LOCUS       NM_001047880            1639 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus solute carrier family 25 member 15 (Slc25a15),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001047880 XM_001064456 XM_001064514 XM_001064627 XM_001064682
            XM_224969
VERSION     NM_001047880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Fiermonte G, Dolce V, David L, Santorelli FM, Dionisi-Vici C,
            Palmieri F and Walker JE.
  TITLE     The mitochondrial ornithine transporter. Bacterial expression,
            reconstitution, functional characterization, and tissue
            distribution of two human isoforms
  JOURNAL   J Biol Chem 278 (35), 32778-32783 (2003)
   PUBMED   12807890
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Camacho JA, Rioseco-Camacho N, Andrade D, Porter J and Kong J.
  TITLE     Cloning and characterization of human ORNT2: a second mitochondrial
            ornithine transporter that can rescue a defective ORNT1 in patients
            with the hyperornithinemia-hyperammonemia-homocitrullinuria
            syndrome, a urea cycle disorder
  JOURNAL   Mol Genet Metab 79 (4), 257-271 (2003)
   PUBMED   12948741
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Morris SM Jr and Kepka-Lenhart D.
  TITLE     Hormonal induction of hepatic mitochondrial ornithine/citrulline
            transporter mRNA
  JOURNAL   Biochem Biophys Res Commun 294 (4), 749-752 (2002)
   PUBMED   12061769
  REMARK    GeneRIF: Transcriptional Activation of ORNT1 mRNA by dexamethasone
            in hepatocytes.
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Tsujino S, Kanazawa N, Ohashi T, Eto Y, Saito T, Kira J and Yamada
            T.
  TITLE     Three novel mutations (G27E, insAAC, R179X) in the ORNT1 gene of
            Japanese patients with hyperornithinemia, hyperammonemia, and
            homocitrullinuria syndrome
  JOURNAL   Ann Neurol 47 (5), 625-631 (2000)
   PUBMED   10805333
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   Camacho JA, Obie C, Biery B, Goodman BK, Hu CA, Almashanu S, Steel
            G, Casey R, Lambert M, Mitchell GA and Valle D.
  TITLE     Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is
            caused by mutations in a gene encoding a mitochondrial ornithine
            transporter
  JOURNAL   Nat Genet 22 (2), 151-158 (1999)
   PUBMED   10369256
REFERENCE   7  (bases 1 to 1639)
  AUTHORS   Indiveri C, Tonazzi A, Stipani I and Palmieri F.
  TITLE     The purified and reconstituted ornithine/citrulline carrier from
            rat liver mitochondria: electrical nature and coupling of the
            exchange reaction with H+ translocation
  JOURNAL   Biochem J 327 (Pt 2) (Pt 2), 349-355 (1997)
   PUBMED   9359400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA339807.1, AY325139.1 and DY310527.1.
            
            On Jul 1, 2017 this sequence version replaced NM_001047880.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY325139.1 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support SAMD00132261,
                                    SAMD00132262 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                CA339807.1         142-201
            61-1078             AY325139.1         41-1058
            1079-1639           DY310527.1         54-614
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1639
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /note="solute carrier family 25 member 15"
                     /db_xref="GeneID:306574"
                     /db_xref="RGD:1311488"
     exon            1..115
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1077
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /note="ornithine transporter) member 15; solute carrier
                     family 25 (mitochondrial carrier; ornithine transporter)
                     member 15"
                     /codon_start=1
                     /product="mitochondrial ornithine transporter 1"
                     /protein_id="NP_001041345.1"
                     /db_xref="GeneID:306574"
                     /db_xref="RGD:1311488"
                     /translation="

MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLRTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVVGLDRQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAASQNTVWSVVKEIFRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPIPLMLSGGFGGICLWLAVYPVDCIKSRIQVLSMTGKQTGLIRTFLSIVKNEGGYRLSESRLYDVSFVQPKTCLSGVHYVGILKLGLREGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMSQLEAC"

     misc_feature    85..342
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /note="Mitochondrial carrier protein; Region: Mito_carr;
                     pfam00153"
                     /db_xref="CDD:395101"
     misc_feature    <424..654
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /note="Mitochondrial carrier protein; Region: Mito_carr;
                     pfam00153"
                     /db_xref="CDD:395101"
     misc_feature    673..1056
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /note="Mitochondrial carrier protein; Region: Mito_carr;
                     pfam00153"
                     /db_xref="CDD:395101"
     exon            116..374
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..512
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..682
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..841
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..952
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1615
                     /gene="Slc25a15"
                     /gene_synonym="Ab1-114; Ornt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggatatgtggttcacatccttccctccagagaattgccttcaacagaaaccagtaacgccatgaagtccaatccagccatccaagctgccatcgacctcacggcaggggccgcagggggcacagcatgcgtcctgactgggcagcccttcgacaccatgaaggtgaagatgcagacatttccagacctctaccgcggcctcactgactgctgcctgaggacctactcccaggtgggcttcagaggcttctacaaggggaccagccccgcactgatcgccaatatcgcagagaactcggtgcttttcatgtgttacggcttctgccagcaggtggtccgcaaagtggttggattggaccggcaggcaaaactgagtgaccttcagaacgcagctgctggctcctttgcttctgcttttgccgctctggttctctgccctacagagcttgtgaagtgccggctacagaccatgtatgaaatggagacgtcgggaaagatagcggccagccagaatacagtttggtcagtcgtgaaggaaatcttcaggaaggatggccccctgggtttctaccatggcctctcaagcactttacttcgagaagtaccaggctatttcttcttctttggtggctatgaactgagcagatcatttttcgcatcagggagatccaaagatgaactgggtcctatcccgctcatgctaagtggtggatttggtgggatttgcctgtggcttgctgtgtatccggtggattgtatcaaatctagaattcaagttctttctatgaccggaaagcagacgggactcatcagaaccttcctgagtatcgtaaagaatgaaggaggatacagactttcagagtcacggctctatgacgtcagcttcgtgcagccaaagacctgtctttctggtgtccactatgtaggcatcttaaaactagggttacgggaaggaataacagccttgtattctggactgaaacccaccatgatccgcgctttccctgccaacggggcactgtttttggcctacgagtatagcaggaagttgatgatgagccaactggaagcatgctgaagtgtcctggtgtgcctggagtcaaggcaggcgtttagcgactggttaactcagggtttcacggagtacaagaacaatgtggaattatgtgattcattgggactttgtccttgtcttcccttcttctattcaaagtcttggattttgtggatggtcctctgttctacacagtgtaatttctgcctgttactgaaccaaaacagaaaagtcactgttctcgtccttggcctcatgcacaggggagctggtggcctcatgcactggctttatgtaccttgtgcaggccctgttcctctcaggataacttccgtggaagtcagctgtacacatgcaatttagatggtcctgtcgtgaggaaaacaaatttttgttctatgtttaactgcaaacggtgaccaatttttacgtaggtggttgtaaatgattgcctaacacatcctagctagagggccgctgctaaaagccgctgagcctgtgcactaagaggttagagcttttgactttttgtggtatattaaagctaaaatacccatctataaaaaaaaaaaaaaaaaaaaaaaaa

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