ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2024-06-18 21:36:37, GGRNA.v2 : RefSeq release 224 (May, 2024)
LOCUS NM_029624 6442 bp mRNA linear ROD 20-FEB-2024
DEFINITION Mus musculus lipase maturation factor 1 (Lmf1), transcript variant
1, mRNA.
ACCESSION NM_029624
VERSION NM_029624.5
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 6442)
AUTHORS Sha,H., Sun,S., Francisco,A.B., Ehrhardt,N., Xue,Z., Liu,L.,
Lawrence,P., Mattijssen,F., Guber,R.D., Panhwar,M.S., Brenna,J.T.,
Shi,H., Xue,B., Kersten,S., Bensadoun,A., Peterfy,M., Long,Q. and
Qi,L.
TITLE The ER-associated degradation adaptor protein Sel1L regulates LPL
secretion and lipid metabolism
JOURNAL Cell Metab 20 (3), 458-470 (2014)
PUBMED 25066055
REFERENCE 2 (bases 1 to 6442)
AUTHORS Mao,H.Z., Ehrhardt,N., Bedoya,C., Gomez,J.A., DeZwaan-McCabe,D.,
Mungrue,I.N., Kaufman,R.J., Rutkowski,D.T. and Peterfy,M.
TITLE Lipase maturation factor 1 (lmf1) is induced by endoplasmic
reticulum stress through activating transcription factor 6alpha
(Atf6alpha) signaling
JOURNAL J Biol Chem 289 (35), 24417-24427 (2014)
PUBMED 25035425
REMARK GeneRIF: determined the alpha-synuclein-binding domain of beta-III
tubulin and demonstrated that a short fragment containing this
domain can suppress alpha-synuclein accumulation in the primary
cultured cells
REFERENCE 3 (bases 1 to 6442)
AUTHORS Ehrhardt,N., Bedoya,C. and Peterfy,M.
TITLE Embryonic viability, lipase deficiency, hypertriglyceridemia and
neonatal lethality in a novel LMF1-deficient mouse model
JOURNAL Nutr Metab (Lond) 11, 37 (2014)
PUBMED 25302068
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 6442)
AUTHORS Hosseini,M., Ehrhardt,N., Weissglas-Volkov,D., Lai,C.M., Mao,H.Z.,
Liao,J.L., Nikkola,E., Bensadoun,A., Taskinen,M.R., Doolittle,M.H.,
Pajukanta,P. and Peterfy,M.
TITLE Transgenic expression and genetic variation of Lmf1 affect LPL
activity in mice and humans
JOURNAL Arterioscler Thromb Vasc Biol 32 (5), 1204-1210 (2012)
PUBMED 22345169
REMARK GeneRIF: variation in Lmf1 expression is a posttranslational
determinant of LPL activity.
REFERENCE 5 (bases 1 to 6442)
AUTHORS Yin,F., Doolittle,M.H. and Peterfy,M.
TITLE A quantitative assay measuring the function of lipase maturation
factor 1
JOURNAL J Lipid Res 50 (11), 2265-2269 (2009)
PUBMED 19471043
REMARK GeneRIF: Results show that cotransfection of LPL with wild-type
Lmf1 restores its ability to support normal lipase maturation.
REFERENCE 6 (bases 1 to 6442)
AUTHORS Ebersole,T., Lai,F. and Artzt,K.
TITLE New molecular markers for the distal end of the t-complex and their
relationships to mutations affecting mouse development
JOURNAL Genetics 131 (1), 175-182 (1992)
PUBMED 1350556
REFERENCE 7 (bases 1 to 6442)
AUTHORS Lai,F. and Artzt,K.
TITLE Map positions of four dinucleotide repeats in the mouse t complex
JOURNAL Mamm Genome 3 (8), 476-477 (1992)
PUBMED 1643311
REFERENCE 8 (bases 1 to 6442)
AUTHORS Oka,K., Nakano,T., Tkalcevic,G.T., Scow,R.O. and Brown,W.V.
TITLE Molecular cloning of mouse hepatic triacylglycerol lipase: gene
expression in combined lipase-deficient (cld/cld) mice
JOURNAL Biochim Biophys Acta 1089 (1), 13-20 (1991)
PUBMED 2025643
REFERENCE 9 (bases 1 to 6442)
AUTHORS Davis,R.C., Ben-Zeev,O., Martin,D. and Doolittle,M.H.
TITLE Combined lipase deficiency in the mouse. Evidence of impaired
lipase processing and secretion
JOURNAL J Biol Chem 265 (29), 17960-17966 (1990)
PUBMED 2211673
REFERENCE 10 (bases 1 to 6442)
AUTHORS Oka,K., Yuan,J.G., Senda,M., Masibay,A.S., Qasba,P.K., Masuno,H.,
Scow,R.O., Paterniti,J.R. Jr. and Brown,W.V.
