LOCUS       NM_026412               3118 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus kinetochore-localized astrin/SPAG5 binding (Knstrn),
            mRNA.
ACCESSION   NM_026412
VERSION     NM_026412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Lau,E.O., Damiani,D., Chehade,G., Ruiz-Reig,N., Saade,R.,
            Jossin,Y., Aittaleb,M., Schakman,O., Tajeddine,N., Gailly,P. and
            Tissir,F.
  TITLE     DIAPH3 deficiency links microtubules to mitotic errors, defective
            neurogenesis, and brain dysfunction
  JOURNAL   Elife 10, e61974 (2021)
   PUBMED   33899739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Cindric Vranesic,A., Reiche,J., Hoischen,C., Wohlmann,A.,
            Bratsch,J., Friedrich,K., Gunes,B., Cappallo-Obermann,H.,
            Kirchhoff,C., Diekmann,S., Gunes,C. and Huber,O.
  TITLE     Characterization of SKAP/kinastrin isoforms: the N-terminus defines
            tissue specificity and Pontin binding
  JOURNAL   Hum Mol Genet 25 (13), 2838-2852 (2016)
   PUBMED   27170314
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Grey,C., Espeut,J., Ametsitsi,R., Kumar,R., Luksza,M., Brun,C.,
            Verlhac,M.H., Suja,J.A. and de Massy,B.
  TITLE     SKAP, an outer kinetochore protein, is required for mouse germ cell
            development
  JOURNAL   Reproduction 151 (3), 239-251 (2016)
   PUBMED   26667018
  REMARK    GeneRIF: important role in the successful outcome of male
            gametogenesis
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006328.1, AK036374.1 and AK028590.1.
            
            On Apr 29, 2009 this sequence version replaced NM_026412.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028590.1, SRR1660817.14208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-725               AK006328.1         2-726
            726-3042            AK036374.1         515-2831
            3043-3118           AK028590.1         2844-2919
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.46 cM"
     gene            1..3118
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="kinetochore-localized astrin/SPAG5 binding"
                     /db_xref="GeneID:51944"
                     /db_xref="MGI:MGI:1289298"
     exon            1..307
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    36..38
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="upstream in-frame stop codon"
     CDS             99..1037
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="TRAF4 associated factor 1 homolog; putative
                     TRAF4-associated factor 1; kinetochore-localized
                     astrin/SPAG5-binding protein; kinastrin;
                     kinetochore-localized astrin-binding protein"
                     /codon_start=1
                     /product="small kinetochore-associated protein"
                     /protein_id="NP_080688.2"
                     /db_xref="CCDS:CCDS16585.1"
                     /db_xref="GeneID:51944"
                     /db_xref="MGI:MGI:1289298"
                     /translation="

MAAPEAEAQETAFRTTGPPTDSEPRPFPPSSRKFPFESAAADSNEDWAVAAEHYLKGSGENGGWEQPAPGVQPSHPATMASAKTVCDAQPHSMPSCGLPADTQTRATSKLPVKSKEADLLRHLHPGGPEPDVTKVTKSRRENGQVKAAETASRRNLRNSYKPFNKQKPEEELKDKNELLEAVNKQLHQKLTETQGELKDLTQKVELLEKFQDNCLALLESKGLNPGQETLASKQEPTTDHTDSMLLLETLKDELKVFNETAKKQMEELQALKVKLKLKEEESVQFLEQQTLCKDEASDFTIILEEMEQLLEM"

     misc_feature    99..611
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9Z1.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    528..>1022
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="phosphodiesterase; Provisional; Region: PRK12704"
                     /db_xref="CDD:237177"
     misc_feature    564..1034
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9Z1.2);
                     Region: Interaction with SPAG5.
                     /evidence=ECO:0000250|UniProtKB:Q9Y448"
     exon            308..399
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..526
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..574
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..680
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..774
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..830
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..905
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..3118
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="major polyA site"
     regulatory      1530..1535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="hexamer: AATAAA"
     polyA_site      1553
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="major polyA site"
     polyA_site      3075
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
ORIGIN      

