2024-09-28 09:29:47, GGRNA.v2 : RefSeq release 225 (Jul, 2024)
LOCUS NM_026067 5067 bp mRNA linear ROD 02-JUN-2024 DEFINITION Mus musculus exoribonuclease 1 (Eri1), mRNA. ACCESSION NM_026067 VERSION NM_026067.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 5067) AUTHORS Pirouz,M., Munafo,M., Ebrahimi,A.G., Choe,J. and Gregory,R.I. TITLE Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance JOURNAL Nat Struct Mol Biol 26 (6), 490-500 (2019) PUBMED 31160785 REMARK GeneRIF: 7SB ribosomal RNA can be oligoadenylated by an unknown enzyme and/or oligouridylated by TUT4/7 and subsequently processed by Dis3l2 and Eri1. REFERENCE 2 (bases 1 to 5067) AUTHORS Hoefig,K.P., Rath,N., Heinz,G.A., Wolf,C., Dameris,J., Schepers,A., Kremmer,E., Ansel,K.M. and Heissmeyer,V. TITLE Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay JOURNAL Nat Struct Mol Biol 20 (1), 73-81 (2013) PUBMED 23202588 REMARK GeneRIF: data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure REFERENCE 3 (bases 1 to 5067) AUTHORS Thomas,M.F., Abdul-Wajid,S., Panduro,M., Babiarz,J.E., Rajaram,M., Woodruff,P., Lanier,L.L., Heissmeyer,V. and Ansel,K.M. TITLE Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function JOURNAL Blood 120 (1), 130-142 (2012) PUBMED 22613798 REMARK GeneRIF: Mouse Eri1 regulates miRNA homeostasis in lymphocytes and is required for normal NK-cell development and antiviral immunity. REFERENCE 4 (bases 1 to 5067) AUTHORS Bian,Y., Zhou,W., Zhao,Y., Li,X., Geng,W., Hao,R., Yang,Q. and Huang,W. TITLE High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels JOURNAL PLoS One 6 (10), e26466 (2011) PUBMED 22039495 REFERENCE 5 (bases 1 to 5067) AUTHORS Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and Robson,P. TITLE Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst JOURNAL Dev Cell 18 (4), 675-685 (2010) PUBMED 20412781 REFERENCE 6 (bases 1 to 5067) AUTHORS Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K., Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T., Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M., Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H. TITLE A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58 JOURNAL Dev Cell 17 (6), 836-848 (2009) PUBMED 20059953 REFERENCE 7 (bases 1 to 5067) AUTHORS Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z. TITLE Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA JOURNAL Mol Cell Biol 29 (15), 4045-4056 (2009) PUBMED 19470752 REFERENCE 8 (bases 1 to 5067) AUTHORS Ansel,K.M., Pastor,W.A., Rath,N., Lapan,A.D., Glasmacher,E., Wolf,C., Smith,L.C., Papadopoulou,N., Lamperti,E.D., Tahiliani,M., Ellwart,J.W., Shi,Y., Kremmer,E., Rao,A. and Heissmeyer,V. TITLE Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing JOURNAL Nat Struct Mol Biol 15 (5), 523-530 (2008) PUBMED 18438418 REMARK GeneRIF: Findings indicate that Eri1 catalyzes the final trimming step in 5.8S rRNA processing, functionally and spatially connecting this regulator of RNAi with the basal translation machinery. REFERENCE 9 (bases 1 to 5067) AUTHORS Hong,J., Qian,Z., Shen,S., Min,T., Tan,C., Xu,J., Zhao,Y. and Huang,W. TITLE High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse JOURNAL Biochem J 390 (Pt 3), 675-679 (2005) PUBMED 16004606 REMARK GeneRIF: The roles of meri-1 (mouse enhanced RNAi) and adar1 in the regulation of RNA interference are reported. COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK014410.1, AK165026.1, AK161031.1 and AK050230.1. On Jan 17, 2008 this sequence version replaced NM_026067.