TITLE Expression of lipoprotein lipase gene in combined lipase deficiency
JOURNAL Biochim Biophys Acta 1008 (3), 351-354 (1989)
PUBMED 2474325
REMARK Erratum:[Biochim Biophys Acta 1989 Nov 2;1009(2):199. Oasba PK
[corrected to Qasba PK]]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC154418.2 and AC134908.5.
On Jan 16, 2024 this sequence version replaced NM_029624.4.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK010312.1, AK154622.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-206 AC154418.2 132101-132306
207-516 AC154418.2 138470-138779
517-527 AC154418.2 141603-141613
528-676 AC154418.2 165223-165371
677-742 AC154418.2 184662-184727
743-910 AC134908.5 19084-19251
911-1097 AC134908.5 28355-28541
1098-1251 AC134908.5 29023-29176
1252-1435 AC134908.5 29320-29503
1436-1548 AC134908.5 29936-30048
1549-6442 AC134908.5 36449-41342
FEATURES Location/Qualifiers
source 1..6442
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="17"
/map="17 12.7 cM"
gene 1..6442
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="lipase maturation factor 1"
/db_xref="GeneID:76483"
/db_xref="MGI:MGI:1923733"
exon 1..206
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
CDS 14..1738
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="transmembrane protein 112"
/codon_start=1
/product="lipase maturation factor 1"
/protein_id="NP_083900.3"
/db_xref="CCDS:CCDS37502.2"
/db_xref="GeneID:76483"
/db_xref="MGI:MGI:1923733"
/translation="
MRPDSLVMAAPEGSLRKRKVGGAEHSPASQPSLARDPADSPARLHTGTFWLTRIVLLRALAFIYFVAFLVAFNQNKALIGDRGLLPCKLYLKNVQEYFQGSTGWAAWTYAPTIMWLLDWSDMNFNLDLIALLGLGISSFVLVTGCANMILMTALWALYMSLVNVGQIWYSFGWESQLLETGFLGIFLSPLWTLSRLPKNTPTSQIVLWGFRWLIFRIMLGAGLIKVRGDKCWLDLTCMDFHYETQPVPNPIAYYLHRSPWWFHRFETLSNHFVELLVPFFLFLGRRMRILHGVLQILFQVILIISGNLSFLNWLTIVPSLACFDDAALGFLFPSGPQGLKKQVLEIQREDTQRVQPKPRDRGCLVRQVVNISLGILVAWLSVPVVINLLSSRQIMNTSFNPLRIVNTYGAFGSVTKERTEVILQGTVSPNASAPDAVWEDYEFKCKPGDPWRQPCLISPYHYRLDWLMWFAAFQTYEQNEWILHLAGKLLAGDSEALALLAVNPFEGRTPPRWIRGEHYRYKFSLPGGQHATQGKWWIRKRIGPYFPPLRLEDLKEYFKTREWPLPEPPSRHTR"
misc_feature 14..130
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 161..229
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
transmembrane region"
misc_feature 395..466
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
transmembrane region"
misc_feature 518..1654
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="Lipase maturation factor; Region: LMF1; pfam06762"
/db_xref="CDD:462004"
misc_feature 635..676
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
transmembrane region"
misc_feature 890..976
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
transmembrane region"
misc_feature 1115..1177
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1);
transmembrane region"
exon 207..516
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 517..527
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 528..676
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 677..742
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 743..910
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 911..1097
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 1098..1251
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 1252..1435
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 1436..1548
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
