LOCUS       NM_025410                760 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus L antigen family, member 3 (Lage3), mRNA.
ACCESSION   NM_025410
VERSION     NM_025410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Cruz-Soto,M.E., Scheiber,M.D., Gregerson,K.A., Boivin,G.P. and
            Horseman,N.D.
  TITLE     Pituitary tumorigenesis in prolactin gene-disrupted mice
  JOURNAL   Endocrinology 143 (11), 4429-4436 (2002)
   PUBMED   12399440
REFERENCE   4  (bases 1 to 760)
  AUTHORS   Alpen,B., Gure,A.O., Scanlan,M.J., Old,L.J. and Chen,Y.T.
  TITLE     A new member of the NY-ESO-1 gene family is ubiquitously expressed
            in somatic tissues and evolutionarily conserved
  JOURNAL   Gene 297 (1-2), 141-149 (2002)
   PUBMED   12384295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK002539.1.
            
            On Apr 6, 2007 this sequence version replaced NM_025410.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002539.1, DV065816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-760               AK002539.1         2-761
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..760
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="L antigen family, member 3"
                     /db_xref="GeneID:66192"
                     /db_xref="MGI:MGI:1913442"
     exon            1..294
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    53..55
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="upstream in-frame stop codon"
     CDS             92..538
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="ITBA2 protein homolog"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Lage3"
                     /protein_id="NP_079686.1"
                     /db_xref="CCDS:CCDS30229.1"
                     /db_xref="GeneID:66192"
                     /db_xref="MGI:MGI:1913442"
                     /translation="

MQTAHTGLSHTADGADGQTSRCCPGNAGTKAVIPSGAHPVARALEASRNSSKSMVPLTQRPGTRHHRFSLFVPFPTSLEAEIACGSLVPDVEPHRGLVGKELKVSGCMLEVRWIAEDSRLLRLSIINFLDQLSLVVNTIQLFGPPVSC"

     misc_feature    92..154
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR70.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    290..511
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="Transcription factor Pcc1; Region: Pcc1; pfam09341"
                     /db_xref="CDD:462764"
     exon            295..423
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..760
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      727..732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="hexamer: AATAAA"
     polyA_site      751
                     /gene="Lage3"
                     /gene_synonym="1110049G11Rik; Eso3; Itba2"
                     /note="major polyA site"
ORIGIN      

cggaggataaggcgggttctgggccgcagcaatggcagaggcggcgggctggtaacgcgaaggtgggttgaaaggaggaacagcagcagacatgcagacagcacacacaggtttaagccacactgcagatggcgccgatggtcagactagccgctgttgtcctggtaatgcaggcacaaaggcagttattcccagtggagctcaccctgttgcaagagcactggaagcctcccgaaattccagcaaaagcatggtgcctttaacccaaaggcctggaacccgacatcacagattctccctcttcgtgcctttcccgacctctttggaggcagaaatcgcctgtgggtccctagttccagatgtcgaaccacatcgaggactggtagggaaggagcttaaagtgagcggctgcatgctggaggtacgctggatcgcggaagattctcgcctcctccgactttccatcatcaactttcttgaccagctttccctagtggtgaacaccatacagctctttgggcccccagtttcctgttaagcctggctggggacccatgtctgaccttatctccgtctcctcctaagcaatacaattttccctagggaaaagattctagaaatagtaactactacataaatgtgggggcctaatatttttttcctgatttggtcctcaggcacttaggagccatttggtctggtgcttcaatgtttgttgctgaagaaaataaagctatgttgctaatctgcatttgagctt

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