LOCUS       NM_001034144            1800 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NK3 homeobox 1 (Nkx3-1), mRNA.
ACCESSION   NM_001034144 XM_224360
VERSION     NM_001034144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Lee JM, Kim U, Yang H, Ryu B, Kim J, Sakuma T, Yamamoto T and Park
            JH.
  TITLE     TALEN-mediated generation of Nkx3.1 knockout rat model
  JOURNAL   Prostate 81 (3), 182-193 (2021)
   PUBMED   33368416
  REMARK    GeneRIF: TALEN-mediated generation of Nkx3.1 knockout rat model.
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Jiang J, Liu Z, Ge C, Chen C, Zhao F, Li H, Chen T, Yao M and Li J.
  TITLE     NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in
            hepatocellular carcinoma and thereby suppresses tumor proliferation
            and invasion
  JOURNAL   J Biol Chem 292 (47), 19146-19159 (2017)
   PUBMED   28972178
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y and Inui H.
  TITLE     Hypoxia enhances transcriptional activity of androgen receptor
            through hypoxia-inducible factor-1alpha in a low androgen
            environment
  JOURNAL   J Steroid Biochem Mol Biol 123 (1-2), 58-64 (2011)
   PUBMED   21056661
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Akamatsu S, Takata R, Ashikawa K, Hosono N, Kamatani N, Fujioka T,
            Ogawa O, Kubo M, Nakamura Y and Nakagawa H.
  TITLE     A functional variant in NKX3.1 associated with prostate cancer
            susceptibility down-regulates NKX3.1 expression
  JOURNAL   Hum Mol Genet 19 (21), 4265-4272 (2010)
   PUBMED   20716579
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gerard D, Armstrong
            F, Ballerini P, Cayuela JM, Baruchel A, Pflumio F and Romeo PH.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   6  (bases 1 to 1800)
  AUTHORS   Carson JA, Fillmore RA, Schwartz RJ and Zimmer WE.
  TITLE     The smooth muscle gamma-actin gene promoter is a molecular target
            for the mouse bagpipe homologue, mNkx3-1, and serum response factor
  JOURNAL   J Biol Chem 275 (50), 39061-39072 (2000)
   PUBMED   10993896
REFERENCE   7  (bases 1 to 1800)
  AUTHORS   Schneider A, Brand T, Zweigerdt R and Arnold H.
  TITLE     Targeted disruption of the Nkx3.1 gene in mice results in
            morphogenetic defects of minor salivary glands: parallels to
            glandular duct morphogenesis in prostate
  JOURNAL   Mech Dev 95 (1-2), 163-174 (2000)
   PUBMED   10906459
REFERENCE   8  (bases 1 to 1800)
  AUTHORS   Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young
            P, Norton CR, Gridley T, Cardiff RD, Cunha GR, Abate-Shen C and
            Shen MM.
  TITLE     Roles for Nkx3.1 in prostate development and cancer
  JOURNAL   Genes Dev 13 (8), 966-977 (1999)
   PUBMED   10215624
REFERENCE   9  (bases 1 to 1800)
  AUTHORS   Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H,
            Lee Y, Lyons GE and Izumo S.
  TITLE     Vertebrate homologs of tinman and bagpipe: roles of the homeobox
            genes in cardiovascular development
  JOURNAL   Dev Genet 22 (3), 239-249 (1998)
   PUBMED   9621431
REFERENCE   10 (bases 1 to 1800)
  AUTHORS   Sciavolino PJ, Abrams EW, Yang L, Austenberg LP, Shen MM and
            Abate-Shen C.
  TITLE     Tissue-specific expression of murine Nkx3.1 in the male urogenital
            system
  JOURNAL   Dev Dyn 209 (1), 127-138 (1997)
   PUBMED   9142502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100628.1.
            