exon 1549..6442
/gene="Lmf1"
/gene_synonym="2400010G15Rik; cld; Tmem112"
/inference="alignment:Splign:2.1.0"
ORIGIN
gccctttgtgctcatgcgcccagacagcctagtaatggctgcgcccgaggggtcgctgagaaaacggaaggtcgggggtgcggagcacagtccagcgtcgcaaccttctctggctagagatcccgcagattctccagctcggctgcacacgggcaccttctggctgactagaatcgtgctcctgcgggccctcgctttcatttactttgtggcctttttggtggcattcaatcagaacaaggccctcatcggtgaccggggcctgctgccctgcaaactgtacctgaagaatgtccaggagtacttccagggcagcactggctgggctgcctggacctatgcaccaaccattatgtggttgttggactggtcagacatgaacttcaacctggacctcattgctcttcttgggctgggcatctcgtcctttgtcctggtgaccggctgtgccaacatgatactcatgactgccctctgggccctctacatgtccctggtcaacgtagggcagatctggtattcttttggatgggagtcacagctgctggaaacaggattcctggggatctttctgagccctctctggacactgtcccgcctgcccaagaacacccccacatcccagattgtcctgtggggcttccgctggctgatcttcagaatcatgcttggagcgggcctcatcaaggtccgcggggacaagtgctggctggatctgacctgcatggacttccactatgagactcagcccgtgcccaacccgatagcctactacctgcacaggtcaccatggtggttccaccgctttgagaccctcagcaaccacttcgtggagcttcttgtgcctttcttcctgttccttggacggcggatgcgcattcttcatggagtgctgcagatccttttccaggtgatcctcatcatcagtgggaacctgagcttcctgaactggctcaccatcgtgcccagccttgcctgcttcgacgatgcagctctgggattcctgtttccctcaggacctcaaggcctaaagaagcaagtcctggagattcagagggaagatacacaaagggtccagcccaagccaagagacagaggctgcttggtgcggcaagtggtcaacatctccctgggcatcctggtggcctggctcagcgtacccgtggttatcaatctgctaagctccaggcagatcatgaacacctccttcaacccgctcaggatcgtcaacacctatggggcctttggaagtgtcaccaaagagcggactgaggtgatcctgcagggcacagtgagccccaacgccagcgcacctgatgcagtgtgggaagactatgagttcaagtgcaaaccgggcgacccctggaggcagccatgcctcatctcgccataccactaccgcctggactggctgatgtggttcgcagctttccagacctatgagcagaacgagtggatccttcatctggcgggtaagctcctagctggtgactctgaagccctggccctacttgctgttaacccctttgagggcaggactccccccaggtggatccgaggagaacactaccggtacaagttcagcctccccgggggccagcacgccacccagggcaagtggtggatccgcaagcgaattggtccttacttccccccactccgccttgaggatctgaaggaatactttaagactcgggagtggccactaccagaacccccatctagacacacacgctgaaataaagaccagagaccaaccgcttctctacctatactgtgctgcggccacgggacccgcacagggacccggcagcccatggatcctgccaagaagagattggaaaaggatgtgcttcctagctgtcagcctcctgtctctatccgtccctgtcaccttgctaacccttccctgttgtggagaggggggtctcagattccctaacctagaggctgcgtcccctgtagcccaaccacacattcctagtcaatcccgtagccaggtctctatcacaagtccggtgtggcagcaccgactcgttcccaccatctccctgagggacaggaggcttgctgttctcagcatgatccctccccagaacccctcacacaccacccaggcacacacacacagatacatgagctcaggaatcccttgcacgctccagtgtaggatatatgcaaatggatagaagccctgtcaccagcttgtggtcatattccagtctcccgtgggtgacctgtggagaaccaagcagagccatgtcagtgggaaccttggccagcagtgcttaaggcttcccttcccagattgcgcacaactgcccaggctcaccagctacaaggacagcagagactctaggaatacctccccatccccctgcttgctaagcatggtgtctggggcccatgttgcctgtccctgggccacactgcagaggatcccagaaaggacaacaaaaaaggttcagttgaggaggctggtcgaggggggcacaagtgtggccttgcagagcaccccctcagcctggctggggagggacggccaacccaggtgcaaacagagagcccgtgttccagctcccaaggaaacagggcgccctgtgtgtgtcagggacagacagcctcagagctatgagactggagccagcaagtctgccatgaccaccacaggagtgactggcagcctgcagcctgagcagcccttcctgggggcggcccagccataccccaggcggtagacgtggggggtggggccctcagcagggatggcagctgcttgggtattctggtgacccgggagagtggcacctagctcactgtgagccctccatgcccttgccggttgccaagaccgcagtctcggggctcagtgggagaaacctcaggcccccagatgtagacttctggcatcggtccagccatgtgccccctccttcctgaggatcctggggagggggctgctggttcagcagagctaaaaaacggtgtttcgacctatgcaggggacaagagctgtgggagggagccaggccctggggcaaccagaatctaccaggatgcctcttgtaagagagacaggatctgacagacagactgcagacagaggacaggtaatagatggtcccctgctggtttcagaatgtcatctccacccagatgccatgctgagtcctgtgctgcatcatgtgtcatggatttgctcacacaacagtcatgctgtatgacatggaggcttagtgactgacatccttgttggttctttgggtacagatctccctatgtagaccaggctgacttcaaactgagctggggttaaaggtgtgcaccaccacgcccagctgcctcttgatttttaccccatgtggtagctgctgtcgtgagctactcttgaaatgggatgagggcaccaatagagccacactgagtgggggttacagggagtgcccatctgatgacactggccctcagcatggatcagggcctcaagccggcagagcccagcaggagtcacagtggacaagctggaatggatgttagtggccaggtcattcccttggtaaacattaagcaaggcttatcactgtccacagcccctggtcatcttgctctctctggtggccttagggacccactgaagagacttagcagctctgactgtggatagccccaccctacccaagctcaccctagggtagacgggtcctgacagtggtgagtcagtcacgctatgtgtctgctcaccaaggacagcacagggacctgatgtcctgatctagaaggcacttacaggtttctacctctgacagatgtaggccctcccaatatacatgtatcctcaaagatccccttgttgaggctgagaggtgcccccagctcccttagcaaatgatctttataccccactggatcactccagccaaggagtctgctctaaggccatccctggggagccccactcacacccatgccttgactacactggggccatactgctgcactggtcagcgtccaggtggagaggggtctcatcctgtcccttagcgcagcagtcatgccatgtgagtctaccaggttaactgtagcatgctaaaggacgtgcccatctgcccctgggcacatgctccctccacggaagaacccaaggaagaaatttccatgttggagggcactgggacaaacgtaggaagcttgggtgccgggctgggccgggggacaggggagaactcaggttcacttagcagtactgtctaacattagggtatgtttctgcacttctctacccaaattcccactccaggggttgggggtgagtggacatagcagctgtgacgtgattagccccaacttcactctgtaggatgtgcaaaagcaaggttagggtccagtgtatgctagttgctagtgacctgggctagcggacatcggccaggagccggacatgggctctgggatgacagaagacagtcatactagactctctacacctgatttcaaactcaggatccaaagtcaccaggcactatctccctgaggtgccatgctgggcctgactattggtcccctaacagttggcagctcaccaggatgcatccttccctctccatcatccagcagaggtgatgtaccctcctcatgcactggtccccagccagctgaagtcctgtggctgcttccactgccaaaagcttcccactcacttgggttagtaaatggaaccaaggaagcatcgtcacgtaccgtaccgtctcacaggatagcaagatgcctgaaggaagccagccagatgggtgaaaccataacatggtgttaaaggggactgaagacagaagagcaggtgacaggtcacctgaaaatgtcactcccgggagccagtgctcctcacggtggctgccttgcaatcctgacacaattccagtagtctctatagaacgggaaccctagctccaaacttgtgtagaactgcaaatgacaaaatcagtgttatactggaacactgctggctgtgaagtgtctgccacacagcatgacgacctgagttcaataccccagaagccccagaaaaggcaggctgcacggttgcttggctgtagccccagcgctggggaagaggaaacaggcagactcctgagctcactgggcaaccatcccagattgattgagctccggatttagtgagagactcgacctcaaaaaaataaggtgcttagaaatcactgcagtcaacaatgtcagcctctggttcccatgtacacacacgtacacacacatgcacacaccaccgtgaatttggggccaacctggactacagagtgacagcctatctcaaggaaaaagtaaaatgcccaggagacgctgacatgtctgttggaatgcttttgacaagagctttaaaagcatgcaaagggaaagaaacacaccattgtctttcttttcataataagaaatattgtctgtggccatatagccccgagcacacccccatctcatctaacaggaaatgcgactttctggaattttctatatgtgtgtggggaaagtgtgtatcgtgtttgggagtactgacaggctagaagagagcattgggtcccccgaagctggagttaagggtccccaaggtgctgggaaccagaaagaacagggtttaaccattgagccatctctctgccccaaaccggtttggagtgggcattgctgagacaaggcagctgacaacatgcagaggacaggagcagctctctttcctcaagtcaaggctggcgagatgctgagcacatgaaggtaccaccaaccccaggactcccaccggtgccctctgacccccacatgcaggccatggcaccaacacacacacatacacacacacatgcatgcaaatgcccacatgcacacacactgctccagccctggctatgtccaatctgctgctttctcttctcccaactcctccagatgcctctctcccttatccacaataaaaaacctttccccagtccaaaaaaataaaaagatgaacttcgggggctggagatggcttttatagaagagcacttgctgctcttacagggaaccccagttcagttcccagcacccatatggaagcttagaaccatctgtatctccaggtccaggggatcccgtaccatccagtaccctctcctggcctcatcagctgtcacgggtgcttgtggagcagttagcatgaatactctgaaagtactcatacacataaagttgttttagtaaaaaaggtgagctctagagctgaggtgtgggctcaagcagagtacttgtctaaaacacatgagtcctcatgttctaccctcagtgatgaggatgatgatggtgacagtgacggtgacagtgacagtgatgatgatgcaaatgaatgaagctcctaaaccaaagaactaacactaaaaactcttaaaacagaagcttcaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]