2024-07-01 23:26:10, GGRNA.v2 : RefSeq release 224 (May, 2024)
LOCUS NM_023258 2135 bp mRNA linear ROD 30-APR-2024 DEFINITION Mus musculus PYD and CARD domain containing (Pycard), mRNA. ACCESSION NM_023258 VERSION NM_023258.4 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2135) AUTHORS Li,J., Yao,H., Zhao,F., An,J., Wang,Q., Mu,J., Liu,Z., Zou,M.H. and Xie,Z. TITLE Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue JOURNAL Autophagy 20 (3), 629-644 (2024) PUBMED 37963060 REMARK GeneRIF: Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue. REFERENCE 2 (bases 1 to 2135) AUTHORS Marques-da-Silva,C., Schmidt-Silva,C., Baptista,R.P. and Kurup,S.P. TITLE Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection JOURNAL J Immunol 212 (4), 596-606 (2024) PUBMED 38149914 REMARK GeneRIF: Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection. REFERENCE 3 (bases 1 to 2135) AUTHORS Huang,W., Wang,B., Ou,Q., Zhang,X., He,Y., Mao,X., Wei,X. and Kou,X. TITLE ASC-expressing pyroptotic extracellular vesicles alleviate sepsis by protecting B cells JOURNAL Mol Ther 32 (2), 395-410 (2024) PUBMED 38093517 REMARK GeneRIF: ASC-expressing pyroptotic extracellular vesicles alleviate sepsis by protecting B cells. REFERENCE 4 (bases 1 to 2135) AUTHORS Ambite,I., Tran,T.H., Butler,D.S.C., Cavalera,M., Wan,M.L.Y., Ahmadi,S. and Svanborg,C. TITLE Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains JOURNAL Pathogens 13 (1), 42 (2023) PUBMED 38251349 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 2135) AUTHORS Li,D., Buhler,M., Runft,S., Gerold,G., Marek,K., Baumgartner,W., Strowig,T. and Gerhauser,I. TITLE ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus JOURNAL Sci Rep 13 (1), 10960 (2023) PUBMED 37414913 REMARK GeneRIF: ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2135) AUTHORS Yamamoto,M., Yaginuma,K., Tsutsui,H., Sagara,J., Guan,X., Seki,E., Yasuda,K., Yamamoto,M., Akira,S., Nakanishi,K., Noda,T. and Taniguchi,S. TITLE ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules JOURNAL Genes Cells 9 (11), 1055-1067 (2004) PUBMED 15507117 REFERENCE 7 (bases 1 to 2135) AUTHORS Mariathasan,S., Newton,K., Monack,D.M., Vucic,D., French,D.M., Lee,W.P., Roose-Girma,M., Erickson,S. and Dixit,V.M. TITLE Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf JOURNAL Nature 430 (6996), 213-218 (2004) PUBMED 15190255 REMARK GeneRIF: cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways REFERENCE 8 (bases 1 to 2135) AUTHORS Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C., Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R., Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A. CONSRTM RIKEN GER Group; GSL Members TITLE Comparative analysis of apoptosis and inflammation genes of mice and humans JOURNAL Genome Res 13 (6B), 1376-1388 (2003) PUBMED 12819136 REFERENCE 9 (bases 1 to 2135) AUTHORS Martinon,F., Hofmann,K. and Tschopp,J. TITLE The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation JOURNAL Curr Biol 11 (4), R118-R120 (2001) PUBMED 11250163 REFERENCE 10 (bases 1 to 2135) AUTHORS Masumoto,J., Taniguchi,S., Nakayama,K., Ayukawa,K. and Sagara,J. TITLE Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos JOURNAL Exp Cell Res 262 (2), 128-133 (2001) PUBMED 11139337 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DT921526.1, AK152677.1, CJ137522.1 and BG071362.2. On Jan 16, 2008 this sequence version replaced NM_023258.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK152677.1, AK018682.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-141 DT921526.1 1-141 142-1405 AK152677.1 2-1265 1406-1611 CJ137522.1 245-450 1612-2135 BG071362.2 1-524 c FEATURES Location/Qualifiers source 1..2135 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="7" /map="7 69.88 cM" gene 1..2135 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="PYD and CARD domain containing" /db_xref="GeneID:66824" /db_xref="MGI:MGI:1931465" exon 1..485 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /inference="alignment:Splign:2.1.0" misc_feature 182..184 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="upstream in-frame stop codon" CDS 215..796 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="PYD and CARD domain-containing protein" /codon_start=1 /product="apoptosis-associated speck-like protein containing a CARD" /protein_id="NP_075747.3" /db_xref="CCDS:CCDS21888.1" /db_xref="GeneID:66824" /db_xref="MGI:MGI:1931465" /translation="
