LOCUS       NM_177884               3360 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus GC-rich sequence DNA binding factor 2 (Gcfc2),
            transcript variant 1, mRNA.
ACCESSION   NM_177884
VERSION     NM_177884.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Ma,Y., Ren,Y. and Guan,J.
  TITLE     Knockdown of GC binding factor 2 by RNA interference inhibits
            invasion and migration of vascular smooth muscle cells
  JOURNAL   Mol Med Rep 20 (2), 1781-1789 (2019)
   PUBMED   31257544
  REMARK    GeneRIF: The inhibition of vascular smooth muscle cells
            proliferation and migration by knockdown of GCF2 by RNA
            interference was mediated by the PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Maga,A.M., Navarro,N., Cunningham,M.L. and Cox,T.C.
  TITLE     Quantitative trait loci affecting the 3D skull shape and size in
            mouse and prioritization of candidate genes in-silico
  JOURNAL   Front Physiol 6, 92 (2015)
   PUBMED   25859222
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129024.4.
            
            On Sep 1, 2022 this sequence version replaced NM_177884.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078171.1, AK050789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC129024.4         86410-86669         c
            261-389             AC129024.4         84454-84582         c
            390-614             AC129024.4         79456-79680         c
            615-712             AC129024.4         77437-77534         c
            713-828             AC129024.4         74327-74442         c
            829-1015            AC129024.4         70782-70968         c
            1016-1139           AC129024.4         68907-69030         c
            1140-1221           AC129024.4         67338-67419         c
            1222-1334           AC129024.4         66807-66919         c
            1335-1534           AC129024.4         65828-66027         c
            1535-1685           AC129024.4         63735-63885         c
            1686-1804           AC129024.4         61967-62085         c
            1805-1881           AC129024.4         60363-60439         c
            1882-1948           AC129024.4         58562-58628         c
            1949-2095           AC129024.4         56928-57074         c
            2096-2220           AC129024.4         53393-53517         c
            2221-3360           AC129024.4         51255-52394         c
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.81 cM"
     gene            1..3360
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="GC-rich sequence DNA binding factor 2"
                     /db_xref="GeneID:330361"
                     /db_xref="MGI:MGI:2141656"
     exon            1..260
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2338
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="GCF; TCF-9; transcription factor 9"
                     /codon_start=1
                     /product="intron Large complex component GCFC2"
                     /protein_id="NP_808552.2"
                     /db_xref="CCDS:CCDS20260.1"
                     /db_xref="GeneID:330361"
                     /db_xref="MGI:MGI:2141656"
                     /translation="

MALRPQRTFRRRQVESSDSDSDSDGAKEQSAEEPASAGGRTEGAERPRGARSARGRGRVWASSRRSPGAAPRGDGGAECRTAELSTDEEEGTHTLTGSKGDRSPSSDSSCSLEERDVSPIVEIPDAAFIQAARRKRELARTPGDYISLDVNHSCSTSDCKRSNEEDPESDPDDHEKRILFTPKPQTLRQRMAEETSIRSEESSEESQEDENQDIWEQQQMRKAVRIPAGQNTDLSHSSKSQTLKKFDTSISFPPVNLEIIKKQLNNRLTLLQESHRSHQREYEKYEQDIKSSKTAIQNLESASDHAQNYRFYRGMKSYVENIIDCLNEKIVSIVELESSMYTLLLKRSEALLKRRQDELKCESSYLQQLSRKDETSANGSLAVDEKDQRILEEIEARRMQRRQARELSGSCDHQEGMSSDDELSPAEMTNFHKCQGDILQDCKKVFEDVHDDFCNVQNILLKFQQWREKFPDSYYEAFVGFCLPKLLSPLIRVQLLDWNPLKMDSIGLDKMPWFTAITEFMESSMDDIGKEDGSDKKILAAVINKTVVPRLTDFVETIWDPLSTSQTRSLTVHCRVAFEQFASENEVSKNKQDLLKSIVARMKKSIEDDIFIPLYPKSSEEGKMSPHSKFQERQFWGALKLFRNILLWNGLLPDDTLQDLGLGKLLNRYLIISLTNAVPGPDVVKKCSQIAACLPERWFENSAMRTSIPQLENFIKFLLQSAQKLSSSEFRNEVSEIILILVKVKALTQAESLREERPLEPLPAQSTGV"

     misc_feature    29..394
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKT3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    74..76
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    77..79
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    83..85
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    281..283
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    284..286
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    380..382
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    428..664
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BKT3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    533..535
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    635..637
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    644..646
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16383; propagated from
                     UniProtKB/Swiss-Prot (Q8BKT3.2); phosphorylation site"
     misc_feature    1394..2038
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="GC-rich sequence DNA-binding factor-like protein;
                     Region: GCFC; pfam07842"
                     /db_xref="CDD:400273"
     exon            261..389
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            390..614
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            615..712
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            713..828
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1015
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1139
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1221
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1334
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1534
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1685
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1804
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1881
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1948
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2095
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2220
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3360
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3222
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="major polyA site"
     polyA_site      3360
                     /gene="Gcfc2"
                     /gene_synonym="A130099G21; GCF2; Tcf9"
                     /note="major polyA site"
ORIGIN      