agcttggctcaatagctccattcaagccagcccagtgagtccctggcccagcctcgaccagcaggctggagcaactctgctcgaaccttccgtacagcatggcggctcccgaggccgaggcacaagagacagccttccgtacaacagggccgcctacagactcggagccgcgccccttccctcccagctcccggaagtttccttttgaaagcgcggcggcagactctaacgaggactgggcagttgctgcggagcattatttgaaagggagcggagagaacggcggatgggagcagccggcaccgggggtccagccaagccacccggctacgatggccagtgctaagacggtgtgcgatgcgcagcctcactcgatgccgagctgcggcttgcccgcagatacacaaactcgagctacttctaaactacctgttaaatccaaagaagcggatttgcttagacatcttcatccaggagggccagagcctgatgttacaaaagtcaccaaatcgagacgagagaatgggcaggtgaaagcggcagagactgccagcaggaggaacctcagaaacagctacaaaccgtttaataagcaaaaaccggaggaggaactaaaggataaaaatgagctgctggaggctgtcaacaagcagttacaccagaagctgacagagactcagggagagctgaaggacctgacacagaaagtggagctactggagaagtttcaggataactgcttagcacttttggagagcaaaggtctcaacccaggccaagagaccctggcatcaaagcaggaacccaccacagatcacacggactccatgctgctgctcgaaactttgaaagacgaactgaaggttttcaatgaaaccgccaagaagcagatggaggagctacaggccttgaaggtgaagttgaagctgaaagaagaggagagtgtccagttcctggaacagcagaccttatgtaaggacgaagccagtgacttcacaataatcctagaggaaatggagcagctcttagaaatgtagctcaaggcaggtggccggacggcttcttcctggataaaccctcggcagaggctacttaggatatcttcaaggactcaccatcccttaggtaaagaccttctgcagcagttgatccgataaggccagttgatgctggggttcctcctttaagcagattgccccaccttcagatggctcagctctcctgcaagagaggaacctgggagtttgactccatttcctgtgcagcagagagagcagcagcccttagaactaggatactaaaccagctgccttggagactctagagactcggaaacatgggaagaaggcccacaccacaacagcacgagtgctgtgcgagagatgtgactgtgagccatgctgtccccttgtctctctggttgagttaagttttatgaacttgaaattcttgaagtttttttggcttaataaatgggggtggaggtatacaaagtagcacctacctaaaactacaactagagctttggaaataaatgtttctatgaatattaatattctgactaacactagggaatgaaagtagcctctttaacccagtgtggtggctcatatctataacaatcataggacttgggaggctgaggcaggagaattgtcttgagttagaggatagcctaggctgcagaaatactgtctcagaaaagcaaggaagatgttggggattaggaaattgccacacaaaccatatgtacaccaatctcagttaagcaagaatagtttagtgaacgcacatcataatatggaagtccgggtccacgagaaggaaaagctcaactgtggcaccagtctgctctcggagtaggctttctataggaaaaaccaggtttaaaggtcaaggagaggagcagctggcttactaggtaaagtattgttagccaacctttaagccaattggtcctgagtgaggtaagaaagatggtggtcaggcggtgaacaagggaatttcagaacactgagataactaggaacaagtgatttaatcacgttgtttttgcttgttagtagcatttttcagtgtcagttacactaatcactatgaccttaatttcaccttgtgactaacattgagcctgaatacaaatggctacagttgtgttaaaaggaacaggcctcaacatgaggaggaggaggaggtaggattaagcggtgtttggtctggatctgtgagttgagcatactggcataagtccaaggtactgtgactgcctttccctccatccgctccgtgcctgtgacaaggcctcctgccttccaggattgtcagttcttccacattcgtagctgtgtgtgccatgctctattcaccgtgttggtggccagatgcctgtgttctgtctgtatgtctgcagcttgtctgtcagagccaacctagagcctggtgcaacaggccctccccattgggatcaccaaaatgcagccatgttctcccccttagctgaaacacagcagcctttgctttggccattcccattgcttttgagctttctgttttctttaccaaacttgcctaatgtctccttcaaaatcactaagactgaccagagtcccgatccccaacgaagctgagtaatgtcccatacttaactttttctttctttctttactttttcaaatgtataaaatggtttataaggtttataaggtacaactaaagaccatcgcacagcaggtgaagcatacctactttatataggttcaccatacacagaatgggactccaggaagagtcctatagaacactgcattctggcttcctgtgtgatccacatctgctcctttgacgtgtgattcttcgaagatgaagtcctagcagaagtcatatgagggagttcacagtctcatggagtgcactgcgctgctgctgtccatgcacgcagtggactgaaggacactagctataggatccacacgggagcaggtgtcccaccatcatggagctgtcttatgtgtcatagtccattcttatatatctatcaaaacgtatactgaacaatgacttctgggttgcaaaagattttaacctgccttccatgcctttgtatacacacacacacaca

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