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.248668.1, AK144223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 AK014410.1 3-74 73-1850 AK165026.1 2-1779 1851-3997 AK161031.1 716-2862 3998-5067 AK050230.1 3063-4132 FEATURES Location/Qualifiers source 1..5067 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="8" /map="8 21.16 cM" gene 1..5067 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="exoribonuclease 1" /db_xref="GeneID:67276" /db_xref="MGI:MGI:1914526" exon 1..262 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" misc_feature 128..130 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="upstream in-frame stop codon" CDS 167..1204 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="three prime histone mRNA exonuclease 1; histone mRNA 3' end-specific exonuclease; enhanced RNAi protein 1; eri-1 homolog; 3'-5' exonuclease ERI1; histone mRNA 3'-exonuclease 1" /codon_start=1 /product="3'-5' exoribonuclease 1" /protein_id="NP_080343.4" /db_xref="CCDS:CCDS22244.1" /db_xref="GeneID:67276" /db_xref="MGI:MGI:1914526" /translation="
MEDERGRERGGDAAQQKTPRPECEESRPLSVEKKQRCRLDGKETDGSKFISSNGSDFSDPVYKEIAMTNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKESSAGDSYYDYICIIDFEATCEEGNPAEFLHEIIEFPVVLLNTHTLEIEDTFQQYVRPEVNDQLSEFCIGLTGITQDQVDRADAFPQVLKKVIEWMKSKELGTKYKYCILTDGSWDMSKFLSIQCRLSRLKHPAFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHSGLDDSKNIARIAIRMLQDGCELRINEKILGGQLMSVSSSLPVEGAPAPQMPHSRK"
misc_feature 167..316 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="propagated from UniProtKB/Swiss-Prot (Q7TMF2.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 329..331 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q8IV48; propagated from UniProtKB/Swiss-Prot (Q7TMF2.2); phosphorylation site" misc_feature 338..340 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q8IV48; propagated from UniProtKB/Swiss-Prot (Q7TMF2.2); phosphorylation site" misc_feature 380..484 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="SAP domain; Region: SAP; pfam02037" /db_xref="CDD:460424" misc_feature 542..1084 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133" /db_xref="CDD:99836" misc_feature order(554..565,569..571,707..709,842..856,866..868, 1031..1033,1046..1048) /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="active site" /db_xref="CDD:99836" misc_feature order(554..565,569..571,707..709,842..856,866..868, 1031..1033,1046..1048) /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:99836" misc_feature order(554..556,560..562,854..856,1031..1033,1046..1048) /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="catalytic site [active]" /db_xref="CDD:99836" exon 263..441 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" exon 442..652 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" exon 653..736 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" exon 737..846 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" exon 