aaggagacgcgccaatcctacttggaacatggctctcaggccccagaggactttcaggcggcgccaggtcgagtccagcgatagcgatagcgatagcgacggcgcgaaggagcagagtgcggaggagccggcgtctgccggcggccgaacagagggagcggagcggccgcgcggggcccgcagcgcccggggccgaggtcgggtctgggcgagttcccgccgcagcccgggagctgctccccgcggggacggcggagcagaatgcagaacagctgagctctcaacggatgaagaggaaggaacacataccttgacaggaagtaagggtgatcggagtccgtcctctgatagctcttgctctctggaagaaagagacgtttcacccatagttgagatccccgatgcagcttttattcaggcagcccgcagaaaacgggagttggccaggaccccaggggactacatttcattggatgtaaaccactcctgctccacttctgactgtaagagaagcaatgaagaggacccagagagcgatcctgatgaccacgaaaagagaatactgtttaccccaaagcctcaaacactccggcaaagaatggctgaagaaacgtcaatcaggagtgaggaatcaagtgaagagagtcaggaagatgaaaaccaagacatctgggagcagcagcagatgaggaaagcagtcaggatcccggcgggacaaaatacagacctttcccacagcagtaagtctcaaaccctgaagaagtttgatacttccatttcatttccaccggtaaatttggaaattataaagaaacagttaaataatagattaacattactacaggagtctcatcgctcacaccagagagaatatgaaaaatatgaacaagacatcaagagttcaaagacggctatccagaatcttgagagtgcatcagaccatgctcaaaactacagattctacaggggcatgaaaagttatgtggaaaatataattgattgtctaaatgaaaagattgtcagcattgtggaactagaatcatccatgtacacgttgcttttaaaacggtcagaagcacttttgaaacgcaggcaagatgaattaaaatgcgaatcatcatatttgcagcagttatcacgcaaagatgagacatcggcaaatggaagcttggctgtggatgaaaaggatcaacggattttagaagagattgaagctcggaggatgcagagaagacaggccagggagctctcgggcagctgtgaccatcaggaagggatgtctagtgatgatgagctgtctcctgcagagatgactaacttccacaagtgccaaggtgacattttacaggattgtaagaaagtttttgaagatgtgcatgatgatttttgtaacgtccagaatattttattgaaatttcagcagtggcgagaaaagtttcctgattcctactatgaagccttcgttggtttctgcttaccaaagcttttaagtcccctgatacgagttcagttgcttgactggaatcctcttaagatggactccataggtctagacaagatgccctggttcacagctataacagagtttatggagagcagcatggacgatatagggaaggaagatggttctgataaaaaaatcttggctgctgtcatcaacaaaacagttgttcctcgacttacagattttgtagagaccatttgggatcccctgtcaacctcacagacaagaagtttaacagtgcactgcagagtggcttttgaacagttcgcttctgaaaatgaagttagtaaaaataaacaggatttacttaaatctattgttgcaagaatgaagaagtcaatagaagatgatatttttattcctctatacccaaagagctctgaagaaggaaaaatgtcaccacactccaagttccaagaaagacagttctggggagctctaaagctcttccgaaatattcttctttggaatggccttctcccagatgacaccttgcaagatctgggactggggaagctgctgaatcgctaccttatcatctctcttactaatgccgtccctggaccagatgtggttaaaaagtgcagccagatagcagcatgtctaccagaaagatggtttgagaactctgctatgaggacatcaattccccagctagaaaacttcattaagtttttgttgcagtctgcacagaaattatcctcaagtgaattcaggaatgaagtcagtgaaataattcttatcctggtgaaggtaaaagctctgactcaagccgaatccctcagagaagagcgtcccctggagcccctcccagcccagagtacaggtgtttgagtgcgccgtgtgggagtgcccagagtcaagatgaccgtgtcacagccgatgccgcctttgctgggtgcccacttggggtgtggccaggcctcctgatgcttcgtagctgagggaagtaatgcacagcagcagccgagctcagtgtgctgctcttttactctctcaatccggaaggaaatgaagcaatctgacacacagaagcatgcctgaatcaaaaccatcttcagcaaactccaatgtttgcagatcagctaatgaggaagctctatctctggatggtttcttttatcttattctttggtggggactcggtctcattctgaagtgtaaggaattacttattaaatagctaacacatttttatacaaactgtcctttcaaaatctgtactgacttactgtgtgaaatcagtgcaagagagtgccagtgatctccagattttgattcattgtcaatttgttaaaaaaaaaaaaactttgaaaaaagatttatttttatatgtgtggtcatgtatgtacctgggtgggtttagcactacctccatgtaggggccagagggcatcaggtcccctggaactggaatccaggaggttgtgggccatctaatgtgcttggaaccaaacccaggtcctcagaagagatcttcaccctccctgtgaagaatgaagctgtggtctgagtcatctgtaagtccttaagtgaggcttttttgctatgttttgtgtaactcatggtaggactaaaaaggccattgctcttttaaatacagaaatgtaaagtatttctctaattaaggtagtctgaggcaaggtgattaagaaattatgaacttttctcaaaatgactgtattaatgttcttaagtatatttgttaagcaactcaatgatgatcctgtatttatttttccgtgttgtcactttagacatttgctcgttacaaaagcatgtgtatatgtgtgcagaaagttttgtatataaatggcagagactttatttttgctgttaaagggcacttttggaaa

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