LOCUS       NM_144843               3788 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 6 (Mtmr6), transcript
            variant 1, mRNA.
ACCESSION   NM_144843
VERSION     NM_144843.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Maekawa,M., Terasaka,S., Mochizuki,Y., Kawai,K., Ikeda,Y.,
            Araki,N., Skolnik,E.Y., Taguchi,T. and Arai,H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Mochizuki,Y., Ohashi,R., Kawamura,T., Iwanari,H., Kodama,T.,
            Naito,M. and Hamakubo,T.
  TITLE     Phosphatidylinositol 3-phosphatase myotubularin-related protein 6
            (MTMR6) is regulated by small GTPase Rab1B in the early secretory
            and autophagic pathways
  JOURNAL   J Biol Chem 288 (2), 1009-1021 (2013)
   PUBMED   23188820
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Mochizuki,Y. and Majerus,P.W.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166113.3.
            
            On Feb 4, 2022 this sequence version replaced NM_144843.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154859.1, AK076218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC166113.3         57551-57658
            109-225             AC166113.3         69426-69542
            226-388             AC166113.3         72380-72542
            389-546             AC166113.3         74234-74391
            547-675             AC166113.3         77214-77342
            676-810             AC166113.3         81840-81974
            811-943             AC166113.3         84291-84423
            944-1053            AC166113.3         85215-85324
            1054-1179           AC166113.3         85681-85806
            1180-1229           AC166113.3         88417-88466
            1230-1430           AC166113.3         88871-89071
            1431-1562           AC166113.3         90360-90491
            1563-1689           AC166113.3         91212-91338
            1690-3788           AC166113.3         92570-94668
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..3788
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
     exon            1..108
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1938
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform 1"
                     /protein_id="NP_659092.1"
                     /db_xref="CCDS:CCDS27176.1"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
                     /translation="

MEHIRTTKVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDEHLLQAISKANPGNRYMYVVDTRPKLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFTQFLECVWHLTQQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLNPLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQSKQLEEDIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLPVKDTLRAIEGSSPADNRYCDYAEEFSKSEPTVVSLEYGVARMTC"

     misc_feature    85..387
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Myotubularian (MTM) related (MTMR) 6 protein
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; Region:
                     PH-GRAM_MTMR6; cd13343"
                     /db_xref="CDD:270151"
     misc_feature    88..507
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VE11.1);
                     Region: Interaction with RAB1B.
                     /evidence=ECO:0000269|PubMed:23188820"
     misc_feature    406..408
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (Q8VE11.1); phosphorylation site"
     misc_feature    472..1377
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; Region:
                     PTP_DSP_cys; cl28904"
                     /db_xref="CDD:475123"
     misc_feature    1753..1755
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y217; propagated from
                     UniProtKB/Swiss-Prot (Q8VE11.1); phosphorylation site"
     misc_feature    1837..1839
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y217; propagated from
                     UniProtKB/Swiss-Prot (Q8VE11.1); phosphorylation site"
     misc_feature    1903..1905
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y217; propagated from
                     UniProtKB/Swiss-Prot (Q8VE11.1); phosphorylation site"
     exon            109..225
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            226..388
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            389..546
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            547..675
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            676..810
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            811..943
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1053
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1179
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1229
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1430
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1562
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1689
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..3788
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3770..3775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="hexamer: ATTAAA"
     polyA_site      3788
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="major polyA site"
ORIGIN      

