaagcaggcacccaaggcaacctcctgcacctggctcatggccaagcatccacctctcaaagtccggtgcgacaggcttcctcctcctcctcttcatcctcctcttcttcagctttgagcgtgggccagttagtcagcaatcctcaaacggcagcgggtgaggtggacggggttaatctggaggagatccgagaatttgccaaagcttttaaaatccgacgcctgtcccttggcctgacacagactcaggtgggacaagccctcagtgccacagagggccctgcatacagccagtcggccatctgcagacacaccatcctgagaagccactttttcctaccacaggaagcccaagagaacactatagctagcagtctgacagccaaactgaaccctggccttttgtatcctgccaggtttgaaaagctggacatcacccctaaaagtgcccagaagattaagccggtgcttgagcggtggatggctgaggctgaggcccgccatcgagcaggtatgcagaatctcacggagtttattgggagtgagccatccaaaaagcgcaagcggcgcacctccttcacaccccaggcccttgagatcctcaatgcccactttgagaagaacacacacccctcagggcaggaaatgaccgagattgctgagaagctaaactatgaccgggaagtagttagagtttggttctgcaataagagacaagctctgaagaacacaatcaaacgtttaaagcagcacgagcccacctctgcggtccccctggaacccttagcggactctccggaagaaaactgttagacacaccgttcatgatcagaaggaagcatctcagaaactgagcattaccccaagtctccacaaaaaagaaagaaaaaagaagaaaaaagaatttaaagacacccccagtcatcatctctcttgtatgtaaaagactaaaaacaaaaactaccaagtgggcagaatggtttatacatgtctgttggttttccaaaaggaaaaaaaaaggagagagaaattttaaatttttaaacaagaaaaaataccacatgaaggagtatgtggtaggatcattcgctccccccacctgtctccctaaagccagttttttaaaagcaaaccaaataaccacttacttttttctgtacgtgatgaaaatgtgaacaccttttaaggaaaaaggaaaaaaaactaaaccaaaaaaaaaaaaaaaaaaagaacaaaagcaaaaaaaccgccaacacaaacttgtatctgttcaaagcgaatgcaagcctgccacctggaggagtgactgcaacccttcagggactaagtgctgatcactgcaaaccctatttaccaaagtcggaaacactgcaaatgctactgctcgtctactcgcctctgcgtgaagagttatgttatgagtttttacatgtgtaccaacaggaaagtggaagcccgctttctcccatctttcttgcctgatgtctgtgccaccacggcggatgctattgttgggagcattctctagggctcactgtctacaatttgcttcttagcagatgaagtagcttcctcttttctttctttctttttttgttattgtttttgttttctgaattgtgtcatttccttttttgttttatttttggcgggtggtggggtggagaaacaacctggattgtgtgccaaagccttcgtggctttctttcactatgagttgtaggtttgagagagaaaatggagttcacacttccctttcttccctattgctccatttccctttcctgtggttccggggaatcttctggaagatggcagaagtgggaagaatggtttctttcccactccaatcctgcagaaacgcaggagacaatccaggataactaagtctgtctgctgaatgactgtcaacactggcagaggctgtaactgctcacggttcacaccagagattgggatttttctcggtctactagccacatatgtggagagctgatacaaattaattctgtaatataaacatacgctgcacatatggttcaatacttaaacctgtgttatgcttctgttcaaagcaaattctctaagaagtctatagccaaagaaaagtctcaagatttcagtcagtacacacgcacacaagcacgtccatgctcattcgcctcacacacagagagagaccacaaaagatgatggtgacctagattgttaggggctgttgagtgtcctgttaacctcgtcttttctgctacttgtttcatcaaacagtgttggcagacatttggagctggggtacatctgttcttgggatatatacatggcataaaaaggtgacaggcaaattgaagcaagtggaactaggctctggcttcttgacaaagaagtttagcaacaaaggctctccaataaaggaaaaatagacaagtagcttataaaacacctcagaagagccttccccattagcatattaattcactttcaaaagagcttccccaaggcatgagccacgagatccaagaaggccacagaatgaaaggcaaagaaacccttggagcctgttaatgttttcaccctggtgagggcagagagttctatcaaagcaggtaagaaccatcaacgtagatactcatgagtagttaaaaagcatgctcgtgtactgtctagaggcaaatcatgaaagggaaaaagaaaccccacctccagttgcccagttggttacaaagaccatcttgtatcccctagcaagctctcccaagcaggggttctagtttttttttctgttggctcctttgctggtaacaaaaatgggacagtaaaatagtccctcagatgcaatcataaatcagcaatcataaaactcccaccaaggaaactaaataataattctggacatagagtcattaataacagtgtctccatgccactagtctgattctaattggaccacaaccagcccgattagtgccaacaacatcatggtagcatttcacaactgcaaagactgaagaaataccagcaacccagaaaccgaaactttattgattaaaacagattttgtattctcctaggacctgctacaaattccatcaagaaaaactccccaagaagagacgctaacaagataacataggacggatgctaaatgtttaaaatctgaaccggaagcaggcacatgaggcctgctcagttctgaggtctatgattgggagagcatagctagaatagtaaaaatataaaataaaactaatcacccagagtagaacaaaaaagaagtgaattcatcccatggttgtaaaactattcacatgcagtgatttttttatagttttataattttgtattgttttataaattatttatatagtgttgtaatgcttcttatattgattttttactgatgaattttttgctacaaggcaaaaaaaaaagatgcctgaacagattcttaggaatataaactatacttgggaacacataagccttcaggaccacacctactgcttaattttattagatatttcttatttcctctggtaaagaacttcatatgccaataacatctaagtgtcttttatgtttccatgaactgaaggttaaggttgctaccaacaaaaagtaaaagccactttgggcaaatgtgattgtatttcaagcttctgtgtctttctcacacattttaaaaattgttgtcatctccattttcttcatcattgatgagacatgacagccgatattgtattttacacttgcttgtggaggttgttttctctttcaaccaaaaagatattttgagtagttaaaagtttcacttgcctttgcaagttttgaactctttctgtcgtgaacacacagtcacacacacacacacacacacacacacacacacacacacacaccacaaaagagaacaaaaaaaaaaaaaaacaaaggaaaaccaagagctgggagaggcagaacaaacaagtagaggcatatcaaagaactcaagctgtaaccaaaaagaaatccaattgcctttgctctcttctctacgctggaccaaagctcagtacgtgtaggaatatgcacattgtgtagatatggctaaatgttgctgacaatcttgcaatactaaactgttcctattttaagaaaaacaaatcacaaactgctcatcaatgttttacctcagcactctacttgtacccagttaacgatcaagcataaaaacaacggagaaaaaggaaattgattttcatttccatgtctgactgtaaaatcagtttggataatattttgtaatgagcttttttgtcatgtgacttgcttgtcttcaacttgcaattctgtgaggcacattggcttatttgttgttgaaaagtgttttttttttaaataccttgaagttttgatttattatttcatcctctgtgctgtgatctagactggtcaccagggtcacttaatgaagcgctgcaaaggaatctgcttctccatgcctggggcaggcagcaggagagagagcaggaaactagactgggttgttctggaaaaaaaaatcatgccgacaagacattgacatgatagactcgtgaccaagaagccaaactggatattgaaaagctccttacttgttctaacattgaaaccaaagctgacttatctgcacaggttgctaaatgtttaaaaaataaaataaaataaaaactgtccttaatctagagcaatatctgtatggtccgtaaagctgcactttgtgtatttctgaacagcttcagatctgtcacttttaatttgtaccatgaaaaataaagacttgtttgacatgaa

//