847..961 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" exon 962..5067 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /inference="alignment:Splign:2.1.0" regulatory 1562..1567 /regulatory_class="polyA_signal_sequence" /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="hexamer: AATACA" polyA_site 1582 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="major polyA site" regulatory 3069..3074 /regulatory_class="polyA_signal_sequence" /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="hexamer: ATTAAA" polyA_site 3095 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="major polyA site" regulatory 3981..3986 /regulatory_class="polyA_signal_sequence" /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="hexamer: ATTAAA" polyA_site 4007 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="major polyA site" regulatory 4392..4397 /regulatory_class="polyA_signal_sequence" /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="hexamer: ATTAAA" polyA_site 4418 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" regulatory 5047..5052 /regulatory_class="polyA_signal_sequence" /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" /note="hexamer: AATAAA" polyA_site 5067 /gene="Eri1" /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1" ORIGIN
cacacgctcccggaagtaggaggcgtccggcggagtttgtgtggcggccgccgcgggaacgtgaagcgcggtagtttttcaagggagagagcgaggcggcttcccgcgggtctcggtggaccgacagtgagcgtccgcggccgtctcgcggcccgcgagaggcggcatggaggacgagcggggccgggagcgtggcggcgacgcggcgcagcagaagacgccgcggccggagtgtgaggagtcccggccgctgagcgtggagaaaaagcagcgatgcagacttgatggcaaagagacagatggatcgaagttcatttcctccaatggcagtgacttcagtgacccggtttacaaagagatcgcaatgacaaacggttgtatcaaccggatgagtaaggaggaactcagagctaaactttcagaatttaagcttgaaacaagaggagtcaaggatgttctaaagaagagactgaaaaactattacaagaagcagaagttgatgctgaaagagagctccgctggggacagttactatgactacatttgtatcattgactttgaggctacttgtgaagaggggaacccagctgagttcctacatgaaatcattgagtttcctgttgtcctgttgaatacacacaccttagaaatcgaagatacgtttcagcagtatgtgaggccagaagtcaatgatcagctttcagagttctgcatcggtcttactggaatcactcaggatcaggtagacagagccgatgctttccctcaggtcctgaaaaaagtgattgagtggatgaagtcaaaggagttgggaactaagtacaagtactgtatactaacagatggctcctgggatatgagtaagttcctgagcatccagtgccggctcagcagactcaaacacccggccttcgctaagaagtggatcaatatccggaagtcatacggaaacttctataaggttcccagaagccagaccaaactaacaataatgcttgaaaaattaggaatggattatgatggacggcctcacagcggtctcgatgactctaagaacattgctagaatagctattcggatgcttcaggatggatgtgaacttcgaatcaatgaaaaaatacttggagggcagttgatgagtgtgtcctcatccttaccagtagagggcgctccagctccacagatgccacatagtagaaagtaactgcagttttgtctgatcagttgctacaaaagtagcaggcgaatgaatctgagttaatgcaaccttcaagcaccttaaacatttaagatcttattacaattacagatagatgggtatgtatgcagacattttgtgggaggacacaccaaattctttgtcaccagcacttttgatctgagcagtatttgttacacacagtaaccagtctctgctcagaactgaattttataatgtaaggtgtccaagatgtgtcccttggcttttaagatggaagttttatcagaaaattctttacatgtcatgttcttattgatactggaatttaaaatgaatttctacattaccaccatgaaattaaatacattttttgaaaatgtggaaaggattgaaaggtagtgtttgcccattgagttttaagtaaaacgtggttcttttaactttgtaagtttgtaggtgaagtgagggctttgtcccaagaaggctgtgtgggtaccagattctgcaagtgttgaagttctatagttcaagtggcataatgtttctatataacctacacgttctcccacatattttaatcatctctgggtagcttatacttaataaactataaagaaatggttgtatcatttagggaataatgacaaggaaaaaaaaaagcctgcaagttgatgtagacacaaccatagtgggccttgctacatagctcatgagctaaaaaaaaaccaagatctgagatggtggaggcaacttcagctgtcccctgcgtcactctctggccagcagctgtccccccctgcgtcactcactctggtccactcagcaaagtgcttgctgagcagcaaattcaggtgtttcttcttggaacattttcggcatatctgtgtatagcctatattcaagccaggaagttgtttctaaaggtgtctactttgacagccctgaacacacatgacccccagaacacacgtgatagactaagagaatcaactcagctcaaggatgataaagtactgggaccagtttcatattataactggaaaccttgtaataggtcatagaatttagttaaaaatctagttactggaggctagcaagatggctcagtggttaaaagtacttgcttctcttgtagaagatccaagttcaattcccagaacccacatggtggctcacaaccatctgtaagtttcaaagaatccaacaggcaaaacattcataaacataaaataactaaatttagaatactgggctggagagatgcctcagaagttaagagtgctggctgctctttgagaggccctgaagttcaattcccagcacccacatagtggctcccaaccccctacaatgagactgctgtcctcttctggcatgcaggcagaatgttgtatatataatatatacatcctttttaaaagtctaattactggtgagactaatggaaagttagaaaaggcagcctggtagcacagatgtgtaatttcagtcctcaagagttaaggcataggtgaatctgaagccactctgagccatataatgagctcctgattccaaaatgtgtcagtagaaaatacaagtgaacttgtgagagctataacttacaaatcaatgggaaaatctgaagatttgctccttgccttccctcaccattgtgaatgtatattcgccctgcttttgagctcatggtaaacatttgtattcagtactgtgaggtgaaatgttttgttccatagtaaaaagtacctggcttgtcttggtgagtgaccagtatatattggaaagtaattcctgcttctaaagtcaagatgtgctctggagatgatgatgtcatactgtctggaggctaacagtgggagcttttggaattaaacccctctaatgctttcctggacccatctcattggcattgcctgttgttttgttttttcaactttccttaatgattgtgatcatattatgtccatcaccactataatcaagtagattgatcatgtttcctaactcggacataggaggaacgacagcgatgcgcttgggaccatgagaatttgctacccaggcttgcggtttcattccccagtgagctctgtcttgaagcaaagggacaggaaatggtcattgtgagggacagaagccagcaggctctctggactgacttactcttcattttctcacataagccatggtgacacaggcaggttcatgccctagaaaaataattgcttgtcacctgattgcatagttgctactgaatagggaaactaccattgggaagttagagaatagcaggacatactaatgccttcctctttgttttgtttttaaatcaggctgtttaaattttttcctaatcaagtgcttaacattttttttttaaagaacttaacactgcaagcttttaaaatgcttttggctctactaagtatttcgccatcttcactcactctgagtctctgtcaaaccatttgatttggctttctgctgatataacctgtctgtaagttatagagtgagtcataattcttgaaaggaaactactgcagcctgcctgcctacgttgtgtgtaaagatactggttcttgttactgctgggatggcttacactggtgctagtgtttgctgatacttacttaaagctttattttctcagtcgccatggtcatctccttgttttccttttacttgcttggacattgagactgatttttccccctgtattattttcaaatccacacaaactggtatatattctcagctacattttgtctgattttgtattaaatactgacattgactctggaaatttttctttctctccacttctccctctgactgggtcaagcaaaagcaggaagaagaggttttcttttttttcagcatgtgtttctgcgtgtatgtgtgcctgggagagtttatgtgcaccatgtacccttagattcctgtggacgcctcagaactggagttgcaggtggccatgagcacctaatgtgggtgctgggatcctgagtcaatgcctctgcaagagccgtcgcactcaactctggggccatctctccagcctcaaggccctttcttgtagcctttagagacctgcttgtcctgctgtagggataggttttctcagctgggttaacaggaaagaccatgggagtcatgctaaactggtcctattgctgacgagtcatttattaaatggtgatttgattacttgaaaggtgaaagaacttttagttcatcgtcccagatattaaagcactattgcgaaggataaggaagaaggggtgggtagtaagatttctggggaaggagggatcacaagtgatcaatacaaggagcaccagtcaagtcacccacctcgagtgagccatgtcctttgtgaagtctgtgagtatgtgtcctgttgcaaggaagactttgagctgctggaggagactgacttccttagtgatgagctgtgaactcctcctttattccagcggggcctgttgagatgctttccgtgtgtaatgattgcagtgttggtaaatgagtagtcccactaagtatcgtccttagtgttgaccctcatttcagctcttcctgcccccacacagcatcaatgcacacactgtagccacgaaccaaatctgatagccaagtggcaagttaaaatcaagagtgcttgtatgtatgcatgtgtgtatgtatgtatatatgtatgtatgtttttgacagggtatgtctgtgtagtctaatcaggtttcaaattcttcggtactggaattacaggtaagtgctacctaccatgccaatgatgtgacttgtagcataggaattttatgaaataaaattttgatgttgtaaataaagctttgtggaatagc
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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