LOCUS       NM_001025773            1410 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus TNF receptor superfamily member 9 (Tnfrsf9),
            mRNA.
ACCESSION   NM_001025773 XM_575963
VERSION     NM_001025773.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Zhao X, Su H, Huang X, Xie L, Liu Z, Liu X and Suo X.
  TITLE     Molecular cloning and protein characterization of swine 4-1BB
  JOURNAL   Vet Immunol Immunopathol 153 (1-2), 35-44 (2013)
   PUBMED   23453329
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Shi Y, Hu S, Song Q, Yu S, Zhou X, Yin J, Qin L and Qian H.
  TITLE     Gene silencing of 4-1BB by RNA interference inhibits acute
            rejection in rats with liver transplantation
  JOURNAL   Biomed Res Int 2013, 192738 (2013)
   PUBMED   23484089
  REMARK    GeneRIF: gene silencing of 4-1BB by RNA interference inhibits the
            acute rejection in rats with liver transplantation.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Zhang J, Chen G, Zhou D and Wang Z.
  TITLE     Expression of CD137 in the cerebral artery after experimental
            subarachnoid hemorrhage in rats: a pilot study
  JOURNAL   Brain Res 1386, 200-208 (2011)
   PUBMED   21352817
  REMARK    GeneRIF: Upregulation of CD137 in the cerebral arterial wall may be
            important in the development of cerebral vasospasm following
            subarachnoid hemorrhage.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Haga T, Suzuki J, Kosuge H, Ogawa M, Saiki H, Haraguchi G, Maejima
            Y, Isobe M and Uede T.
  TITLE     Attenuation of experimental autoimmune myocarditis by blocking T
            cell activation through 4-1BB pathway
  JOURNAL   J Mol Cell Cardiol 46 (5), 719-727 (2009)
   PUBMED   19233196
  REMARK    GeneRIF: Blockade of T cell activation through the 4-1BB/4-1BBL
            pathway regulates development of experimental autoimmune
            myocarditis.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K and Ishikawa S.
  TITLE     Increased Foxp3(+) CD4(+) regulatory T cells with intact
            suppressive activity but altered cellular localization in murine
            lupus
  JOURNAL   Am J Pathol 173 (6), 1682-1692 (2008)
   PUBMED   19008373
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Shao Z, Sun F, Koh DR and Schwarz H.
  TITLE     Characterisation of soluble murine CD137 and its association with
            systemic lupus
  JOURNAL   Mol Immunol 45 (15), 3990-3999 (2008)
   PUBMED   18640726
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Goodwin RG, Din WS, Davis-Smith T, Anderson DM, Gimpel SD, Sato TA,
            Maliszewski CR, Brannan CI, Copeland NG, Jenkins NA et al.
  TITLE     Molecular cloning of a ligand for the inducible T cell gene 4-1BB:
            a member of an emerging family of cytokines with homology to tumor
            necrosis factor
  JOURNAL   Eur J Immunol 23 (10), 2631-2641 (1993)
   PUBMED   8405064
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097483.1.
            
            On Jul 22, 2005 this sequence version replaced XM_575963.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1410
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="TNF receptor superfamily member 9"
                     /db_xref="GeneID:500590"
                     /db_xref="RGD:1598208"
     exon            1..405
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            406..530
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    419..421
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="upstream in-frame stop codon"
     CDS             431..1207
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="tumor necrosis factor receptor superfamily, member
                     9"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 9 precursor"
                     /protein_id="NP_001020944.1"
                     /db_xref="GeneID:500590"
                     /db_xref="RGD:1598208"
                     /translation="

MGSSCYNMVVTVLLVVGTEEVRATRNPCDSCEAGTFCSKYPPVCTSCPPSTYSSTGGQPNCDICRVCQGYFRFKKPCSSTHNAECECVEGFHCLGPKCTRCEKDCRPGQELTEQGCKNCGLGTFNDQDGAGVCRPWTNCSLDGRSVLKNGTKEKDVVCGPPVVSLSPSTTPSAVTTPERESGERPLQVLTLFLALTLALLLFLIFIILWFSVPKWLRKKFPHIFKQPFKKAVRTAQEEDACSCRFPEEEEGGGGSYEL"

     sig_peptide     431..499
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    497..910
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="Tumor necrosis factor receptor superfamily member 9
                     (TNFRSF9), also known as CD137; Region: TNFRSF9; cd13410"
                     /db_xref="CDD:276915"
     misc_feature    497..562
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="CRD1 [structural motif]; Region: CRD1"
                     /db_xref="CDD:276915"
     misc_feature    569..685
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="CRD2 [structural motif]; Region: CRD2"
                     /db_xref="CDD:276915"
     misc_feature    689..778
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="CRD3 [structural motif]; Region: CRD3"
                     /db_xref="CDD:276915"
     misc_feature    785..904
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /note="CRD4 [structural motif]; Region: CRD4"
                     /db_xref="CDD:276915"
     exon            531..635
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            636..773
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            774..843
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            844..974
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1109
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1386
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggaggaaggtcagctgggtgttttctctgcctctctgagctaacaggctttccaccgtagtggctgccttccaagtgttcactggtgaaaaggaacgattgagattttgtggggtggggaatcctgtgaagggatctttaatatcgagttattttcagtattagggttaaaccaaagaaaaacgtccaaacaaacaaacaaaaaaaatcaagcaaagaagaaaagtctaagatctgggtcaggctgtgacgctgtagctgcagctgccccaccccccaccatccgaccatcggtcattcctggaattcaggtgctgaaggccagccctcagcgtaaagagctgacagagaccctgtggccaggggttctgagttccagccaccattcattctttttcacctttggtgtcctgtgcatgtgacgtttcgctatgggaagcagctgttacaacatggtggtcaccgtgctgctggtggtgggcaccgaggaggtgagagccacgcggaacccctgtgacagctgtgaggctgggactttctgcagtaaataccctccggtctgcaccagctgccctccaagtacctactccagcacaggtggacagccgaactgtgacatctgcagagtgtgtcaaggctatttcaggttcaagaagccttgctcctctacccacaacgcagagtgtgagtgcgtggagggattccactgcttggggccaaagtgtaccaggtgtgagaaggactgcaggcccggccaggaactaacggagcagggttgtaaaaactgtggcttgggaacgtttaatgaccaggacggcgccggcgtctgccgaccctggacgaactgctctctagacggaaggtctgtgcttaagaatgggaccaaggagaaagacgtggtctgtggaccccctgtggtcagcctctctcccagtaccactcctagtgctgtgactactccagagagagaatcaggagagcgccccttgcaggttcttaccttgttcctggcgctgacattagcgctgctcctgttcctgatcttcatcattctctggttctctgtgcccaaatggctcaggaagaagttcccccacatattcaagcaaccatttaagaaggcggttagaactgctcaagaggaagatgcttgtagctgccggtttccagaggaagaagaaggaggaggaggaagctacgagctgtaatgtgccatcctaggagatgtggggaccctcaggaaaccgagaagcactaagacccccaccctcctagggagtagcacaagttaccccacccccctgttcttaaaaccatcctagatggcatttgagcacgcaccccgtccaagtctcttctgatgctaatatatttgttaatttttaaaaaaaaaaaaaaaaaaaaaaaaaaa

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