agttcctgcgggtggctgtcaccgccccgtttctctcccgatggtgctctcctgaggccagctgcctgcgggcgtcgccccgggatggagcacatccggacaaccaaggttgaacaagtaaagttacttgaccggtttagtaccaacaacaagtcactgacaggaacactgtatcttacggccacacacctattatttattgacgctcagcaaaaagaaacctggatactacaccaccatattgcctctgtggagaaacttgctctgaccacttctggatgcccacttgtgattcagtgcaagaacttcaggattgtgcatttcattgttcccagggaaagagattgccacgatatttataactctctcctgcagctatcaaaacaagcaaaatatgaagatctctatgccttctcttataatcccaagcaaaatgatactgaacgacggaatggttggcagcttattgaccttgctgcggagtatgagaggatgggagtgcccaatgcaaactggcaactgtcggatgccaaccgagagtacaaggtctgtgagacttatcccagagagctgtatgttcctcggacagctagccggccggtgatcgtgggcagttccaacttccggagcaagggcagacttccggtcctatcctactgccggcagggcactgaggctgccatttgtcgatgtagtcagccattgtcaggcttcagtgccaggtgcctagaggatgagcatttgcttcaagccattagtaaagccaacccaggaaaccgctacatgtatgttgtggataccaggcccaagctcaatgcaatagctaacagagcagctggaaaaggttatgaaaatgaagacaactattctaatattagatttcagttcgttggaatagaaaatattcatgtcatgagatccagccttcagaaattactggaagtgaatggtagcaaggggctttctgtcaatgatttctactctggtttggaaagttcaggatggcttcgccatatcaaggctgttttggatgctgcaatcttcttagccaaagcaatagtggttgaaaatgcaagtgtgttggtccactgttccgatgggtgggacaggacctcccaagtgtgctccctcggctcactgttgttggattcctactacaggacaatgaaaggattcatggttttaatagaaaaagattggatatcatttgggcataaattttcagagaggtgtggccatttggatggagacccgagggaggtctcaccagtgttcactcagttcttggagtgtgtctggcacctgactcagcagttcccacaagccttcgagttcaacgaagcgtttcttcttcagatccatgagcacattcattcatgccaatttgggaacttccttggcaactgtcagaaggagagagaggaactcaggttaaaggagaaaacttactccctgtggccttttcttttggatgacaaaaagaagtacttaaatcctctctacagttccaaatctcagagactgacagtcttggagccaaatacagcctctttcaattttaagttttggagaaacatgtaccaccagtttgatcggacgctccatcctcggcagtctgtgctgagcataattatgaatatgaatgagcaaagcaagcagttagaggaagacattaaagacctcgaggctaaaattaagcaatgcaaaaatggcatcctaacgaaggagttgctgcatgctgtccaccctgaatcacctgccctgaaaacctcgctgtgtctcaaagagccgagtctgcttcccgtgaaggacacactccgagctatagagggcagcagcccagcagataatcgctactgtgactatgccgaggaattttctaagtcggagcctaccgtggtcagcttggagtacggggtggccagaatgacttgttagcctccttccgtgatccctggatgactgtagtgtaagaaatgtatagttgtgaggatggtctgtacacatgggcaggaggggttgttgagtgactttggggcttagcagtaagtgagaaagtaggtagctgagaaaaggatcatagcaactcttgagaggagtgagtcagctaagtgccatttgtaacaagaacatactcatttctgtaggaagtgagtgctagtgtgtgtatgtactggaaaggggttacacaggactggtgagctgacagtctgttgattcagatgttaattccagccacgctcagtagctttcctctaactctgagaaaacagacctgacaacctgaaccctcagtgactgatgtggcatgtgctttcagttctggagctgtgtgactgtggattttgcagtcacaaaaatccaaatatatagtcaaaaatatagtgacgttttaacattaaagtgccatgaaaagtacttatgggacagccttaaagtagactctcagtttattctgtgggttttatagccgaggacaggatgtttgatctctcctttaatcagccttatttcatatgaagaactaactgcactctgattacttgggggccgcacactgcagtgctccaccatggaaagttgtagacatactctgctagtttgtaattagccagctccacccgtatttaaaatcagtgttaccgaaggctttgttctcgttgtcatttgttccaagctgcagctgacagttcattattcacagcttagaggactcatttcttaggctagtataagcacatttggcatttactttcggcttactgcagtctattaattcttactctgtggttggctttaatcctttgataactgtacatttaaagtggcaaagctctaaagcgttctgagtactaaatacatttttaacttgactgtagctgcctataaactttcaggtaaaggaaaaagggaagtgcgggtagtggagattttgcttggttacgaattctaaagcaatcatttttgtgtggagcatatttccttactcttaatataggaggggcagagaagggagcactgggggagccagctaatgtccaacagaagcagctttgacgcaggaaaaggtttattttgctttataggctcattgttattctgtgcactggggcatacatatcttttctaaaaaatcacttacaactgtcagtattaccagctggctctcaaagtttaatatcattgatggtgtgtgaggtacagttcaggggcactacaaaatctgtgtacattgtcttatatacctcctgaccacacctatatctgtagtatttcttgtgttagttttgaacatatgtatcttttttttttttttgggaaaaaaaaggaaagctttatcgtatatgattttatctagtccttatttttccaattcacttctgtaagaccttatgtaataaaaacactgcattttaaaaagtaacagaaatatactaaaaattacaatgtataatgaacagtgtttagacattgagaaaggaaacttaatctctgtgtccacaacaggagggttttgtgccttggttccagtcaagttgtggttttagacttctgtggcagacttcctagtcatcttctgggttccttatgctaattttcaacttcacatgtatatatgtgtttacatgctcacacagaaaacatcctgagtgacgtacaggacatacgttggcaaaagtctgtgtaaatgtctcataaaattagatttatgttcattgtgttttgggatgtatagcatgtaaattatttcatgtattatttaaaggcaattaaatgttcatgcttta

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