MGRARDAILDALENLSGDELKKFKMKLLTVQLREGYGRIPRGALLQMDAIDLTDKLVSYYLESYGLELTMTVLRDMGLQELAEQLQTTKEESGAVAAAASVPAQSTARTGHFVDQHRQALIARVTEVDGVLDALHGSVLTEGQYQAVRAETTSQDKMRKLFSFVPSWNLTCKDSLLQALKEIHPYLVMDLEQS"
misc_feature 227..472 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="Pyrin Death Domain found in ASC; Region: Pyrin_ASC-like; cd08321" /db_xref="CDD:260033" misc_feature 545..787 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins; Region: CARD_ASC_NALP1; cd08330" /db_xref="CDD:260039" misc_feature 791..793 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9EPB4.1); phosphorylation site" exon 486..542 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /inference="alignment:Splign:2.1.0" exon 543..2135 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /inference="alignment:Splign:2.1.0" polyA_site 875 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="major polyA site" regulatory 1387..1392 /regulatory_class="polyA_signal_sequence" /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" /note="hexamer: ATTAAA" polyA_site 1412 /gene="Pycard" /gene_synonym="9130417A21Rik; Asc; CARD5; masc; TMS-1; TNS1" ORIGIN
caaaaagccaagtctgaaagtcttaggggcggaaaccaaaactagtttgctggggaaagaacaggagctgtaagaaaagagggtgggggagtcccagcatgcccatcggcctaagcagctgacttcctggtcttggcgggctggcagcaggcaggctgcagcaggcgagcagcagcaagagtaaaaggtgaccgcggctgcccaccccagagccatggggcgggcacgagatgccatcctggacgctcttgaaaacttgtcaggggatgaactcaaaaagttcaagatgaagctgctgacagtgcaactgcgagaaggctatgggcgcatcccacgcggggccctgctgcagatggacgccatagatctcactgacaaacttgtcagctactatctggagtcgtatggcttggagctcacaatgactgtgcttagagacatgggcttacaggagctggctgagcagctgcaaacgactaaagaagagtctggagctgtggcagctgcagccagtgtccctgctcagagtacagccagaacaggacactttgtggaccagcacaggcaagcactcattgccagggtcacagaagtggacggagtgctggatgctttgcatggcagtgtgctgactgaaggacagtaccaggcagttcgtgcagagaccaccagccaagacaagatgaggaagctcttcagctttgttccatcctggaacctgacctgcaaggactccctcctccaggccttgaaggaaatacatccctacttggtgatggacctggagcagagctgaggtatcttttccagctacattatctagctcctgactttgtatacacaatttttgaaaaaacaatttgtatttgtgtttactctctgggatgtttttgctgagctaagctacatttccaaaggccatatgtggcccagtggtagaacatataccaaacatgcacaaatcagtctccaacacctaaattccacagacccaagttatggcttctccattctagtgcaaaggcttctcaaatgattcctggctccccatttgggagcttttcccatattatcccaaaaggctacctttgagaacacatgtaacattatccaggtcaagctaaaaagcgagagggggggatgggaaccaggtaatggttaatcccagcaaccaggaggcagaggaggctgttccagaacagccaagggtacagagagaaaccctatctcaaaaaaacaaaaacaaaaaaaaaacaggcaatggggcttagaaaggcacctagaaacaaaccagtccgtagaagactttgggctctgggaactcctgtctagacaaggctggcctaactcaagagatctgcccagctctgcctcctgagttatgagattaaatgcatgtatcaccatgcccagcccaagcctttttttttttttaattatgtgtggattttgggggtggggctgttcatatgtgtgcaccatttcatgcaatgccaaccaaagccagaagagggcatcagatcccctggaacaggagttactggctgagcctccacacaatgctgggaatttaacatgggtttcccctggaaaaagcagtcgttacgactgcagaatcatctctccaaccccaagggcttatcctttaaagaaatgaagatcgtattgtgtgaatataaacacgggtgcatgtctgcacagaagcttgaagacaaactccagagttctgtttcttaccttgaggtagggaggagttcctgttctttttgctgcatactaactctgggctgtgagcttcagggccattctgtttctctcatctgtactttcaggtctctcagcagtgctgagattaacaggtattgccatcattcagtggacagaagacaaaaccagggtgaacgaagctctctacaaccgagtttcatccccagtccagtagctactcttccaagtgttatttatggtcctacctatggaattttttgaatctcacttgacccctagatccctgtcttaaataggcctgggatcaaaggcctaacaagttcacgtgaaatcttattagtgattggagaggacaaaaaaggttgccttttattggtatgcacagtctattagaagggtcctttgtg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]