            On Oct 14, 2005 this sequence version replaced XM_224360.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100628.1, CA339706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..1800
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="NK3 homeobox 1"
                     /db_xref="GeneID:305999"
                     /db_xref="RGD:1305369"
     exon            1..299
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..721
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="NK-3 transcription factor, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-3.1"
                     /protein_id="NP_001029316.1"
                     /db_xref="GeneID:305999"
                     /db_xref="RGD:1305369"
                     /translation="

MLRVAEPQEARLEAGGRSPWAAPPTQSKRLTSFLIQDILRDHAERRGGQPSTPQHQCQPDPKRDSASELDEAEGSSVTLEDPPGIRSSPTETRAETESDAHFETYLLDCEHTPVLSSAPQVTKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRRQLSEDLGVLEKNSTLSLPTLKDDSLSRASLVSVYASYPYYPYLYCLGSWHPTFW"

     misc_feature    order(383..397,401..403,452..454,470..472,509..511,
                     515..520,527..532,536..544,548..553)
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    389..550
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(389..391,398..400,518..520,527..532,539..541)
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            300..1782
                     /gene="Nkx3-1"
                     /gene_synonym="Nkx3.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgggatgcttagggtagcggagccccaagaggcacggttggaggcgggtggtcgcagtccctgggcagcgccacccacgcagtccaagcggctcacgtccttcctcatccaggacatcctgcgggaccacgcagagcggcgtgggggacagccgagcaccccgcagcaccagtgccaaccagaccctaagagggattctgcttcagagctcgacgaagcagagggtagcagtgtgactctggaggacccgccaggtatccggtcgagccccacagagacacgggctgaaaccgagtcagatgcacattttgagacttatctgttggactgtgaacatactccagtcttatcaagtgccccccaggtcaccaagcagccacagaagcgttcccgggctgctttctctcacactcaggtgattgagttggagaggaagttcagccatcagaagtacctgtccgcccctgaaagggctcacctggccaagaacctcaaactcaccgaaacccaagtaaaaatatggttccagaacagacgctacaagactaagcgaaggcagctgtcagaagacctgggagtcttggagaagaactccacattgtctttgccaaccctgaaagatgacagcctatccagggcctccttggtctccgtgtatgctagctacccctactacccctacctatactgtctgggcagctggcatccaactttctggtaacaacagttcagatgacaactgcatagatcagaaactgccttccctgggggtccctgggaaaaagccagagtggctgatgtcaaggagttgaaagcaagaagtgtacagacacaaactgttgggtgttcccagggaatactccgattcttctctggtggccaatgaaagatctggggcagtggacattttattatgtagtcacagttccaagtgttctgtaggtcacggctgtcagttccctgtttagagagagctagacaagttcaagtcttatttccagagcttagagtggctatggctgcaatggctacatcgttcctaagaattctgttgctgcaatttcatcctctcccataactgggtatcatgaaagggccaagcaaggggagggatggccccttagatgaggatttcctcttgaattaaacttgtgtttaaaagtctcttgttggccttggactctgaccagagtttccctctgcccttgtaaaagtgagggtaaacgggagatttgaagaaggggagaaaaaaccttagtgattaagcaggttggcataggacatgaaggggctggaaggtggcattttcaacttcttactccttttgcagtgatgtgccaatccaaggatttacagggcagcctgagtgcagcagggtacatatactgaagggggttaagacaagctgtgtaaacagtttgcctgcaggggtgggcttcagaacagacttcctgtccaagacaagggcctatggggtttccaaactccaggtgagctgcttcggtcatgacattttattaccagtgaagggggaggggagatcttagactcaggagatcctgcagcttccctggtctgagaattcacacctcattatgacagaggtgccatcatttttaaacaaaggatcttccttctattcttttatttcttgttctttcttacaggactcctcagttcattgttttcatatatgcctgtcttatttagtgtaagatttgctcccaccacctcccaagttttatctttcccagtttaataactaactagcttcagacagataaaaaaaaaaaaaaaaaa

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