LOCUS       NM_001025770            2481 bp    mRNA    linear   ROD 05-JAN-2023
DEFINITION  Rattus norvegicus centrosomal protein 41 (Cep41), transcript
            variant 1, mRNA.
ACCESSION   NM_001025770 XM_575421
VERSION     NM_001025770.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Ishikawa H, Thompson J, Yates JR 3rd and Marshall WF.
  TITLE     Proteomic analysis of mammalian primary cilia
  JOURNAL   Curr Biol 22 (5), 414-419 (2012)
   PUBMED   22326026
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Lee JE, Silhavy JL, Zaki MS, Schroth J, Bielas SL, Marsh SE, Olvera
            J, Brancati F, Iannicelli M, Ikegami K, Schlossman AM, Merriman B,
            Attie-Bitach T, Logan CV, Glass IA, Cluckey A, Louie CM, Lee JH,
            Raynes HR, Rapin I, Castroviejo IP, Setou M, Barbot C, Boltshauser
            E, Nelson SF, Hildebrandt F, Johnson CA, Doherty DA, Valente EM and
            Gleeson JG.
  TITLE     CEP41 is mutated in Joubert syndrome and is required for tubulin
            glutamylation at the cilium
  JOURNAL   Nat Genet 44 (2), 193-199 (2012)
   PUBMED   22246503
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
            Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
            and Andersen JS.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA and Mann
            M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098832.1.
            
            On Aug 30, 2012 this sequence version replaced NM_001025770.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098832.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2481              BC098832.1         3-2483
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2481
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="centrosomal protein 41"
                     /db_xref="GeneID:500069"
                     /db_xref="RGD:1562034"
     exon            1..107
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    29..31
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="upstream in-frame stop codon"
     CDS             65..1084
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 41 kDa; testis specific gene A14;
                     testis specific, 14; testis-specific gene A14 protein;
                     centrosomal protein 41kDa"
                     /codon_start=1
                     /product="centrosomal protein of 41 kDa isoform 1"
                     /protein_id="NP_001020941.1"
                     /db_xref="GeneID:500069"
                     /db_xref="RGD:1562034"
                     /translation="

MSDSPIDGSPQPEPDYRYKKDELFKRIKVTTFAQLVIQVASLSDQTLEVTAEEIQRLEDSDSATSEADTDIAAKTNGKGSPEEQSPSPVQFINSTGAGDASRSTLQSVISGVGELDVDKGLVKKEEPSGKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLVTGSLPASCQQALPFGSVRKRPGPKMPALPAENKWRFTPEDLKKIECYLEADQGPANNPSRLNQNNSAGRDLKVPAGRGGQNLPTGCPTSHSNSRTLNSGHLQGKPWK"

     misc_feature    230..361
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KM37.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    248..250
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    257..259
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    287..289
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99NF3; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    302..304
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    323..325
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    470..727
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Rhodanese-like domain; Region: Rhodanese;
                     pfam00581"
                     /db_xref="CDD:425764"
     misc_feature    638..640
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="active site residue [active]"
                     /db_xref="CDD:238089"
     misc_feature    911..1081
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KM37.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    989..991
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q99NF3; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); methylation site"
     exon            108..169
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            170..239
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            240..384
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            385..536
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            537..604
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            605..719
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            720..935
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            936..2481
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccttttttataaaatttaaaactctgcttaaggctttggcttgatctcgtatctccaagcagccatgtcagacagtcccattgacggctcgcctcagccagaaccagattatagatacaaaaaagatgaacttttcaagagaataaaagttaccacttttgcccagctggtcattcaagttgcttccctgtcagatcaaacactggaagtgacagctgaggagatccaaagactcgaagacagtgattctgcaacgtcagaggctgacactgacattgctgccaagaccaatgggaaagggagccctgaggaacagtcgcccagccctgtccagttcatcaacagcacgggagcaggggacgccagccgctccactctgcagagcgtcatcagtggcgttggggaactggatgtagacaaagggctcgtaaagaaagaagagcccagtggcaaagacaagccttatcccgactgtcccttcctgctgctagatgtgcgtgacagagattcttatcagcagtgtcacattgtcggggcctacagttaccccattgcaactctatccaggacaatgaacccctattcaaacgatattcttgagtataaaaatgctcatggcaagatcatcatcttgtacgatgacgacgagaggctagccagccaggcagccaccaccatgtgcgagcgcgggtttgaaaacctcttcatgctttccgggggtctgaaagtcttagctcagaagtttccggaaggactggtcactggttccctgccagcctcttgccaacaggcccttccttttggttctgtccggaaacgacctggccccaaaatgccagccctgccagctgagaacaagtggagatttaccccagaagacttaaaaaagatagaatgttacctggaagcggaccagggaccagccaacaaccctagccgactgaaccagaataactctgctggaagagacttgaaggtgcctgccggccggggtggccaaaacctgcccaccggctgtcctaccagccactcgaactcccgaacactcaacagtggtcacctgcaaggcaaaccctggaagtgaaggcctgtgttgtttagtcaaataaatgtcccctccttttggaacccccaacactcccaacttggtccttttcagaactgctgtagggaaacagccatgctactcgggctggaccaggcccacttctcactgtcttagctcccttcccttcattcaggaaggattttgacagctgaccacgaaagccagaggcttgacaggcaggctctagttgctttccctatttgtttacacaagattcatgtcttttgaaactgaataggaaaaaagaaagatactttcttttaaataaggtccagcctgtttggtctgtaaccagtgttgttctttaaataattcagtcacatctgctgctgtgttcttcccagccagcttttttcattcactgttgatttctgaaaaattctccaggtgggcctggccttggccactgtccccaggggcacagatgagttcttggttcctgcagcccacaggccccacactgggccaggtggctggctgagtcttagctctctatgtgctggcgctgcaggctctacgtgctgcaggctctacgtgctgcaggctctacgtgctgcaggctctatgtgctgcaggctctgctgggcacttgaagctgaggggtgatccgtgagcatgggtccatcttactggtttagcagaaaaactctctgcaaaatgatcccctccttaaatggtttcccgggaccagaaagctgtgtgctcagctgtcctcaccagaagaccccagtattctacaggtctatgctgagaaccctgcccgggaggccgctgcagctgtccccttcattatgagccttatatcaattaaaatttcccattgcctgatttgagtcccgcgatagtagatggatagaaatcacggtcatttgaaagcttcactttgacaaggggacacacaggtgaggaggactcgtgagtcctttgtcagggctgacaaccccttaagcccttgcttaaaatacagtattagtctaattgagtaattagtgcaatttcctgcttgcttttcattctcacgactgagctgtgattagaagtctgtgattatagattctggttttggccggaatttcgaatcggcattaattgaattgctagatgactgacatccattctatttaattgggggaacaaaagacctcaggtaaggatgaggcccatgaagtcataggcaaggacgagccttgttcatttttatggtctgtgatcgtagctctgataagggactgaagaataaattgtgcgctttgtcatggcaaccagcttctgaaaagccagctgaaaattgcctatccttaggtagttattgctggtgggtaagattcgccttagcagtacgatttcttcaccactttaaaaaaaaaaaaaaa

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